Detection of variations in the dna methylation profile

ABSTRACT

The invention describes a set of oligonucleotides as probes for the detection of relevant variations of DNA methylation in a target group of genes, the use thereof for the detection of gene variants with respect to DNA methylation, a medical device which uses a set of oligonucleotides, a method for investigating the methylation state of an individual as well as a method for creating a model for evaluating the probability of occurrence of a health problem of an individual. Such disorders can be: undesired drug interactions cancer diseases CNS malfunctions, damage or disease symptoms of aggression or behavioral disturbances clinical, psychological and social consequences of brain lesions psychotic disturbances and personality disorders dementia and/or associated syndromes cardiovascular disorder, malfunction and damage malfunction, damage or disorder of the gastrointestinal tract malfunction, damage or disorder of the respiratory system lesion, inflammation, infection, immunity and/or convalescence malfunction, damage or disease of the body as an abnormality in the development process malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones endocrine and metabolic malfunction, damage or disorder headaches or sexual malfunction.

The invention concerns a set of oligonucleotides as probes for the detection of relevant variations of DNA methylation in a target group of genes, the use thereof for the detection of gene variants with respect to DNA methylation, a medical device which uses a set of oligonucleotides, a method for the investigation of the methylation state of an individual as well as a method for the construction of a model for evaluating the probability of occurrence of a health problem in an individual.

The levels of observation that have been well studied in molecular biology according to developments in methods in recent years include the genes themselves, the transcription of these genes into RNA and the translation to proteins therefrom. During the course of development of an individual, which gene is turned on and how the activation and inhibition of certain genes in certain cells and tissues are controlled can be correlated with the extent and nature of the methylation of the genes or of the genome. In this regard, pathogenic states are also correlated with a modified methylation pattern of individual genes or of the genome. The present invention describes sets of oligomers and a method for the detection of relevant variations of the DNA methylation in a target group of genes, which are associated with adverse events for patients/individuals or are associated with specific disorders.

5-Methylcytosine is the most frequent covalently modified base in the DNA of eukaryotic cells. For example, it plays a role in the regulation of transcription, in genetic imprinting and in tumorigenesis. The identification of 5-methylcytosine as a component of genetic information is thus of considerable interest. 5-Methylcytosine positions, however, cannot be identified by sequencing, since 5-methylcytosine has the same base-pairing behavior as cytosine. In addition, in the case of a PCR amplification, the epigenetic information which is borne by the 5-methylcytosines is completely lost.

A relatively new method that in the meantime has become the most widely used me-method for investigating DNA for 5-methylcytosine is based on the specific reaction of bisulfite with cytosine, which, after subsequent alkaline hydrolysis, is then converted to uracil, which corresponds in its base-pairing behavior to thymidine. In contrast, 5-methylcytosine is not modified under these conditions. Thus, the original DNA is converted so that methylcytosine, which originally cannot be distinguished from cytosine by its hybridization behavior, can now be detected by “standard” molecular biology techniques as the only remaining cytosine, for example, by amplification and hybridization or sequencing. The prior art, which concerns sensitivity, is defined by a method that incorporates the DNA to be investigated in an agarose matrix, so that the diffusion and renaturation of the DNA is prevented (bisulfite reacts only on single-stranded DNA) and all precipitation and purification steps are replaced by rapid dialysis (Olek, A. et al., Nucl. Acids Res. 1996, 24, 5064-5066). Individual cells can be investigated by this method, which illustrates the potential of the method. Of course, up until now, only individual regions of up to approximately 3000 base pairs long have been investigated; a global investigation of cells for thousands of possible methylation analyses is not possible. Of course, this method also cannot reliably analyze very small fragments of small quantities of sample. These are lost despite the protection from diffusion through the matrix.

An overview of other known possibilities for detecting 5-methylcytosines can be derived from the following review article: Rein, T., DePamphilis, M. L., Zorbas, H., Nucleic Acids Res. 1998, 26, 2255.

With just a few exceptions (e.g. Zechnigk, M. et al., Eur. J. Hum. Gen. 1997, 5, 94-98), the bisulfite technique has only been applied in research up to now. However, short, specific segments of a known gene are always amplified after a bisulfite treatment and either completely sequenced (Olek, A. und Walter, J., Nat. Genet. 1997, 17, 275-276) or individual cytosine positions are detected by a “primer extension reaktion” (Gonzalgo, M. L. and Jones, P. A., Nucl. Acids Res. 1997, 25, 2529-2531, WO Patent 95-00669) or an enzyme step (Xiong, Z. and Laird, P. W., Nucl. Acids. Res. 1997, 25, 2532-2534). Detection by hybridization has also been described (Olek et al., WO 99 28498).

Other publications which are concerned with the application of the bisulfite technique for the detection of methylation in the case of individual genes are: Xiong, Z. and Laird, P. W. (1997), Nucl. Acids Res. 25, 2532; Gonzalgo, M. L. and Jones, P. A. (1997), Nucl. Acids Res. 25, 2529; Grigg, S. and Clark, S. (1994), Bioassays 16, 431; Zeschnik, M. et al. (1997), Human Molecular Genetics 6, 387; Teil, R. et al. (1994), Nucl. Acids Res. 22, 695; Martin, V. et al. (1995), Gene 157, 261; WO 97 46705, WO 95 15373 and WO 45560.

An overview of the state of the art in oligomer array production can be derived also from a special issue of Nature Genetics which appeared in January 1999 (Nature Genetics Supplement, Volume 21, January 1999), the literature cited therein and U.S. Pat. No. 5,994,065 on methods for the production of solid supports for target molecules such as oligonucleotides in the case of reduced nonspecific background signal.

Probes with multiple fluorescent labels are used for scanning an immobilized DNA array. The fluorescence of the hybridized probes is detected, for example, by means of confocal optics.

More recent methods for the detection of mutations, which also can be used, in principle but with several modifications, for methylation analyses after the bisulfite treatment of DNA samples, are listed below:

-   -   As a special case of sequencing, single-base primer extension         (Genetic Bit Analysis) is worthy of mention (Head, S R., Rogers,         Y H., Parikh K., Lan, G., Anderson, S., Goelet, P., Boycejacino         M T., Nucleic Acids Research. 25(24): 5065-5071, 1997;         Picoult-Newberg, L., Genome Res. 9(2): 167-174, 1999). A         combined amplification and sequencing is described in U.S. Pat.         NO. 5,928,906, in which a base-specific termination on matrix         molecules is utilized. Another method utilizes a         ligase/polymerase reaction for the identification of nucleotides         (U.S. Pat. No. 5,952,174).

Genomic DNA is obtained from DNA of cells, tissue or other test samples by standard methods. This standard methodology is found in references such as Fritsch and Maniatis, eds., Molecular Cloning: A Laboratory Manual, 1989.

At present, it is not state of the art to investigate large quantities of samples relative to a multiple number of methylation positions that are important for diseases.

The object of the present invention is to make up sets of oligomer probes that bind to genes which are of importance relative to adverse events for patients or relative to specific groups of diseases, so that comprehensive prognostic information will be possible for the patient in question by analysis of the respective methylation state. The data detected in this way are combined to make up methylation patterns. In addition, a method will be created which makes possible to a great extent the analysis of methylation positions with the use of the above-mentioned oligomer probes.

The object is [solved] according to the invention by a set of nucleotide probes and a method for the investigation of the methylation profile of a patient or individual. The presence or absence of the relevant methylation variants from the target group of genes is detected by means of the set of oligonucleotide probes and/or by means of the method. A diagnosis is made from the methylation pattern by comparing it to methylation patterns in a database, which have already been assigned to specific phenotypes, prognoses or effects on the patient.

This object is solved according to the invention by a set of nucleotide probes according to one or more of the claims. In addition, to solve the object, a method or a device can be utilized, which contains a set of the above-mentioned nucleotide probes. Advantageous embodiments of the invention are characterized in the respective subclaims.

The set of oligonucleotide probes according to the invention or a device which contains this set preferably serves for the prognosis and planned treatment of patients who suffer from the consequences of subsequent adverse events or in whom there is a risk of the occurrence of the following adverse events:

-   -   undesired drug interactions     -   cancer diseases     -   CNS malfunctions, damage or disease     -   symptoms of aggression or behavioral disturbances     -   clinical, psychological and social consequences of brain lesions     -   psychotic disturbances and personality disorders     -   dementia and/or associated syndromes     -   cardiovascular disorder, malfunction and damage     -   malfunction, damage or disorder of the gastrointestinal tract     -   malfunction, damage or disorder of the respiratory system     -   lesion, inflammation, infection, immunity and/or convalescence     -   malfunction, damage or disorder of the body as an abnormality in         the development process     -   malfunction, damage or disorder of the skin, the muscles, the         connective tissue or the bones     -   endocrine and metabolic malfunction, damage or disorder     -   headaches or     -   sexual malfunction.

This list is not conclusive and it is clear to the person of average skill in the art that the concept of the invention is applicable to any disease or malfunction of an organism or individual.

The oligomer probes comprise sequences which bind to genes that are associated with these adverse events. The oligomer probes bind to sequences as they are present after a treatment of the DNA sample which converts unmethylated cytosine to uracil. The genes are listed in detail in the claims. According to the invention, these genes belong to at least one of the following protein functions: enzyme, transport, storage, structure, immunity, neuronal transmission, growth and differentiation.

The method will be described in the following for an evaluation of whether adverse events will occur or will probably occur in a patient, an individual or a population, by using the set of oligomer probes. In the first step, a DNA sample is taken from the patient or individual, in whom an adverse event was diagnosed not and from a control group in whom the event was diagnosed. In the second step of the method, the DNA samples, which have been pretreated by means of the solution of a bisulfite, hydrogen sulfite or disulfite, are hybridized with a set of oligonucleotides as probes, which bind to the sequences in which a cytosine methylation is potentially present after bisulfite treatment within the respective target group of genes, in order to detect relevant gene variants with respect to DNA methylation. A hybridization pattern results, which is translated into a methylation pattern of the genes of the respective DNA sample in the third step of the method.

The procedure would be the same if one wanted to construct a model for evaluating risks for patients or patient groups.

According to the invention, these genes belong to at least one of the following protein functions: enzyme, transport, storage, structure, immunity, neuronal transmission, growth and differentiation. Said genes are associated with a multiple number of adverse events, including:

-   -   undesired drug interactions     -   cancer diseases     -   CNS malfunctions, damage or disease     -   symptoms of aggression or behavioral disturbances     -   clinical, psychological and social consequences of brain lesions     -   psychotic disturbances and personality disorders     -   dementia and/or associated syndromes     -   cardiovascular disorder, malfunction and damage     -   malfunction, damage or disorder of the gastrointestinal tract     -   malfunction, damage or disorder of the respiratory system     -   lesion, inflammation, infection, immunity and/or convalescence     -   malfunction, damage or disorder of the body as an abnormality in         the development process     -   malfunction, damage or disorder of the skin, the muscles, the         connective tissue or the bones     -   endocrine and metabolic malfunction, damage or disorder     -   headaches or     -   sexual malfunction.

The oligonucleotide probes are characterized by the fact that they are complementary to the DNA sequences of the target group of genes or correspond to them as they are present after a chemical treatment which converts unmethylated cytosines to uracil, preferably a treatment with sodium bisulfite.

In the last step of the method, the frequency of alleles with different methylation patterns is calculated and compared with the frequencies of alleles in patients and individuals with adverse events and the corresponding control group.

Preferably, at least one of the steps of the method will be conducted with a computer.

In a preferred variant of the method, the methylation pattern of an individual is compared with the entries already present in the database or with a model derived therefrom, in order to evaluate the risk of the occurrence of adverse events.

The set of oligonucleotides is preferably comprised of oligonucleotides, which are arranged on a support at known loci in a rectangular or hexagonal grid. This support is comprised of silicon, glass, polystyrene, aluminum, steel, iron, copper, nickel, silver, or gold.

A technical medical device which contains said set of oligonucleotides is preferably used for the detection of gene variants relative to methylation and different gene expression.

In a preferred variant of the method, said set of oligonucleotides or a device that contains them is used for predicting probable therapeutic consequences or adverse events as a consequence of a therapeutic intervention or as a consequence of taking specific medications.

In a preferred variant of the method, said set of oligonucleotides or a device is used for predicting probable symptoms when the above-listed adverse events occur and for predicting the probability of the occurrence of consequential disorders or other symptoms.

In another preferred variant of the method, said set of oligonucleotides or a device is used for the following objectives:

-   -   Development of new strategies for therapeutic intervention and         in clinical studies     -   Modeling and evaluating the effects of disorders and providing         measures for predicting health for individuals, ethnic groups,         patient groups, and populations     -   Optimizing therapeutic intervention

Another subject of the present invention is a kit for conducting an assay, with which the risk of a patient or individual of being subject to adverse events can be estimated. This kit comprises possibilities for testing for the presence or absence of relevant variations with respect to DNA methylation of the above-listed genes in a sample of genomic DNA. Reagents for use in the detection method are also included, such as well script, which describes the probability of a patient or individual of experiencing to undesired events.

The object of the invention is thus solved by a set of oligonucleotides as probes for the detection of relevant variations of DNA methylation in a target group of genes, characterized in that the oligonucleotides are complementary to the DNA sequence of the target group of genes or correspond to them as they are present after a chemical treatment which converts unmethylated cytosines to uracil, wherein the target group essentially comprises genes that are associated with a health problem of an individual.

It is preferred according to the invention that the set of oligonucleotides is characterized in that the health problems are: undesired drug interactions; cancer; CNS malfunctions, damage or disease; symptoms of aggression or behavioral disturbances; clinical, psychological and social consequences of a brain lesion; dementia and/or associated syndromes; psychotic disturbances and personality disorders; cardiovascular disease, malfunction or damage; malfunction, damage or disease of the gastrointestinal tract; damage or disease of the respiratory system; lesion, inflammation, infection, immunity and/or convalescence; malfunction, damage or disease of the body as a consequence of an abnormality in the development process; malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones; endocrine and metabolic malfunction; headaches; sexual malfunctions.

It is additionally preferred that the set of oligonucleotides is characterized in that the genes that are associated with undesired drug interactions are selected from Table 1, the genes that are associated with cancer are selected from Table 2, the genes associated with symptoms and consequences of CNS malfunction are selected from Table 3, the genes associated with symptoms of aggression or behavioral disturbances are selected from Table 4, the genes associated with the consequences of clinical, psychological and social consequences of a brain lesion are selected from Table 5, the syndromes associated with dementia and/or associated syndromes are selected from Table 6, the genes that are associated with psychotic disturbances and personality disorders are selected from Table 7, the genes associated with cardiovascular disease, malfunction or damage are selected from Table 8, the genes associated with malfunction, damage or disease of the gastrointestinal tract are selected from Table 9, the genes associated with malfunction, damage or disease of the respiratory system are selected from Table 10, the genes associated with lesion, inflammation, infection, immunity and/or convalescence are selected from Table 11, the genes associated with malfunction, damage or disease of the body as a consequence of an abnormality in the development process are selected from Table 12, the genes associated with a malfunction, damage or disease of the skin, the muscles, the connective tissue or the bones are selected from Table 13, the genes associated with endocrine and metabolic malfunction, damage or disease are selected from Table 14, the genes that are associated with headaches are selected from Table 15, and the genes that are associated with sexual malfunctions are selected from Table 16.

According to the invention, a set of oligonucleotides is preferred, in which oligonucleotides with up to 5% of the listed genes are not included.

In particular, a set of oligonucleotides is preferred, in which oligonucleotides with at least 95% of the listed genes are included, together with a limited number of additional, unlisted oligonucleotides.

A set of oligonucleotides is advantageous, in which up to 5% of the corresponding oligonucleotides of the listed genes are replaced by a complete set of 25% of other unlisted oligonucleotides.

In addition, a set of oligonucleotides for a target group of genes is advantageous, in which the chemically pretreated DNA sequence of the genes to be detected coincides at least up to 95% with the correspondingly pretreated DNA sequence of the genes from the above list.

A set of oligonucleotides is particularly advantageous, wherein the chemical pre-treatment is conducted by means of the solution of a bisulfite, hydrogen sulfite or disulfite.

A set of oligonucleotides that consists of a subgroup of the target group of genes is particularly advantageous.

According to the invention, a set of oligonucleotides is preferred in which the oligonucleotides are arranged on a support at known loci in a rectangular or hexagonal grid.

In addition, a set of oligonucleotides is preferred, wherein the oligonucleotides are arranged on a support, which is comprised of silicon, glass, polystyrene, aluminum, steel, iron, copper, nickel, silver or gold.

A set is particularly preferred, wherein the oligonucleotide probes are labeled via their mass, electrostatics, charge or fluorescence, or are labeled with radionuclides.

In particular, a set of oligonucleotides is preferably used in a biological investigation for the detection of said gene variants relative to DNA methylation.

A technical medical device is advantageous, which contains a set of oligonucleotides according to the invention, for use in an investigation for the detection of said gene variants, particularly as an indication of a higher risk of a patient or individual of developing symptoms and consequential signs of cancer or as an indication for a higher risk of the development of CNS malfunction, damage or disorder or for the patient or individual to experience symptoms and consequences of CNS malfunction, damage or disorder.

A technical medical device is particularly advantageous, which contains a set of oligonucleotides according to the invention, for use in an investigation for the detection of varying gene expression and/or for the prognosis and for the management of patients who suffer from the risk of developing symptoms and consequential signs of cancer and/or for use in an investigation of whether a patient or individual may have developed CNS malfunction, damage or disorder or whether it is probable that the patient or individual will experience the symptoms and consequences of CNS malfunction, damage or disorder.

According to the invention, a method for the investigation of the DNA methylation profile of a patient or an individual, which detects the presence or lack of the relevant methylation variants from the target group of genes is preferred in which a chemically pretreated nucleic acid sample of said patient or individual is hybridized to a set of oligonucleotides according to the invention and relating the hybridization pattern with the variations.

Particularly preferred is the use of a set of oligonucleotides according to the invention or a device according to the invention for the prognosis and/or planned treatment in patients, who suffer from a health problem or in whom the risk of onset of a health problem exists.

The use according to the invention is particularly advantageous for the prognosis and/or planned treatment for patients who suffer from the consequences of undesired drug interactions or in whom the risk of the occurrence of undesired drug interactions exists, who suffer from the risk of developing symptoms and consequential signs of cancer, who are affected by an increased risk of CNS malfunction, damage or disorder, who suffer from the consequences of symptoms of aggression or behavioral disturbances or in whom exists the risk of the occurrence of symptoms of aggression or behavioral disturbances, who suffer from the consequences of clinical, psychological and social consequences of a brain lesion or in whom exists the risk of the occurrence of consequences of clinical, psychological and social consequences of a brain lesion, who suffer from dementia and/or associated syndromes or in whom exists the risk of the occurrence of dementia and/or associated syndromes, who suffer from symptoms and consequences of psychotic disorders and personality disturbances or in whom the risk exists of the occurrence of psychotic disorders and personality disturbances, who suffer from symptoms or consequences of cardiovascular disease, malfunction or damage or in whom the risk exists of the occurrence of symptoms or consequences of cardiovascular disease, malfunction or damage, who suffer from symptoms and consequences of the malfunction, damage or disease of the gastrointestinal tract or in whom the risk exists of the occurrence of symptoms and consequences of the malfunction, damage or disease of the gastrointestinal tract, who experience clinical or social consequences that result from the malfunction, damage or disease of the respiratory system or in whom the risk exists of clinical or social consequences that result from malfunction, damage or disease of the respiratory system, who suffer from the symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence or in whom the risk exists of the occurrence of symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence, who suffer from the consequences of malfunction, damage or disorder of the body as a consequence of an abnormality in the development process or in whom the risk exists of the occurrence of malfunction, damage or disorder of the body as a consequence of an abnormality in the development process, who suffer from the consequences of a malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones or in whom the risk exists of the occurrence of a malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones, who suffer from the consequences of endocrine and metabolic malfunction, damage or disorder or in whom the risk exists of the occurrence of endocrine and metabolic malfunction, damage or disorder, who suffer from the consequences of headaches or in whom the risk exists of the occurrence of headaches, and/or who suffer from the consequences of sexual malfunctions or in whom the risk exists of the occurrence of sexual malfunctions.

The use of a set of oligonucleotides according to the invention or of a device according to the invention is preferred for predicting the probable therapeutic consequences of undesired drug interactions as a consequence of a therapeutic intervention and/or for predicting the probable therapeutic consequences and adverse results as a consequence of a therapeutic intervention.

In addition, the use of a set of oligonucleotides according to the invention or a device according to the invention is preferred for predicting probable therapeutic risks or of undesired drug interactions as a consequence of taking specific medications.

The use of a set of oligonucleotides according to the invention or of a device according to the invention is particularly preferred for predicting the probable symptoms if undesired drug interactions occur and the probability of the occurrence of consequential disorders or other symptoms and/or for predicting probable patterns of disease symptoms and the probability of the occurrence of consequential disorders or other symptoms.

The use of a set of oligonucleotides according to the invention or a device according to the invention is advantageous for the development of new strategies in therapeutic intervention and in clinical studies and/or for the prognosis or management of patients, who suffer from developing symptoms of aggression or behavioral disturbances or who belong to risk groups for said disturbances, and/or for modeling and evaluating the effects of disorders and providing precautionary measures health measures for individuals, ethnic groups, patient groups, and populations, and/or for generating a model in order to estimate the risk for individuals, ethnic groups, patient groups, and populations, for developing symptoms and consequential signs of cancer, and/or for generating a model for evaluating the risk of the development of symptoms and consequential signs of CNS malfunction, damage or disease, and/or for optimizing the therapeutic intervention.

A method is particularly advantageous for creating a model for evaluating whether a health problem will occur or will probably occur in a patient, an individual, or ethnic groups, which comprises the following steps:

-   -   a) a DNA sample is taken from the patient or individual, in whom         a health problem has been diagnosed;     -   b) DNA samples are taken from a control group of individuals in         whom the presence of this health problem has been concluded         diagnostically;     -   c) the samples obtained in a) and b) are analyzed to determine         the DNA methylation variation with the target group of genes         according to the invention;     -   d) the frequency of alleles with different methylation patterns         in samples from a) and b) is calculated;     -   e) the frequencies of the alleles in the samples from a) and b)         are compared,     -   f) a statistical analysis is conducted of the results obtained         under e) in order to obtain a model for evaluating the risk of         the occurrence of health problems.

A method according to the invention is preferred, wherein the health problem is selected from: undesired drug interactions; cancer; symptoms and consequential signs of CNS malfunction, damage or disorder; developing symptoms of aggression or behavioral disturbances; consequences of clinical, psychological and social consequences of a brain lesion; dementia and/or associated syndromes; psychotic disturbances and personality disorders; symptoms or consequences of cardiovascular disorder, malfunction or damage; symptoms and consequences of malfunction, damage or disease of the gastrointestinal tract; malfunction, damage or disease of the respiratory system; symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence, malfunction, damage or disease of the body as a consequence of an abnormality in the development process; malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones; endocrine and metabolic malfunction, damage or disorder; headaches; sexual malfunctions.

A method is of advantage for evaluating whether a specific individual bears the risk of the occurrence of a health problem, wherein the methylation profile is compared with the model constructed according to the invention.

A method is particularly of advantage according to which at least one of the steps is conducted by a computer.

In addition, a configured assay [hit] is advantageous for utilizing the estimation of the risk of a patient or individual of experiencing adverse events and/or health problems, said kit containing:

-   -   a) Possibilities for testing for the presence or absence of key         relevant polymorphic DNA variations of the core group of genes         according to the invention in a sample of genomic DNA.     -   b) Reagents for use in the detection method.     -   c) A script, which describes the probability of a patient or         individual of experiencing adverse events and/or health         problems.

A configured assay [kit] is particularly advantageous for utilizing the estimation of the risk of a patient or an individual of experiencing adverse events and/or health problems, characterized in that the adverse event or the health problem is selected from the following:

-   -   undesired drug interactions; cancer; symptoms and consequential         signs of CNS malfunction, damage or disorder; developing         symptoms of aggression or behavioral disturbances;     -   consequences of clinical, psychological and social consequences         of a brain lesion; dementia and/or associated syndromes;         psychotic disturbances and personality disorders; symptoms or         consequences of cardiovascular disorder, malfunction or damage;         symptoms and consequences of malfunction, damage or disease of         the gastrointestinal tract; malfunction, damage or disease of         the respiratory system;

symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence; malfunction, damage or disease of the body as a consequence of an abnormality in the development process; malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones; endocrine and metabolic malfunction, damage or disorder; headaches; sexual malfunctions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00001 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00002 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00003 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00004 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00005 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00006 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00007 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00008 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00009 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00010 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00011 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00012 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00013 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00014 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00015 Please refer to the end of the specification for access instructions. LENGTHY TABLE REFERENCED HERE US20070026393A1-20070201-T00016 Please refer to the end of the specification for access instructions. LENGTHY TABLE The patent application contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20070026393A1) An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3). 

1. A set of oligonucleotides as probes for the detection of relevant variations of 5 DNA methylation in a target group of genes, hereby characterized in that the oligonucleotides are complementary to the DNA sequence of the target group of genes or correspond to them, as they are present after a chemical treatment, which converts unmethylated cytosines to uracil, wherein the target group essentially comprises genes that are associated with a health problem of an individual.
 2. The set of oligonucleotides according to claim 1, further characterized in that the health problems are undesired drug interactions; cancer; CNS malfunctions, damage or disease, symptoms of aggression or behavioral disturbances; clinical, psychological and social consequences of a brain lesion; dementia and/or associated syndromes; psychotic disturbances and personality disorders; cardiovascular disorder, malfunction or damage malfunction, damage or disease of the gastrointestinal tract; damage or disease of the respiratory system; lesion, inflammation, infection, immunity and/or convalescence; malfunction, damage or disease of the body as a consequence of an abnormality in the development process; malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones; endocrine and metabolic malfunction; headaches or sexual malfunctions.
 3. The set of oligonucleotides according to one of claims 1 or 2, further characterized in that the genes associated with the undesired drug interactions are selected from: HUGO Protein- List of genes gene symbol function 5-Adenosyl homocysteine hydrolase 1 Acetoacetyl 1-CoA-thiolase ACAT1 1 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetyl CoA acyltransferase ACAA 1 Acetylcholine receptor, nicotinic, alpha A1 CHRNA1 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor, nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNB1 5 Acetylcholine receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTA1 3 Actin, alpha, smooth, aortic ACTA2 3 Actin, beta ACTB 3 Actin, gamma 2 ACTG2 3 Acyl CoA dehydrogenase, short chain ACADS 1 Adenine phosphoribosyltransferase APRT 2 Adenosine deaminase ADA 1 Adenosine monophosphate deaminase AMPD 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adenylate kinase AK1 1 Adenylate transferase 1 Adenylosuccinate lyase ADSL 1 ADP-ribosyltransferase ADPRT 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Adrenoleukodystrophy gene ALD 1 Albumin, ALB ALB 2 Alkaptonuria gene AKU 6 Alpha I acid glycoprotein AAG, AGP 2 Alpha-1-antitrypsin PI 1 Alpha-2-antiplasmin PLI 1 Alpha-amylase 1 Alpha-fetoprotein AFP 6 Alpha-glucosidase, neutral AB GANAB 1 Alpha-glucosidase, neutral C GANC 1 Aminomethyltransferase AMT 1 Aminopeptidase P XPNPEP2 1 Amyloid beta (A4) precursor protein-binding, APBB1 5 APBB1 Amyloid beta (A4) precursor protein APP 5 Androgen binding protein ABP 2 Androgen receptor AR 6 Angiotensin converting enzyme ACE, DCP1 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Annexin I ANX 1 Apurinic endonuclease APE 1 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 1B AVPR1B 5 Arginine vasopressin receptor 2 AVPR2 5 Aryl hydrocarbon receptor AHR 2 Arylsulfatase E ARSE 1 Aspartate transcarbamoylase 1 Ataxia teiangiectasia gene, AT ATM 6 ATP cobalamin adenoxyltransferase 1 ATP sulphurylase atpsk2 1 ATP/ADP translocase 1 Atriai natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 BCL2-associated X protein BAX 6 Benzodiazepine receptor 5 Beta-endorphin receptor 5 Bile acid coenzyme A: amino acid N- BAAT 1 acyltransferase Bile salt export pump BSEP, PFIC2 2 Bile salt-stimulated lipase CEL 1 Billrubin UDP-glucuronosyltransferase 1 Biliverdin reductase 2 Bleomycin hydrolase BLMH 1 Bradykinin receptor B1 4 Bradykinin receptor B2 4 Breakpoint cluster region BCR 6 Breast cancer 1 BRCAI 6 Breast cancer 2 BRCA2 6 Brush border guanylyl cyclase 1 Butyrylcholinesterase BCHE 1 Ca(2+) transporting ATPase, fast twitch ATP2A1 2 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Calcineurin A1 CALNA1 4 Calcineurin A2 CALNA2 4 Calcineurin A3 CALNA3 4 Calcineurin B Calcitonin receptor/Calcitonin gene-related CALCR 5 peptide receptor Calcium channel, voltage-dependent, alpha 1F CACNA1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA1C 5 1C Calcium channel, voltage-dependent, Alpha- CACNA1D 5 1D Calcium channel, voltage-dependent, Alpha- CACNA1E 5 1E (CACNLIA6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNBI 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNA1S 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Canalicular multispecific organic anion CMOAT 2 transporter Cannabinoid receptor CNR1 5 Carbamoylphosphate synthetase 1 CPS1 1 Carbamoylphosphate synthetase 2 CPS2 1 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Carnitine transporter protein CDSP, SCD 2 Carnosinase 5 Cartilage-hair hypoplasia gene CHH 5 Catalase CAT 4 Catechol-o-methyltransferase COMT 1 Catenin, beta CTNNBL 6 Cell adhesion molecule, vascular, VCAM VCAM1 6 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Cholesterol ester transfer protein CETP 2 Choline acetyltransferase CHAT 1 CoA transferase 1 Colony-stimulating factor 1 CSF1 6 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 3 CSF3 6 Colony-stimulating factor 3 receptor CSF3R 6 Complex V MTATP6 1 Coproporphyrinogen oxidase CPO 1 Cortico-steroid binding protein 2 Corticosteroid nuclear receptor 4 Corticotrophin-releasing hormone receptor CRHR1 2 Creb binding protein CREBBP 6 Crystallin, alpha A CRYAA 3 Crystallin, alpha B CRYAB 3 Crystallin, beta B2 CRYBB2 3 Crystallin, gamma A CRYGA 3 Cu2+ transporting ATPase alpha polypeptide ATP7A 1 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cyclic AMP response element binding protein CREB 6 Cyclic AMP response element modulator CREM 6 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase I B I PDEIB1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin F CCNF 6 Cyclin-dependent kinase inhibitor 1 A (P21, CDKNIA 6 cipi) Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 Cyclophilin 4 CYPL1A1 CYPl1A1 1 CYPlIB1 CYPI1B1 1 CYPL1B2 CYPl1B2 1 CYPI7 CYP17 1 CYP19 CYPI9 1 CYPlA1 CYPlA1 1 CYPIA2 CYPlA2 1 CYPIBL cyplb1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2CI8 CYP2C18 1 CYP2CI9 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2EI 1 CYP2F1 CYP2FI 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4AI1 GYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytokine-suppressive antiinflammatory drug- CSBPL 4 binding protein I Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 Deoxycytidine kinase DCK 1 Deoxyuridine triphosphatase; dUTPase 1 DHEA sulfotransferase STD 1 Dihydrodiol dehydrogenase 1 DDHL 1 Dihydrofolate reductase DHFR 1 Dihydrolipoamide branched chain transacylase DBT 5 Dihydroiipoamide dehydrogenase DLD 5 Dihydrolipoyl dehydrogenase 2 PDHA 1 Dihydrolipoyl transacetylase PDHA 1 Dihydroorotase 1 Dihyropyrimidine dehydrogenase DPYD 1 Disrupted meiotic CDNA 1, homolog DMC1 6 DNA damage binding protein, DDBI DDBI 3 DNA damage binding protein, DDB2 DDB2 3 DNA directed polymerase, alpha POLA 1 DNA glycosylases 1 DNA helicases 1 DNA Ligase 1 LIGI 1 DNA methyltransferase DNMT 1 DNA polymerase 1 1 DNA polymerase 2 1 DNA polymerase 3 1 DNA primase 1 DNA-damage-inducible transcript 3 DDIT3 3 DNA-dependant RNA polymerase 1 Dopamine receptors Di DRDI 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Erythropoietin EPO 4 Erythropoietin receptor EPOR 4 Estrogen receptor ESR 6 Excision repair complementation group 1 ERCCI 1 protein Excision repair complementation group 2 ERCC2 1 protein Excision repair complementation group 3 ERCC3 1 protein Excision repair complementation group 4 ERCC4 1 protein Excision repair complementation group 6 ERCC6 1 protein Factor H HFI 4 Factor IX F9 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Fafty acid binding proteins FABPL 2 Fafty acid binding proteins FABP2 2 Fafty acid binding proteins FABP3 2 Fafty acid binding proteins FABP4 2 Fafty acid binding proteins FABP5 2 Fafty acid binding proteins FABP6 2 Fibroblast growth factor FGF1 6 Flavin-containing monooxygenase 1 FMO1 1 Flavin-containing monooxygenase 2 FMO2 1 Flavin-containing monooxygenase 3 FMO3 1 Flavin-containing monooxygenase 4 FMO4 1 Folic acid receptor FOLR 6 Follicle stimulating hormone receptor FSHR, ODG1 6 Follicle stimulating hormone, FSH FSHB 6 Forkhead transcription factor 10 FKHL10 6 Forkhead transcription factor 14 FKHL14 6 Forkhead transcription factor 7 FKHL7 6 G/T mismatch binding protein GTBP, MSH6 6 GABA receptor, alpha 1 GABRAI 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRBI 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Gadd45 (growth arrest & DNA-damage-inducible protein) 1 Galactose 1-phosphate uridyl-transferase GALT 1 Gamma-glutamyl carboxylase GGCX 2 Gamma-glutamyltransferase I GGTL 2 Gamma-glutamyltransferase 2 GGT2 2 Gastric inhibitory polypeptide receptor, GIPR GIPR 2 Gastric lipase, LIPF 2 Glucagon receptor GCGR 6 Glucocorticoid receptor GRL 6 Glucosaminyl (N-acetyl) transferase 2, I- GCNT2 1 branching enzyme Glucosidase, acid beta GBA 1 Glutamate decarboxylase, GAD GAD1 1 Glutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutamine phosphoribosylpyrophosphate 1 amidotransferase/PRPP amidotransferase Glutathione GSH 2 Glutathione peroxidase, GPXL GPXI 1 Glutathione peroxidase, GPX2 GPX2 1 Glutathione reductase, GSR GSR 1 Glutathione S-transferase mu 1, GSTMI GSTM1 1 Glutathione S-transferase mu 4, GSTM4 1 Glutathione S-transferase theta 1, GSTT1 GSTT1 1 Glutathione S-transferase theta 2, GSTT2 1 Glutathione S-transferase, GSTP1 GSTP1 1 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glutathione synthetase GSS 1 Glyceraidehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycinamide ribanucleotide (GAR) GART 1 transformylase Glycine receptor, alpha GLRA2 5 Glycine receptor, beta 5 Glycine transporter GLYT 5 Gonadotropin releasing hormone GNRH 6 Gonadotropin releasing hormone receptor GNRHR 6 Growth arrest-specific homeobox GAX 6 Growth hormone I GHI 6 Growth hormone 2 (placental) GH2 6 Growth hormone receptor GHR 6 Growth hormone releasing hormone (GHRH) GHRH 6 Growth hormone releasing hormone receptor GHRHR 6 GTP cyclohydrolase I GCH1 6 GTPase-activating protein, GAP RASAI 6 Guanidinoacetate N-methyltransferase GAMT 1 Guanine nucleotide-binding protein, alpha GNA01 5 activating activity polypeptide, GNAO Guanine nucleotide-binding protein, alpha GNAI1 5 inhibiting activity polypeptide 1, GNAI1 Guanine nucleotide-binding protein, alpha GNAI2 5 inhibiting activity polypeptide 2, GNAI2 Guanine nucleotide-binding protein, alpha GNAI3 5 inhibiting activity polypeptide 3, GNAI3 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, alpha GNATI 5 transducing activity polypeptide, GNAT1 Guanine nucleotide-binding protein, alpha GNAT2 5 transducing activity polypeptide, GNAT2 Guanine nucleotide-binding protein, beta GNB3 5 polypeptide 3 Guanine nucleotide-binding protein, gamma GNG5 5 polypeptide 5 Guanine nucleotide-binding protein, GNAQ 5 polypeptide Guanylate cyclase 2D, membrane (retina- GUCY2D 1 specific) Guanylate cyclase activator 1A (retina) GUCALA 1 Guanylate kinase 1 Guanylin GUCA2 2 Guanylyl cyclase 1 H(+), K(+) - ATPase ATP4B 5 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Hemopexin HPX 4 Hepatic lipase LIPC 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 HLH transcription factor HAND1 HAND1 6 HLH transcription factor HAND2 HAND2 6 HMG-COA lyase HMGCL 1 HMG-COA reductase HMGCR 1 HMG-COA synthase HMGCS2 1 Hormone-sensitive lipase HSL 1 HSSB, replication protein HPRT 1 Hypoxanthine-guanine HGPRT 1 phosphoribosyltransferase, Ibonucleoside diphosphate reductase 1 Ikaros gene IKAROS 6 Inosine monophosphate dehydrogenase IMPDH 1 Inosine triphosphatase ITPA 1 Inositol monophosphatase IMPAL 5 Insulin INS 6 Insulin receptor INSR 6 Insulin-like growth factor 1 receptor IGFI R 6 Insulin-like growth factor 2 receptor IGF2R 6 Interferon alpha IFNAL 4 Interferon beta IFNB 4 Interferon gamma IFNG 4 Interferon gamma receptor 1 IFNGRL 4 Interferon gamma receptor 2 IFNGR2 4 Interferon regulatory factor 1 IRF1 4 Interferon regulatory factor 4 IRF4 4 Interleukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) II IL11 4 Interleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta I IL12RB1 4 Interleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 Interleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 Interleukin(IL) 5 receptor IL5R 4 Interleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 Interleukin(IL) 9 IL9 4 Interleukin(IL) 9 receptor IL9R 4 Interleukin(IL) receptor antagonist 1 IL1RN, IL1RA 4 Kallikrein 3 KAK3 4 Kinectin KTNL 6 Kinesin, heavy chain KNSLI 6 Kinesin, light chain KNS2 6 Kininbgen, High molecular weight KNG 4 Leptin LEP 6 Leptin receptor LEPR 6 Leukotriene A4 hydrolase 4 Leukotriene B4 receptor 4 Leukotriene C4 receptor 4 Leukotriene D4/E4 receptor 4 LH/choriogonadotropin (CG) receptor LHCGR 6 LIM homeobox transcription factor 1, beta LMXL B 6 Lipoprotein lipase LPL 4 Lipoprotein receptor, Low Density LDLR 2 Lipoxygenase 12 (platelets) LOG12 4 Lipoxygenase 5 (leukocytes) 4 Low density lipoprotein receptor-related protein LRP 2 precursor Lysosomal acid lipase LIPA 1 Malonyl CoA decarboxylase 1 Malonyl CoA transferase 1 Maltase-glucoamylase 1 Mannose binding protein MBP 4 Mannosyl-(alpha-1,6-)-glycoprotein beta-1,2- MGAT2 2 N-acetylglucosaminyltransferase MAPK kinase 1 MAPKK1; MEK1 6 MAPK kinase 4 MAPKK4; MEK4; 6 SERKI MAPK kinase 6 MAPKK6; MEK6 6 MAPKK kinase MAPKKK 6 Matrix Gia protein MGP 6 MEK kinase, MEKK 1 Melanocortin 2 receptor MC2R 2 Melanocortin 4 receptor MC4R 2 Methionine adenosyltransferase MAT1A, MAT2A 1 Methionine synthase MTR 1 Methionine synthase reductase MTRR 1 Methylguanine-DNA methyltransferase MGMT 1 Mevalonate kinase MVK 1 MHC Class I: Tap1 ABCR, TAP1 4 MHC Class II: Tap2 TAP2, PSF2 4 Microphthalmia-associated transcription factor MITF 6 Mismatch repair gene, PMSLI PMS1 6 Mismatch repair gene, PMSL2 PMS2 6 Mitochondrial trifunctional protein, alpha. HADHA 1 subunit Mitochondrial trifunctional protein, beta subunit HADHB 1 Mitogen-activated protein (MAP) kinase MAPK 6 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Multidrug resistance associated protein MRP 6 Muscarinic receptor, MI CHRMI 5 Muscarinic receptor, M2 CHRM2 5 Muscadnic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Na+, K+ ATPase, alpha ATPIAI 6 Na+, K+ ATPase, beta 1 ATPIBI 6 Na+, K+ ATPase, beta 2 ATPIB2 6 Na+, K+ ATPase, beta 3 ATP1B3 6 Na+/H+ exchanger 1 NHFI 2 Na+/H+ exchanger 2 NHE2 2 Na+/H+ exchanger 3 NHE3 2 Na+/H+ exchanger 4 NHE4 2 Na+/H+ exchanger 5 NHE5 2 N-acetylgalactosamine-6-sulfate sulfatase GALNS 1 N-acetylglucosamine-6-sulfatase GNS 1 N-acetylglucosaminidase, alpha NAGLU 1 N-acetyltransferase 1 NATI 1 N-acetyltransferase 2 NAT2 1 N-acyl hydrolase 4 NADH dehydrogenase (ubiquinone) NDUFVL 1 Flavoprotein I NADH-cytochrome b5 reductase DIA1 1 Nephrolithiasis 2 NPHL2 2 Nephronophthisis 2 NPHP2 2 Nephrosis 1 NPHSI 2 Neuroendocrine convertase 1 NEC1, PCSK1 1 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPYLR 5 Neuropeptide Y receptor Y2 NPY2R 5 Niacin receptor 6 Niemann-Pick disease protein NPCL 2 Nuclear factor kappa beta NFKB 4 Nuclear factor of activated T cells (NFAT) NFATC 6 complex, cytosolic Nuclear factor of activated T cells (NFAT) NFATP 6 complex, preexisting component Nucleoside diphosphate kinase-A NDPKA 1 Oncogene spil 6 Opioid receptor, delta OPRDI 5 Opioid receptor, kappa OPRK1 5 Opiold receptor, mu OPRM1 5 Ornithine transcarbamoylase OTC, NME1 1 Osteoprotegerin OPG 6 Otoferlin OTOF 5 Oxytocin OXT 5 Oxytocin receptor OXTR 5 Paired-like homeodomain transcription factor 2 PITX2 6 Paired-like homeodomain transcription factor 3 PITX3 6 Paraoxonase PON1 PON1 1 Paraoxonase PON2 PON2 1 Paraoxonase PON3 PON3 1 Parathyroid hormone PTH 6 Parathyroid hormone receptor PTHR1 6 Parathyroid hormone related-peptide PTHRP 6 Parathyroid hormone-like hormone PTHLH 6 Parvalbumin PVALB 6 PCNA (proliferating cell nuclear antigen) 1 Peanut-like PNUTLI 4 Peroxisomal membrane protein I Pxmp1 3 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome proliferative activated receptor, PPARA 2 alpha Peroxisome proliferative activated receptor, PPARG 2 gamma P-glycoprotein 1 PGY1 2 P-glycoprotein 3 PGY3 2 Phenylethanolamine N-methyltransferase, PNMT 1 PNMT Phosphodiesterase 1/nucleotide PDNPI 6 pyrophosphatase I Phosphodiesterase I/nucleotide PDNP2 6 pyrophosphatase 2 Phosphodiesterase 1/nucleotide PDNP3 6 pyrophosphatase 3 Phospholipase A2, group 10 PLA2G 10 4 Phospholipase A2, group 1B PLA2G 1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Phosphomannomutase-2 PMM2 2 Phosphomannose isomerase-1, PMI I MPI 2 Phosphoribosyl pyrophosphate synthetase PRPS1 1 Pituitary adenylate cyclase activating peptide PACAP 5 Pituitary adenylate cyclase activating peptide PACAPLR 5 receptor Plasminogen activator, Tissue PLAT, TPA 1 Platelet-activating factor receptor PAFR 4 Plectin I PLEC1 2 Polycystin 1 PKD1 2 Polycystin 2 PKD2 2 Porphobilinogen deaminase HMBS 1 Potassium channel, calcium-activated, KCNN4 5 Potassium channel, subfamily K, member 1 KCNK1 5 Potassium channel, subfamily K, member 2 KCNK2 5 Potassium channel, subfamily K, member 3 KCNK3 5 Potassium inwardly-rectifying channel JI KCNJ1 5 Potassium inwardly-rectifying channel JII KCNJ11 5 Potassium voltage-gated channel AI KCNA1 5 Potassium voltage-gated channel EI KCNE1 5 Potassium voltage-gated channel QI KCNQ1 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCNQ3 5 POU domain, class 1, transcription factor I POUI F1 6 (Piti) POU domain, class 3, transcription factor 4 POU3F4 6 POU domain, class 4, transcription factor 3 POU4F3 6 Pre-B-cell leukemia transcription factor 1 PBx1 6 Preproglucagon GCG, GLP1, GLP2 6 receptor) Prolactin PRL 6 Prolactin receptor PRLR 6 Proopiomelanocortin POMC 5 Prostacyclin synthase 4 Prostaglandin 15-OH dehydrogenase HGPD, PGDH 4 Prostaglandin D-DP receptor 4 Prostaglandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F-FP receptor 4 Prostaglandin F2 alpha receptor 4 Prostaglandin IP receptor 4 Prostaglandin-endoperoxidase synthase 2 PTGS2 6 Protease nexin 2 PN2 1 Protein C PROC 4 Protein kinase DNA-activated PRKDC 1 Protein S PROS1 4 Pterin-4-alpha-carbinolamine PCBD Purine nucleoside phosphorylase NP 1 Purinergic receptor P1A1 5 Purinergic receptor P1A2 5 Purinergic receptor P1A3 5 Purinergic receptor P2X, 1 P2RX1 5 Purinergic receptor P2X, 2 P2RX2 5 Purinergic receptor P2X, 3 P2RX3 5 Purinergic receptor P2X, 4 P2RX4 5 Purinergic receptor P2X, 5 P2RX5 5 Purinergic receptor P2X, 6 P2RX6 5 Purinergic receptor P2X, 7 P2RX7 5 Purinergic receptor P2Y, 1 P2RY1 5 Purinergic receptor P2Y, 11 P2RY11 5 Purinergic receptor P2Y, 2 P2RY2 5 RAD51, DNA repair protein RAD51 6 RAD52, DNA repair protein RAD52 6 RAD54, DNA repair protein RAD54 6 RAD55, DNA repair protein RAD55 6 RAD57, DNA repair protein RAD57 6 Recombination activating gene 1 RAG1 6 Recombination activating gene 2 RAG2 6 Red cone pigment RCP 3 Replication factor A 1 Replication factor C RFC2 1 Retinaldehyde binding protein 1 RLBPL 2 Retinoic acid receptor, alpha RARA 6 Retinoic acid receptor, beta RARB 6 Retinoic acid receptor, gamma RARG 6 Retinoid X receptor, alpha RXRA 6 Retinoid X receptor, beta RXRB 6 Retinoid X receptor, gamma RG 6 Retinol binding protein 1 2 Retinol binding protein 2 2 Retinol binding protein 4 RBP4 2 Ribonucleotide reductase, RRM 1 Ribosephosphate pyrophosphokinase 1 Ribosomal protein L13A RPL13A 6 Ribosomal protein S19 RPS19 1 Ribosomal protein S4, X-linked RPS4X 1 Ribosomal protein S6 kinase RPS6KA3 1 Ribosomal protein S9 RPS9 6 S-Adenosylmethionine decarboxylase, AMD 1 Secretin SCT 2 Secretin receptor, SCTR SCTR 2 Serine hydroxymethyltransferase SHMT 1 Serotonin-N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Slug protein 6 Small nuclear ribonucleoprotein polypeptide N SNRPN 3 Sodium channel, non-voltage gated 1, alpha SCNNA 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNNIG 5 Sodium channel, voltage gated, type IV, alpha SCN4A 5 polypeptide Sodium channel, voltage gated, type V, alpha SCN5A 5 polypeptide Sodium channel, voltage gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 1 (amino acid transporter), SLC1A6 2 member 6 Solute carrier family 1 (glial high affinity SLC1A3 2 glutamate transporter), member 3 Solute carrier family 1 (glutamate transporter), SLC1A1 2 member 1 Solute carrier family I (glutamate transporter), SLCIA2 2 member 2 Solute carrier family 1(neutral amino acid SLCIA4 2 transporter), member 4 Solute carrier family IO (sodium/bile acid SLCIOA1 2 cotransporter family), member 1 Solute carrier family IO (sodium/bile acid SLCIOA2 2 cotransporter family), member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 14, member 2 SLC14A2 2 Solute carrier family 15 (H+/peptide SLC15A1 2 transporter, intestinal), member 1 Solute carrier family 15 (H+/peptide SLC15A2 2 transporter, kidney), member 2 Solute carrier family 16 (monocarboxylate SLC16A1 2 transporter), member 1 Solute carrier family 16 (monocarboxylate SLC16A7 2 transporter), member 7 Solute carrier family 17, member 1 SLC17A1 2 Solute carrier family 17, member 2 SLC17A2 2 Solute carrier family 18, member 3 SLC18A3 2 Solute carrier family 19 (folate transporter), SLC19A1 2 member 1 Solute carrier family 2 (facilitated glucose SLC2A1 2 transporter), member 1 Solute carrier family 2 (facilitated glucose SLC2A2 2 transporter), member 2 Solute carrier family 2 (facilitated glucose SLC2A3 2 transporter), member 3 Solute carrier family 2 (facilitated glucose SLC2A4 2 transporter), member 4 Solute carrier family 2 (facilitated glucose SLC2A5 2 transporter), member 5 Solute carrier family 20, member 1 SLC2OA1 2 Solute carrier family 20, member 2 SLC2OA2 2 Solute carrier family 20, member 3 SLC2OA3 2 Solute carrier family 21, member 2 SLC21A2 2 Solute carrier family 21, member 3 SLC21A3 2 Solute carrier family 22, member 1 SLC22A1 2 Solute carrier family 22, member 2 SLC22A2 2 Solute carrier family 22, member 5 SLC22A5 2 Solute carrier family 25, member 12 SLC25A12 2 Solute carrier family 3 (facilitated glucose SLC3A1 2 transporter), member 1 Solute carrier family 4 (anion exchanger), SLC4A1 2 member 1 Solute carrier family 4 (anion exchanger), SLC4A2 2 member 2 Solute carrier family 4 (anion exchanger), SLC4A3 2 member 3 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmitter SLC6A4 2 transporter, serotonin), member 4 Solute carrier family 6, member 10 SLC6A10 2 Solute carrier family 6, member 6 SLC6A6 2 Solute carrier family 6, member 8 SLC6A8 2 Solute carrier family 7(amino acid transporter), SLC7A1 2 member 1 Solute carrier family 7(amino acid transporter), SLC7A2 2 member 2 Solute carrier family 7(amino acid transporter), SLC7A7 2 member 7 Solute carrier family 8 (sodium/calcium SLC8A1 2 exchanger), member 1 Somatostatin SST 5 Somatostatin receptor, SSTR1 SSTR1 5 Somatostatin receptor, SSTR2 SSTR2 6 Somatostatin receptor, SSTR3 SSTR3 5 Somatostatin receptor, SSTR4 SSTR4 5 Somatostatin receptor, SSTR5 SSTR5 5 Sorcin SRI 2 SOSI guanine nucleotide exchange factor sosi 6 Steroid 5 alpha reductase 1 SRD5AI 1 Steroid 5 alpha reductase 2 SRD5A2 1 Steroid hormone receptor responsive DNA 6 elements Sterol carrier protein 2 SCP2 2 Succinic semi-aldehyde dehydrogenase SSADH 1 Sucrase 1 Sulfonylurea receptor SUR 6 Synaptic vesicle amine transporter SVAT 5 Tachykinin receptor, NK1R TACR1 5 Tachykinin receptor, NK2R TACR2 5 Tachykinin receptor, NK3R TACR3 5 Terminal deoxynucleotidyltransferase TDT 4 Thiopurine-S-methyltransferase TPMT 1 Thrombopoietin THPO 6 Thromboxane A synthase I TBXASI 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thymidylate synthase TYMS 1 Thymopoietin TMPO 6 Thyroid hormone receptor, beta THRB 6 Thyroid-stimulating hormone receptor TSHR 6 Thyroid-stimulating hormone, alpha TSHA 6 Thyroid-stimulating hormone, beta TSHB 6 Topoisomerase I 1 Topoisomerase II 1 Transcription factor 1, hepatic TCF1 6 Transcription factor 2, hepatic TCF2 6 Transcription factor 3 TCF3 6 Transcription factor binding to IGHM enhancer 3 TFE3 6 Transcription factor, TUPLE1 TUPLE1 5 Transcription termination factor, RNA TTF1 6 polymerase 1 Transcription termination factor, RNA TTF2 6 polymerase 2 Transcription termination factor, RNA TTF3 6 polymerase 3 Transferrin TF 6 Transferrin receptor TFRC 6 Transthyretin TTR 2 Tubulin 3 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tumour Suppressor gene DRA DRA 4 Ubiquitin 6 Ubiquitin activating enzyme, E1 1 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin carboxyl-terminal esterase L1 UCHL1 6 Ubiquitin protein ligase E3A UBE3A 1 UDP-glucose pyrophosphorylase 1 UDP-glucuronosyltransferase 1 ugtld, UGTL 1 UDP-glucuronosyltransferase 2 UGT2 1 Uncoupling protein 1 2 Uncoupling protein 3 UCP3 2 Uridine monophosphate kinase UMPK 4 Uridine manophosphate synthetase UMPS 4 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Vimentin VIM 4 Vitamin B12-binding (R) protein 6 Vitamin D receptor VDR 6 Xanthine dehydrogenase XDH 1 Xeroderma pigmentosum, complementation XPA 1 group A Xeroderma pigmentosum, complementation XPB 1 group B Xeroderma pigmentosum, complementation XPC 1 group C Xeroderma pigmentosum, complementation 1 group D Xeroderma pigmentosum, complementation 1 group E Xeroderma pigmentosum, complementation XPF 1 group F Xeroderma pigmentosum, complementation ERCC5 1 group G X-ray repair gene XRCC9 6 Xylitol dehydrogenase 1 YY1 transcription factor YY1 6

that the gene with cancer are selected from: HUGO Protein- List of genes gene symbol function Absent in melanoma 1 gene AIM1 6 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTA1 3 Actin, alpha, smooth, aortic ACTA2 3 Activin 6 Activin A receptor, type 2B ACVR2B 6 Activin A receptor, type 2-like kinase 1 ACVRL1 6 Adenomatous polyposis coli tumour supressor APC 6 gene Adenosine deaminase ADA 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenyl cyclase 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic receptor, alphal ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, betal ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Albumin, ALB ALB 2 Alcohol dehydrogenase 3 ADH3 1 Aidehyde dehydrogenase 1 ALDH1 1 Aidehyde dehydrogenase 10 ALDH10 1 Aidehyde dehydrogenase 2 ALDH2 1 Aldehyde dehydrogenase 5 ALDH5 1 Aldehyde dehydrogenase 6 ALDH6 1 Aldehyde dehydrogenase 7 ALDH7 1 Aldosterone receptor MLR 6 alpha tectorin TECTA 6 alpha1-antitrypsin P1 1 alpha-actinin 2 ACTN2 6 alpha-actinin 3 ACTN3 6 Alpha-fetoprotein AFP 6 alpha-synuclein SNCA 5 Amphiregulin AREG 6 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Androgen receptor AR 6 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCP1 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Annexin 1 ANX 1 4 Antidiuretic hormone receptor ADHR 2 Antithrombin III AT3 1 AP-2, alpha TFAP2A 6 AP-2, beta TFAP2B 6 AP-2, gamma TFAP2C 6 Apaf-1 3 Apoptosis antigen 1 APT1 4 Apoptosis antigen ligand 1 APT1LG 1 4 Apoptosis-inducing factor AIF 4 Apurinic endonuclease APE 1 Arginine vasopressin AVP 5 Arginosuccinate synthetase ASS 1 Aryl hydrocarbon receptor AHR 2 Aryil hydrocarbon receptor nuclear translocator ARNT 2 Asparagine synthetase AS 1 Aspartate receptor 5 Ataxia telangiectasia complementation group D ATD, ATDC 6 Ataxia telangiectasia gene, AT ATM 6 ATP cobalamin adenoxyltransferase 1 ATP sulphurylase atpsk2 1 ATP-binding cassette transporter 7 ABC7 4 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Atrophin 1 DRPLA 6 Bagpipe homeobox, drosophila homolog of, 1 BAPX1 6 B-cell CLL/lymphoma 1 BCL1 4 B-cell CLL/lymphoma 10 BCL10 4 B-cell CLL/lymphoma 3 BCL3 4 B-cell CLUlymphoma 4 BCL4 4 B-cell CLL/lymphoma 5 BCL5 4 B-cell CLU[ymphoma 6 BCL6 4 B-cell CLL/lymphoma 7 BCL7 4 B-cell CLUlymphoma 8 BCL8 4 B-cell CLL/lymphoma 9 BCL9 4 BCL2-associated X protein BAX 6 BCL2-related protein A1 BCL2A1 6 Beckwith-Wiedemann region 1A BWR1A 6 Benzodiazepine receptor 5 beta 2 microglobulin B2M 4 beta-endorphin receptor 5 beta-synuclein SNCB 5 Bleomycin hydrolase BLMH 1 Bone morphogenetic protein, BMP1 BMP1 6 Bone morphogenetic protein, BMP2 BMP2 6 Bone morphogenetic protein, BMP3 BMP3 6 Bone morphogenetic protein, BMP4 BMP4 6 Bone morphogenetic protein, BMP5 BMP5 6 Bone morphogenetic protein, BMP6 BMP6 6 Bone morphogenetic protein, BMP7 BMP7 6 Bone morphogenetic protein, BMP8 BMP8 6 Bradykinin receptor B1 4 Bradykinin receptor B2 4 Brain derived neurotrophic factor BDNF 6 Brain derived neurotrophic factor (BDNF) BDNFR 6 receptor Branched chain aminotransferase 1, cytosolic BCAT1 1 Branched chain aminotransferase 2, BCAT2 1 mitochondrial BRCA1-associated RING domain gene 1 BARD1 6 Breakpoint cluster region BCR 6 Breast cancer 1 BRCA1 6 Breast cancer 2 BRCA2 6 Breast cancer, ductal, 1 BRCD1 6 Breast cancer, ductal, 2 BRCD2 6 Bruton agammaglobulinaemia tyrosine kinase BTK 6 C1 inhibitor 1 Cadherin E CDH1 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin I CALBI 6 Calbindin D9K- CALB3 6 Calcitonin receptor/Calcitonin gene-related CALCR 5 peptide receptor Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, alpha 1 F CACNA1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA1C 5 1C Calcium channel, voltage-dependent, Alpha- CACNA1D 5 1 D Calcium channel, voltage-dependent, Alpha- CACNA1E 5 1 E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/detta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNA1S 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase 11 CAMK2A 6 Calnexin CANX 6 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Cardiac-specific homeobox, CSX CSX 6 Cartilage-hair hypoplasia gene CHH 5 Caspase1 CASP1 6 Caspase 10 CASP10 6 Caspase 2 CASP2 6 Caspase 3 CASP3 6 Caspase 4 CASP4 6 Caspase 5 CASP5 6 Caspase 6 CASP6 6 Caspase 7 CASP7 6 Caspase 8 CASP8 6 Caspase 9 CASP9 6 Catenin, beta CTNNB1 6 CD1 CD1 4 CD10 CD10 4 CD4 CD4 4 CEA 6 Cell adhesion molecule, intercellular, ICAM ICAM1 6 Cell adhesion molecule, leukocyte-endothelial, LECAM1 6 LECAM (CD62) Cell adhesion molecule, liver, LCAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM1 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 c-erbB1 ERBB1 6 c-erbB2 ERBB2 6 c-erbB3 ERBB3 6 c-erbB4 ERB64 6 Ceruloplasmin precursor CP 1 Chemokine receptor CXCR1 CXCR1 4 Chemokine receptor CXCR2 CXCR2 4 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Ciliary neurotrophic factor (CNTF) CNTF 6 Ciliary neurotrophic factor (CNTF) receptor CNTFR 6 c-kit receptor tyrosine kinase 6 Clathrin 2 Clusterin CLU 6 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Colony-stimulating factor 1 CSF1 6 Colony-stimulating factor 1 receptor CSF1R 6 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 2 alpha receptor CSF2RA 6 Colony-stimulating factor 2 beta receptor CSF2RB 6 Colony-stimulating factor 3 CSF3 6 Colony-stimulating factor 3 receptor CSF3R 6 Complement component C1 inhibitor C1NH 4 Complement component C1qa CIQA 4 Complement component C1qb CLQB 4 Complement component C1qg CLQG 4 Complement component C1r C1R 4 Complement component C1s C1S 4 Complement component C2 C2 4 Complement component C3 C3 4 Complement component C4A C4A 4 Complement component C4B C4B 4 Complement component C5 C5 4 Complement component C6 C6 4 Complement component C7 C7 4 Complement component C8 C8B 4 Complement component C9 C9 1 Complex III 1 Core-binding factor, alpha I CBFA1 6 Core-binding factor, alpha 2 CBFA2 6 Core-binding factor, beta CBFB 6 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 c-src tyrosine kinase CSK 6 Cyclic AMP-dependent protein kinase PKA 1 Cyclin A CCNA 6 Cyclin B CCNB 6 Cyclin C CCNC 6 Cyclin D CCND1 6 Cyclin E CCNE 6 Cyclin F CCNF 6 Cyclin-dependent kinase 1 CDK1 6 Cyclin-dependent kinase 10 CDKI 0 6 Cyclin-dependent kinase 2 CDK2 6 Cyclin-dependent kinase 3 CDK3 6 Cyclin-dependent kinase 4 CDK4 6 Cyclin-dependent kinase 5 CDK5 6 Cyclin-dependent kinase 6 CDK6 6 Cyclin-dependent kinase 7 CDK7 6 Cyclin-dependent kinase 8 CDK8 6 Cyclin-dependent kinase 9 CDK9 6 Cyclin-dependent kinase inhibitor 1A (P21, CDKN1A 6 CIP1) Cyclin-dependent kinase inhibitor I B (P27, CDKN1B 6 KIP1) Cyclin-dependent kinase inhibitor IC (P57, CDKN1C 6 KIP2) Cyclin-dependent kinase inhibitor 2A (p16) CDKN2A 6 Cyclin-dependent kinase inhibitor 3 CDKN3 6 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 GYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 GYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 Defender against cell death 1 DAD1 6 Deleted in colorectal carcinoma DCC 6 Deleted in malignant brain tumours 1 DMBT1 6 Deoxycytidine kinase DCK 1 Deoxyuridine triphosphatase; dUTPase 1 Desert hedgehog, dhh 6 Dihydrofolate reductase DHFR 1 Dihydrolipoyl dehydrogenase 1 Dihyropyrimidine dehydrogenase DPYD 1 DM-Kinase DMPK 1 DNA damage binding protein, DDB1 DDB1 3 DNA damage binding protein, DDB2 DDB2 3 DNA directed polymerase, alpha POLA 1 DNA glycosylases 1 DNA helicases 1 DNA Ligase 1 LIG1 1 DNA methyltransferase DNMT 1 DNA polymerase 1 1 DNA polymerase 2 1 DNA polymerase 3 1 DNA primase 1 DNA-damage-inducible transcript 3 DDIT3 3 DNA-dependant RNA polymerase 1 DOPA decarboxylase DDC 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Dynamin DNM1 6 Dynorphin receptor 5 Dysfedin DYS, DYSF 1 Dyskerin DKC1 3 EB1 6 Endoglin ENG 3 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase EN01 1 Ephrin receptor tyrosine kinase A EPHA 6 Ephrin receptor tyrosine kinase B EPHB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Estrogen receptor ESR 6 Eukaryotic initiation translation factor EIF4E 6 EWS RNA-binding protein EWSR1 6 Excision repair complementation group 1 ERCCI 1 protein Excision repair complementation group 2 ERCC2 1 protein Excision repair complementation group 2 ERCC3 1 protein Excision repair complementation group 4 ERCC4 1 protein Excision repair complementation group 6 ERCC6 1 protein Exostosin 1 EXT1 3 Exostosin 2 EXT2 3 FADH dehydrogenase 1 Fanconi anemia, complementation group C FANCC 2 Fanconi anemia, complementation group D FANCD 2 Fc fragment of IgG, high affinity IA, receptor for FCGRL A 6 Fc fragment of IgG, low affinity IIa, receptor for FCGR2A 6 (CD32) Fc fragment of IgG, low affinity llla, receptor for FCGR3A 6 (CD16) Ferrochelatase FECH 1 Fibrillin 1 FBN1 6 Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FN1 6 Folic acid receptor FOLR 6 Follicle stimulating hormone receptor FSHR, ODG1 6 Follicle stimulating hormone, FSH FSHB 6 Follicular lymphoma variant translocation 1 FVT1 4 Forkhead rhabdomyosarcoma gene FKHR 6 Forkhead transcription factor 14 FKHL14 6 Forkhead transcription factor 7 FKHL7 6 Fucosyltransferase 2 FUT2 2 Fucosyltransferase 3 FUT3 2 GIT mismatch binding protein GTBP, MSH6 6 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 Gadd45 (growth arrest & DNA-damage-inducible protein) 1 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1, 3 GGTA1 6 Galactosyltransferase, beta 3 B3GALT 6 Gastrin GAS 6 Gastrin releasing peptide GRP 2 Glioma chloride ion channel, GCC 6 Glucagon receptor GCGR 6 Glucagon synthase 2 Glucocorticoid receptor GRL 6 Glutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionctropic, NMDA 2D NMDAR2D 5 Glutathione GSH 2 Glutathione S-transferase mu 1, GSTM1 GSTM1 1 Glutathione S-transferase theta 1, GSTT1 GSTT1 1 Glutathione S-transferase, GSTZI GSTZ1 1 Glyceraldehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycine receptor, alpha GLRA2 5 Glycine receptor, beta 5 Glycine transporter GLYT 5 Glypican 3 GPC3, SDYS 6 Gonadotropin releasing hormone GNRH 6 Gonadotropin releasing hormone receptor GNRHR 6 Growth factor receptor-bound protein 2 GRB2 6 Growth hormone 1 GH1 6 Growth hormone 2 (placental) GH2 6 Growth hormone receptor GHR 6 Growth hormone releasing hormone (GHRH) GHRH 6 Growth hormone releasing hormone receptor GHRHR 6 Growth/differentiation factor 5 GDF5 6 Growth-regulated protein precursor, GRO GRO 4 GTPase-activating protein, GAP RASA1 6 Guanine nucleotide-binding protein, alpha GNAI1 5 inhibiting activity polypeptide 1, GNA11 Guanine nucleotide-binding protein, alpha GNAI2 5 inhibiting activity polypeptide 2, GNA12 Guanine nucleotide-binding protein, alpha GNAI3 5 inhibiting activity polypeptide 3, GNA13 Guanine nuclootide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, q GNAQ 5 polypeptide Guanylate kinase 1 H(+), K(+) - ATPase ATP4B 5 Hairless HR 6 Hela tumor suppression gene HTS1 6 Heparin binding epidermal growth factor HBEGF 6 Hepatitis 8 virus integration site 1 HVBS1 4 Hepatitis B virus integration site 2 HVBS6 4 High mobility group protein C HMGIC 6 High mobility group protein Y HMGIY 6 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 HLH transcription factor HAND1 HAND1 6 HLH transcription factor HAND2 HAND2 6 HMG-CoA reductase HMGCR 1 HMG-CoA synthase HMGCS2 1 Homeobox (HOX) gene A13 HOXA13 6 Homeobox 11 HOX11 6 Homeobox HB24 HLX1 6 Homogentisate 1,2 dioxygenase HGD 1 Hormone-sensitive lipase HSL 1 HSSB, replication protein 1 Human placental lactogen CSH1 6 bonucleoside diphosphate redudtase 1 Ikaros gene IKAROS 6 lnhibin, alpha INHA 6 lnhibin, beta A INHBA 6 lnhibin, beta B INHBB 6 lnhibin, beta C INHBC 6 Inositol 1,4,5-triphosphate receptor 3 ITPR3 6 Insulin INS 6 Insulin receptor INSR 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 Integrin beta 1 ITGB1 6 Integrin beta 2 ITGB2 6 lntegrin beta 3 ITGB3 6 lntegrin beta 4 ITGB4 6 lntegrin beta 5 ITGB5 6 lntegrin beta 6 ITGB6 6 Integrin beta 7 ITGB7 6 lntegrin, alpha 1 ITGA1 6 Integrin, alpha 2 ITGA2 6 Integrin, alpha 4 ITGA4 6 lntegrin, alpha 5 ITGA5 6 lntegrin, alpha 6 ITGA6 6 lntegrin, alpha M ITGAM 6 Interferon alpha IFNA1 4 Interferon beta IFNB 4 Interferon gamma IFNG 4 Interferon gamma receptor 1 IFNGR1 4 Interferon gamma receptor 2 IFNGR2 4 Interferon regulatory factor 1 IRF1 4 Interferon regulatory factor 4 IRF4 4 Interleukin(IL) I receptor ILIR 4 Interleukin(IL) 1, alpha ILIA 4 lnterleukin(IL) 1, beta ILIB 4 Interleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) II IL11 4 lnterleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta I IL12RB1 4 Interleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 lnterleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 lnterleukin(IL) 5 IL5 4 Interleukin(IL) 5 receptor IL5R 4 Interleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 lnterleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 lnterleukin(IL) 9 IL9 4 lnterleukin(IL) 9 receptor IL9R 4 lnterleukin(IL) receptor antagonist I IL1RN, IL1RA 4 Janus kinase 1 JAK1 6 Janus kinase 2 JAK2 6 Janus kinase 3 JAK3 6 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMR1 6 Latent transforming growth factor-beta binding LTBP2 6 protein 2 Leptin LEP 6 Leptin receptor LEPR 6 Leukaemia inhibitory factor LIF 6 Leukaemia inhibitory factor receptor LIFR 6 Leukotriene A4 hydrolase 4 Leukotriene B4 receptor 4 Leukotriene C4 receptor 4 Leukotriene D4/E4 receptor 4 LH/choriogonadotropin (CG) receptor LHCGR 6 LIM homeobox protein 1 LHX1 6 LIM. homeobox protein 2 LHX2 6 LIM homeobox protein 3 LHX3 6 LIM homeobox protein 4 LHX4 6 Limbic associated membrane protein LAMP 6 LIM-domain only protein 1 LMO1 6 LIM-domain only protein 2 LMO2 6 LIM-domain only protein 3 LMO3 6 LIM-domain only protein 4 LMO4 6 Lipoma-preferred partner gene LPP 6 Lipoxygenase 12 (platelets) LOG12 4 Lipoxygenase 5 (leukocytes) 4 Long QT-type 2 potassium channels LQT2, KCNH2 2 Lowe oculocerbrorenal syndrome gene OCRL 1 Luteinizing hormone-releasing hormone 5 Luteinizing hormone-releasing hormone 5 receptor Lymphoblastic leukemia derived sequence 1 LYL1 4 Lymphocyte-specific protein tyrosine kinase LCK 4 Lymphoid enhancer-binding factor LEF-1 6 Macrophage activating factor MAF 4 MAD (mothers against decapentaplegic, MADH3 6 Drosophila) homologue 3 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 MADS box transcription-enhancer factor 2A MEF2A 6 MADS box transcription-enhancer factor 2B MEF2B 6 MADS box transcription-enhancer factor 2C MEF2C 6 MADS box transcnption-enhancer factor 2D MEF2D 6 Malignant proliferation, eosinophil gene MPE 4 MAPK kinase 1 MAPKK1; MEK1 6 MAPK kinase 4 MAPKK4; MEK4; 6 SERK1 MAPK kinase 6 MAPKK6; MEK6 6 MAPKK kinase MAPKKK 6 MAX-interacting protein 1 MXI 1 6 MEK kinase, MEKK 1 Melanocortin 1 receptor MCI R 2 Menin MEN1 6 Methionine adenosyltransferase MAT1 A, MAT2A 1 Methionine synthase MTR 1 Methionine synthase reductase MTRR 1 Methylguanine-DNA methyltransferase MGMT 1 MHC Class 1: A 4 MHC Class 1: B 4 MHC Class 1: C 4 MHC Class 1: LMP-2, LMP-7 4 MHC Class 1: Tap1 ABCR, TAP1 4 MHC Class 11: DP HLA-DPBL 4 MHC Class II: DQ 4 MHC Class II: DR 4 MHC Class II: Tap2 TAP2, PSF2 4 MHC Class II: Complementation group A MHC2TA 4 MHC Class II: Complementation group B rfxank 4 MHC Class II: Complementation group C RFX5 4 MHC Class II: Complementation group D RFXAP 4 Midline 1 MIDI 6 Mismatch, repair gene, PMSL1 PMS1 6 Mismatch repair gene, PMSL2 PMS2 6 Mitogen-activated protein (MAP) kinase MAPK 6 Motilin MLN 6 Msh homeobox homolog 1 MSX1 6 Msh homeobox homolog 2 MSX2 6 Mucin 18 MUC18 2 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Mutated in colorectal cancers, MCC MCC 6 MutL homolog 1 MLHI 6 MutS homolog 2 MSH2 6 MutS homolog 3 MSH3 6 Myelin protein peripheral 22 PMP22 3 Myelodysplasia syndrome 1 gene MDS1 6 Myeloid leukemia factor-1 MLF1 4 N-acetyltransferase 1 NAT1 1 N-acetyltransferase 2 NAT2 1 reductase Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neuregulin HGL 6 Neurexin 5 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuronal apoptosis inhibitory protein NAIP 4 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neurotensin NTS 5 Neurotensin receptor NTSR1 5 Neurotrophic tyrosine kinase receptor 1 NTRK1 6 Neutral endopeptidase 1 Niacin receptor 6 Nodal NODAL 6 Norrie disease protein NDP 6 Notch 3 NOTCH3 6 Notch ligand - jagged 1 JAG 1, AGS 6 Nuclear factor kappa beta NFKB 4 Nuclear factor of activated T cells (NFAT) NFATC 6 complex, cytosolic Nuclear factor of activated T cells (NFAT) NFATP 6 complex, preexisting component Nuclear mitotic apparatus protein 1 NUMA1 6 Nucleophosmin NPM1 2 Oligophrenin-1 OPHN1 6 Oncogene abl1 ABLI 6 Oncogene abl2 6 Oncogene akt1 6 Oncogene akt2 AKT2 6 Oncogene axl AXL 6 Oncogene bcl2 6 Oncogene bcr/abi 6 Oncogene B-lym 6 Oncogene B-raf 6 Oncogene clkl 6 Oncogene c-myc 6 Oncogene cot 6 Oncogene crk 6 Oncogene crkI 6 Oncogene ect2 6 Oncogene ELK1 ELK1 6 Oncogene ELK2 ELK2 6 Oncogene ems1 6 Oncogene ERB 6 Oncogene ERB2 6 Oncogene ERBA 6 Oncogene ERBAL2 6 Oncogene ERG (early reponse gene) 6 Oncogene ETSI 6 Oncogene ETS2 6 Oncogene EVI1 EVI1 6 Oncogene fes 6 Oncogene fgr 6 Oncogene fos FOS 6 Oncogene fps 6 Oncogene GLI1 GLI 6 Oncogene GLI2 GLI2 6 Oncogene GLI3 GLI3 6 Oncogene gro1 6 Oncogene gro2 6 Oncogene Ha-ras HRAS 6 Oncogene hs1 6 Oncogene hst FGF4 6 Oncogene int1 WNT1 6 Oncogenein FGF3 6 Oncogene int3 Notch4 6 Oncogene int4 WNT3 6 Oncogenejun JUN 6 Oncogene KIT KIT, PBT 6 Oncogene LCO LCO 6 Oncogene I-myc 6 Oncogene Ipsa 6 Oncogene lyn 6 Oncogene maf 6 Oncogene mas1 6 Oncogene mcf2 6 Oncogene mdm2 MDM2 6 Oncogene mel 6 Oncogene met MET 6 Oncogene mos 6 Oncogene mpl 6 Oncogene MUM1 MUM1 6 Oncogene myb MYB 6 Oncogene myc MYC 6 Oncogene n-myc 6 Oncogene N-ras (neuroblastoma v-ras) NRAS 6 Oncogene ovc 6 Oncogene pim1 6 Oncogene pti-1 sea 6 Oncogene pvt1 6 Oncogene raf RAF 6 Oncogene ralb 6 Oncogene re1 6 Oncogene ret RET 6 Oncogene r-myc 6 Oncogene ros 6 Oncogene R-ras 6 Oncogene sis PDGFB 6 Oncogene ski 6 Oncogene sno 6 Oncogene spi1 6 Oncogene src 6 Oncogene tc21 6 Oncogene TEL ETV6 6 Oncogene tim 6 Oncogene vavtrk 6 Oncogene v-Ki-ras2 KRAS2 6 Oncogene yes 6 Oncogene yuasa 6 Oncostatin M OSM 6 Oncostatin M receptor OSMR 6 Opioid receptor, delta OPRD1 5 Opioid receptor, kappa OPRK1 5 Opioid receptor, mu OPRM1 5 Orexin OX 6 Osteopontin OPN 6 Oxytocin OXT 5 Oxytocin receptor OXTR 5 Paired box homeotic gene 3 PAX3 6 Paired box homeotic gene 6 PAX6 6 Paired box homeotic gene 7 PAX7 6 Paired-like homeodomain transcription factor 2 PITX2 6 Paired-like homeodomain transcription factor 3 PITX3 6 Parathyroid hormone PTH 6 Parathyroid hormone receptor PTHR1 6 Parathyroid hormone related-peptide PTHRP 6 Parvalbumin PVALB 6 Patched (Drosophila) homolog, PTCH PTCH 6 PCNA (proliferating cell nuclear antigen) 1 Peanut-like 1 PNUTL1 4 Peroxisome proliferative activated receptor, PPARA 2 alpha Peroxisome proliferative activated receptor, PPARG 2 gamma P-glycoprotein 1 PGY1 2 P-glycoprotein 3 PGY3 2 Phenylalanine hydroxylase PAH 1 Phosphatase & tensin homolog PTEN 6 Phosphatidylinositol glycan, class A PIGA 6 (paroxysmal nocturnal hemoglobinuria) Phospholipase A2, group 10 PLA2G 10 4 Phospholipase A2, group 1B PLA2G1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C epsilon 4 Phosphomannomutase 1 PMM1 6 Phosphomannomutase 2 PMM2 6 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI1 1 Plasminogen activator inhibitor 2 PAI2 1 Plasminogen activator receptor, Urokinase UPAR; PLAUR 3 Plasminogen activator, Tissue PLAT; TPA 1 Plasminogen activator, Urokinase UPA; PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Platelet glycoprotein 1b, beta GP1BB 4 Platelet glycoprotein I b, gamma GP1BG 4 Platelet glycoprotein IX GP9 4 Platelet glycoprotein V GP5 4 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium inwardly-rectifying channel J11 KCNJ11 5 Potassium voltage-gated channel A1 KCNA1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCNQ3 5 POU domain, class 1, transcription factor 1 POU1F1 6 (Pit1) POU domain, class 3, transcription factor 4 POU3F4 6 POU domain, class 4, transcription factor 3 POU4F3 6 Pre-B-cell leukemia transcription factor 1 PBXL 6 Preproglucagon GCG; GLPL; GLP2 6 Preproglucagon 2 Prion protein PRNP 5 Prodynorphin 5 Prohibitin PHB 6 Prolactin PRL 6 Prolactin receptor PRLR 6 Prolactin releasing hormone PRH 6 Proliferin PLF 6 Promyelocytic-leukemia gene PML 6 Proopiomelanocortin POMC 5 Prophet of Pit1 PROP1 6 Prostacyclin synthase 4 Prostagiandin 15-OH dehydrogenase HGPD; PGDH 4 Prostaglandin D - DP receptor 4 Prostagiandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostagiandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostagiandin IP receptor 4 Prostate cancer anti-metastasis gene KAI I KAI 1 6 Protein kinase B PRKB Protein kinase C, alpha PRKCA 1 Protein phosphatase 2, regulatory subunit A, PPP2R1B 1 beta isoform Protein tyrosine phosphatase, non-receptor PTPN12 6 type 12 Purine nucleoside phosphorylase NP 1 Purinergic receptor P1A1 5 Purinergic receptor P1A2 5 Purinergic receptor P1A3 5 Purinergic receptor P2X, 1 P2RX1 1 Purinergic receptor P2X, 2 P2RX2 5 Purinergic receptor P2X, 3 P2RX3 5 Purinergic receptor P2X, 4 P2RX4 5 Pudnergic receptor P2X, 5 P2RX5 5 Purinergic receptor P2X, 6 P2RX6 5 Purinergic receptor P2X, 7 P2RX7 5 Purinergic receptor P2Y, 1 P2RY1 5 Purinergic receptor P2Y, 11 P2RY11 5 Purinergic receptor P2Y, 2 P2RY2 5 Rabphilin 5 RAD51, DNA repair protein RAD51 6 RAD52, DNA repair protein RAD52 6 RAD54, DNA repair protein RAD54 6 RAD55, DNA repair protein RAD55 6 RAD57, DNA repair protein RAD57 6 RAS-associated protein, RAB3A RAB3A 5 Ras-G-protein RAS 6 Receptor tyrosine kinase (RTK), Nsk2 NSK2 6 Relaxin H1 RLN1 6 Relaxin H2 RLN2 6 Replication factor A 1 Replication factor C RFC2 1 Retinoblastoma 1 RB1 6 Retinoic acid receptor, alpha RARA 6 Retinoic acid receptor, beta RARB 6 Retinoic acid receptor, gamma RARG 6 Retinoschisis, X-linked, juvenile RS 6 Rhabdoid tumors SMARCSI 6 Ribonucleotide reductase, RRM 1 Ribosomal protein L13A RPL13A 6 Ribosomal protein L17 RPL17 6 Ribosomal protein S6 kinase RPS6KA3 1 RIGUI RIGUI 6 Rim 5 Ryanodine receptor 1, skeletal RYR1 6 5-adenosylmethionine decarboxylase, AMD 1 SAP (SLAM-associated protein) SH2D1A 4 Secretin SCT 2 Secretin receptor, SCTR SCTR 2 Serine hydroxymethyltransferase SHMT 1 Serine/threonine kinase 11 STK11 6 Serine/threonine kinase 2 STK2 6 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Signal transducer and activator of transcription I STATI 6 Signal transducer and activator of transcription 2 STAT2 6 Signal transducer and activator of transcription 3 STAT3 6 Signal transducer and activator of transcription 4 STAT4 6 Signal transducer and activator of transcription 5 STAT5 6 Signaling lymphocyte activation molecule SLAM 4 Sine oculis homeobox, drosophila, homolog 1 SIX1 6 Sine oculis homeobox, drosophila, homolog 2 SIX2 6 Sine oculis homeobox, drosophila, homolog 5 SIX5 6 Small nuclear ribonucleoprotein polypeptide N SNRPN 3 Smoothened (Drosophila) homolog SMOH 6 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage gated, type V, alpha SCN5A 5 polypeptide Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 1 (glutamate transporter), SLC1A1 2 member 1 Solute carrier family 1 (glutamate transporter), SLC1A2 2 member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 19 (folate transporter), SLC19A1 2 member 1 Solute carrier family 25, member 12 SLC25A12 2 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmitter SLC6A4 2 transporter, serotonin), member 4 Somatostatin SST 5 Somatostatin receptor, SSTR1 SSTR1 5 Somatostatin receptor, SSTR2 SSTR2 6 Somatostatin receptor, SSTR3 SSTR3 5 Somatostatin receptor, SSTR4 SSTR4 5 Somatostatin receptor, SSTR5 SSTR5 5 Sorcin SRI 2 SOSI guanine nucleotide exchange factor SOS1 6 SRY-box 11 SOX11 6 Stem cell factor SCF 6 Steroid hormone receptor responsive DNA 6 elements Steroidogenic acute regulatory protein STAR 2 Substance P 5 Sulfonylurea receptor SUR 6 Suppression of tumorigenicity 3 gene ST3 6 Suppression of tumorigenicity 8 gene ST8 6 Surfeit 1 SURF1 6 Synapsin I a & 1b SYN1 5 Synapsin 2a & 2b SYN2 5 Synaptic vesicle protein 2 SV2 5 Synaptobrevin 1 SyB1 5 Synaptobrevin 2 SYB2 5 Synaptogyrin 5 Synaptophysin SYP 5 Synaptosomal-associated protein, 25 KD SNAP25 5 Synaptotagmin 1 SYT1 5 Synaptotagmin 2 SYT2 5 Syndecan 1 SYND1 6 Syndecan 2 SYND2 6 Syndecan 3 SYND3 6 Syndecan 4 SYND4 6 Synovial sarcoma gene 1 SSX1 6 Synovial sarcoma gene 2 SSX2 6 Syntaxin 1 STX1 5 Tachykinin receptor, NK1R TACR1 5 Tachykinin receptor, NK2R TACR2 5 Tachykinin receptor, NK3R TACR3 5 Talin TLN 6 Talin, TLN 3 T-cell acute lymphocytic leukemia 1 TAL1 4 T-cell acute lymphocytic leukemia 2 TAL2 4 T-cell receptor, alpha TCRA 4 T-cell receptor, delta TCRD 4 Telomerase protein component 1 Tenascin (cytotactin) 3 Tenascin XA TNXA 3 Terminal deoxynucleotidyltransferase, TDT 1 Testis-specific protein Y TSPY 6 Thrombopoietin THPO 6 Thromboxane A synthase 1 TBXAS1 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thy-1 T-cell antigen THY1 4 Thymidylate synthase TYMS 1 Thymopoietin TMPO 6 Thymosin 4 Thyroid-stimulating hormone receptor TSHR 6 Thyroid-stimulating hormone, alpha TSHA 6 Thyroid-stimulating hormone, beta TSHB 6 Thyrotropin releasing hormone TRH 5 Thyrotropin releasing hormone TRH 6 Thyrotropin releasing hormone receptor TRHR 5 Tip-associated protein TAP 4 Tissue inhibitor of metalloproteinase 1, TIMP1 TIMP1 1 Tissue inhibitor of metalloproteinase 2, TIMP2 TIMP2 1 Tissue inhibitor of metalloproteinase 3, TIMP3 TIMP3 1 Tissueinhibitorofmetalloproteinase4, TIMP4 TIMP4 1 Topoisomerase II 1 Transacylase 1 Transcobalamin 1, TCN1 2 Transcobalamin 2, TCN2 TCN2 2 Transcription factor 1, hepatic TCF1 6 Transcription factor 2, hepatic TCF2 6 Transcription factor 3 TCF3 6 Transcription factor binding to IGHM enhancer 3 TFE3 6 Transcription termination factor, RNA TTF1 6 polymerase 1 Transcription termination factor, RNA TTF2 6 polymerase 2 Transcription termination factor, RNA TTF3 6 polymerase 3 Transferrin TF 6 Transferrin receptor TFRC 6 Transforming growth factor, alpha TGFA 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFBI 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Translocation in renal carcinoma on TRC8 6 chromosome 8 gene Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tubulin 3 Tumor susceptibility gene 101 TSG101 6 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tumour protein p73 TP73 6 Tumour protein, translationally-controlled 1 TPT1 6 Tumour suppresssor gene DRA DRA 4 Twist (Drosophila) homolog TWIST 6 Ubiquitin 6 Ubiquitin activating enzyme, E1 1 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin fusion degeneration 1-like UFD1L 6 Ubiquitin protein ligase E3A UBE3A 1 Vacuolar proton pump, subunit 1 VPP1 5 Vacuolar proton pump, subunit 3 VPP3 5 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Vitamin B12-binding (R) protein 6 Vitamin D receptor VDR 6 v-myc avian myelocytomatosis viral oncogene MYC 6 homolog Von Hippel-Lindau gene VHL 6 Werner syndrome helicase WRN 6 Wilms tumour gene 1 VVT I 6 Wi ms tumour gene 2 WT2 6 Wilms tumour gene 4 WT4 6 Winged helix nude WHN 6 Wiskott-Aldrich syndrome protein WASP, THC 4 Xeroderma pigmentosum, complementation XPB 1 group B Xeroderma pigmentosum, complementation XPC 1 group C Xeroderma pigmentosum, complementation 1 group D Xeroderma pigmentosum, complementation 1 group E Xeroderma pigmentosum, complementation XPF 1 group F Xeroderma pigmentosum, complementation ERCC5 1 group G X-ray repair gene XRCC9 6 YY1 transcription factor YY1 6 Zinc finger protein HRX ALL1  4,

that the genes associated with symptoms and consequences of CNS malfunctions are selected from: HUGO Protein- List of genes gene symbol function 11-beta hydroxysteroid dehydrogenase 2 HSD11B2 1 2,3-bisphosphoglycerate mutase BPGM 1 2,4-dienoyl CoA reductase DECR 1 3 beta hydroxysteroid dehydrogenase 2 HSD3B2 1 3-oxoacid CoA transferase OXCT 1 4-hydroxyphenylpyruvate dioxygenase HPD 1 5,10-methylenetetrahydrofolate reductase MTHFR 1 (NADPH) 6-pyruvoyltetrahydropterin synthase PTS 1 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetyl CoA acyltransferase ACAA 1 Acetyl CoA carboxylase alpha ACACA 1 Acetylcholine receptor, nicotinic, alpha A1 CHRNAI 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor, nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNB1 5 Acetylcholine receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Acyl CoA dehydrogenase, long chain ACADL 1 Acyl CoA dehydrogenase, medium chain ACADM 1 Acyl CoA dehydrogenase, short chain ACADS 1 Acyl-CoA thioesterase 1 Adaptin, beta 3A ADTB3A 2 Adducin, alpha ADD1 3 Adducin, beta ADD2 3 Adenosine monophosphate deaminase AMPD 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenyl cyclase 5 Adenylate cyclase I ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adenylosuccinate lyase ADSL 1 Adrenergic receptor, alpha1 ADRAL 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Adrenoleukodystrophy gene ALD 1 Albumin, ALB ALB 2 Aldehyde dehydrogenase 10 ALDH10 1 Aldolase A ALDOA 1 Aldolase B ALDOB 1 Aldolase C ALDOC 1 Aldosterone receptor MLR 6 Alpha 2 macroglobulin A2M 4 alpha tectorin TECTA 6 alpha thalassemia gene ATRX 5 alpha1-antitrypsin PI 1 alpha2-antiplasmin PLI 1 alpha-Galactosidase A GLA 1 alpha-ketoglutarate dehydrogenase 1 alpha-L-Iduronidase IDUA 1 alpha-synuclein SNCA 5 Aminomethyltransferase AMT 1 Aminopeptidase P XPNPEP2 1 Amylo-1,6-glucosidase AGL 1 Amyloid beta (A4) precursor protein-binding, APBB1 5 APBB1 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCP1 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Antidiuretic hormone receptor ADHR 2 Antithrombin III AT3 1 Apolipoprotein A I APOA1 2 Apolipoprotein A 11 APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOC1 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Archaete-scute homolog 2 ASH2 6 Arginase ARG1 1 Arginine vasopressin AVP 5 Arginosuccinate lyase ASL 1 Arginosuccinate synthetase ASS 1 Arylsulfatase A ARSA 1 Arylsulfatase B ARSB 1 Arylsulfatase D ARSD 1 Arylsulfatase E ARSE 1 Arylsulfatase F ARSF 1 Aspaftoacylase ASPA 1 Aspartylglucosaminidase AGA 1 Astrotactin ASTN 6 Ataxia telangiectasia complementation group D ATD, ATDC 6 Ataxia telangiectasia gene, AT ATM 6 ATP-binding cassette transporter 7 ABC7 4 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Bagpipe homeobox, drosophila homolog of, 1 BAPX1 6 beta-Glucuronidase GUSB 1 beta-synuclein SNCB 5 Bilirubin UDP-glucuronosyltransferase 1 Bloom syndrome protein BLM 6 Bradykinin receptor B1 Bradykinin receptor B2 Brain derived neurotrophic factor BDNF 6 Brain derived neurotrophic factor (BDNF) BDNFR 6 receptor Butyrylcholinesterase BCHE 1 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Cadherin E CDH1 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin 1 CALB1 6 Calbindin D9K CALB3 6 Calcineurin A1 CALNA1 Calcineurin A2 CALNA2 Calcineurin A3 CALNA3 Calcineurin B Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, alpha CACNA1F 5 1 F subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1 B (CACNLI A5) Calcium channel, voltage-dependent, Alpha- CACNA1C 5 I C Calcium channel, voltage-dependent, Alpha- CACNA1D 5 1 D Calcium channel, voltage-dependent, Alpha- CACNA1E 5 I E (CACNLL A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNA1S 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1 A subunit Calcium channel, voltage-dependent, T-type 5 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase 11 CAMK2A 6 Calnexin CANX 6 Calpain CAPN, CAPN3 1 Calretinin CALB2 5 Cannabinoid receptor CNR1 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Cardiac-specific homeobox, CSX CSX 6 Carnitine acetyltransferase CRAT 1 Camitine acyicamitine translocase CACT 1 Camitine transporter protein CDSP, SCD 2 Carnosinase 5 Caspasel CASP1 6 Catechol-o-methyltransferase COMT 1 CD1 CD1 CD4 CD4 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM120 NCAM120 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Ceroid lipofuscinosis neuronal 2 CLN2 5 Ceroid lipofuscinosis neuronal 3 CLN3 5 Ceroid lipofuscinosis neuronal 4 CLN4 5 Ceroid lipofuscinosis neuronal 5 CLN5 5 Ceroid lipofuscinosis neuronal 6 CLN6 5 Chemokine receptor CCR2 CCR2 Chemokine receptor CCR3 CCR3 Chemokine receptor CCR5 CCR5 4 Chemokine receptor CXCR4 CXCR4 4 Chloride channel 1, skeletal muscle CLCN1 3 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Choline acetyltransferase CHAT 1 Choroideremia gene CHM 3 Chromogranin A CHGA 6 Chymotrypsinogen 1 Ciliary neurotrophic factor (CNTF) CNTF 6 Ciliary neurotrophic factor (CNTF) receptor CNTFR 6 Clathrin 2 CoA transferase 1 Cochlin COCH 4 Cockayne syndrome gene, CKN1 CKN1 6 Cofilin 3 Collagen I alpha 1 COL1A1 3 Collagen I alpha 2 COL1A2 3 Collagen II alpha 1 COL2AI 3 Collagen III alpha 1 COL3AI 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, EDM2 3 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6A1 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen X alpha 1 COL11AI 3 Collagen XI alpha 2 COLL 1A2 3 Collagen XVII alpha 1 COL17A1 3 Coliagenic-like tall subunit of asymmetric COLQ 1 acetylcholinesterase Colony-stimulating factor 1 CSF1 6 Colony-stimulating factor 1receptor CSFIR 6 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 2 alpha receptor CSF2RA 6 Colony-stimulating factor 2 beta receptor CSF2RB 6 Complex V MTATP6 1 Cone-rod homeobox-containing gene CRX 6 Contactin CNTN1 6 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Creb binding protein CREBBP 6 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cyclic AMP response element binding protein CREB 6 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide gated channel alpha 1, CNGAL 5 CNGA1 Cyclic nucleotide gated channel alpha 3, CNGA3 5 CNGA3 Cyclic nucleotide phosphodiesterase 1B PDEIB 1 Cyclic nucleotide phosphodiesterase 1B1 PDELBI 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin-dependent kinase 2 CDK2 6 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYPL1A1 1 CYP11BI CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A33 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cystatin B CSTB 2 Cystatin C CST3 2 Cystinosin CTNS 2 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 DAX1 nuclear receptor DAX1 4 Deafness autosomal dominant 5 DFNA5 5 Deafness dystonia peptide DDP 5 Deleted in malignant brain tumours 1 DMBT1 6 Delta aminolevulinate dehydratase ALAD 1 Delta-7-dehydrocholesterol reductase DHCR7 1 DHEA sulfotransferase STD 1 Diaphanous 1 DIAPH1 5 Diaphanous 2 DIAPH2 5 Dihydrolipoamide branched chain DBT 5 transacylase Dihydrolipoamide dehydrogenase DLD 5 Dihydrolipoyl dehydrogenase 2 PDHA 1 Dihydrolipoyl transacetylase PDHA 1 Dihydroxyacetonephosphate acyltransferase DHAPAT 1 DNA glycosylases 1 DNA helicases 1 DNA Ligase I LIG1 1 DNA methyltransferase DNMT 1 DOPA decarboxylase DDC 1 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Doublecortin, DCX DCX 3 Dynamin DNM1 6 Dystonia 1 DYT1 3 Dystonia 3 DYT3 3 Dystonia 6 DYT6 3 Dystonia 7 DYT7 3 Dystonia 9 CSE 3 Dystrophia myotonica DM, DMPK 1 Dystrophia myotonica, atypical DM2 1 Dystrophin DMD 3 Ectodermal Dysplasia 1 gene ED1 3 Electron-transfering-flavoprotein alpha ETFA 2 Electron-transfering-flavoprotein beta ETFB 2 Electron-transferring flavoprotein ETFDH 1 dehydrogenase Emerin EMD 2 Empty spiracles (drosophila) homologue 1 EMX1 6 Empty spiracies (drosophila) homologue 2 EMX2 6 Endobrevin VAMP8 5 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENO1 1 Enoyl CoA isomerase 1 Enoyl CoA reductase 1 Enterokinase PRSS7, ENTK 1 Ephrin-A EFNA 6 Ephrin-B EFNB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Epilepsy, progressive myoclonic 2 gene EPM2A 1 EWS RNA-binding protein EWSR1 6 Excision repair complementation group 4 ERCC4 1 protein Exostosin 1 EXTI 3 Exostosin 2 EXT2 3 Factor I (No. one) F1 4 Factor III F3 4 Factor IX F9 4 Factor V F5 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Factor XI F11 4 Factor Xii F12 4 Factor XIII A & B F13A & F13B 4 Fanconi anemia, complementation group A FANCA 2 Fanconi anemia, complementation group C FANCC 2 Fanconi anemia, complementation group D FANCD 2 Fibrillin 2 FBN2 6 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FN1 6 Flightless-11, Drosophila homolog of FLII 6 Follicle stimulating hormone receptor FSHR, ODG1 6 Fol icle stimulating hormone, FSH FSHB 6 Forkhead transcription factor IO FKHL10 6 Formiminotransferase 1 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Fragile site, folic acid type, rare, fra(X) E FRAXE 5 Fragile site, folic acid type, rare, fra(X) F FRAXF 5 Frataxin FRDA 6 Fructose-1,6-diphosphatase FBP1 1 Fukuyama type congenital muscular FCMD 6 dystrophy GABA receptor, alpha 1 GABRAL 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Galactocerebrosidase GALC 1 Galactose 1-phosphate uridyi-transferase GALT 1 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1,3 GGTAL 6 Galactosyltransferase, beta 3 B3GALT 6 Galanin GAL 5 Galanin receptor GALNRL 5 Gamma-glutamyltransferase 1 GGTI 2 Gap junction protein beta 2 GJB2 2 Gap junction protein beta 3 GJB3 2 Gastric Intrinsic factor, GIF GIF 1 Gastrulation brain homeobox 2 GBX2 6 Geniospasm I GSM1 6 Gephyrin 5 Glial-cell derived neurotrophic factor (GDNF) 5 receptor Glial-cell derived neurotrophic factor, GDNF GDNF 5 Glucosidase, acid alpha GAA 1 Glutamate decarboxylase, GAD GAD1 1 Glutamate dehydrogenase GLUD1 1 Glutamate receptor 1 GLURI 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutamate-cysteine ligase GLCLC 1 Glutaryl-CoA dehydrogenase GCDH 1 Glutathione GSH 2 Glutathione S-transferase, GSTZ1 GSTZI 1 Glutathione synthetase GSS 1 Glyceraldehyde-3-phosphate GAPDH 1 dehydrogenase, GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycine dehydrogenase GLDC 1 Glycine receptor, alpha GLRA2 5 Glycine receptor, beta 5 Glycine transporter GLYT 5 Glycogen phosphorylase PYGL 1 GM2 ganglioside activator protein, GM2A GM2A 1 Gonadotropin releasing hormone receptor GNRHR 6 GTP cylcohydrolase 1 GCH1 6 Guanidinoacetate N-methyltransferase GAMT 1 Guanine nucleotide-binding protein, alpha GNA01 5 activating activity polypeptide, GNAO Guanine nucleotide-binding protein, alpha GNAI1 5 inhibiting activity polypeptide 1, GNAI1 Guanine nucleotide-binding protein, alpha GNAI2 5 inhibiting activity polypeptide 2, GNAI2 Guanine nucleotide-binding protein, alpha GNAI3 5 inhibiting activity polypeptide 3, GNAI3 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, alpha GNAT1 5 transducing activity polypeptide, GNAT1 Guanine nucleotide-binding protein, alpha GNAT2 5 transducing activity polypeptide, GNAT2 Guanine nucleotide-binding protein, beta GNB3 5 polypeptide 3 Guanine nucleotide-binding protein, gamma GNG5 5 polypeptide 5 Guanine nucleotide-binding protein, q GNAQ 5 polypeptide Guanylate cyclase 2D, membrane (retina- GUCY2D 1 specific) Guanylate cyclase activator 1A (retina) GUCA1A 1 Guanylate kinase 1 Guanylyl cyclase 1 Gustducin, alpha (taste-specific G protein) GDCA 5 Haeme regulated inhibitor kinase Haemoglobin alpha 1 HBA1 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin gamma A HBG1 2 Haemoglobin gamma B HBG2 2 Haemoglobin gamma G HBGG 2 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Heat shock protein, HSPAL 4 Heat shock protein, HSPA2 4 Heparan sulfamidase 1 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor II HCF2 4 Hepatic lipase LIPC 1 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 Hippocampal cholinergic neurostimulating peptide, HCNP 5 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 Histidase 1 HLA-B associated transcript 1 BAT1 4 HLH transcription factor HAND1 HAND1 6 HLH transcription factor HAND2 HAND2 6 HMG-CoA lyase HMGCL 1 HMG-CoA reductase HMGCR 1 Holocarboxylase synthetase HLCS 1 Homeobox HB9 HLXB9 6 Human atonal gene ATOH1 6 Hypoxanthine-guanine HPRT 1 phosphoribosyltransferase, HGPRT Hypoxia inducible factor 1 HIFIA 1 Hypoxia inducible factor 2 1 IC7 A and B Inositol 1,4,5-triphosphate receptor I ITPR1 6 Inositol monophosphatase IMPA1 5 Inositol polyphosphate 1-phosphatase INPP1 5 Insulin INS 6 Insulin receptor INSR 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 Integrin beta 1 ITGB1 6 Integrin beta 2 ITGB2 6 Integrin beta 3 ITGB3 6 Integrin, alpha 1 ITGA1 6 Integrin, alpha M ITGAM 6 Inter-alpha-trypsin inhibitor, IATI 1 Interleukin(IL) 1 receptor IL1 R 4 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) 11 IL11 4 Interleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RB1 4 Interleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 Intern(IL) 2 receptor, alpha IL2RA 4 Interleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 Interleukin(IL) 5 receptor IL5R 4 Interleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 Interleukin(IL) 9 IL9 4 Interleukin(IL) 9 receptor IL9R 4 Interleukin(IL) receptor antagonist 1 IL1RN, IL1RA 4 IP3 kinase 1 Isovaleric acid CoA dehydrogenase IVD 1 Kallikrein 3 KAK3 4 Kallman syndrome gene 1 KAL1 6 Ketohexokinase KHK 1 Kininogen, High molecular weight KNG 4 Kynureninease 1 L1 cell adhesion molecule L1CAM 5 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor I LAMR1 6 Latent transforming growth factor-beta LTBP2 6 binding protein 2 Leptin LEP 6 Leptin receptor LEPR 6 Leukaemia inhibitory factor LIF 6 Leukaemia inhibitory factor receptor LIFR 6 Leukin 4 Leukocyte-specific transcript 1 LST-1 4 Leukotriene A4 hydrolase 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 Leukotriene D4/E4 receptor 4 LIM homeobox protein 1 LHX1 6 LIM homeobox protein 2 LHX2 6 LIM homeobox protein 3 LHX3 6 LIM homeobox protein 4 LHX4 6 Limbic associated membrane protein LAMP 6 LIM-domain only protein 1 LM01 6 LIM-domain only protein 2 LM02 6 LIM-domain only protein 3 LM03 6 LIM-domain only protein 4 LM04 6 LIM-Kinase I (LINK-I) 4 Lipoprotein receptor, Low Density LDLR 2 Lipoprotein, High Density HDLDT1 2 Lipoprotein, Intermediate Density 2 Lipoprotein, Low Density 1 2 Lipoprotein, Low Density 2 2 Lipoprotein, Very Low Density VLDLR 2 Low density lipoprotein receptor-related LRP 2 protein precursor Lymphoid enhancer-binding factor LEF-1 6 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 Malonyl CoA decarboxylase 1 Mannosidase, alpha B lysosomal MANB 1 Mannosidase, beta A lysosomal MANBA 1 Marenostrin MEFV 2 Melatonin receptor 1A MTNRLA 5 Melatonin receptor 1 B MTNRLB 5 Methylguanine-DNA methyltransferase MGMT 1 Methylmalonyl-CoA mutase MUT 1 Mevalonate kinase MVK 1 Microsomal triglyceride transfer protein MTP 2 Microtuble associated protein MAP 3 Mismatch repair gene, PMSL2 PMS2 6 Molybdenum cofactor synthesis 1 MOCS1 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Msh homeobox homolog 2 MSX2 6 Mucolipidoses GNPTA 1 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Myelin protein peripheral 22 PMP22 3 Myelin protein zero MPZ 3 Myogenic factor 3 MYF3 6 Myogenic factor 4 MYF4 6 Myogenic factor 5 MYF5 6 Myosin 6 MY06 3 Myosin 7A MY07A 3 Myotubularin MTMI 3 Na+, K+ ATPase, alpha ATP1A1 6 Na+, K+ ATPase, beta 1 ATP1B1 6 Na+, K+ ATPase, beta 2 ATP1B2 6 Na+, K+ ATPase, beta 3 ATP1B3 6 N-acetylglucosamine-6-sulfatase GNS 1 N-acetylglucosaminidase, alpha NAGLU 1 NADH dehydrogenase 1 reductase NB6 4 Nebulin NEB 3 Necdin NDN 6 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neural retina-specific gene NRL 6 Neuraminidase sialidase NEU 2 Neuregulin HGL 6 Neurite growth-promoting factor 2 MDK 5 Neurite inhibitory protein 5 Neuroendocrine convertase 1 NEC1, PCSKI 1 Neurofibromin I NF1 6 Neurofibromin 2 NF2 6 Neurofilament protein, heavy NFH 3 Neurofilament protein, NF68 NF68 3 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuronal apoptosis inhibitory protein NAIP 4 Neuronal molecule-1 4 Neuronal molecule-1 receptor 4 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neurotensin NTS 5 Neurotensin receptor NTSR1 5 Neutral endopeptidase 1 Niemann-Pick disease protein NPC1 2 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Notch 1 NOTCH1 6 Notch 2 NOTCH2 6 Notch 3 NOTCH3 6 Notch ligand-jagged 1 JAG 1, AGS 6 Nuclear factor I-kappa-B-like gene IKBL 4 Nucleoside diphosphate kinase-A NDPKA 1 Oncogene bcl2 6 Oncogene GLI I GLI 6 Oncogene GLI2 GLI2 6 Oncogene GLI3 GLI3 6 Oncogene sis PDGFB 6 Opioid receptor, delta OPRD1 5 Opioid receptor, kappa OPRK1 5 Opioid receptor, mu OPRM1 5 Ornithine delta-aminotransferase OAT 1 Ornithine transcarbamoylase OTC, NME1 1 Orthodenticle (Drosophila) homolog I OTX1 6 Orthodenticle (Drosophila) homolog 2 OTX2 6 Otoferlin OTOF 5 Paired box homeotic gene 2 PAX2 6 Paired box homeotic gene 3 PAX3 6 Palmitoyi-protein thioesterase PPT 2 Parkin PARK2 5 Patched (Drosophila) homolog, PTCH PTCH 6 Peanut-like 1 PNUTLL 4 PeptidylglyCihe alpha-amidating PAM 1 monooxygenase Peripherin, PRPH 3 Peroxisomal membrane protein 1 PXMP1 3 Peroxisomal membrane protein 3 PXMP3 2 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome receptor 1 PXR1 2 Persyn 3 Phosphate regulating gene with homologies PHEX 6 to endopeptidases on the X chromosome Phosphatidylinositol transfer protein PITPN 6 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase I PGKL 1 Phospholipase A2, group 10 PLA2G I 0 4 Phospholipase A2, group 1B PLA2G1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Phosphomannomutase 2 PMM2 6 Phosphoribogyl pyrophosphate synthetase PRPS1 1 Phytanoyi-CoA hydroxylase PHYH 6 Plakophilin 1 PKP1 2 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI 1 1 Plasminogen activator inhibitor 2 PAI2 1 Plasminogen activator receptor, Urokinase UPAR, PLAUR 3 Plasminogen activator, Tissue PLAT, TPA 1 Plasminogen activator, Urokinase UPA, PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Platelet-activating factor receptor PAFR 4 Plectin 1 PLEC1 2 Postsynaptic density-95 protein PSD95 5 Potassium channel, calcium-activated KCNN4 5 Potassium channel, subfamily K, member 1 KCNK1 5 Potassium channel, subfamily K, member 2 KCNK2 5 Potassium channel, subfamily K, member 3 KCNK3 5 Potassium inwardly-rectifying channel J 1 KCNJ1 5 Potassium voltage-gated channel A1 KCNA1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCNQ3 5 Potassium voltage-gated channel Q4 KCNQ4 5 POU domain, class 1, transcription factor 1 POU1F1 6 (Pit1) POU domain, class 3, transcription factor 4 POU3F4 6 POU domain, class 4, transcription factor 3 POU4F3 6 Prekallikrein 4 Preproenkephalin PENK 5 Presenitin PSEN1 2 Presenilin 2 PSEN2 2 Prion protein PRNP 5 Procollagen N-protease 1 Proline dehydrogenase PRODH 1 Pro-melanin-concentrating hormone PMCH 6 Proopiomelanocortin POMC 5 Prosaposin PSAP 5 Prostacyclin synthase 4 Prostaglandin 15-OH dehydrogenase HGPD, PGDH 4 Prostaglandin D - DP receptor 4 Prostaglandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostaglandin I2 receptor 2 Prostaglandin IP receptor 4 Protease nexin 2 PN2 1 Protective protein for beta-galactosidase PPGB 1 Protein C PROC 4 Protein C inhibitor PCI 4 Protein kinase C, alpha PRKCA 1 Protein kinase C, gamma PRKCG 1 Protein kinase G 1 Protein phosphatase 1, regulatory (inhibitor) PPP1R3 1 subunit 3 Protein S PROS1 Prothrombin precursor F2 Purine nucleoside phosphorylase NP 1 Pyrroline-5-carboxylate synthetase PYCS 1 Pyruvate carboxylase PC 1 Pyruvate decarboxylase PDHA 1 Ras-G-protein RAS 6 Rathke pouch homeobox, RPX RPX 6 Renin REN 1 Replication factor C RFC2 1 Retinal pigment epithelium specific protein RPP65 3 (65 kD) Retinaldehyde binding protein 1 RLBP1 2 Retinoblastoma 1 RB1 6 Rhodopsin kinase RHOK 1 RIGUI RIGUI 6 S100 calcium-binding protein A3 S I00A3 5 S100 calcium-binding protein A4 S100A4 5 S100 calcium-binding protein A5 S100A5 5 S100 calcium-binding protein A7 S100A7 5 S100 calcium-binding protein A8 S100A8 5 S100 calcium-binding protein A9 S100A9 5 S100 calcium-binding protein P S100P 5 Secretase, alpha 5 Secretase, beta 5 Secretase, gamma 5 Selectin E SELE 5 Selectin L SELL 5 Selectin P SELP 5 Semaphorin A4 SEMA4 3 Semaphorin A5 SEMA5 3 Semaphorin D 3 Semaphorin E SEMAE 3 Semaphorin F SEMA3/F 3 Semaphorin W SEMAW 3 Serotonin N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTRIA 5 Serotonin receptor, 5HT1B HTRIB 5 Serotonin receptor, 5HT1C HTRLC 5 Serotonin receptor, 5HT1D HTRL D 5 Serotonin receptor, 5HT1E HTRI E 5 Serotonin receptor, 5HT1F HTRL F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Signaling lymphocyte activation molecule SLAM 4 Slug protein 6 Small nuclear ribonucleoprotein polypeptide SNRPNN 3 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, SCNN1G 5 gamma Sodium channel, voltage gated, type IV, SCN4A 5 alpha polypeptide Sodium channel, voltage-gated, type 1, beta SCNLB 5 polypeptide Solute carrier family 1 (amino acid SLC1A6 2 transporter), member 6 Solute carrier family 1 (glial high affinity SLC1A3 2 glutamate transporter), member 3 Solute carrier family 1 (glutamate SLC1A1 2 transporter), member 1 Solute carrier family 1 (glutamate SLC1A2 2 transporter), member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 16 (monocarboxylate SLC16A1 2 transporter), member 1 Solute carrier family 16 (monocarboxylate SLC16A7 2 transporter), member 7 Solute carrier family 18, member 3 SLC18A3 2 Solute carrier family 2 (facilitated glucose SLC2A1 2 transporter), member I Solute carrier family 20, member 3 SLC20A3 2 Solute carrier family 25, member 12 SLC25A12 2 Solute carrier family 4 (anion exchangers, SLC4A1 2 member 1 Solute carrier family 4 (anion exchanger), SLC4A2 2 member 2 Solute carrier family 4 (anion exchanger), SLC4A3 2 member 3 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member I Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmitter SLC6A4 2 transporter, serotonin), member 4 Solute carrier family 6, member 6 SLC6A6 2 Solute carrier family 7(amino acid SLC7A1 2 transporter), member 1 Solute carrier family 7(amino acid SLC7A2 2 transporter), member 2 Solute carrier family 7(amino acid SLC7A7 2 transporter), member 7 Somatostatin SST 5 Somatostatin receptor, SSTR1 SSTR1 5 Somatostatin receptor, SSTR2 SSTR2 6 Somatostatin receptor, SSTR3 SSTR3 5 Somatostatin receptor, SSTR4 SSTR4 5 Somatostatin receptor, SSTR5 SSTR5 5 Spastic paraplegia 7 SPG7 6 Spectrin beta SPTB 3 Sphingomyelinase SMPD1 1 Spinocerebellar ataxia 8 gene SCA8 5 SRY-box 11 SOX11 6 Steroid 5 alpha reductase 1 SRD5AI 1 Steroid 5 alpha reductase 2 SRD5A2 1 Steroid sulphatase STS 1 Substance P 5 Succinic semi-aldehyde dehydrogenase SSADH 1 Sulfamidase SGSH 6 Sulfite oxidase SUOX 1 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 Surfeit 1 SURF1 6 Survival of motor neuron 1, telomeric SMN1 2 Synapsin 1a & 1b SYN1 5 Synapsin 2a & 2b SYN2 5 Synaptic vesicle amine transporter SVAT 5 Synaptic vesicle protein 2 SV2 5 Synaptobrevin 1 SYB1 5 Synaptobrevin 2 SYB2 5 Synaptogyrin 5 Synaptophysin SYP 5 Synaptosomal-associated protein, 25 KD SNAP25 5 Synaptotagmin 1 SYT1 5 Synaptotagmin 2 SYT2 5 Syntaxin 1 STX1 5 Tachykinin receptor, NK1R TACR1 5 Tachykinin receptor, NK2R TACR2 5 Tachykinin receptor, NK3R TACR3 5 Talin TLN 6 Tau protein MAPT 3 TEK, tyrosine kinase, endothelial TEK 1 Telomerase protein component 1 Thiolase, perioxisomal 1 Thrombin receptor F2R 4 Thrombopoietin THPO 6 Thromboxane A synthase 1 TBXAS1 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thy-1 T-cell antigen THY1 4 Thyroxin-binding globulin TBG 2 Tocopherol (alpha) transfer protein TTPA 2 Topoisomerase I 1 Tofticollis, keloids, cryptorchidism and renal TKCR 6 dysplasia gene Transacylase 1 Transferrin receptor TFRC 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFB1 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transketolase-like 1 TKTL1 1 Transthyretin TTR 2 Tremor, essential 1 ETM1 5 Tremor, essential 2 ETM2 5 Triosephosphate isomerase TPI1 1 Tropomyosin 3 (non-muscle) TPM3 3 Tryptophan hydroxylase TPH 1 Tubby-like protein 1 TULP1 6 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p73 TP73 6 Tyrosine aminotransferase TAT 1 Tyrosine hydroxylase TH 1 Ubiquitin 6 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin carboxyl-terminal esterase L1 UCHL1 6 UDP-glucuronosyltransferase 1 ugt1d, UGTL 1 UDP-glucuronosyltransferase 2 UGT2 1 Urate oxidase UOX 1 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Uroporphyrinogen III synthase UROS 1 Usher syndrome 2A USH2A 3 Vacuolar proton pump, subunit 1 VPP1 5 Vacuolar proton pump, subunit 3 VPP3 5 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Vesicular monoamine transporter 1 VMAT1 5 Vesicular monoamine transporter 2 VMAT2 5 Vitamin B12-binding (R) protein 6 Von Hippel-Lindau gene VHL 6 Wolf-Hirschhorn syndrome candidate I gene WHSC1 6 Wolfram syndrome 1 gene WFS1 3 Xanthine dehydrogenase XDH 1 Xeroderma pigmentosum, complementation XPA 1 group A Zinc finger protein 2 ZIC2 3

that the genes associated with symptoms of aggression or behavioral disturbances are selected from: HUGO Protein- List of genes gene symbol function 11 beta Hydroxysteroid dehydrogenase 2 HSD11B2 1 4-Hydroxyphenylpyruvate dioxygenase HPD 1 Acetylcholine receptor, nicotinic, alpha A1 CHRNA1 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor, nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNB1 5 Acety choline receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 alpha-Synuclein SNCA 5 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Androgen binding protein ABP 2 Androgen receptor AR 6 Apolipoprotein E APOE 2 Arginosuccinate synthetase ASS 1 Ataxia telangiectasia gene, AT ATM 6 beta-synuclein SNCB 5 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Cannabinoid receptor CNR1 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Catechol-o-methyltransferase COMT 1 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Choline acetyltransferase CHAT 1 Ciliary neurotrophic factor (CNTF) CNTF 6 Ciliary neurotrophic factor (CNTF) receptor CNTFR 6 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Cryptochrome 1 CRY1 3 Cryptochrome 2 CRY2 3 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cyclic AMP-dependent protein kinase PKA 1 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYPIA2 CYPIA2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Dihydrolipoamide branched chain transacylase DBT 5 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Doublecortin, DCX DCX 3 Enolase EN01 1 Flightless-II, Drosophila homolog of FLII 6 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Fragile site, folic acid type, rare, fra(X) E FRAXE 5 Fragile site, folic acid type, rare, fra(X) F FRAXF 5 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 Galactose 1-phosphate uridyl-transferase GALT 1 Geniospasm 1 GSM1 6 Glutathione GSH 2 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glyceraidehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase GM2 ganglioside activator protein, GM2A GM2A 1 Gustducin, alpha (taste-specific G protein) GDCA 5 Inositol monophosphatase IMPA1 5 IP3 kinase 1 Mannosidase, beta A lysosomal MAN1A 1 Melatonin receptor 1 A MTNR1A 5 Melatonin receptor 1 B MTNR1B 5 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 N-acetylglucosamine-6-sulfatase GNS 1 reductase Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neurotensin NTS 5 Neurotensin receptor NTSR1 5 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Ocular albinism 1 OA1 3 Opioid receptor, delta OPRD1 5 Opioid receptor, kappa OPRK1 5 Opioid receptor, mu OPRM1 5 Orexin OX 6 Orexin 1 receptor OX1R 6 Orexin 2 receptor OX2R 6 Phosphoglycerate kinase 1 PGK1 1 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Preproenkephalin PENK 5 Preproglucagon GCG, GLP1, 6 GLP2 Prion protein PRNP 5 Proline dehydrogenase PRODH 1 Pro-melanin-concentrating hormone PMCH 6 Proopiomelanocortin POMC 5 Purine nucleoside phosphorylase NP 1 RIGUI RIGUI 6 Serotonin N-acetyltransferase SNAT Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Solute carrier family 18, member 3 SLC18A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmitter SLC6A4 2 transporter, serotonin), member 4 Synapsin 1a & 1 b SYN1 5 Synapsin 2a & 2b SYN2 5 Synaptogydn 5 Synaptophysin SYP 5 Synaptosomal-associated protein, 25 KD SNAP25 5 Syntaxin 1 STx1 5 Tachykinin receptor, NKIR TACR1 5 Tachykinin receptor, NK2R TACR2 5 Tachykinin receptor, NK3R TACR3 5 Tau protein MAPT 3 Tryptophan hydroxylase TPH 1 Tyrosine hydroxyiase TH 1 Ubiquitin 6 Ubiquitin B UBB 6 Ubiquitin C UBC 6 UDP-glucuronosyltransferase 1 ugt1d, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Vacuolar proton pump, subunit 1 VPPI 5 Vacuolar proton pump, subunit 3 VPP3 5 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR  5,

that the genes associated with the consequences of clinical, psychological and social consequences of a brain lesion are selected from: HUGO Protein- List of genes gene symbol function 2,3-bisphosphoglycerate mutase BPGM 1 3-beta hydroxysteroid dehydrogenase 2 HSD3B2 1 4-hydroxyphenylpyruvate dioxygenase HPD 1 5,10-methylenetetrahydrofolate reductase MTHFR 1 (NADPH) 6-pyruvoyltetrahydropterin synthase PTS 1 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetyl CoA acyltransferase ACAA 1 Acetylcholine receptor, nicotinic, alpha Al CHRNAL 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor, nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNBL 5 Acetylcholine receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Adducin, alpha ADDI 3 Adducin, beta ADD2 3 Adenosine receptor Al ADORAL 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic receptor, alphal ADRAL 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRBI 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Albumin, ALB ALB 2 Aldehyde dehydrogenase 10 ALDH10 1 Aldosterone receptor MLR 6 Alpha 1 acid glycoprotein AAG; AGP 2 Alpha 2 macroglobulin A2M 4 alpha thalassemia gene ATRX 5 alpha 1-antitrypsin PI 1 alpha 2-antiplasmin PLI 1 alpha-synuclein SNCA 5 Aminomethyltransferase AMT 1 Aminopeptidase P XPNPEP2 1 Amyloid beta (A4) precursor protein-binding, APBB1 5 APBB1 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCPI 1 Angiotensin receptor 1 AGTRL 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Annexin 1 ANX 1 1 Antidiuretic hormone receptor ADHR 2 Antithrombin III AT3 1 Apolipoprotein A I APOAL 2 Apolipoprotein A II APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein Cl APOCI 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Apoptosis antigen 1 APTI 4 Arginase ARG1 1 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 1 B AVPR1B 5 Arginine vasopressin receptor 2 AVPR2 5 Arginosuccinate lyase ASL 1 Arginosuccinate synthetase ASS 1 Arylsulfatase A ARSA 1 Arylsulfatase D ARSD 1 Arylsulfatase E ARSE 1 Arylsulfatase F ARSF 1 Aspartoacylase ASPA 1 Ataxia telangiectasia gene, AT ATM 6 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPRI 6 Atdal natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Bagpipe homeobox, drosophila homolog of, 1 BAPXL 6 beta-synuclein SNCB 5 Bleomycin hydrolase BLMH 1 Bradykinin receptor B1 1 Bradykinin receptor B2 1 Brain derived neurotrophic factor BDNF 6 Brain derived neurotrophic factor (BDNF) BDNFR 6 receptor Butyrylcholinesterase BCHE 1 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Cadherin E CDHI 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin CALB1 6 Calbindin D9K CALB3 6 Calcineurin Al CALNAL 1 Calcineurin A2 CALNA2 1 Calcineurin A3 CALNA3 1 Calcineurin B Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, alpha CACNA1F 5 1F subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha-1C CACNA1C 5 Calcium channel, voltage-dependent, Alpha-1D CACNA1D 5 Calcium channel, voltage-dependent, Alpha- CACNA1E 5 1E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNBI 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNA1S 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase II CAMK2A 6 Calnexin CANX 6 Calpain CAPN, 1 CAPN3 Calretinin CALB2 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Cardiac-specific homeobox, CSX CSX 6 Carnosinase 5 Caspase 1 CASP1 6 Caspase 10 CASP10 6 Caspase 2 CASP2 6 Caspase 3 CASP3 6 Caspase 4 CASP4 6 Caspase 5 CASP5 6 Caspase 6 CASP6 6 Caspase 7 CASP7 6 Caspase 8 CASP8 6 Caspase 9 CASP9 6 Catechol-o-methyltransferase COMT 1 CD1 CD1 1 CD4 CD4 1 Cell adhesion molecule, intercellular, LCAM ICAM1 6 Cell adhesion molecule, leukocyte- LECAM1 6 endothelial, LECAM (CD62) Cell adhesion molecule, liver, LCAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 Ceroid lipofuscinosis neuronal 2 CLN2 5 Ceroid lipofuscinosis neuronal 3 CLN3 5 Cerold lipofuscinosis neuronal 4 CLN4 5 Ceroid lipofuscinosis neuronal 5 CLN5 5 Ceroid lipofuscinosis neuronal 6 CLN6 5 Chemokine receptor CXCR4 CXCR 4 Choline acetyltransferase CHAT 1 Chymotrypsinogen 1 Cockayne syndrome gene, CKN1 CKN1 6 Cofilin 3 Collagen I alpha 1 COL1A1 3 Collagen I alpha 2 COL1A2 3 Collagen II alpha 1 COL2A1 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, 3 EDM2 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6A1 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen X alpha 1 COL11A1 3 Collagen XI alpha 2 COL11A2 3 Collagen XVII alpha 1 COL17A1 3 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Creb binding protein CREBBP 6 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystatin B CSTB 2 Cystatin C CST3 2 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBPI 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 DAX1 nuclear receptor DAX1 Deleted in malignant brain tumours 1 DMBT1 6 Delta-7-dehydrocholesterol reductase DHCR7 1 Dihydrolipoamide branched chain DBT 5 transacylase Dihydroxyacetonephosphate acyltransferase DHAPAT 1 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Dystonia 9 CSE 3 Dystrophia myotonica DM, 1 DMPK Dystrophia myotonica, atypical DM2 1 Dystrophin DMD 3 Ectodermal Dysplasia 1 gene ED1 3 Empty spiracles (drosophila) homologue 1 EMXL 6 Empty spiracles (drosophila) homologue 2 EMX2 6 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENOI 1 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Epilepsy, benign neonatal 4 gene ICCA 1 Epilepsy, female restricted EFMR 1 Epilepsy, progressive myocionic 2 gene EPM2A 1 Excision repair complementation group 4 ERCC4 1 protein Factor 1 (No. one) F1 4 Factor III F3 4 Factor IX F9 4 Factor V F5 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Factor XI F11 4 Factor XII F12 4 Factor XIII A & B F13A & 4 F13B Fanconi anemia, complementation group C FANCC 2 Fanconi anemia, complementation group D FANCD 2 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FN1 6 Flightless-II, Drosophila homolog of FLII 6 Follicle stimulating hormone receptor FSHR, 6 ODG1 Follicle stimulating hormone, FSH FSHB 6 Formiminotransferase 1 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Fragile site, folic acid type, rare, fra(X) E FRAXE 5 Fragile site, folic acid type, rare, fra(X) F FRAXF 5 Frataxin FRDA 6 Fukuyama type congenital muscular dystrophy FCMD 6 Fumarase FH 1 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1,3 GGTA1 6 Galactosyltransferase, beta 3 B3GALT 6 Galanin GAL 5 Galanin receptor GALNR1 5 Gamma-glutamyltransferase I GGT1 2 Gastric Intrinsic factor, GIF GIF 1 GDP dissociation inhibitor I GDI1 6 Glial-cell derived neurotrophic factor (GDNF) 5 receptor Gilal-cell derived neurotrophic factor, GDNF GDNF 5 Glioma chloride ion channel, GCC 6 Glutamate decarboxylase, GAD GADI 1 Glutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutaryl-CoA dehydrogenase GCDH 1 Glutathione GSH 2 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glutathione synthetase GSS 1 Glyceraldehyde-3-phosphate GAPDH 1 dehydrogenase, GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycine dehydrogenase GLDC 1 GM2 ganglioside activator protein, GM2A GM2A 1 Gonadotropin releasing hormone receptor GNRHR 6 GTP cylcohydrolase I GCH1 6 Guanine nucleotide-binding protein, alpha GNAOI 5 activating activity polypeptide, GNAO Guanylate cyclase 2D, membrane (retina- GUCY2D 1 specific) Guanylate cyclase activator 1A (retina) GUCA1A 1 Guanylyl cyclase 1 Haeme regulated inhibitor kinase 1 Haemoglobin alpha 1 HBA1 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin gamma A HBG1 2 Haemoglobin gamma B HBG2 2 Haemoglobin gamma G HBGG 2 Heparan sulfamidase 1 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor II HCF2 4 Hepatic lipase LIPC 1 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 Histidase 1 HLA-B associated transcript 1 BAT1 HMG-CoA reductase HMGCR 1 Holocarboxylase synthetase HLCS 1 Holoprosencephaly 1 HPE1 6 Holoprosencephaly 2 HPE2 6 Holoprosencephaly 3 HPE3 6 Holoprosenceohaly 4 HPE4 6 Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 IC7 A and B 4 lnositol 1,4,5-triphosphate receptor 1 ITPR1 6 Inositol monophosphatase IMPA1 5 Insulin INS 6 Insulin receptor INSR 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 lntegrin beta 1 ITGB1 6 Integrin beta 2 ITGB2 6 Integrin beta 3 ITGB3 6 Integrin beta 4 ITGB4 6 Integrin beta 5 ITGB5 6 Integrin beta 6 ITGB6 6 Integrin beta 7 ITGB7 6 Integrin, alpha 1 ITGAL 6 Integrin, alpha 2 ITGA2 6 Integrin, alpha 3 ITGA3 6 Integrin, alpha 4 ITGA4 6 lntegrin, alpha 5 ITGA5 6 Integrin, alpha 6 ITGA6 6 Integrin, alpha 7 ITGA7 6 lntegrin, alpha 8 ITGA8 6 Integrin, alpha 9 ITGA9 6 Integrin, alpha M ITGAM 6 lntegrin, alpha X ITGAX 6 Inter-alpha-trypsin inhibitor, IATI 1 Interleukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 lnterleukin(IL) 1, beta IL1B 4 lnterleukin(IL) 10 IL10 4 lnterleukin(IL) 10 receptor IL10R 4 lnterieukin(IL) 11 IL11 4 lnterleukin(IL) 11 receptor IL11R 4 lnterleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta IL12RB1 4 Interleukin(IL) 13 IL13 4 lnterleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 lnterleukin(IL) 2 receptor, alpha IL2RA 4 Interleukin(IL) 2 receptor, gamma IL2RG 4 lnterleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 lnterleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 lnterleukin(IL) 5 receptor IL5R 4 lnterleukin(IL) 6 IL6 4 lnterleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 lnterleukin(IL) 8 receptor IL8R 4 lnterleukin(IL) 9 IL9 4 lnterleukin(IL) 9 receptor IL9R 4 lnterleukin(IL) receptor antagonist 1 ILI RN, 1 IP3 kinase IL1RA Kallikrein 3 KAK3 4 Kininogen, High molecular weight KNG 4 Kynureninease 1 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMR1 6 Latent transforming growth factor-beta LTBP2 6 binding protein 2 Leptin LEP 6 Leptin receptor LEPR 6 Leukin 4 Leukocyte-specific transcript 1 LST-1 4 Leukotriene A4 hydrolase Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 Leukotriene D4/E4 receptor 4 LIM homeobox protein 1 LHX1 6 LIM-Kinase I (LINK-1) 4 Lipocortin 1 ANX4 4 Lipoprotein lipase LPL 4 Lipoprotein receptor, Low Density LDLR 2 Lipoprotein, High Density HDLDT1 2 Lipoprotein, Intermediate Density 2 Lipoprotein, Low Density 1 2 Lipoprotein, Low Density 2 2 Lipoprotein, Very Low Density VLDLR 2 Lipoprotein-associated coagulation factor LACI 4 Low density lipoprotein receptor-related LRP 2 protein precursor Lymphoid enhancer-binding factor LEF-1 6 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 Malonyl CoA decarboxylase 1 Mannosidase, alpha B lysosomal MANB 1 Mannosidase, -beta A lysosomal MANBA 1 Methionine synthase MTR 1 Methylmalonyl-CoA mutase MUT 1 Mevalonate kinase MVK 1 Mismatch repair gene, PMSL2 PMS2 6 Molybdenum cofactor synthesis 1 MOCS1 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Mucolipidoses GNPTA 1 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Myelin basic protein 3 N-acetylglucosamine-6-sulfatase GNS 1 N-acetylglucosaminidase, alpha NAGLU 1 reductase NB6 4 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neurite inhibitory protein 5 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neurofilament protein, NF68 NF68 3 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Notch 3 NOTCH3 6 Notch ligand-jagged 1 JAG 1, AGS 6 Nuclear factor 1-kappa-B-like gene IKBL 4 Nucieoside diphosphate kinase-A NDPKA 1 Oncogene bcI2 6 Oncogene sis PDGFB 6 Ornithine delta-aminotransferase OAT 1 Ornithine transcarbamoylase OTC, NME1 1 Orthodenticle (Drosophila) homolog 1 OTX1 6 Orthodenticle (Drosophila) homolog 2 OTX2 6 Patched (Drosophila) homolog, PTCH PTCH 6 Peroxisomal membrane protein 1 PXMP1 3 Peroxisomal membrane protein 3 PXMP3 2 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome receptor 1 PXR1 2 Persyn 3 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase 1 PGK1 1 Phospholipase A2, group 10 PLA2G 10 1 Phospholipase A2, group 1B PLA2G 1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Phosphomannomutase 2 PMM2 6 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI1 1 Plasminogen activator inhibitor 2 PAI2 1 Plasminogen activator receptor, Urokinase UPAR; 3 PLAUR Plasminogen activator, Tissue PLAT; TPA 1 Plasminogen activator, Urokinase UPAPLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Platelet glycoprotein I b, alpha GP1BA 4 Platelet glycoprotein I b, beta GP1BB 4 Platelet glycoprotein I b, gamma GPIBG 4 Platelet glycoprotein IX GP9 4 Platelet glycoprotein V GP5 4 Platelet-activating factor acetylhydrolase 2 PAFAH2 4 Platelet-activating factor receptor PAFR 4 Plectin 1 PLEC1 2 Polycystin 1 PKD1 2 Polycystin 2 PKD2 2 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQI 5 Potassium voltage-gated channel Q2 KCN02 5 Potassium voltage-gated channel Q3 KCNQ3 5 POU domain, class 1, transcription factor 1 POU1F1 6 (Pit1) Prekallikrein Prion protein PRNP 5 Procollagen N-protease 1 Proline dehydrogenase PRODH 1 Proopiomelanocortin POMC 5 Prostacyclin synthase 4 Prostaglandin 15-OH dehydrogenase HGPD, 4 PGDH Prostaglandin D - DP receptor 4 Prostaglandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostaglandin I2 receptor 2 Prostaglandin IP receptor 4 Protective protein for beta-galactosidase PPGB 1 Protein C PROC 4 Protein C inhibitor PCI 4 Protein kinase C, alpha PRKCA 1 Protein kinase C, gamma PRKCG 1 Protein kinase G 1 Protein phosphatase 1, regulatory (inhibitor) PPPIR3 1 subunit 3 Protein S PROS1 4 Prothrombin precursor F2 4 Purine nucleoside phosphorylase NP 1 Pyrroline-5-carboxylate synthetase PYCS 1 Pyruvate carboxylase PC 1 Ras-G-protein RAS 6 Renin REN 1 Replication factor C RFC2 1 RIGUI RIGUI 6 S100 calcium-binding protein A1 S100A1 5 S100 calcium-binding protein A4 S100A4 5 S100 calcium-binding protein A5 S100A5 5 S100 calcium-binding protein A6 S100A6 5 S100 calcium-binding protein A7 S100A7 5 S100 calcium-binding protein A9 S100A9 5 S100 calcium-binding protein B S100B 5 Secretase, alpha 5 Secretase, beta 5 Secretase, gamma 5 Selectin E SELE 5 Selectin L SELL 5 Selectin P SELP 5 Serotonin N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1 D HTR1D 5 Serotonin receptor, 5HT1 E HTR1E 5 Serotonin receptor, 5HT1 F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, SCNN1G 5 gamma Sodium channel, voltage-gated, type 1, beta SCN B 5 polypeptide Solute carder family 1 (glutamate SLC1A1 2 transporter), member 1 Solute carrier family 1 (glutamate SLC1A2 2 transporter), member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 16 (monocarboxylate SLC16A1 2 transporter), member 1 Solute carrier family 16 (monocarboxylate SLC16A7 2 transporter), member 7 Solute carrier family 18, member 3 SLC18A3 2 Solute carrier family 2 (facilitated glucose SLC2A1 2 transporter), member 1 Solute carrier family 20, member 3 SLC2OA3 2 Solute carrier family 5 (sodium/glucose SLC5AI 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member. Solute carrier family 6 (neurotransmifter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmifter SLC6A2 2 transporter, noradrenaline), member 2 Solute carder family 6 (neurotransmifter SLC6A4 2 transporter, serotonin), member 4 Solute carrier family 7(amino acid SLC7A1 2 transporter), member 1 Solute carrier family 7(amino acid SLC7A2 2 transporter), member 2 Solute carrier family 7(amino acid SLC7A7 2 transporter), member 7 Sphingomyelinase SMPD1 1 Spinocerebellar ataxia 8 gene SCA8 5 Steroid 5 alpha reductase 1 SRD5A1 1 Steroid 5 alpha reductase 2 SRD5A2 1 Substance P 5 Succinic semi-aldehyde dehydrogenase SSADH 1 Sulfamidase SGSH 6 Sulfite oxidase SUOX 1 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 Surfeit 1 SURF1 6 Synapsin 1 a & 1 b SYN1 5 Synapsin 2a & 2b SYN2 5 Synaptic vesicle amine transporter SVAT 5 Synaptobrevin 1 SYB1 5 Synaptobrevin 2 SYB2 5 Synaptogyrin 5 Synaptophysin SYP 5 Synaptotagmin 1 SYT1 5 Synaptotagmin 2 SYT2 5 Syntaxin 1 STX1 5 Talin TLN 6 Tau protein MAPT 3 TEK, tyrosine kinase, endothelial TEK 1 Telomerase protein component 1 Thrombin receptor F2R 4 Thrombopoietin THPO 6 Thromboxane A synthase I TBXASI 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thyroxin-binding globulin TBG 2 Topoisomerase I 1 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (‘I NF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tyrosine aminotransferase TAT 1 Tyrosine hydroxylase TH 1 Ubiquitin 6 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin carboxyl-terminal esterase L1 UCHL1 6 UDP-glucuronosyltransferase 1 ugt1d, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Undulin 1 COL14A1 3 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Uroporphyrinogen III synthase UROS Vacuolar proton pump, subunit 1 VPP1 5 Vacuolar proton pump, subunit 3 VPP3 5 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Von Hippel-Lindau gene VHL 6 Wolf-Hirschhorn syndrome candidate 1 gene WHSC1 6 Xanthine dehydrogenase XDH 1 Zinc finger protein 2 ZIC2 3,

that the genes associated with dementia and/or associated syndromes are selected from: HUGO Protein- List of genes gene symbol function 2,3-Bisphosphoglycerate mutase BPGM 1 3 beta Hydroxysteroid dehydrogenase 2 HSD3B2 1 5,10-Methylenetetrahydrofolate reductase MTHFR 1 (NADPH) Acetylcholine receptor, nicotinic, alpha A1 CHRNA1 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor, nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNB1 5 Acetylcholine receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Adducin, alpha ADD1 3 Adducin, beta ADD2 3 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 AOCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Albumin, ALB ALB 2 Aldosterone receptor MLR 6 alpha 2 Macroglobulin A2M 4 alpha1-Antitrypsin PI 1 alpha2-Antiplasmin PLI 1 alpha-Synuclein SNCA 5 Aminopeptidase P XPNPEP2 1 Amyloid beta (A4) precursor protein-binding, APBB1 5 APBB1 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCP1 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Antidiuretic hormone receptor ADHR 2 Antithrombin III AT3 1 Apolipoprotein A 1 APOA1 2 Apoiipoprotein A 1 APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOC1 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Apoptosis antigen 1 APT1 4 Arginase ARG1 1 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 1B AVPRL1B 5 Arginine vasopressin receptor 2 AVPR2 5 Arginosuccinate lyase ASL 1 Arginosuccinate synthetase ASS 1 Ataxia telangiectasia gene, AT ATM 6 ATP/ADP translocase 1 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Bagpipe homeobox, drosophila homolog of, 1 BAPX1 6 beta-synuclein SNCB 5 Bleomycin hydrolase BLMH 1 Bradykinin receptor B1 4 Bradykinin receptor B2 4 Brain derived neurotrophic factor BDNF 6 Brain derived neurotrophic factor (BDNF) BDNFR 6 receptor Butyrylcholinesterase BCHE 1 Cadherin E CDH1 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin 1 CALB1 6 Calbindin D9K CALB3 6 Calcineurin A1 CALNA1 4 Calcineurin A2 CALNA2 4 Calcineurin A3 CALNA3 4 Calcineurin B Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, alpha 1 F CACNA1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha-1 C CACNA1C 5 Calcium channel, voltage-dependent, Alpha-1 D CACNA1D 5 Calcium channel, voltage-dependent, Alpha- CACNA1E 5 1 E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNAL S 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase II CAMK2A 6 Calnexin CANX 6 Calpain CAPN, CAPN3 1 Calretinin CALB2 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Cardiac-specific homeobox, CSX CSX 6 Caspase 1 CASP1 6 Caspase 10 CASP10 6 Caspase 2 CASP2 6 Caspase 3 CASP3 6 Caspase 4 CASP4 6 Caspase 5 CASP5 6 Caspase 6 CASP6 6 Caspase 7 CASP7 6 Caspase 8 CASP8 6 Caspase 9 CASP9 6 Catechol-o-methyltransferase COMT 1 CD1 CD1 CD4 CD4 Cell adhesion molecule, intercellular, ICAM ICAM1 6 Cell adhesion molecule, leukocyte-endothelial, LECAM1 6 LECAM (CD62) Cell adhesion molecule, liver, LCAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cel adhesion molecule, platelet-endothelial, PECAM1 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 Chemokine receptor CXCR4 CXCR4 4 Choline acetyltransferase CHAT 1 Chymotrypsinogen 1 Cockayne syndrome gene, CKN1 CKN1 6 Cofilin 3 Collagen I alpha 1 COLIA1 3 Collagen I alpha 2 COLIA2 3 Collagen II alpha 1 COL2A1 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, EDM2 3 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6A1 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen X alpha 1 COL11A1 3 Collagen XI alpha 2 COL11A2 3 Collagen XVII alpha 1 COL17A1 3 Corticotrophin releasing hormone CRH 2 Corticotrophin releasing hormone receptor CRHR1 2 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathione beta synthase CBS 1 Cystatin C CST3 2 Cystinosin CTNS 2 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Dihydrolipoyl succinyltransferase DLST 1 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Doublecortin, DCX DCX 3 Emerin EMD 2 Endothelin 1 DNI 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENO1 1 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Epilepsy, progressive myoclonic 2 gene EPM2A 1 Excision repair complementation group 4 ERCC4 1 protein Factor I (No. one) F1 4 Factor III F3 4 Factor IX F9 4 Factor V F5 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Factor XI F11 4 Factor XII F12 4 Factor XIII A & B F13A & F13B 4 Fanconi anemia, complementation group A FANCA 2 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibroblast growth factor FGFI 6 Fibroblast growth factor receptor 1 FGFRL 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FN1 6 Follicle stimulating hormone receptor FSHR, ODG1 6 Follicle stimulating hormone, FSH FSHB 6 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1, 3 GGTA1 6 Galactosyltransferase, beta 3 B3GALT 6 Gastric Intrinsic factor, GIF GIF 1 Glial-cell derived neurotrophic factor (GDNF) 5 receptor Glial-cell derived neurotrophic factor, GDNF GDNF 5 Glutamate decarboxylase, GAD GAD1 1 Glutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutaryl-CoA dehydrogenase GCDH 1 Glutathione GSH 2 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glyceraldehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Gonadotropin releasing hormone receptor GNRHR 6 Guanylyl cyclase 1 Haemoglobin alpha 1 HBAL 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin gamma A HBGL 2 Haemoglobin gamma B HBG2 2 Haemoglobin gamma G HBGG 2 Heparan sulfamidase 1 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor II HCF2 4 Hepatic lipase LIPC 1 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 Hippocampal cholinergic neurostimulating peptide, HCNP 5 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 Histidase 1 HLA-B associated transcript 1 BAT1 HMG-CoA reductase HMGCR 1 Holocarboxylase synthetase HLCS 1 Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 IC7 A and B 4 Inositol monophosphatase IMPA1 5 Insulin INS 6 Insulin receptor INSR 6 Integrin beta 1 ITGB1 6 Integrin beta 2 ITGB2 6 Integrin beta 3 ITGB3 6 Integrin beta 4 ITGB4 6 Integrin beta 5 ITGB5 6 Integrin beta 6 ITGB6 6 Integrin beta 7 ITGB7 6 Integrin, alpha 1 ITGA1 6 Integrin, alpha 2 ITGA2 6 Integrin, alpha 3 ITGA3 6 Integrin, alpha 4 ITGA4 6 lntegrin, alpha 5 ITGA5 6 Integrin, alpha 6 ITGA6 6 lntegrin, alpha 7 ITGA7 6 Integrin, alpha 8 ITGA8 6 lntegrin, alpha 9 ITGA9 6 Integrin, alpha M ITGAM 6 Integrin, alpha, X ITGAX 6 Interleukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) II IL11 4 Interleukin(IL) I 1 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RB1 4 lnterleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 Interleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 lnterleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 Interleukin(IL) 5 receptor IL5R 4 lnterleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R I′ Interleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 Interleukin(IL) 9 IL9 4 lnterleukin(IL) 9 receptor IL9R 4 Interleukin(IL) receptor antagonist 1 IL1 RN, IL1RA 4 IP3 kinase 1 Kallikrein 3 KAK3 4 Kininogen, High molecular weight KNG 4 Kynureninease 1 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMR1 6 Latent transforming growth factor-beta binding LTBP2 6 protein 2 Leptin LEP 6 Leptin receptor LEPR 6 Leukin 4 Leukocyte-specific transcript 1 LST-1 4 Leukotriene A4 hydrolase 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 Leukotriene D4/E4 receptor 4 LIM homeobox protein 1 LHX1 6 LIM-Kinase I (LINK-1) 4 Lipoprotein receptor, Low Density LDLR 2 Lipoprotein, High Density HDLDT1 2 Lipoprotein, Intermediate Density 2 Lipoprotein, Low Density I 2 Lipoprotein, Low Density 2 2 Lipoprotein, Very Low Density VLDLR 2 Low density lipoprotein receptor-related protein LRP 2 precursor Lymphoid enhancer-binding factor LEF-1 6 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 Mannosidase, alpha B lysosomal MANB 1 Mannosidase, beta A lysosomal MANBA 1 Methionine synthase MTR 1 Mismatch repair gene, PMSL2 PMS2 6 Molybdenum cofactor synthesis 1 MOSC1 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Muscarinic receptor, M1 CHRM1 5 Muscadnic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Myelin basic protein 3 N-Acetylglucosamine-6-sulfatase GNS 1 N-Acetylglucosaminidase, alpha reductase NB6 NAGLU 1 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neurite inhibitory protein 5 Neuroendocrine convertase 1 NEC1, PCSK1 1 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neurofilament protein, NF68 NF68 3 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Notch 3 NOTCH3 6 Nuclear factor 1-kappa-B-like gene IKB1 4 Nucleoside diphosphate kinase-A NDPKA 1 Oncogene bcI2 6 Oncogene sis PDGFB 6 Omithine delta-aminotransferase OAT 1 Omithine transcarbamoylase OTC, NME1 1 Parkin PARK2 5 Persyn 3 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase 1 PGK1 1 Phospholipase A2, group 10 PLA2G 10 4 Phospholipase A2, group 1B PLA2G1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI1 1 Plasminogen activator inhibitor 2 PAI2 1 Plasminogen activator receptor, Urokinase UPAR; PLAUR 3 Plasminogen activator, Tissue PLAT; TPA 1 Plasminogen activator, Urokinase UPA; PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Platelet-activating factor receptor PAFR 4 Postsynaptic density-95 protein PSD95 5 Potassium inwardly-rectifying channel J1 KCNJI 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 POU domain, class 1, transcription factor 1 (Pit1) POU1F1 6 Prekallikrein Presenilin 1 PSEN1 2 Presenilin 2 PSEN2 2 Prion protein PRNP 5 Procoliagen N-protease 1 Proopiomelanocortin POMC 5 Prostacyclin synthase 4 Prostagiandin 15-OH dehydrogenase HGPD; PGDH 4 Prostagiandin D - DP receptor 4 Prostagiandin El receptor 4 Prostaglandin E2 receptor 4 Prostagiandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostaglandin 12 receptor 2 Prostaglandin IP receptor 4 Protective protein for beta-galactosidase PPGB 1 Protein C PROC 4 Protein C inhibitor PCI 4 Protein kinase C, alpha PRKCA 1 Protein kinase C, gamma PRKCG 1 Protein kinase G 1 Protein phosphatase 1, regulatory (inhibitor) PPP1R3 1 subunit 3 Protein S PROS1 4 Prothrombin precursor F2 4 Purine nucleoside phosphorylase NP 1 Pyruvate carboxylase PC 1 Renin REN 1 Replication factor C RFC2 1 RIGUI RIGUI 6 S100 calcium-binding protein A3 S 100A3 5 S100 calcium-binding protein A4 S 100A4 5 S100 calcium-binding protein A5 S 100A5 5 S100 calcium-binding protein A7 S 100A7 5 S100 calcium-binding protein A8. S 100A8 5 S100 calcium-binding protein B S 100B 5 S100 calcium-binding protein P S 100P 5 Secretase, alpha 5 Secretase, beta 5 Secretase, gamma 5 Selectin E SELE 5 Selectin L SELL 5 Selectin P SELP 5 Serotonin N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 1 (glutamate transporter), SLC1A1 2 member 1 Solute carrier family 1 (glutamate transporter), SLC1A2 2 member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 8, member 3 SLC18A3 2 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5 member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmifter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmifter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmifter SLC6A4 2 transporter, serotonin), member 4 Sphingomyelinase SMPD1 1 Substance P 5 Succinic semi-aidehyde dehydrogenase SSADH 1 Sulfite oxidase SUOX 1 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 Surfeit 1 SURF1 6 Synaptogyrin 5 Synaptophysin SYP 5 Syntaxin 1 STXI 5 Talin TLN 6 Tau protein MAPT 3 TEK, tyrosine kinase, endothelial TEK 1 Telomerase protein component 1 Thrombin receptor F2R 4 Thrombopoietin THPO 6 Thromboxane A synthase 1 TBXAS1 4 Topoisomerase 1 1 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tyrosine aminotransferase TAT 1 Tyrosine hydroxylase TH 1 Ubiquitin 66 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin carboxyl-terminal esterase L1 UCHL1 6 UDP-glucuronosyltransferase 1 ugt1d, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Uroporphyrinogen III-synthase UROS 1 Vacuolar proton pump, subunit 1 VPP1 5 Vacuolar proton pump, subunit 3 VPP3 5 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Xanthine dehydrogenase XDH 1

that the genes associated with psychotic disturbances and personality disorders are selected from: HUGO Protein- List of genes gene symbol function 11 beta hydroxysteroid dehydrogenase 2 HSD11B2 1 5,10-methylenetetrahydrofolate reductase MTHFR 1 (NADPH) Acetylcholine receptor, nicotinic, alpha A1 CHRNA1 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor. nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNB1 5 Acetylcholine receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADO 2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adenylosuccinate lyase ADSL 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Albumin, ALB ALB 2 alpha 1-antichymotrypsin AACT 1 alpha-synuclein SNCA 5 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Apolipoprotein A I APOA1 2 Apolipoprotein A II APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOC1 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Arginosuccinate synthetase ASS 1 Arylsuffatase A ARSA 1 Ataxia telangiectasia gene, AT ATM 6 ATP/ADP translocase 1 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Bagpipe homeobox, drosophila homolog of, 1 BAPX1 6 beta-synuclein SNCB 5 Brain derived neurotrophic factor BDNF 6 Brain derived neurotrophic factor (BDNF) BDNFR 6 receptor C1 inhibitor 1 Ca(2+) transporting ATPase, slow twitch albindin ATP2A2 2 Calbindin D9K CALB1 6 Calcineurin A1 CALB3 6 Calcineurin A2 CALNA1 4 Calcineurin A3 CALNA2 4 Calcineurin B CALNA3 4 Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, alpha 1 F CACNA 1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA 1B 5 I B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA 1C 5 I C Calcium channel, voltage-dependent, Alpha- CACNA 1D 5 1 D Calcium channel, voltage-dependent, Alpha- CACNA 1E 5 I E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, T-type 5 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase II CAMK2A 6 Calnexin CANX 6 Calpain CAPN, 1 CAPN3 Calretinin CALB2 5 Cannabinoid receptor CNR1 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Cardiac-specific homeobox, CSX CSX 6 Caspase 1 CASP1 6 Catechol-o-methyltransferase COMT 1 Ceroid lipofuscinosis neuronal 2 CLN2 5 Ceroid lipofuscinosis neuronal 3 CLN3 5 Ceroid lipofuscinosis neuronal 4 CLN4 5 Ceroid lipofuscinosis neuronal 5 CLN5 5 Ceroid lipofuscinosis neuronal 6 CLN6 5 Chemokine receptor CCR5 CCR5 4 Chemokine receptor CXCR4 CXCR4 4 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Choline acetyltransferase CHAT 1 Chymotrypsinogen 1 Ciliary neurotrophic factor (CNTF) CNTF 6 Ciliary neurotrophic factor (CNTF) receptor CNTFR 6 Citrate synthase 1 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 2 alpha receptor CSF2RA 6 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cyclic AMP response element binding protein CREB 6 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1 B PDE1B 1 Cyclic nucleotide phosphodiesterase 1 B 1 PDE1B1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Delta aminolevulinate dehydratase ALAD 1 Delta-7-dehydrocholesterol reductase DHCR7 1 Dihydrolipoamide succinyltransferase 5 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENO1 1 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Excision repair complementation group 4 ERCC4 1 protein Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Flightless-II, Drosophila homolog of FLII 6 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Fragile site, folic acid type, rare, fra(X) E FRAXE 5 Fragile site, folic acid type, rare, fra(X) F FRAXF 5 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRGI 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 GDP dissociation inhibitor 1 GDI 1 6 Geniospasm 1 GSM1 6 Glial-cell derived neurotrophic factor (GDNF) 5 receptor Glial-cell derived neurotrophic factor, GDNF GDNF 5 Glutamate decarboxylase, GAD GAD1 1 Glutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutaryl-CoA dehydrogenase GCDH 1 Glutathione GSH 2 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glyceraldehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Gonadotropin releasing hormone receptor GNRHR 6 Guanidinoacetate N-methyltransferase GAMT 1 Guanine nucleotide-binding protein, alpha GNAO1 5 activating activity polypeptide, GNAO Guanine nucleotide-binding protein, alpha GNAI1 5 inhibiting activity polypeptide 1, GNAI1 Guanine nucleotide-binding protein, alpha GNAI2 5 inhibiting activity polypeptide 2, GNAI2 Guanine nucleotide-binding protein, alpha GNAI3 5 inhibiting activity polypeptide 3, GNAI3 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, alpha GNAT1 5 transducing activity polypeptide, GNAT1 Guanine nucleotide-binding protein, alpha GNAT2 5 transducing activity polypeptide, GNAT2 Guanine nucleotide-binding protein, beta GNB3 5 polypeptide 3 Guanine nucleotide-binding protein, GNAQ 5 polypeptide Guanylate cyclase 2D, membrane (retina- GUCY2D 1 specific) Guanylate cyclase activator 1A (retina) GUCA1A 1 Guanylyl cyclase 1 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Heat shock protein, HSPA1 4 Heat shock protein, HSPA2 4 Heparan sulfamidase 1 Hepatic lipase LIPC 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 HMG-CoA reductase HMGCR 1 Huntingtin HD 2 Hypoxanthine-guanine HPRT 1 phosphoribosyltransferase, HGPRT Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 Inositol monophosphatase IMPA1 5 Insulin INS 6 Insulin receptor INSR 6 lnterleukin(IL) 1 receptor IL1R 4 lnterleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 lnterleukin(IL) 10 receptor IL10R 4 lnterleukin(IL) 11 IL11 4 Interleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RB1 4 Interleukin(IL) 13 IL13 4 lnterleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 lnterleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 3 IL3 4 lnterleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 Interleukin(IL) 5 receptor IL5R 4 Interleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 lnterleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 lnterleukin(IL) 9 IL9 4 Interleukin(IL) 9 receptor IL9R 4 lnterleukin(IL) receptor antagonist 1 IL1 RN, 4 IL1RA IP3 kinase 1 Leukin 4 Mismatch repair gene, PMSL2 PMS2 6 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Myelin basic protein 3 Myosin, light chain 3 MYL3 3 reductase Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neurite inhibitory protein 5 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neurofilament protein, NF68 NF68 3 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neurotensin NTS 5 Neurotensin receptor NTSR1 5 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Nucleoside diphosphate kinase-A NDPKA 1 Oncogene sis PDGFB 6 Opioid receptor, delta OPRD1 5 Opioid receptor, kappa OPRKI 5 Opioid receptor, mu OPRMI 5 Ornithine delta-aminotransferase OAT 1 Paraoxonase PON1 PON1 1 Parkin PARK2 5 Phospholipase A2, group 10 PLA2G10 4 Phospholipase A2, group 1B PLA2G1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Potassium inwardly-rectifying channel J1 KCNJL 5 POU domain, class 1, transcription factor 1 POU1F1 6 (Pit1) Presenilin 1 PSEN1 2 Presenilin 2 PSEN2 2 Prion protein PRNP 5 Proline dehydrogenase PRODH 1 Proopiomelanocortin POMC 5 Prosaposin PSAP 5 Protective protein for beta-galactosidase PPGB 1 Protein kinase C, alpha PRKCA 1 Protein kinase C, gamma PRKCG 1 Protein kinase G 1 Protein phosphatase 1, regulatory (inhibitor) PPP1R3 1 subunit 3 Proteolipid protein PLP 5 RIGUI RIGUI 6 S100 calcium-binding protein A2 S100A2 5 S100 calcium-binding protein A3 S100A3 5 S100 calcium-binding protein A4 S100A4 5 S100 calcium-binding protein A5 S100A5 5 S100 calcium-binding protein A7 S100A7 5 S100 calcium-binding protein A8 S100A8 5 S100 calcium-binding protein A9 S100A9 5 S100 calcium-binding protein B S100B 5 S100 calcium-binding protein P S100P 5 Secretase, alpha 5 Secretase, beta 5 Secretase, gamma 5 Serotonin N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 4 (anion exchanger), SLC4A1 2 member 1 Solute carrier family 4 (anion exchanger), SLC4A2 2 member 2 Solute carrier family 4 (anion exchanger), SLC4A3 2 member 3 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A2 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmitter SLC6A4 2 transporter, serotonin), member 4 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 Synapsin 1a & 1b SYN1 5 Synapsin 2a & 2b SYN2 5 Synaptic vesicle amine transporter SVAT 5 Synaptogyrin 5 Synaptophysin SYP 5 Synaptosomal-associated protein, 25 KD SNAP25 5 Syntaxin 1 STX1 5 Tachykinin receptor, NK1R TACR1 5 Tachykinin receptor, NK2R TACR2 5 Tachykinin receptor, NK3R TACR3 5 Talin TLN 6 TEK, tyrosine kinase, endothelial TEK 1 Telomerase protein component 1 Transcobalamin 1, TCN1 2 Transcobalamin 2, TCN2 TCN2 2 Transcription factor, TUPLE1 TUPLE1 5 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFBI 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transthyretin TTR 2 Trypsin inhibitor 1 Tryptophan 2,3-dioxygenase TDO2 5 Tryptophan hydroxylase TPH 1 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tyrosinase TYR 1 Tyrosine hydroxylase TH 1 Ubiquitin 6 Ubiquitin activating enzyme, E1 1 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin protein ligase E3A UBE3A 1 UDP-glucuronosyltransferase 1 ugtld, UGTI 1 UDP-glucuronosyltransferase 2 UGT2 1 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Vacuolar proton pump, subunit 1 VPP1 5 Vacuolar proton pump, subunit 3 VPP3 5 Vesicular monoamine transporter 1 VMAT1 5 Vesicular monoamine transporter 2 VMAT2  5,

that the genes associated with cardiovascular disorder, malfunction or damage are selected from: HUGO List of genes gene symbol Protein-function 17beta hydroxysteroid oxidoreductase 1 2,3-bisphosphoglycerate mutase BPGM 1 3 beta hydroxysteroid dehydrogenase 2 HSD3B2 1 3-oxoacid CoA transferase OXCT 1 5,10-methylenetetrahydrofolate reductase MTHFR 1 (NADPH) Acetoacetyl 1-CoA-thiolase ACAT1 1 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetyl CoA acyltransferase ACAA 1 Acety[cholinesterase ACHE 1 Acid phosphatase 2, lysosomal ACP2 1 Acidic amino acid transporter 2 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTAL 3 Actin, alpha, smooth, aortic ACTA2 3 Activin A receptor, type 2B ACVR2B 6 Acyl CoA dehydrogenase, long chain ACADL 1 Acyl CoA dehydrogenase, very long chain ACADVL 1 Adaptin, beta 3A ADTB3A 2 Adducin, alpha ADDI 3 Adducin, beta ADD2 3 Adenosine deaminase ADA 1 Adenosine receptor A1 ADORAL 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase I ADCYI 1 Adenylate cyclase
 2. ADGY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adenylate kinase AK1 1 Adrenergic receptor, alphal ADRAI 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, betal ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) receptor ACTHR 6 Alanine aminotransferase 2 Alanine-glyoxylate aminotransferase AGXT 1 Albumin, ALB ALB 2 Alcohol dehydrogenase 1 ADHL 1 Alcohol dehydrogenase 2 ADH2 1 Alcohol dehydrogenase 3 ADH3 F = Alcohol dehydrogenase 5 ADH5 1 Alcohol dehydrogenase 6 ADH6 1 Alcohol dehydrogenase 7 ADH7 1 Aidehyde dehydrogenase 1 ALDHL 1 Aidehyde dehydrogenase 10 ALDH10 1 Aidehyde dehydrogenase 2 ALDH2 1 Aldehyde dehydrogenase 5 ALDH5 1 Aldehyde dehydrogenase 6 ALDH6 1 Aldehyde dehydrogenase 7 ALDH7 1 Aldolase A ALDOA 1 Aidolase B ALDOB 1 Aldolase C ALDOC 1 Aldosterone receptor MLR 6 Alpha 1 acid glycoprotein G; AGP 2 Alpha 2 macroglobulin A2M 4 alphal-antitrypsin Pi 1 alpha2-antiplasmin PLI 1 alpha-actinin 2 ACTN2 6 alpha-actinin 3 ACTN3 6 alpha-Galactosidase A GLA 1 alpha-L-Iduronidase IDUA 1 Aminopeptidase P XPNPEP2 1 Amphiregulin AREG 6 Amylo-1,6-glucosidase AGL 1 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCPL 1 Angiotensin receptor 1 AGTRI 2 Angiotensi'n receptor 2 AGTR2 2 Angiotensinogen AGT 1 Ankyrin 1 ANKI 3 Ankyrin 2 ANK2 3 Ankyrin 3 ANK3 3 Annexin I ANXI 4 Antidiuretic hormone receptor ADHR 2 Antithrombin III AT3 1 Apolipoprotein (a) LPA 2 Apolipoprotein A 4 APOA4 2 Apolipoprotein A I APOAI 2 Apolipoprotein A 11 APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOCI 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Aquaporin I AQPL 2 Aquaporin 2 AQP2 2 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPRLA 5 Arginine vasopressin receptor 1B AVPRLB 5 Arginine vasopressin receptor 2 AVPR2 5 Arginosuccinate lyase ASL 1 Arylsuffatase B ARSB 1 Aspartylglucosaminidase AGA 1 Ataxia telangiectasia gene, AT ATM 6 ATP/ADP transiocase 1 ATP-binding cassette transporter 7 ABC7 4 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPRL 6 Atria natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide@ receptor C NPR3 6 Autoimmune regulator, AIRE AIRE 4 BCL2-related protein A1 BCL2AI 6 beta 2 microglob@ulin B2M beta-endorphin receptor N Bile acid coenzyme A: amino acid N- BAAT 1 acyltransferase Bile salt export pump BSEP, PFIC2 2 Bile salt-stimulated lipase CEL 1 Bilirubin UDP-glucuronosyltransferase 1 Bloom syndrome protein BLM 6 Bradykinin receptor BI Bradykinin receptor B2 Butyrylcholinesterase BCHE 1 Ca(2+) transporting ATPase, fast twitch ATP2AI 2 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Cadherin E CDHL 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin I CALB1 6 Calbindin D9K CALB3 6 Calcineurin A1 CALNAL 4 Calcineurin A2 CALNA2 Calcineurin A3 CALNA3 Calcineurin B Calcium channel, voltage-dependent, alpha CACNAL F 5 1 F subunit Calcium channel, voltage-dependent, Alpha- CACNAIB 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha-I c CACNAL C 5 Calcium channel, voltage-dependent, Alpha-1 D CACNAL D 5 Calcium channel, voltage-dependent, Alpha- CACNAL E 5 1E (CACNLIA6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNBI 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNAL S 5 alpha IS subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNALA 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calmodulin I CALMI 6 Calmodutin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase 11 CAMK2A 6 Calpain CAPNCAPN3 1 Calretinin CALB2 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Carboxypeptidase CPN 1 Cardiac-specific homeobox, CSX csx 6 Carnitine acylcarnitine translocase CACT 1 Carnitine transporter protein CDSP, SCD 2 Cartilage-hair hypoplasia gene CHH 5 Catechol-0-methyltransferase COMT 1 Caveolin 3 CAV3 1 CD1 CDI CD4 CD4 Cdc 25 phosphatase 6 Cell adhesion molecule, intercellular, ICAM ICAMI 6 Cell adhesion molecule, leukocyte- LECAM1 6 endotheiial, LECAM (CD62) Cell adhesion molecule, liver, LCAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM1 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 Cellubrevin CEB 5 Ceroid lipofuscinosis neuronal 3 CLN3 5 Ceruloplasmin precursor CP 1 Chemokine receptor CCR2 CCR2 Chemokine receptor CCR3 CCR3 Chemokine receptor CCR5 CCR5 Chemokine receptor CXCRI CXCR1 Chemokine receptor CXCR2 CXCR2 Chemokine receptor CXCR4 CXCR4 Chloride channel KB CLCNKB 3 Cholestasis, progressive familial intrahepatic FICI 6 1 gene Cholesterol ester transfer protein CETP 2 Choline acetyltransferase CHAT 1 Chymase CHYI Clathrin 2 Cockayne syndrome gene, CKNI CKNI 6 Collagen I alpha 1 COLIAL 3 Collagen I alpha 2 COLIA2 3 Collagen 11 alpha 1 COL2AI 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4AI 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, EDM2 3 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5AI 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6Al 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7Al 3 Collagen X alpha I COLlOAl 3 Collagen X alpha 1 COLIlAl 3 Collagen Xi alpha 2 COLL IA2 3 Collagen XVII alpha I COL17AI 3 Collagenic-like tail subunit of asymmetric COLQ 1 acetylcholinesterase Colony-stimulating factor 2 beta receptor CSF2RB 6 Colony-stimulating factor 3 CSF3 6 Colony-stimulating factor 3 receptor CSF3R 6 Corticosteroid binding globulin CBG 5 Cortico-sterold binding protein 2 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Creb binding protein CREBBP 6 Cu2+ transporting ATPase alpha polypeptide ATP7A 1 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cubilin CUBN 2 Cyclic AMP-dependent protein kinase PKA 1 Cyclin-dependent kinase 2 CDK2 6 Cyclin-dependent kinase inhibitor 1C (P57, KIP2) CDKNIC 6 Cyclooxygenase I coxi 1 Cyclooxygenase 2 COX2 1 CYPL 1A1 CYPllA1 1 CYPL 1 B1 CYPllB1 1 CYPI 1 B2 CYPllB2 1 CYP17 CYP17 1 CYP19 cypig 1 CYPIAI CYPlA1 1 CYPlA2 CYPIA2 1 CYPIBL CYPIBI 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27BI PDDR 1 CYP2AI CYP2AI 1 CYP2Al3 CYP2Al3 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2Cl8 CYP2Cl8 F- CYP2CI9 CYP2Cl9 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2El CYP2El 1 CYP2Fl CYP2Fl 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4AIl CYP4All 1 CYP4B1 CYP4BI 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5AI CYP5Al 1 CYP7A CYP7A I CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome b-5 CYB5 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 DAX1 nuclear receptor DAX1 4 Delta aminolevulinate dehydratase ALAD 1 Delta(4)-3-oxosteroid 5-beta-reductase 1 Delta-7-dehydrocholesterol reductase DHCR7 1 Deoxycorticosterone (DOC) receptor 1 Desmin DES 3 Dihydrodiol dehydrogenase 1 DDHL 1 Dihydrofolate reductase DHFR 1 Dihydrolipoyl dehydrogenase 1 Dihydrolipoyl dehydrogenase 2 PDHA 1 Dihydrolipoyl transacetylase PDHA 1 DM-Kinase DMPK 1 DOPA decarboxylase DDC 1 Dopamine beta hydroxylase DBH 1 Dopamine receptors DI DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Duffy blood group FY 2 Dynamin DNMI 6 Dystrophia myotonica DM, DMPK 1 Dystrophia myotonica, atypical DM2 1 Dystrophin DMD 3 Elastin ELN 3 Emerin EMD 2 Endocardial fibroelastosis 2 gene EFE2 3 Endoglin ENG 3 Endometrial bleeding-associated factor EBAF 6 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase EN01 1 Enoyl CoA isomerase 1 Ephrin receptor tyrosine kinase A EPHA 6 Ephrin receptor tyrosine kinase B EPHB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Erythrocyte membrane protein band 4.1 EPB41 3 Erythrocyte membrane protein band 4.2 EPB42 3 Erythrocyte membrane protein band 7.2 EPB72 3 Erythroid kruppel-like factor EKLF 6 Erythropoietin EPO Erythropoietin receptor EPOR Estrogen receptor ESR 6 Faciogenital dysplasia FGD1, FGDY 2 Factor 1 (No. one) F1 Factor B, properdin Factor D Factor H HFI Factor I (letter 1) IF Factor III F3 Factor IX F9 Factor V F5 Factor VI I F7 4 Factor VI II F8 4 Factor X F10 4 Factor Xi Fil 4 Factor XI I F12 4 Factor XIII A & B F13A & F13B 4 Fanconi anemia, complementation group A FANCA 2 Fanconi anemia, complementation group C FANCC 2 Fanconi anemia, complementation group D FANCD 2 Fatty acid binding proteins FABPI 2 Fatty acid binding proteins FABP2 FABP2 2 Fatty acid binding proteins FABP3 2 Fatty acid binding proteins FABP4 2 Fatty acid binding proteins FABP5 2 Fatty acid binding proteins FABP6 2 Fc fragment of IgG, high affinity IA, receptor for FCGRIA 6 Fc fragment of IgG, low affinity Ila, receptor FCGR2A 6 for (CD32) Fc fragment of IgG, low affinity llla, receptor FCGR3A 6 for (CD 1 6) Fibrillin 1 FBNI 6 Fibrillin 2 FBN2 6 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibroblast growth factor FGFI 6 Fibroblast growth factor receptor 1 FGFRI 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FNI 6 Flightless-11, Drosophila homolog of FLII 6 Follicle stimulating hormone receptor FSHR, ODG1 6 Follicle stimulating hormone, FSH FSHB 6 Formiminotransferase 1 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Fucosidase alpha-L-2 1 Fucosyltransferase 2 FUT2 2 Fucosyltransferase 3 FUT3 2 Fucosyltransferase 6 FUT6 2 Fukuyama type congenital muscular dystrophy FCMD 6 GABA receptor, alpha 1 GABRAL 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta I GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRGI 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Galactose 1-phosphate uridyl-transferase GALT 1 Galactosyltransferase I GTI 6 Galactosyltransferase, alpha 1,3 GGTAL 6 Galactosyltransferase, beta 3 B3GALT 6 Galanin GAL 5 Galanin receptor GALNRI 5 Gamma-glutamyl carboxylase GGCX 2 Gap junction protein alpha I GJAL 2 Gap junction protein beta I GJBL 2 Gap junction protein beta 2 GJB2 2 Glucocorticoid receptor GRL 6 Glucosaminyl (N-acetyl) transferase 2, I- GCNT2 1 branching enzyme Glucosidase, acid alpha GAA 1 Glucosidase, acid beta GBA 1 Glutamate decarboxylase, GAD GAD1 1 Glutamate receptor 1 GLURI 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutamate-cysteine ligase GLCLC 1 Glutaryi-CoA dehydrogenase GCDH 1 Glutathione GSH 2 Glutathione peroxidase, GPXI GPXL 1 Glutathione reductase, GSR GSR 1 Glutathione S-transferase, GSTZI GSTZI 1 Glyceraldehyde-3-phosphate GAPDH 1 dehydrogenase, GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) transformylase GART 1 Glycophorin A GYPA 3 Glycophorin B GYPB 3 Glycophorin C GYPC 3 Glycosyltransferases, ABO blood group ABO 1 Growth arrest-specific homeobox GAX 6 Guanine nucleotide-binding protein, alpha GNAOI 5 activating activity polypeptide, GNAO Guanine nucleotide-binding protein, alpha GNAll 5 inhibiting activity polypeptide 1, GNAII Guanine nucleotide-binding protein, alpha GNA 2 5 inhibiting activity polypeptide 2, GNA12 Guanine nucleotide-binding protein, alpha GNA13 5 inhibiting activity polypeptide 3, GNA13 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, beta GNB3 5 polypeptide 3 Guanine nucleotide-binding protein, gamma GNG5 5 polypeptide 5 Guanine nucleotide-binding protein, q GNAQ 5 polypeptide Guanylyl cyclase 1 H(+), K(+) - ATPase ATP4B 5 Haemoglobin alpha I HBAL 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin epsilon 2 Haemoglobin gamma A HBGL 2 Haemoglobin gamma 8 HBG2 2 Haemoglobin gamma G HBGG 2 Haptoglobin, alpha 1 HPAI Haptoglobin, alpha 2 HPA2 Haptoglobin, beta HPB Heat shock protein, HSP60 Heat shock protein, HSP70 Heat shock protein, HSP90 Heat shock protein, HSPAI Heat shock protein, HSPA2 Hemochromatosis HFE 2 Hemopexin HPX 4 Heparan sulfamidase 1 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor 11 HCF2 4 Hepatic lipase LIPC 1 Hermansky-pudiak syndrome gene HPS 2 Hexokinase 1 HKI 1 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 Histidine-rich glycoprotein HRG 2 HLA-B associated transcript 1 BATI 4 HLH transcription factor HAND1 HAND1 6 HLH transcription factor HAND2 HAND2 6 HMG-COA lyase HMGCL 1 HMG-COA reductase HMGCR 1 HMG-COA synthase HMGCS2 1 Homeobox (HOX) gene Al 3 HOXA13 6 Homeobox HB24 HLXL 6 Hormone-sensitive lipase HSL 1 Human chorionic gonadtrophin, hCG CG 6 Human placental lactogen CSHI 6 Hypoxanthine-guanine HPRT 1 phosphoribosyltransferase, HGPRT Hypoxia inducible factor I HiFlA 1 Hypoxia inducible factor 2 1 IC7 A and B 4 Iduronate 2 sulphatase IDS 1 Indian hedgehog, ihh IHH 6 lnosine triphosphatase ITPA 1 lnositol 1,4,5-triphosphate receptor 1 ITPRL 6 Inositol 1,4,5-triphosphate receptor 3 ITPR3 6 Inositol monophosphatase IMPAL 5 Inositol polyphosphate 1-phosphatase INPPI 5 Insulin INS 6 Insulin receptor INSR 6 Insulin receptor substrates IRS1 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1 R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 Integrin beta 1 ITGBL 6 lntegrin beta 2 ITGB2 6 Integrin beta 3 ITGB3 6 Integrin beta 4 ITGB4 6 Integrin beta 5 ITGB5 6 Integrin beta 6 ITGB6 6 Integrin beta 7 ITGB7 6 Integrin, alpha 1 ITGAL 6 Integrin, alpha 2 ITGA2 6 Integrin, alpha 3 ITGA3 6 lntegrin, alpha 4 ITGA4 6 Integrin, alpha 5 ITGA5 6 lntegrin, alpha 6 ITGA6 6 lntegrin, alpha 7 ITGA7 6 lntegrin, alpha 8 ITGA8 6 lntegrin, alpha 9 ITGA9 6 lntegrin, alpha M ITGAM 6 Integrin, alpha X ITGAX 6 Inter-alpha-trypsin inhibitor, IATI 1 Intercellular adhesion molecule 1 ICAMI lntercellular adhesion molecule 2 ICAM2 lntercellular adhesion molecule 3 ICAM3 Interferon alpha IFNAI Interferon beta IFNB Interferon gamma IFNG Interferon gamma receptor 1 IFNGRL Interferon gamma receptor 2 IFNGR2 Interleukin(IL) 1 receptor ILl R Interieukin(IL) 1, alpha ILLA lnterieukin(IL) 1, beta ILLB lnterieukin(IL) 10 ILIO lnterleukin(IL) 10 receptor ILIOR Intedeukin(IL) 1 1 ILl 1 Interieukin(IL) 1 1 receptor ILIIR lntedeukin(IL) 12 IL12 Intedeukin(IL) 12 receptor, beta 1 IL12RB1 4 Intedeukin(IL) 13 IL13 4 Interfeukin(IL) 13 receptor IL13R 4 Intedeukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 lnterleukin(IL) 2 receptor, gamma IL2RG 4 lnterleukin(IL) 3 IL3 Interleukin(IL) 3 receptor IL3R Interieukin(IL) 4 IL4 Interieukin(IL) 4 receptor IL4R Interieukin(IL) 5 IL5 Interleukin(IL) 5 receptor IL5R lntedeukin(IL) 6 IL6 lnterieukin(IL) 6 receptor IL6R Interleukin(IL) 7 IL7 lnterleukin(IL) 7 receptor IL7R Interieukin(IL) 8 IL8 Intedeukin(IL) 8 receptor IL8R 4 lnterfeukin(IL) 9 IL9 4 Interleukin(IL) 9 receptor IL9R Interieukin(IL) receptor antagonist 1 ILlRN, ILLRA IP3 kinase 1 Isovaleric acid CoA dehydrogenase IVD 1 Kallikrein 3 KAK3 4 Kell blood group precursor XK, KEL 2 Ketohexokinase KHK 1 Kininogen, High molecular weight KNG 4 Kynureninease 1 Lactate dehydrogenase, A LDHA 1 Lactate dehydrogenase, B LDHB 1 Lamin A/C LMNA 6 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMRI 6 Latent transforming growth factor-beta LTBP2 6 binding protein 2 Lecithin-cholesterol acyltransferase LCAT Lectin, mannose-binding 1 LMANI Lectin, mannose-binding 2 MBL2 Leptin LEP 6 Leptin receptor LEPR 6 Leukocyte-specific transcript 1 LST-1 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 synthase LTC4S 1 LIM homeobox protein I LHXL 6 Lipocortin I ANX4 4 Lipoprotein lipase LPL 4 Lipoprotein receptor, Low Density LDLR 2 Lipoprotein, High Density HDLDTI 2 Lipoprotein, Very Low Density VLDLR 2 Lipoprotein-associated coagulation factor LACI 4 Lipoxygenase 1 Lipoxygenase 12 (platelets) LOG12 4 Long QT-type 2 potassium channels LQT2, KCNH2 2 Low density lipoprotein receptor-related LRP 2 protein precursor Lymphoid enhancer-binding factor LEF-1 6 Lysosomat acid lipase LIPA 1 Macrophage inflammatory protein-2 MIP2 4 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 MADS box transcription-enhancer factor 2A MEF2A 6 MADS box transcription-enhancer factor 2B MEF2B 6 Mannosidase, alpha B lysosomal MANB 1 Matrix Gla protein MGP 6 Matrix metalloproteinase I mmpl 1 Matrix metalloproteinase IO mmplo 1 Matrix metalloproteinase 1 1 mmpl 1 1 Matrix metalloproteinase 12 MMP12 1 Matrix metalloproteinase 13 MMP13 1 Matrix metalloproteinase 4 MMP14 1 Matrix metalloproteinase 15 MMP15 1 Matrix metalloproteinase 16 MMP16 1 Matrix metalloproteinase 17 MMP17 1 Matrix metalloproteinase 18 MMP18 1 Matrix metalloproteinase 19 m P19 1 Matrix metalloproteinase 2 MMP2 1 Matrix metalloproteinase 3 MMP3, STMY1 1 Matrix metalloproteinase 4 MMP4 1 Matrix metalloproteinase 5 MMP5 1 Matrix metalloproteinase 6 MMP6 1 Matrix metalloproteinase 7 MMP7 1 Matrix metalloproteinase 8 MMP8 1 Matrix metalloproteinase 9 MMP9 1 Melanocort'in 2 receptor MC2R 2 Melanocortin 4 receptor MC4R 2 Methionine synthase MTR 1 Methionine synthase reductase MTRR 1 Methylmalonyl-CoA mutase MUT 1 Mevalonate kinase MVK MHC Class 1: A MHC Class 1: B MHC Class 1: C MHC Class 1: LMP-2, LMP-7 MHC Class 1: Tapl ABCR, TAP1 MHC Class II: DP HLA-DPBI MHC Class 11: DQ MHC Class 11: DR MHC Class II: Tap2 TAP2, PSF2 MHC Class ll: Complementation group A MHC2TA MHC Class ll: Complementation group B rfxank MHC Class ll: Complementation group C RFX5 MHC Class ll: Complementation group D RFXAP Microsomal triglyceride transfer protein MTP 2 Mismatch repair gene, PMSL2 PMS2 6 Mitochondrial trifunctional protein, alpha subunit HADHA 1 Mitochondrial trifunctional protein, beta subunit HADHB 1 Molybdenum cofactor synthesis 1 mocsi 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Monocyte chemoaftractant protein 1 mcpl 4 Mucolipidoses GNPTA 1 Mulibrey nanism MUL 2 Muscarinic receptor, M1 CHRM1 5 Musca nic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 MutS homolog 3 MSH3 6 Myoglobin 2 Myosin, cardiac MYH7 3 Myosin, light chain 2 MYL2 3 Myosin, light chain 3 MYL3 3 Myosin-binding protein C, cardiac MYBPC3 3 Myotubularin MTM1 3 Na+, K+ ATPase, alpha ATPIAL 6 Na+, K+ ATPase, beta 1 ATPIBL 6 Na+, K+ ATPase, beta 2 ATPIB2 6 Na+, K+ ATPase, beta 3 ATPIB3 6 Na+/H+ exchanger 1 NHEL 2 Na+/H+ exchanger 2 NHE2 2 Na+/H+ exchanger 3 NHE3 2 Na+/H+ exchanger 4 NHE4 2 Na+/H+ exchanger 5 NHE5 2 N-acetylglucosamine-6-sulfatase GNS 1 NADPH oxidase 4 reductase NB6 Nebulin NEB 3 Nephronophthisis 1 NPHP1 2 Neuraminidase sialidase NEU 2 Neuregulin HGL 6 Neurite inhibitory protein 5 Neuroendocrine convertase 1 NEC1, PCSK1 1 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Yi NPYIR 5 Neuropeptide Y receptor Y2 NPY2R 5 Neutrophil cystolic factor 1 NCF1 Neutrophil cystolic factor 2 NCF2 Niemann-Pick disease protein NPCL 2 Nitric oxide synthase 1, NOSI NOSI 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Notch ligand - jagged 1 JAG 1, AG S 6 Nuclear factor 1-kappa-B-like gene IKBL 4 Oncogene sis PDGFB 6 Oncostatin M osm 6 Oncostatin M receptor OSMR 6 Osteonectin ON 6 Osteopontin OPN 6 Osteoprotegedn OPG 6 Pancreatic lipase PNLIP 1 Pancreatic lipase related protein 1 PLRPI 1 Pancreatic lipase related protein 2 PLRP2 1 Paraoxonase PONI PONI 1 Paraoxonase PON2 PON2 1 Paraoxonase PON3 1 Parvalbumin PVALB 6 Patched (Drosophila) homolog, PTCH PTCH 6 PCNA (proliferating cell nuclear antigen) 1 Pepsinogen 1 Peroxidase, salivary SAPX 1 Peroxisomal membrane protein 1 PXMPI 3 Peroxisomal membrane protein 3 PXMP3 2 Peroxisome biogenesis factor I PEXI 2 Peroxisome biogenesis factor 1 9 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome proliferative activated receptor, PPARA 2 alpha Peroxisome proliferative activated receptor, PPARG 2 gamma Peroxisome receptor 1 PXRI 2 P-glycoprotein 3 PGY3 2 Phosphatidylinositol glycan, class A PIGA 6 (paroxysmal nocturnal hemoglobinuria) Phosphatidylinositol transfer protein PITPN 6 Phosphofructokinase, muscle PFKM 1 Phosphoglucose isomerase GPI 1 Phospholipase A2, group IO PLA2GIO 4 Phospholipase A2, group 1 B PLA2G 1 B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG 4 Phosphomannomutase-2 PMM2 2 Phosphoribosyl pyrophosphate synthetase PRPS1 1 Phosphorylase kinase, alpha 2 PHKA2 1 Phytanoyi-CoA hydroxylase PHYH 6 Plasminogen PLG 1 Plasminogen activator inhibitor I PAI 1 1 Plasminogen activator inhibitor 2 PA 2 1 Plasminogen activator receptor, Urokinase UPAR; PLAUR 3 Plasminogen activator, Tissue PLAT; TPA 1 Plasminogen activator, Urokinase UPA; PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Platelet glutaminase GLS 2 Platelet glycoprotein I b, alpha GPI BA Platelet glycoprotein I b, beta GPIBB Platelet glycoprotein I b, gamma GPLBG Platelet glycoprotein IX GP9 Platelet glycoprotein V GP5 Platelet monamine oxidase 2 Platelet-activating factor acetylhydrolase 1 B PAFAH1B1or 4 LISI Platelet-activating factor acetylhydrolase 2 PAFAH2 4 Platelet-activating factor receptor PAFR 4 Poly (ADP-ribose) synthetase PARS F Polycystic kidney and hepatic disease 1 PKHDL 2 Polycystin I PKDL 2 Polycystin 2 PKD2 2 Potassium inwardly-rectifying channel Jl KCNJL 5 Potassium inwardly-rectifong channel JI 1 KCNJ I 1 5 Potassium voltage-gated channel Al KCNAL 5 Potassium voltage-gated channel El KCNEI 5 Potassium voltage-gated channel Q1 KCNQI 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCNQ3 5 POU domain, class 1, transcription factor 1 (Piti) POUlF1 6 Prekallikrein Procollagen N-protease 1 receptor) Pro-melanin-concentrating hormone PMCH 6 Proopiomelanocortin POMC 5 Prostagiandin (PG) D synthase, PGDS 1 hematopoietic Prostagiandin E2 receptor Prostaglandin-endoperoxidase synthase 2 PTGS2 6 Protease inhibitor 1 2 Protease nexin 2 PN2 1 Protective protein for beta-galactosidase PPGB 1 Protein C PROC Protein C inhibitor PCI Protein S PROS1 Prothrombin precursor F2 Protoporphyrinogen oxidase PPOX 1 Purine nucleoside phosphorylase NP 1 Purinergic receptor PlA1 5 Purinergic receptor PIA2 5 Purinergic receptor PIA3 5 Purinergic receptor P2X, 1 P2RX1 5 Purinergic receptor P2X, 2 P2RX2 5 Purinergic receptor P2X, 3 P2RX3 5 Purinergic receptor P2X, 4 P2RX4 5 Purinergic receptor P2X, 5 P2RX5 5 Purinergic receptor P2X, 6 P12RX6 5 Purinergic receptor P2X, 7 P2RX7 5 Purinergic receptor P2Y, 1 P2RYI 5 Purinergic receptor P2Y, I 1 P2RY1 1 5 Purinergic receptor P2Y, 2 P2RY2 5 Pyruvate carboxylase PC 1 Pyruvate decarboxylase PDHA 1 Pyruvate kinase PKLR 1 Radixin RDX 3 Renin REN 1 Replication factor C RFC2 1 Retinoic acid receptor, alpha RARA 6 Retinoic acid receptor, beta RARB 6 Retinoic acid receptor, gamma RARG 6 Retinoid X receptor, alpha RXRA 6 Retinoid X receptor, beta RXRB 6 Retinoid X receptor, gamma RXRG 6 Rhesus blood group, CcEe antigens RHCE 2 Rhesus blood group, D antigen RHD 2 Rhesus blood group-associlated glycoprotein RHAG 2 Ribosomal protein S19 RPS19 1 RIGUI RIGUI 6 SIOO calcium-binding protein A1 SIOOAI 5 S 1 00 calcium-binding protein A2 S I 0OA2 5 SI OO calcium-binding protein A3 S 1 0OA3 5 SIOO calcium-binding protein A7 S 1 0OA7 5 SI OO calcium-binding protein A8 S I 0OA8 5 SIOO calcium-binding protein B SIOOB 5 SIOO calcium-binding protein P sloop 5 SA homolog SAH 6 SAP (SLAM-associated protein) SH2DlA 4 Secretase, alpha 5 Secretase, beta 5 Secretase, gamma 5 Selectin E SELE 5 Selectin L SELL 5 Selectin P SELP 5 Serotonin receptor, 5HTIA HTRIA 5 Serotonin receptor, 5HTlB HTRI B 5 Serotonin receptor, 5HTIC HTRIC 5 Serotonin receptor, 5HT1 D HTRID 5 Serotonin receptor, 5HTI E HTRL E 5 Serotonin receptor, 5HT1 F HTRL F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Serum amyloid A SAA 2 Serum amyloid P SAP 2 Sjoegren (Siogren) syndrome antigen A1 SSAI 4 Sodium channel, non-voltage gated 1, alpha SCNNLA 5 Sodium channel, non-voltage gated 1, beta SCNN1 B 5 Sodium channel, non-voltage gated 1, SCNNLG 5 gamma Sodium channel, voltage gated, type IV, SCN4A 5 alpha polypeptide Sodium channel, voltage gated, type V, alpha SCN5A 5 polypeptide Sodiumchannel, voltage-gated, type1, beta SCNLB 5 polypeptide Solute carrier family 1 (glutamate SLCIAL 2 transporter), member 1 Solute carrier family 1 (glutamate SLC1A2 2 transporter), member 2 Solute carrier family 1 0 (sodium/bile acid SLC1OA1 2 cotransporter family), member 1 Solute carrier family IO (sodium/bile acid SLC1OA2 2 cotransporter family), member 2 Solute carrier family 12, member I SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 2 (facilitated glucose SLC2AI 2 transporter), member I Solute carrier family 2 (facilitated glucose SLC2A2 2 transporter), member 2 Solute carrier family 2 (facilitated glucose SLC2A3 2 transporter), member 3 Solute carrier family 2 (facilitated glucose SLC2A4 2 transporter), member 4 Solute carrier family 2 (facilitated glucose SLC2A5 2 transporter), member 5 Solute carder family 21, member 2 SLC21A2 2 Solute carrier family 21, member 3 SLC21A3 2 Solute carrier family 22, member 5 SLC22A5 2 Solute carrier family 3 (facilitated glucose SLC3AI 2 transporter), member I Solute carrier family 4 (anion exchanger), member 1 SLC4AI 2 Solute carrier family 4 (anion exchanger), member 2 SLC4A2 2 Solute carrier family 4 (anion exchanger), member 3 SLC4A3 2 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member I Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmifter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmifter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmifter SLC6A4 2 transporter, serotonin), member 4 Solute carrier family 8 (sodium/calcium SLC8A1 2 exchanger), member 1 Sonic hedgehog, SHH SHH 6 So@cin SRI 2 Spectrin alpha SPTAI 3 Spectrin beta SPTB 3 Sphingomyelinase SMPD1 1 Stem cell factor SCF 6 Steroid 5 alpha reductase 1 SRD5A1 1 Steroid 5 alpha reductase 2 SRD5A2 1 Steroidogenic acute regulatory protein STAR 2 Sterol carrier protein 2 SCP2 2 Succinate dehydrogenase I SDHL 1 Succinate dehydrogenase 2 SDH2 1 Succinate thiokinase 1 Superoxide dismutase 1 SODI 1 Superoxide dismutase 3 SOD3 1 Surfeit I SURF1 6 Synapsin I a& b SYNI 5 Synapsin 2a & 2b SYN2 5 Synaptic vesicle amine transporter 8VAT 5 Synaptobrevin 1 SYBI 5 Synaptobrevin 2 SYB2 5 Synaptogyrin 5 Synaptophysin SYP 5 Synaptosomal-associated protein, 25 KD SNAP25 5 Synaptotagmin I SyTi 5 Synaptotagmin 2 SYT2 5 Syntaxin I STxl 5 Talin TLN 6 T-BOX 1 TBXL 6 T-BOX 3 TBX3 6 TEK, tyrosine kinase, endothelial TEK 1 Terminal deoxynucleotidyltransferase TDT 4 Tetranectin TNA 2 Thiolase, perioxisomal 1 Thiopurine S-methyltransferase TPMT 1 Thrombin receptor F2R Thrombomodulin THBD Thrombopoietin THPO 6 Thrombospondin THBSI 6 Thromboxane A synthase 1 TBXASI Thromboxane A2 TXA2 Thromboxane A2 receptor TBXA2R Thy-I T-cell antigen THYI Thymic humoral factor Thymopoietin TMPO 6 Thymosin 4 Thyroid hormone receptor, alpha THRA 6 Thyroid hormone receptor, beta THRB 6 TIE receptor tyrosine kinase TIE-1 6 Tip-associated protein TAP 4 Tissue inhibitor of metalloproteinase 1, TIMP1 1 TiMP1 Tissue inhibitor of metalloproteinase 2, TIMP2 1 TIMP2 Tissue inhibitor of metalloproteinase 3, TIMP3 1 TIMP3 Tissue inhibitor of metalloproteinase 4, TIMP4 1 TIMP4 Topoisomerase I 1 Torticollis, keloids, cryptorchidism and renal TKCR 6 dysplasia gene Transcobalamin 2, TCN2 TCN2 2 Transcription factor 2, hepatic TCF2 6 Transferrin TF 6 Transferdn receptor TFRC 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFBI 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transtocation in renal carcinoma on TRC8 6 chromosome 8 gene Transthyretin TTR 2 Triosephosphate isomerase TP11 1 Tropomyosin 1 alpha TPM1 3 Troponin C 3 Troponin I TNN13 3 Troponin T2, cardiac TNNT2 3 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tumour necrosis factor (TNF) receptor TRAFI associated. factor 1 Tumour necrosis factor (TNF) receptor TRAF2. associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 associated factor 6 Tumour necrosis factor alpha TNFA Tumour necrosis factor alpha receptor TNFAR Tumour necrosis factor beta TNFB Tumour necrosis factor beta receptor TNFBR Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tyrosine hydroxylase TH 1 Ubiquitin 6 Ubiquitin B UBB 6 Ubiquitin C UBC 6 UDP-glucose pyrophosphorylase 1 UDP-glucuronosyltransferase 1 ugtld, UGTI 1 UDP-glucuronosyltransferase 2 UGT2 1 Uncoupling protein I 2 Uncoupling protein 3 UCP3 2 Undulin I COL14Al 3 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Uroporphyrinogen III synthase UROS 1 Vacuolar proton pump, subunit 1 VPPI 5 Vacuolar proton pump, subunit 3 VPP3 5 Vascular endothelial growth factor VEGF 6 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Vasoinhibitory peptide 6 Vimentin vim 4 Vinculin 3 Vitamin D receptor VDR 6 Von Hippel-Lindau gene VHL 6 Von Willebrand factor VWF 2 Werner syndrome helicase WRN 6 Wiskoft-Aldrich syndrome protein WASP, THC 4 Wolf-Hirschhorn syndrome candidate 1 gene WHSCI 6 Wolfram syndrome I gene WFS1 3 Xanthine dehydrogenase XDH 1 Zinc finger protein 3 ZIC3  3,

that the genes associated with malfunction, damage or disease of the gastrointestinal tract are selected from: List of genes HUGO gene symbol Protein-function 11beta hydroxysteroid dehydrogenase 2 HSD11B2 1 17beta hydroxysteroid dehydrogenase 1 HSD17B1 1 17beta hydroxysteroid dehydrogenase 3 HSD17B3 1 17beta hydroxysteroid dehydrogenase 4 HSD17B4 1 17beta hydroxysteroid oxidoreductase 1 2,3-Bisphosphoglycerate mutase BPGM 1 3 beta Hydroxysteroid dehydrogenase 2 HSD3B2 1 6-Phosphofructo-2-kinase PFKFB1 1 Acetoacetyl 1-CoA-thiolase ACAT1 1 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetyl CoA carboxylase ACC 1 Acetyl CoA carboxylase alpha ACACA 1 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Acid phosphatase 2, lysosomal ACP2 1 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTAL 3 Actin, alpha, smooth, aortic ACTA2 3 Actin, beta ACTB 3 Actin, gamma 2 ACTG2 3 Acyl CoA dehydrogenase, long chain ACADL 1 Acyl CoA dehydrogenase, medium chain ACADM 1 Acyl CoA dehydrogenase, short chain ACADS 1 Acyl CoA dehydrogenase, very long chain ACADVL 1 Acyl CoA synthetase, long chain, 1 LACS1 1 Acyl CoA synthetase, long chain, 2 LACS2 1 Acyl CoA synthetase, long chain, 4 ACS4 1 Acyl malonyl condensing enzyme 1 Acyl-CoA thioesterase 1 Adaptin, beta 3A ADTB3A 2 Adenine phosphoribosyltransferase APRT 2 Adenomatous polyposis coli tumour supressor APC 6 gene Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Alanine aminotransferase 2 Alanine-glyoxylate aminotransferase AGXT 1 Albumin, ALB ALB 2 Alcohol dehydrogenase 1 ADH1 1 Alcohol dehydrogenase 2 ADH2 1 Alcohol dehydrogenase 3 ADH3 1 Alcohol dehydrogenase 4 ADH4 1 Alcohol dehydrogenase 5 ADH5 1 Alcohol dehydrogenase 6 ADH6 1 Alcohol dehydrogenase 7 ADH7 1 Aldehyde dehydrogenase 1 ALDH1 1 Aldehyde dehydrogenase 2 ALDH2 1 Aldehyde dehydrogenase 5 ALDH5 1 Aldehyde dehydrogenase 6 ALDH6 1 Aldehyde dehydrogenase 7 ALDH7 1 Aldolase A ALDOA 1 Aldolase B ALDOB 1 Aldolase C ALDOC 1 Aldose reductase 2 Aldosterone receptor MLR 6 Alkaline phosphatase, liver/bone/kidney ALPL 2 Alpha 2 macroglobulin A2M 4 alpha1-Antitrypsin PI 1 alpha2-Antiplasmin PLI 1 alpha-Actinin 2 ACTN2 6 alpha-Actinin 3 ACTN3 6 alpha-Amylase 1 alpha-Dextrinase 1 alpha-Galactosidase A GLA 1 alpha-Ketoglutarate dehydrogenase 1 alpha-L-Iduronidase IDUA 1 Aminomethyltransferase AMT 1 Aminopeptidase P XPNPEP2 1 Amphiregulin AREG 6 Amylo-1,6-glucosidase AGL 1 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCPI 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Antidiuretic hormone receptor ADHR 2 Antithrombin III AT3 1 AP-2, alpha TFAP2A 6 AP-2, beta TFAP2B 6 AP-2, gamma TFAP2C 6 Apolipoprotein A I APOA1 2 Apolipoprotein A II APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOC1 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Aquaporin 1 AQP1 2 Aquaporin 2 AQP2 2 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 1B AVPR1B 5 Arginine vasopressin receptor 2 AVPR2 5 Arginosuccinate lyase ASL 1 Arginosuccinate synthetase ASS 1 Aryl hydrocarbon receptor nuclear translocator ARNT 2 Arylsulfatase A ARSA 1 Arylsulfatase B ARSB 1 Aspartate transaminase 2 Aspartylglucosaminidase AGA 1 Ataxia telangiectasia gene, AT ATM 6 ATP/ADP translocase 1 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Autoimmune regulator, AIRE AIRE 4 Azoospermia factor 1 AZF1 6 beta 2 Microglobulin B2M 4 beta-Galactosidase GLB1 1 beta-Glucosidase, neutral 1 beta-Glucuronidase GUSB 1 beta-Ketoacyl reductase 1 Bile acid coenzyme A: amino acid N- BAAT 1 Acyltransferase Bile salt export pump BSEP, PFIC2 2 Bile salt-stimulated lipase CEL 1 Bilirubin UDP-glucuronosyltransferase 1 Biliverdin reductase 2 Bradykinin receptor B1 4 Bradykinin receptor B2 4 Branched chain keto acid dehydrogenase E1, BCKDHA 1 alpha polypeptide Branched chain keto acid dehydrogenase E1, BCKDHB 1 beta polypeptide Brush border guanylyl cyclase 1 Ca(2+) transporting ATPase, fast twitch ATP2AI 2 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Cadherin E CDH1 6 Cadherin EP 6 Cadheein N CDH2 6 Cadherin P CDH3 6 Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, Alpha 1F CACNA 1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA 1B 5 1 B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA 1C 5 1 C Calcium channel, voltage-dependent, Alpha- CACNA 1D 5 1 D Calcium channel, voltage-dependent, Alpha- CACNA 1E 5 I E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta I CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, T-type 5 Calcium sensing receptor CASR 2 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin dependent kinase 2 Calmodulin-dependant protein kinase II CAMK2A 6 Calnexin CANX 6 Canalicular multispecific organic anion CMOAT 2 transporter Carbamoylphosphate synthetase 1 CPS1 1 Carbamoylphosphate synthetase 2 CPS2 1 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Carboxylesterase 1 CES1 1 Carboxypeptidase CPN 1 Camitine acylcarnitine translocase CACT 1 Carnitine palmitoyltransferase I CPT1A 1 Carnitine palmitoyltransferase II CPT2 1 Carnitine transporter protein CDSP, SCD 2 Cartilage-hair hypoplasia gene CHH 5 Catalase CAT 4 Cathepsin B 1 Cathepsin D 1 Cathepsin E 1 Cathepsin G CTSG 1 Cathepsin H 1 Cathepsin K CTSK 1 Cathepsin L 1 Cathepsin S 1 CD1 CD1 4 CD4 CD4 4 Cell adhesion molecule, intercellular, ICAM ICAM1 6 Cell adhesion molecule, leukocyte-endothelial, LECAM1 6 LECAM (CD62) Cell adhesion molecule, liver, LCAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM1 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 c-erbB2 FRBB2 6 c-erbB3 ERBB3 6 c-erbB4 ERBB4 6 Ceruloplasmin precursor CP 1 Chemokine receptor CCR2 CCR2 4 Chemokine receptor CCR3 CCR3 4 Chemokine receptor CCR5 CCR5 4 Chemokine receptor CXCR4 CXCR4 4 Chitotriosidase CHIT 1 Chloride channel 5 CLCN5 3 Chloride channel KB CLCNKB 3 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Cholestasis, progressive familial intrahepatic 1 FIC1 6 gene Cholesterol ester hydroxylase 1 Choline acetyltransferase CHAT 1 Chromogranin A CHGA 6 Chymotrypsinogen 1 Citrate synthase 1 Clathrin 2 Clusterin CLU 6 CoA transferase 1 Cockayne syndrome gene, CKN1 CKN1 6 Collagen I alpha 1 COL1A1 3 Collagen I alpha 2 COL1A2 3 Collagen II alpha 1 COL2A1 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, EDM2 3 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6A1 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen X alpha 1 COL11A1 3 Collagen XI alpha 2 COL11A2 3 Collagen XVII alpha 1 COL17A1 3 Colony-stimulating factor 1 CSF1 6 Complement component C1 inhibitor C1 NH 4 Complex I 1 Complex II 1 Complex III 1 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 C-reactive protein CRP 4 Creb binding protein CREBBP 6 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cubilin CUBN 2 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1 B PDE1B 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin F CCNF 6 Cyclin-dependent kinase 2 CDK2 6 Cyclin-dependent kinase inhibitor 1C (P57, CDKN 1C 6 KIP2) Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2FI CYP2FI 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5AI CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cysteine-rich intestinal protein 2 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cystinosin CTNS 2 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBPI 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 DAX1 nuclear receptor DAX1 4 Deleted in colorectal carcinoma DCC 6 Delta aminolevulinate dehydratase ALAD 1 Delta(4)-3-oxosteroid 5-beta-reductase 1 Delta-7-dehydrocholesterol reductase DHCR7 1 Dihydrodiol dehydrogenase 1 DDHI 1 Dihydrolipoamide branched chain transacylase DBT 5 Dihydrolipoamide dehydrogenase DLD 5 DNA glycosylases 1 Dopamine beta hydroxylase DBH 1 Dopamine receptors Dl DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Dynamin DNMI 6 Dynein 6 Dystrophia myotonica DM, DMPK 1 Dystrophia myotonica, atypical DM2 1 Dystrophin DMD 3 EBI 6 Elastase I ELASI 1 Elastase 2 ELAS2 1 Electron-transfering-flavoprotein alpha ETFA 2 Electron-transfering-flavoprotein beta ETFB 2 Electron-transferring flavoprotein ETFDH 1 dehydrogenase Endothelin I EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENO1 1 Enoyl CoA isomerase 1 Enoyl CoA reductase 1 Enteric lipase 2 Enterokinase PRSS7, ENTK 1 Ephrin receptor tyrosine kinase A EPHA 6 Ephrin receptor tyrosine kinase B EPHB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Erythrocyte membrane protein band 4.1 EPB41 3 Erythropoietin EPO 4 Excision repair complementation group 2 ERCC2 1 protein Excision repair complementation group 2 ERCC3 1 protein Eyes absent 1 EYAI 6 Faciogenital dysplasia FGD1, FGDY 2 Factor 1 (No. one) F1 4 Factor B, properdin 4 Factor D 4 Factor H HF1 4 Factor I (letter 1) IF 4 Factor III F3 4 Factor IX F9 4 Factor V F5 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Factor XI F11 4 Factor XII F12 4 Factor XIII A & B F13A & F13B 4 FADH dehydrogenase 1 Fanconi anemia, complementation group A FANCA 2 Fanconi anemia, complementation group C FANCC 2 Fanconi anemia, complementation group D FANCD 2 Fatty acid binding proteins FABP1 2 Fatty acid binding proteins FABP2 FABP2 2 Fatty acid binding proteins FABP3 2 Fatty acid binding proteins FABP4 2 Fatty acid binding proteins FABP5 2 Fatty acid binding proteins FABP6 2 Ferritin, H subunit 2 Ferritin, L subunit FTL 2 Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FN1 6 Flavin-containing monooxygenase 1 FMOL 1 Flavin-containing monooxygenase 2 FMO2 1 Flavin-containing monooxygenase 3 FMO3 1 Flavin-containing monooxygenase 4 FMO4 1 Folic acid receptor FOLR 6 Follicle stimulating hormone receptor FSHR, ODG1 6 Follicle stimulating hormone, FSH FSHB 6 Forkhead transcription factor I0 FKHL10 6 Forkhead transcription factor 14 FKHL14 6 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Fructose-1,6-diphosphatase FBP1 1 Fucosidase alpha-L-1 FUCA1 1 Fucosidase alpha-L-2 1 Fucosyltransferase 2 FUT2 2 Fucosyltransferase 3 FUT3 2 Fumarase FH 1 G/T mismatch binding protein GTBP, MSH6 6 Galactocerebrosidase GALC 1 Galactose 1-phosphate uridyl-transferase GALT 1 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1,3 GGTA1 6 Galactosyltransferase, beta 3 B3GALT 6 Galanin GAL 5 Galanin receptor GALNRL 5 Gamma-glutamyltransferase 1 GGT1 2 Gamma-glutamyltransferase 2 GGT2 2 Gap junction protein beta I GJB1 2 Gastric inhibitory polypeptide GIP GIP 2 Gastric inhibitory polypeptide receptor, GIPR GIPR 2 Gastric Intrinsic factor, GIF GIF 1 Gastric lipase, LIPF 2 Gastrin GAS 6 Gastrin releasing peptide GRP 2 Gastrin releasing peptide receptor GRPR 2 Glial-cell derived neurotrophic factor (GDNF) 5 receptor Glial-cell derived neurotrophic factor, GDNF GDNF 5 Glucagon receptor GCGR 6 Glucagon synthase 2 Glucagon-like peptide receptor 1 GLP1R 6 Glucokinase GCK 1 Glucose-6-phosphatase G6PC 1 Glucose-6-phosphatase translocase G6PT1 1 Glucose-6-phosphate dehydrogenase G6PD 1 Glucosidase, acid alpha GAA 1 Glutamate dehydrogenase GLUD1 1 Glutamine synthase 1 Glutamine transporter 2 Glutathione GSH 2 Glutathione peroxidase, GPX2 GPX2 1 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glyceraldehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycine dehydrogenase GLDC 1 Glycogen branching enzyme GBEI 1 Glycogen phosphorylase PYGL 1 Glycogen synthase 1 (muscle) GLYS1 1 Glycogen synthase 2 (liver) GYS2 1 Glycosyltransferases, ABO blood group ABO 1 Gonadotropin releasing hormone GNRH 6 Goosecoid GSC 6 Growth arrest-specific homeobox GAX 6 Growth hormone receptor GHR 6 Guanylin GUCA2 2 H(+), K(+) - ATPase ATP4B 5 Haem oxygenase 2 Haemoglobin alpha 1 HBA1 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin gamma A HBG1 2 Haemoglobin gamma B HBG2 2 Haemoglobin gamma G HBGG 2 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Heat shock protein, HSPA1 4 Heat shock protein, HSPA2 4 Heparan sulfamidase 1 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor 11 HCF2 4 Hepatic nuclear factor-3-beta HNF3B 1 Hepatic nuclear factor-4-alpha HNF4A 1 Hepatitis B virus integration site 1 HVBS1 Hepatitis B virus integration site 2 HVBS6 Hepatocyte growth factor HGF 6 Hermansky-pudlak syndrome gene HPS 2 Hexokinase 1 HKI 1 Hexokinase 2 HK2 1 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 Histatin 1 4 Histatin 2 4 Histatin 3 HTN3 4 HLA-B associated transcript I BAT1 4 HMG-CoA lyase HMGCL 1 HMG-CoA reductase HMGCR 1 HMG-CoA synthase HMGCS2 1 Holocarboxylase synthetase HLCS 1 Hormone-sensitive lipase HSL 1 Hydroxyacyl glutathione hydrolase HAGH 1 Hypoxanthine-guanine HPRT 1 phosphoribosyltransferase, HGPRT IC7 A and B 4 Iduronate 2 sulphatase IDS 1 lmmunoglobulin E (IgE) reponsiveness gene IGER 4 lmmunoglobulin E (IgE) serum concentration IGES 4 regulator gene lmmunoglobulin gamma (IgG) 2 IGHG2 4 lmmunoglobulin heavy mu chain IGHM 4 Immunoglobulin J polypeptide IGJ 4 Immunoglobulin kappa constant region IGKC 4 Immunoglobulin kappa variable region IGKV 4 lnhibin, alpha INHA 6 lnhibin, beta A INHBA 6 lnhibin, beta B INHBB 6 Inhibin, beta C INHBC 6 lnositol 1,4,5-triphosphate receptor 3 ITPR3 6 Insulin INS 6 Insulin receptor INSR 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGFIR 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 lntegrin beta 1 ITGBL 6 Integrin beta 2 ITGB2 6 ntegrin beta 3 ITGB3 6 lntegrin beta 6 ITGB6 6 Integrin, alpha M ITGAM 6 lntegrin, alpha X ITGAX 6 Inter-alpha-trypsin inhibitor, IATI 1 Interferon alpha IFNA1 4 Interferon beta IFNB 4 Interferon gamma IFNG 4 Interferon gamma receptor 1 IFNGR1 4 Interferon gamma receptor 2 IFNGR2 4 Interferon regulatory factor 1 IRF1 4 Interferon regulatory factor 4 IRF4 4 Interieukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 lnterleukin(IL) 1, beta IL1B 4 lnterleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 lnterleukin(IL) 11 IL11 1 lnterleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RBI 4 Interleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 lnterleukin(IL) 2 receptor, alpha IL2RA 4 lnterleukin(IL) 2 receptor, gamma IL2RG 4 lnterleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 lnterleukin(IL) 4 IL4 4 lnterleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 lnterleukin(IL) 5 receptor IL5R 4 lnterleukin(IL) 6 IL6 4 lnterleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 lnterleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 lnterleukin(IL) 9 IL9 4 lnterleukin(IL) 9 receptor IL9R 4 Interleukin(IL) receptor antagonist 1 IL1RN, IL1RA 4 Intestinal alkaline phosphatase IAP 2 Islet amyloid polypeptide IAPP 5 Isocitrate dehydrogenase 1 lsovaleric acid CoA dehydrogenase IVD 1 Kallikrein 3 KAK3 4 Kaliman syndrome gene 1 KAL1 6 Ketohexokinase KHK 1 ketolase 1 Kininogen, High molecular weight KNG 4 Kynurenine hydroxylase 1 Kynureninease 1 Lactase 1 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMR1 6 Latent transforming growth factor-beta binding LTBP2 6 protein 2 Lecithin-cholesterol acyltransferase LCAT 1 Leptin LEP 6 Leptin receptor LEPR 6 Leukocyte-specific transcript 1 LST-1 4 Leukotriene A4 hydrolase 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 Leukotriene D4/E4 receptor 4 LIM homeobox protein 1 LHX1 6 LIM homeobox transcription factor 1, beta LMX1B 6 Lipoamide dehydrogenase OGDH 1 Lipoprotein lipase LPL 4 Lipoprotein receptor, Low Density LDLR 2 Lipoprotein, High Density HDLDT1 2 Lipoprotein, Intermediate Density 2 Lipoprotein, Low Density 1 2 Lipoprotein, Low Density 2 2 Lipoprotein, Very Low Density VLDLR 2 Low density lipoprotein receptor-related protein LRP 2 precursor Lymphoid enhancer-binding factor LEF-1 6 Lysosomal acid lipase LIPA 1 Lysozyme LYZ 4 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 MADS box transcription-enhancer factor 2A MEF2A 6 MADS box transcription-enhancer factor 2B MEF2B 6 MADS box transcription-enhancer factor 2C MEF2C 6 MADS box transcription-enhancer factor 2D MEF2D 6 Malonyl CoA decarboxylase 1 Malonyl CoA transferase 1 Maltase-glucoamylase 1 Mannosidase, alpha B lysosomal MANB 1 Marenostrin MEFV 2 MAX-interacting protein 1 mxi I 6 MEK kinase, MEKK 1 Melanocortin 2 receptor MC2R 2 Melanocortin 4 receptor MC4R 2 Menin MEN1 6 Metallothionein 2 Mevalonate kinase MVK 1 MHC Class 1: A 4 MHC Class 1: B 4 MHC Class 1: C 4 MHC Class 1: LMP-2, LMP-7 4 MHC Class 1: Tapl ABCR, TAP1 4 MHC Class II: DP HLA-DPB1 4 MHC Class II: DO 4 MHC Class II: DR 4 MHC Class II: Tap2 TAP2, PSF2 4 MHC Class II: Complementation group A MHC2TA 4 MHC Class II: Complementation group B RFXANK 4 MHC Class II: Complementation group C RFX5 4 MHC Class II: Complementation group D RFXAP 4 Microsomal triglyceride transfer protein MTP 2 Mitochondrial trifunctional protein, alpha HADHA 1 subunit Mitochondrial trifunctional protein, beta subunit HADHB 1 Molybdenum cofactor synthesis 1 MOCS1 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Motilin MLN 6 Msh homeobox homolog 2 MSX2 6 Mucin 18 MUC18 2 Mucin, MUC2 2 Mucin, MUC5AC 2 Mucin, MUC6 2 Mucolipidoses GNPTA 1 Mulibrey nanism MUL 2 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Muscle phosphorylase PYGM 1 Mutated in colorectal cancers, MCC MCC 6 MutL homolog 1 MLHI 6 MutS homolog 2 MSH2 6 MutS homolog 3 MSH3 6 Myoglobin 2 Myosin 5A MY05A 3 Myosin 6 MY06 3 Myosin 7A MY07A 3 Myosin, cardiac MYH7 3 Myosin, light chain 2 MYL2 3 Myosin, light chain 3 MYL3 3 Myotubularin MTM1 3 Na+, K+ ATPase, alpha ATP1A1 6 Na+, K+ ATPase, beta 1 ATP1B1 6 Na+, K+ ATPase, beta 2 ATP1B2 6 Na+, K+ ATPase, beta 3 ATP1B3 6 Na+/H+ exchanger 1 NHE1 2 Na+/H+ exchanger 2 NHE2 2 Na+/H+ exchanger 3 NHE3 2 Na+/H+ exchanger 4 NHE4 2 Na+/H+ exchanger 5 NHE5 2 Na+coupled glucose/galactose transporter 2 N-acetylgalactosamine-6-sulfate sulfatase GALNS 1 N-acetylglucosamine-6-sulfatase GNS 1 N-acetylglucosaminidase, alpha NAGLU 1 NADH dehydrogenase 1 NADH dehydrogenase (ubiquinone) Fe—S NDUFS1 1 protein I NADH dehydrogenase (ubiquinone) Fe—S NDUFS4 1 protein 4 NADH dehydrogenase (ubiquinone) NDUFV1 1 flavoprotein 1 NADH-cytochrome b5 reductase DIA1 1 NB6 4 Nephrolithiasis 2 NPHL2 2 Nephronophthisis 1 NPHP1 2 Nephronophthisis 2 NPHP2 2 Nephrosis 1 NPHS1 2 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neuraminidase sialidase NEU 2 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neurotensin NTS 5 Neurotensin receptor NTSR1 5 Notch ligand-jagged I JAG 1, AGS 6 Nuclear factor I-kappa-B-like gene IKBL 4 Oncogene ERB 6 Oncogene ERB2 6 Oncogene ERBA 6 Oncogene ERBAL2 6 Oncogene GLI 1 GLI 6 Oncogene GLI2 GLI2 6 Oncogene GLI3 GLI3 6 Oncogene met MET 6 Oncogene myb MYB 6 Oncogene myc MYC 6 Oncogene n-myc 6 Oncogene ret RET 6 Oncogene r-myc 6 Oncogene sis PDGFB 6 Oncogene spil 6 Oncogene src 6 Oncogene v-Ki-ras2 KRAS2 6 Orexin ox 6 Orexin 1 receptor OX1R 6 Orexin 2 receptor OX2R 6 Omithine transcarbamoylase OTC, NME1 1 Osteopontin OPN 6 Paired box homeotic gene 2 PAX2 6 Paired box homeotic gene 3 PAX3 6 Paired box homeotic gene 6 PAX6 6 Paired box homeotic gene 8 PAX8 6 Palmitoyl-protein thioesterase PPT 2 Pancreatic amylase 1 Pancreatic colipase 2 Pancreatic lipase PNLIP 1 Pancreatic lipase related protein 1 PLRP1 1 Pancreatic lipase related protein 2 PLRP2 1 Paraoxonase PON1 PON1 1 Paraoxonase PON2 PON2 1 Paraoxonase PON3 1 Parathyroid hormone PTH 6 Parathyroid hormone receptor PTHR1 6 Parathyroid hormone related-peptide PTHRP 6 Parathyroid hormone-like hormone PTHLH 6 Parvalbumin PVALB 6 Patched (Drosophila) homolog, PTCH PTCH 6 Pepsin 2 Pepsinogen 1 Peptidases A 2 Peptidases B 2 Peptidases C 2 Peptidases D PEPD 2 Peptidases E 2 Peptidases S 2 Peroxidase, salivary SAPX 1 Peroxisomal membrane protein 1 PXMP1 3 Peroxisomal membrane protein 3 PXMP3 2 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome receptor 1 PXR1 2 Phenylalanine monooxygenase 1 Phosphatase & tensin homolog PTEN 6 Phosphate regulating gene with homologies to PHEX 6 endopeptidases on the X chromosome Phosphoenolpyruvate carboxykinase PCK1 1 Phosphofructokinase, liver PFKL 1 Phosphofructokinase, muscle PFKM 1 Phosphoglucomutase 1 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase 1 PGKI 1 Phosphoglycerate mutase 2 PGAM2 1 Phospholipase A2, group 10 PLA2G 10 4 Phospholipase A2, group 1B PLA2G 1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCGI 4 Phosphomannomutase 2 PMM2 6 Phosphomannomutase 2 PMM2 2 Phosphomannose isomerase 1, PMI1 MPI 2 Phosphoribosyl pyrophosphate synthetase PRPS1 1 Phosphorylase kinase deficiency, liver PHK 1 Phosphorylase kinase, alpha 1 (muscle) PHKA1 1 Phosphorylase kinase, alpha 2 PHKA2 1 Phosphorylase kinase, beta PHKB 1 Phosphorylase kinase, delta 1 Phosphorylase kinase, gamma 2 PHKG2 1 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI 1 1 Plasminogen activator inhibitor 2 PA12 1 Plasminogen activator receptor, Urokinase UPAR, PLAUR 3 Plasminogen activator, Tissue PLAT, TPA 1 Plasminogen activator, Urokinase UPA, PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Platelet monamine oxidase 2 Platelet-activating factor receptor PAFR 4 Polycystic kidney and hepatic disease 1 PKHD1 2 Polycystin 1 PKD1 2 Polycystin 2 PKD2 2 Polymorphonuclear elastase 2 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium inwardly-rectifying channel J11 KCNJ 11 5 Potassium voltage-gated channel E1 KCNE1 5 Prekallikrein 4 Preproenkephalin PENK 5 Preproglucagon GCG, GLPL, GLP2 6 Preproglucagon 2 Preproinsulin 2 Procoliagen N-protease 1 Proline dehydrogenase PRODH 1 Proline-rich protein BstNI subfamily 1 PRB1 3 Proline-rich protein BstNI subfamily 3 PRB3 3 Proline-rich protein BstNI subfamily 4 PRB4 3 Prolyl-4-hydroxylase 1 Pro-melanin-concentrating hormone PMCH 6 Proopiomelanocortin POMC 5 Prosaposin PSAP 5 Prostacyclin synthase 4 Prostaglandin 15-OH dehydrogenase HGPD, PGDH 4 Prostaglandin D - DP receptor 4 Prostaglandin E1 receptor 4 Prostagiandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostagiandin F2 alpha receptor 4 Prostaglandin 12 receptor 2 Prostaglandin IP receptor 4 Protease inhibitor 1 2 Protective protein for beta-galactosidase PPGB 1 Protein C PROC 4 Protein C inhibitor PCI 4 Protein kinase B PRKB 4 Protein S PROSI 4 Protein tyrosine phosphatase, non-receptor PTPNI2 6 type 12 Prothrombin precursor F2 4 Pterin-4-alpha-carbinolamine PCBD Pyruvate carboxylase PC 1 Pyruvate decarboxylase PDHA 1 Pyruvate kinase PKLR 1 Quinoid dihydropteridine reductase QDPR 1 Renal glutaminase 2 Renin REN 1 Replication factor C RFC2 1 Retinoblastoma 1 RB1 6 Retinol binding protein 1 2 Retinol binding protein 2 2 Retinoschisis, X-linked, juvenile RS 6 RIGUI RIGUI 6 SA homolog SAH 6 Salivary amylase, AMY1 2 SAP (SLAM-associated protein) SH2D1A 4 Secretin SCT 2 Secretin receptor, SCTR SCTR 2 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage-gated, type 1, beta SCNLB 5 polypeptide Solute carrier family 10 (sodium/bile acid SLC10A1 2 cotransporter family), member 1 Solute carrier family 10 (sodium/bile acid SLC10A2 2 cotransporter family), member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carder family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 14, member 2 SLC14A2 2 Solute carrier family 15 (H+/peptide SLC15A1 2 transporter; intestinal), member 1 Solute carrier family 15 (H+/peptide SLC15A2 2 transporter, kidney), member 2 Solute carrier family 16 (monocarboxylate SLC16A1 2 transporter), member 1 Solute carrier family 16 (monocarboxylate SLC16A7 2 transpofter), member 7 Solute carrier family 17, member 1 SLC17A1 2 Solute carrier family 17, member 2 SLC17A2 2 Solute carrier family 2 (facilitated glucose SLC2A1 2 transporter), member 1 Solute carrier family 2 (facilitated glucose SLC2A2 2 transporter), member 2 Solute carrier family 2 (facilitated glucose SLC2A3 2 transporter), member 3 Solute carrier family 2 (facilitated glucose SLC2A4 2 transporter), member 4 Solute carrier family 2 (facilitated glucose SLC2A5 2 transpofter), member 5 Solute carrier family 21, member 2 SLC21A2 2 Solute carrier family 21, member 3 SLC21A3 2 Solute carrier family 22, member 1 SLC22A1 2 Solute carrier family 22, member 2 SLC22A2 2 Solute carrier family 22, member 5 SLC22A5 2 Solute carrier family 3 (facilitated glucose SLC3A1 2 transporter), member 1 Solute carrier family 4 (anion exchanger), SLC4A1 2 member I Solute carrier family 4 (anion exchanger), SLC4A2 2 member 2 Solute carrier family 4 (anion exchanger), SLC4A3 2 member 3 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transpofter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmifter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmifter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6, member 6 SLC6A6 2 Solute carrier family 7(amino acid transporters, SLC7AI 2 member 1 Solute carrier family 7(amino acid transporters, SLC7A2 2 member 2 Solute carrier family 7(amino acid transporters, SLC7A7 2 member 7 Somatostatin SST 5 Somatostatin receptor, SSTR1 SSTR1 5 Somatostatin receptor, SSTR2 SSTR2 6 Somatostatin receptor, SSTR3 SSTR3 5 Somatostatin receptor, SSTR4 SSTR4 5 Somatostatin receptor, SSTR5 SSTR5 5 Sphingomyelinase SMPD1 1 Steroid 5 alpha reductase 1 SRD5A1 1 Steroid 5 alpha reductase 2 SRD5A2 1 Sterol carrier protein 2 SCP2 2 Substance P 5 Succinyl CoA synthase 1 Sucrase 1 Sucrase-isomaltase SI 2 Superoxide dismutase 1 SOD1 1 Surfeit I SURF1 6 Talin TLN 6 Talin, TLN 3 TATA binding protein TBP 6 T-BOX 1 TBXI 6 T-BOX 2 TBX2 6 T-BOX 3 TBX3 6 Thiolase, perioxisomal 1 Thrombin receptor F2R 4 Thrombopoietin THPO 6 Thromboxane A synthase 1 TBXAS1 4 Tip-associated protein TAP 4 Topoisomerase I 1 Torticollis, keloids, cryptorchidism and renal TKCR 6 dysplasia gene Transacylase 1 Transcobalamin 1, TCN1 2 Transcobalamin 2, TCN2 TCN2 2 Transcription factor 1, hepatic TCF1 6 Transcription factor 2, hepatic TCF2 6 Transferrin TF 6 Transferrin receptor TFRC 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFB1 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transglutaminase 4 TGM4 6 Transketolase TKT 1 Transketolase-like I TKTLI 1 Translocation in renal carcinoma on TRC8 6 chromosome 8 gene Transthyretin TTR 2 Trehalase 2 Triosephosphate isomerase TPI 1 1 Trypsin inhibitor 1 Trypsinogen 1 TRY1 1 Trypsinogen 2 TRY2 1 Trypsinogen activation peptide 2 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tumour suppresssor gene DRA DRA 4 Tyrosinase TYR 1 UDP-glucose pyrophosphorylase 1 UDP-glucuronosyltransferase 1 ugtld, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Uroporphyrinogen decarboxylase UROD 1 Uroporphyrinogen III synthase UROS 1 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Vasoinhibitory peptide 6 Villin 3 Von Hippel-Lindau gene VHL 6 Von Willebrand factor VWF 2 Wiskoft-Aldrich syndrome protein WASP, THC 4 Wolf-Hirschhom syndrome candidate 1 gene WHSC1 6 Wolfram syndrome 1 gene WFS1 3 Xanthine dehydrogenase XDH 1 Xeroderma pigmentosum, complementation XPA 1 group A Xeroderma pigmentosum, complementation XPB 1 group B Xeroderma pigmentosum, complementation XPC 1 group C Xeroderma pigmentosum, complementation 1 group D Xeroderma pigmentosum, complementation 1 group E Xeroderma pigmentosum, complementation XPF 1 group F Xeroderma, pigmentosum, complementation ERCC5 1 group G Zinc finger protein 3 ZIC3 3,

that the genes associated with malfunction, damage or disease of the respiratory system are selected from: HUGO Protein- List of genes gene symbol function 11 beta hydroxysteroid dehydrogenase 2 HSD11B2 1 2,3-bisphosphoglycerate mutase BPGM 1 3 beta hydroxysteroid dehydrogenase 2 HSD3B2 1 Acetoacetyl 1-CoA-thiolase ACAT1 1 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetyl CoA synthase 1 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Aconitase 1 Acyl CoA dehydrogenase, long chain ACADL 1 Acyl CoA dehydrogenase, medium chain ACADM 1 Acyl CoA dehydrogenase, short chain ACADS 1 Acyl CoA dehydrogenase, very long chain ACADVL 1 Adaptin, beta 3A ADTB3A 2 Adenosine deaminase ADA 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic.receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Albumin, ALB ALB 2 Alcohol dehydrogenase 1 ADH1 1 Alcohol dehydrogenase 2 ADH2 1 Alcohol dehydrogenase 3 ADH3 1 Alcohol dehydrogenase 4 ADH4 1 Alcohol dehydrogenase 5 ADH5 1 Alcohol dehydrogenase 6 ADH6 1 Alcohol dehydrogenase 7 ADH7 1 Aldolase A ALDOA 1 Aldolase B ALDOB 1 Aldolase C ALDOC 1 Aldosterone receptor MLR 6 Alpha 2 macroglobulin A2M 4 Alpha1-antichymotrypsin AACT 1 alpha1-Antitrypsin PI 1 alpha2-Antiplasmin PLI 1 alpha-Actinin 2 ACTN2 6 alpha-Actinin 3 ACTN3 6 alpha-Galactosidase A GLA 1 alpha-ketoglutarate dehydrogenase 1 Aminopeptidase P XPNPEP2 1 Amphiregulin AREG 6 Androgen receptor AR 6 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCP1 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Annexin 1 ANX 1 1 Antidiuretic hormone receptor ADHR 2 Antithrombin III AT3 1 Apolipoprotein E APOE 2 Arginase ARG1 1 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 1 B AVPR1B 5 Arginine vasopressin receptor 2 AVPR2 5 Arginosuccinate lyase ASL 1 Arylsulfatase D ARSD 1 Arylsulfatase E ARSE 1 Arylsulfatase F ARSF 1 Aspartate transaminase 2 Ataxia telangiectasia gene, AT ATM 6 ATP/ADP translocase 1 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 beta-galactosidase GLB1 1 beta-Glucuronidase GUSB 1 Blotinidase BTD 1 Bloom syndrome protein BLM 6 Bradykinin receptor B1 Bradykinin receptor B2 Butyrylcholinesterase BCHE 1 C1 inhibitor 1 Cadherin E CDH1 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calcitonin receptor/Calcitonin gene-related CALCR 5 peptide receptor Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, alpha CACNA1F 5 1F subunit Calcium channel, voltage-dependent, Alpha- CACNAL B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA1C 5 1 C Calcium channel, voltage-dependent, Alpha- CACNA1D 5 1 D Calcium channel, voltage-dependent, Alpha- CACNA1E 5 E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, T-type 5 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calnexin CANX 6 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Carnitine acetyltransferase CRAT 1 Camitine acylcarnitine translocase CACT 1 Catalase CAT 4 Cathepsin B 1 Cathepsin D 1 Cathepsin E 1 Cathepsin G CTSG 1 Cathepsin H 1 Cathepsin K CTSK 1 Cathepsin L 1 Cathepsin S 1 CD1 CD1 4 CD4 CD4 4 Cell adhesion molecule, intercellular, ICAM ICAM1 6 Cell adhesion molecule, leukocyte- LECAM1 6 endothelial, LECAM (CD62) Cell adhesion molecule, liver, LCAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM1 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 Chemokine receptor CXCR4 CXCR4 4 Chitotriosidase CHIT 1 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Choline acetyltransferase CHAT 1 Citrate synthase 1 Coenzyme Q (CoQ)/ubiquinone 1 Collagen I alpha 1 COL1A1 3 Collagen I alpha 2 COL1A2 3 Collagen II alpha 1 COL2A1 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, EDM2 3 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6A1 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen X alpha 1 COL11A1 3 Collagen XI alpha 2 COL11A2 3 Collagen XVII alpha 1 COL17A1 3 Colony-stimulating factor 1 CSF1 6 Colony-stimulating factor 1 receptor CSF1R 6 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 2 alpha receptor CSF2RA 6 Colony-stimulating factor 2 beta receptor CSF2RB 6 Colony-stimulating factor 3 CSF3 6 Colony-stimulating factor 3 receptor CSF3R 6 Complement component C1 inhibitor C1NH 4 Complement component C1qa C1QA 4 Complement component C1qb C1QB 4 Complement component C1qg C1QG 4 Complement component C1r C1R 4 Complement component C1s C1S 4 Complement component C2 C2 4 Complement component C3 C3 4 Complement component C4A C4A 4 Complement component C4B C4B 4 Complement component C5 C5 4 Complement component C6 C6 4 Complement component C7 C7 4 Complement component C8 C8B 4 Complement component C9 C9 4 Complement component receptor 1 CR1 4 Complement component receptor 2 CR2 4 Complement component receptor 3 CR3 4 Complex I 1 Complex II 1 Complex III 1 Complex III 1 Complex V MTATP6 1 Coproporphyrinogen oxidase CPO 1 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Cortisol receptor 4 C-reactive protein CRP 4 Creatine kinase - B and m CKBE 1 Creb binding protein CREBBP 6 Cu2+ transporting ATPase alpha polypeptide ATP7A 1 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase 1B1 PDE1B1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin-dependent kinase 2 CDK2 6 Cyclin-dependent kinase inhibitor 2A (p 16) CDKN2A 6 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cytidine deaminase CDA 1 Cytidine-5-prime-tdphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome b-5 CYB5 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 4 binding protein I Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 DAX1 nuclear receptor DAX1 4 D-beta-hydroxybutyrate dehydrogenase 1 Delta 4-5 alpha-reductase 1 Desmin DES 3 Dihydrolipoamide dehydrogenase DLD 5 DNA glycosylases 1 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Dystrophin DMD 3 Elastase 1 ELAS1 1 Elastase 2 ELAS2 1 Elastin ELN 3 Electron-transfering-flavoprotein alpha ETFA 2 Electron-transfedng-flavoprotein beta ETFB 2 Electron-transferring flavoprotein ETFDH 1 dehydrogenase Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase EN01 1 Enoyl CoA hydratase 1 Enoyl CoA isomerase 1 Enoyl CoA reductase 1 Enterokinase PRSS7, ENTK 1 Ephrin receptor tyrosine kinase A EPHA 6 Ephrin receptor tyrosine kinase B EPHB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Epoxide hydrolase 1, microsomal EPHX1 1 Estrogen receptor ESR 6 EWS RNA-binding protein EWSR1 6 Eyes absent 1 EYA1 6 Faciogenital dysplasia FGD1, FGDY 2 Factor 1 (No. one) F1 4 Factor B, properdin 4 Factor D 4 Factor H HF1 4 Factor I (letter 1) IF 4 Factor III F3 4 Factor IX F9 4 Factor V F5 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Factor XI F11 4 Factor XII F12 4 Factor XIII A & B F13A & F13B 4 Fc fragment of IgG, high affinity IA, receptor FCG1A 6 for Fc fragment of IgG, low affinity IIa, receptor FCGR2A 6 for (CD32) Fc fragment of IgG, low affinity IIIa, receptor FCGR3A 6 for (CD 1 6) Fibrillin 1 FBN1 6 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FNI 6 Flightless-II, Drosophila homolog of FLII 6 Follicle stimulating hormone receptor FSHR, ODGI 6 Follicle stimulating hormone, FSH FSHB 6 Forkhead rhabdomyosarcoma gene FKHR 6 Fructose-1,6-diphosphatase FBP1 1 Furin 2 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRBI 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Galactocerebrosidase GALC 1 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1,3 GGTA1 6 Galactosyltransferase, beta 3 B3GALT 6 Glucocorticoid receptor GRL 6 Glucokinase GCK 1 Glucosidase, acid alpha GAA 1 Glutamate dehydrogenase GLUD1 1 Giutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutathione GSH 2 Glutathione peroxidase, GPX1 GPX1 1 G utathione peroxidase, GPX2 GPX2 1 Glutathione reductase, GSR GSR 1 Glutathione S-transferase mu 1, GSTM1 GSTM1 1 Glutathione S-transferase mu 4, GSTM4 1 Glutathione S-transferase theta 1, GSTT1 GSTT1 1 Glutathione S-transferase theta 2, GSTT2 1 Glutathione S-transferase, GSTP1 GSTPI 1 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glutathione synthetase GSS 1 Glyceraldehyde-3-phosphate GAPDH 1 dehydrogenase, GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase GM2 ganglioside activator protein, GM2A GM2A 1 Growth arrest-specific homeobox GAX 6 Guanylyl cyclase 1 Haemoglobin alpha 1 HBA1 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin gamma A HBG1 2 Haemoglobin gamma B HBG2 2 Haemoglobin gamma G HBGG 2 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Heat shock protein, HSPA1 4 Heat shock protein, HSPA2 4 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor II HCF2 4 Hermansky-pudlak syndrome gene HPS 2 Hexokinase 1 HK1 1 Hexokinase 2 HK2 1 Hexosaminidase A HEXA, TSD 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 HMG-CoA lyase HMGCL 1 HMG-CoA reductase HMGCR 1 HMG-CoA synthase HMGCS2 1 Holocarboxylase synthetase HLCS 1 Hyaluronidase 2 Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 Immunoglobulin E (IgE) reponsiveness gene IGER 4 Immunoglobulin E (IgE) serum concentration IGES 4 regulator gene Immunoglobulin gamma (IgG) 2 IGHG2 4 Insulin INS 6 Insulin receptor INSR 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 Integrin beta 1 ITGB1 6 Integrin beta 2 ITGB2 6 Integrin beta 5 ITGB5 6 Integrin beta 6 ITGB6 6 Integrin, alpha M ITGAM 6 Inter-alpha-trypsin inhibitor IATI 1 Interferon alpha IFNA1 4 Interferon beta IFNB 4 Interferon gamma IFNG 4 Interferon gamma receptor 1 IFNGR1 4 Interferon gamma receptor 2 IFNGR2 4 Interferon regulatory factor 1 IRF1 4 Interferon regulatory factor 4 IRF4 4 Interleukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) 11 IL11 4 Interleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RB1 4 Interleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 Interleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 Interleukin(IL) 5 receptor IL5R 4 Interleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 Interleukin(IL) 9 IL9 4 Interleukin(IL) 9 receptor IL9R 4 Interleukin(IL) receptor antagonist 1 IL1RN, IL1RA 4 Isocitrate dehydrogenase 1 Kallikrein 3 KAK3 4 Kininogen, High molecular weight KNG 4 Kynureninease 1 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMR1 6 Latent transforming growth factor-beta LTBP2 6 binding protein 2 Lecithin-cholesterol acyltransferase LCAT 1 Leptin LEP 6 Leptin receptor LEPR 6 Leukotriene A4 hydrolase 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 Leukotriene D4/E4 receptor 4 LIM homeobox protein 1 LHX1 6 Lipoamide dehydrogenase OGDH 1 Lipoprotein lipase LPL 4 Lipoprotein receptor, Low Density LDLR 2 Lipoprotein, High Density HDLDT1 2 Lipoprotein, Intermediate Density 2 Lipoprotein, Low Density 1 2 Lipoprotein, Low Density 2 2 Lipoprotein, Very Low Density VLDLR 2 Lipoxygenase 1 Low density lipoprotein receptor-related LRP 2 protein precursor Lymphoid enhancer-binding factor LEF-1 6 Lysosomal acid lipase LIPA 1 Lysozyme LYZ 4 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 Malate dehydrogenase, mitochondrial MDH2 1 Malonyl CoA transferase 1 Mannose binding protein MBP 4 Mannosidase, alpha B lysosomal MANB 1 Mannosidase, beta A lysosomal MANBA 1 Matrix Gla protein MGP 6 Matrix metalloproteinase 1 MMP1 1 Matrix metalloproteinase 10 MMP10 1 Matrix metalloproteinase 11 MMP11 1 Matrix metalloproteinase 12 MMP12 1 Matrix metalloproteinase 13 MMP13 1 Matrix metalloproteinase 14 MMP14 1 Matrix metalloproteinase 15 MMP15 1 Matrix metalloproteinase 16 MMP16 1 Matrix metalloproteinase 17 MMP17 1 Matrix metalloproteinase 18 MMP18 1 Matrix metalloproteinase 19 MMP19 1 Matrix metalloproteinase 2 MMP2 1 Matrix metalloproteinase 3 MMP3, STMY1 1 Matrix metalloproteinase 4 MMP4 1 Matrix metalloproteinase 5 MMP5 F Matrix metalloproteinase 6 MMP6 1 Matrix metalloproteinase 7 MMP7 1 Matrix metalloproteinase 8 MMP8 1 Matrix metalloproteinase 9 MMP9 1 Methionine adenosyltransferase MAT1A, MAT2A 1 Midline I MID1 6 Mitochondrial trifunctional protein, alpha HADHA 1 subunit Mitochondrial trifunctional protein, beta HADHB 1 subunit Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Myoglobin 2 Myotubularin MTM1 3 Na+, K+ ATPase, alpha ATP1A1 6 Na+, K+ ATPase, beta 1 ATP1B1 6 Na+, K+ ATPase, beta 2 ATP1B2 6 Na+, K+ ATPase, beta 3 ATP1B3 6 NADH dehydrogenase 1 NADH dehydrogenase (ubiquinone) Fe—S NDUFS1 1 protein 1 NADH dehydrogenase (ubiquinone) Fe—S NDUFS4 1 protein 4 NADH dehydrogenase (ubiquinone) NDUFV1 1 flavoprotein 1 NADH-cytochrome b5 reductase DIA1 1 reductase Nebulin NEB 3 Nephrosis 1 NPHS1 2 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neuraminidase sialidase NEU 2 Neuregulin HGL 6 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1 R 5 Neuropeptide Y receptor Y2 NPY2R 5 Nitric oxide synthase 1, NOS 1 NOSI 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Notch ligand - jagged 1 JAG 1, AGS 6 Nucleoside diphosphate kinase-A NDPKA 1 Oncogene ELK1 ELK1 6 Oncogene ELK2 ELK2 6 Oncogene sis PDGFB 6 Omithine delta-aminotransferase OAT 1 Paired box homeotic gene 6 PAX6 6 Parathyroid hormone PTH 6 Parathyroid hormone receptor PTHR1 6 Parathyroid hormone related-peptide PTHRP 6 Parathyroid hormone-like hormone PTHLH 6 Patched (Drosophila) homolog, PTCH PTCH 6 Peroxisomal membrane protein 3 PXMP3 2 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome receptor 1 PXR1 2 Phenylalanine hydroxylase PAH 1 Phenylalanine monooxygenase 1 Phenylethanolamine N-methyltransferase, PNMT 1 PNMT Phosphofructokinase, liver PFKL 1 Phosphofructokinase, muscle PFKM 1 Phosphoglucomutase 1 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase 1 PGK1 1 Phosphoglycerate mutase 2 PGAM2 1 Phospholipase A2, group 10 PLA2G 10 4 Phospholipase A2, group 1B PLA2G1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 P 2G5 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C epsilon 4 Pineolytic beta-receptors 1 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI 1 1 Plasminogen activator inhibitor 2 PA12 1 Plasminogen activator receptor, Urokinase UPAR; PLAUR 3 Plasminogen activator, Tissue PLAT; TPA 1 Plasminogen activator, Urokinase UPA; PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Platelet-activating factor receptor PAFR 4 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium voltage-gated channel E1 KCNE1 5 Prekallikrein 4 Procollagen N-protease 1 receptor) Proliferin PLF 6 Proopiomelanocortin POMC 5 Properdin P factor, complement PFC, PFD 4 Prosaposin PSAP 5 Prostacyclin synthase 4 Prostagiandin 15-OH dehydrogenase HGPD; PGDH 4 Prostaglandin D - DP receptor 4 Prostaglandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostaglandin F2 alpha receptor 4 Prostaglandin 12 receptor 2 Prostaglandin IP receptor 4 Protein C PROC 4 Protein C inhibitor PCI 4 Protein phosphatase 2, regulatory subunit A, PPP2R1B 1 beta isoform Protein S PROS1 4 Prothrombin precursor F2 4 Pyruvate carboxylase PC 1 Pyruvate decarboxylase PDHA 1 Pyruvate kinase PKLR 1 Quinoid dihydropteridine reductase QDPR 1 Renin REN 1 Replication factor C RFC2 1 Retinoblastoma 1 RB1 6 RIGUI RIGUI 6 Salivary amylase, AMY1 2 Selectin E SELE 5 Selectin L SELL 5 Selectin P SELP 5 Sedne hydroxymethyltransferase SHMT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1 D HTR1D 5 Serotonin receptor, 5HT1 E HTR1E 5 Serotonin receptor, 5HT1 F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, SCNN1G 5 gamma Sodium channel, voltage gated, type IV, SCN4A 5 alpha polypeptide Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 21, member 2 SLC21A2 2 Solute carrier family 4 (anion exchanger), SLC4A1 2 member 1 Solute carrier family 4 (anion exchanger), SLC4A2 2 member 2 Solute carrier family 4 (anion exchanger), SLC4A3 2 member 3 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Somatostatin receptor, SSTR2 SSTR2 6 Sphingomyelinase SMPD1 1 Substance P 5 Succinate dehydrogenase 2 SDH2 1 Succinate thiokinase 1 Succinyl CoA synthase 1 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 Surfactant pulmonary-associated protein A1 SFTPA1 2 Surfactant pulmonary-associated protein A2 SFTPA2 2 Surfactant pulmonary-associated protein B SFTPB 2 Surfactant pulmonary-associated protein C SFTPC 2 Surfactant puimonary-associated protein D SFTPD 2 Surfeit 1 SURF1 6 Survival of motor neuron 1, telomeric SMN1 2 Talin TLN 6 T-BOX 2 TBX2 6 T-BOX 3 TBX3 6 TEK, tyrosine kinase, endothelial TEK 1 Telomerase protein component 1 Thiolase, perioxisomal 1 Thrombin receptor F2R 4 Thrombomodulin THBD 4 Thrombopoietin THPO 6 Thrombospondin THBS1 6 Thromboxane A synthase 1 TBXAS1 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thyroglobulin TG 6 Thyroid hormone receptor, alpha THRA 6 Thyroid hormone receptor, beta THRB 6 Thyroid peroxidase TPO 6 Thyroid receptor auxiliary protein TRAP 6 Thyroid-stimulating hormone receptor TSHR 6 Thyroid-stimulating hormone, alpha TSHA 6 Thyroid-stimulating hormone, beta TSHB 6 Thyrotropin releasing hormone receptor TRHR 6 Topoisomerase I 1 Transacylase 1 Transferrin TF 6 Transferrin receptor TFRC 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFBI 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transketolase TKT 1 Transketolase-like 1 TKTL1 1 Triosephosphate isomerase TPI 1 1 Trypsin inhibitor 1 Uncoupling protein I 2 Uroporphyrinogen III synthase UROS 1 Vasoactive intestinal polypeptide receptor VIPR 5 Vasoinhibitory peptide 6 Vitronectin receptor, alpha VNRA 2 Von Hippel-Lindau gene VHL 6 Wolf-Hirschhorn syndrome candidate 1 gene WHSC1 6 Xanthine dehydrogenase XDH 1

HUGO Protein- Liste der Gene Gensymbol funktion 5,10-Methylenetetrahydrofolate reductase MTHFR 1 (NADPH) Acetylcholinesterase ACHE 1 Acidic amino acid transporter 2 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTAL 3 Actin, alpha, smooth, aortic ACTA2 3 Actin, beta ACTB 3 Actin, gamma 2 ACTG2 3 ADAM (A disintegrin and metalloproteinase) 1 ADAM 1 1 ADAM (A disintegrin and metalloproteinase) 10 ADAM 1 10 ADAM (A disintegrin and metalloproteinase) 11 ADAM 1 11 ADAM (A disintegrin and metalloproteinase) 12 ADAM 1 12 ADAM (A disintegrin and metalloproteinase) 13 ADAM 1 13 ADAM (A disintegrin and metalloproteinase) 14 ADAM 1 14 ADAM (A disintegrin and metalloproteinase) 15 ADAM 1 15 ADAM (A disintegrin and metalloproteinase) 16 ADAM 1 16 ADAM (A disintegrin and metalloproteinase) 17 ADAM 1 17 ADAM (A disintegrin and metalloproteinase) 18 ADAM 1 18 ADAM (A disintegrin and metalloproteinase) 19 ADAM 1 19 ADAM (A disintegrin and metalloproteinase) 2 ADAM 2 1 ADAM (A disintegrin and metalloproteinase) 3A ADAM 1 3A ADAM (A disintegrin and metalloproteinase) 3B ADAM 1 3B ADAM (A disintegrin and metalloproteinase) 4 ADAM 4 1 ADAM (A disintegrin and metalloproteinase) 5 ADAM 5 1 ADAM (A disintegrin and metalloproteinase) 6 ADAM 6 1 ADAM (A disintegrin and metalloproteinase) 7 ADAM 7 1 ADAM (A disintegrin and metalloproteinase) 8 ADAM 8 1 ADAM (A disintegrin and metalloproteinase) 9 ADAM 9 1 Adducin, alpha ADD1 3 Adducin, beta ADD2 3 Adenosine deaminase ADA 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate pyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Albumin, ALB ALB 2 Aldosterone receptor MLR 6 Alpha 1 acid glycoprotein AAG, AGP 2 Alpha 2 macroglobulin A2M 4 alpha1-antitrypsin Pi 1 alpha2-antiplasmin PLI 1 Alpha-fetoprotein AFP 6 alpha-glucosidase, neutral AB GANAB 1 alpha-glucosidase, neutral C GANC 1 Aminopeptidase P XPNPEP2 1 Amylo-1,6-glucosidase AGL 1 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Androgen binding protein ABP 2 Androgen receptor AR 6 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCPI 1 Angiotensin receptor 1 AGTRL 2 Angiotensin receptor 2 AGTR2 2 Anglotensinogen AGT 1 Annexin I ANX 1 4 Antidiuretic hormone receptor ADHR 2 Anti-Mullerian hormone AMH 6 Antithrombin III AT3 1 Apaf-1 3 Apolipoprotein E APOE 2 Apoptosis antigen 1 APT1 4 Apoptosis antigen ligand 1 APT1LG1 4 Apoptosis-inducing factor AIF 4 Arginosuccinate lyase ASL 1 Aryl hydrocarbon receptor AHR 2 Asparagine synthetase AS 1 Aspartylglucosaminidase AGA 1 Ataxia telangiectasia complementation group D ATD, ATDC 6 Ataxia telangiectasia gene, AT ATM 6 ATP-binding cassette transporter 7 ABC7 4 Attractin 4 Autoimmune regulator, AIRE AIRE 4 B-cell CLL/lymphoma 1 BCL1 4 B-cell CLL/lymphoma 10 BCL10 4 B-cell CLL/lymphoma 3 BCL3 4 B-cell CLL/lymphoma 4 BCL4 4 B-cell CLL/lymphoma 5 BCL5 4 B-cell CLL/lymphoma 6 BCL6 4 B-cell CLLUlymphoma 7 BCL7 4 B-cell CLL/lymphoma 8 BCL8 4 B-cell CLL/lymphoma 9 BCL9 4 BCL2-associated X protein BAX 6 BCL2-related protein A1 BCL2A1 6 Beckwith-Wiedemann region 1A BWR1A 6 beta 2 Microglobulin B2M 4 Bleomycin hydrolase BLMH 1 Bloom syndrome protein BLM 6 Bradykinin receptor B1 Bradykinin receptor B2 Brain derived neurotrophic factor BDNF 6 Brain derived neurotrophic factor (BDNF) BDNFR 6 receptor BRCAI-associated RING domain gene 1 BARD1 6 Breakpoint cluster region BCR 6 Breast cancer I BRCAL 6 Breast cancer 2 BRCA2 6 Breast cancer, ductal, 1 BRCD1 6 Breast cancer, ductal, 2 BRCD2 6 Butyrylcholinesterase BCHE 1 C3 convertase 1 Cadherin E CDH1 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin 1 CALB1 6 Calbindin D9K CALB3 6 Calcineurin A1 CALNA1 4 Calcineurin A2 CALNA2 4 Calcineurin A3 CALNA3 4 Calcineurin B 4 Calcitonin receptor/Calcitonin gene-related CALCR 5 peptide receptor Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, Alpha 1F CACNA1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA1C 5 1C Calcium channel, voltage-dependent, Alpha- CACNA1D 5 1D Calcium channel, voltage-dependent, Alpha- CACNA1E 5 1E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNA1S 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase II CAMK2A 6 Calnexin CANX 6 Calpain CAPN, 1 CAPN3 Calretinin CALB2 5 Canalicular multispecific organic anion CMOAT 2 transporter Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Carboxylesterase 1 CES1 1 Cardiac-specific homeobox, CSX CSX 6 Cartilage-hair hypoplasia gene CHH 5 Caspase 1 CASP1 6 Catalase CAT 4 Cathepsin G CTSG 1 CD1 CD1 4 CD10 CD10 4 CD100 CD100 4 CD112 CD112 4 CD113 CD113 4 CD114 CD114 4 CD115 CD115 4 CD116 CD116 4 CD117 CD117 4 CD118 CD118 4 CD119 CD119 4 CD12 CD12 4 CD13 CD13 4 CD14 CD14 4 CD15 CD15 4 CD17 CD17 4 CD19 CD19 4 CD2 CD2 4 CD20 CD20 4 CD22 CD22 4 CD23 CD23 4 CD24 CD24 4 CD25 CD25 4 CD26 CD26 4 CD27 CD27 4 CD28 CD28 4 CD3 CD3 4 CD30 CD30 4 CD31 CD31 4 CD33 CD33 4 CD34 CD34 4 CD36 CD36 4 CD37 CD37 4 CD38 CD38 4 CD39 CD39 4 CD4 CD4 4 CD40 CD40 4 CD41 CD41 4 CD42 CD42 4 CD43 CD43 4 CD44 CD44 4 CD45 CD45 4 CD46 CD46 4 CD47 CD47 4 CD48 CD48 4 CD5 CD5 4 CD50 CD50 4 CD52 CD52 4 CD53 CD53 4 CD55 CD55 4 CD57 CD57 4 CD58 CD58 4 CD59 CD59 4 CD6 CD6 4 CD60 CD60 4 CD63 CD63 4 CD65 CD65 4 CD66 CD66 4 CD67 CD67 4 CD68 CD68 4 CD69 CD69 4 CD7 CD7 4 CD70 CD70 4 CD71 CD71 4 CD72 CD72 4 CD73 CD73 4 CD74 CD74 4 CD75 CD75 4 CD76 CD76 4 CD77 CD77 4 CD78 CD78 4 CD79 CD79 4 CD8 CD8 4 CD80 CD80 4 CD81 CD81 4 CD83 CD83 4 CD84 CD84 4 CD85 CD85 4 CD86 CD86 4 CD88 CD88 4 CD89 CD89 4 CD9 CD9 4 CD90 CD90 4 CD91 CD91 4 CD92 CD92 4 CD93 CD93 4 CD94 CD94 4 CD96 CD96 4 CD97 CD97 4 CD98 CD98 4 CD99 CD99 4 Cell adhesion molecule, intercellular, ICAM ICAM1 6 Cell adhesion molecule, leukocyte-endothelial, LECAM1 6 LECAM (CD62) Cell adhesion molecule, liver, ICAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM1 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 Chediak-Higashi syndrome 1 gene CHS1 2 Chemokine MCAF MCAF 4 Chemokine receptor CCR2 CCR2 4 Chemokine receptor CCR3 CCR3 4 Chemokine receptor CCR5 CCR5 4 Chemokine receptor CXCR1 CXCR1 4 Chemokine receptor CXCR2 CXCR2 4 Chemokine receptor CXCR4 CXCR4 4 Cholesteryiester hydrolase 4 Chondritin Sulphate A - placental receptor 4 Chromogranin A CHGA 6 Chymase CHY1 Clathrin 2 CoA transferase 1 Collagen I alpha 1 COL1A1 3 Collagen I alpha 2 COL1A2 3 Collagen II alpha 1 COL2A1 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, 3 EDM2 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6A1 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen XI alpha 1 COL11A1 3 Collagen XI alpha 2 COL11A2 3 Collagen XVII alpha 1 COLL 7A1 3 Coliagenic-like tail subunit of asymmetric COLQ 1 acetylcholinesterase Colony-stimulating factor I CSF1 6 Colony-stimulating factor 1 receptor CSF1R 6 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 2 alpha receptor CSF2RA 6 Colony-stimulating factor 2 beta receptor CSF2RB 6 Colony-stimulating factor 3 CSF3 6 Colony-stimulating factor 3 receptor CSF3R 6 Complement component C1 inhibitor Cl NH 4 Complement component Clqa CIQA 4 Complement component Clqb CLQB 4 Complement component C1qg CIQG 4 Complement component C1r C1R 4 Complement component Cls C1S 4 Complement component C2 C2 4 Complement component C3 C3 4 Complement component C4A C4A 4 Complement component C4B C4B 4 Complement component C5 C5 4 Complement component C6 C6 4 Complement component C7 C7 4 Complement component C8 C8B 4 Complement component C9 C9 4 Complement component receptor 1 CR1 4 Complement component receptor 2 CR2 4 Complement component receptor 3 CR3 4 Contactin CNTN1 6 Core-binding factor, alpha 1 CBFA1 6 Core-binding factor, alpha 2 CBFA2 6 Core-binding factor, beta CBFB 6 Cortico-steroid binding protein 2 Corticosteroid nuclear receptor 4 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Cortisol receptor C-reactive protein CRP c-src tyrosine kinase CSK 6 Cyclic AMP response element binding protein CREB 6 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase 1B1 PDE1B1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin D CCND1 6 Cyclin-dependent kinase 1 CDK1 6 Cyclin-dependent kinase 10 CDK10 6 Cyclin-dependent kinase 2 CDK2 6 Cyclin-dependent kinase 3 CDK3 6 Cyclin-dependent kinase 4 CDK4 6 Cyclin-dependent kinase 5 CDK5 6 Cyclin-dependent kinase 6 CDK6 6 Cyclin-dependent kinase 7 CDK7 6 Cyclin-dependent kinase 8 CDK8 6 Cyclin-dependent kinase 9 CDK9 6 Cyclin-dependent kinase inhibitor 1A (P21, CDKN1A 6 CIP1) Cyclin-dependent kinase inhibitor 1 B (P27, CDKN 1B 6 KIP1) Cyclin-dependent kinase inhibitor 1 C (P57, CDKN1C 6 KIP2) Cyclin-dependent kinase inhibitor 2A (pl 6) CDKN2A 6 Cyclin-dependent kinase inhibitor 3 CDKN3 6 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 Cyclophilin 4 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 Defender against cell death 1 DAD1 6 Deleted in colorectal carcinoma DCC 6 Deoxycorticosterone (DOC) receptor 1 Deoxycytidine kinase DCK 1 Dihydrolipoyl dehydrogenase 2 PDHA 1 Dihydrolipayl transacetylase PDHA 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Duffy blood group FY 2 Dynamin DNM1 6 EB1 6 Elastase 1 ELAS1 1 Elastase 2 ELAS2 1 Endoglin ENG 3 Endo-P-D-glucuronidase 4 Enolase ENO1 1 Erythroid kruppel-like factor EKLF 6 Erythropoietin EPO 4 Erythropoietin receptor EPOR 4 Estrogen receptor ESR 6 EWS RNA-binding protein EWSR1 6 Factor 1 (No. one) F1 4 Factor B, properdin 4 Factor D 4 Factor H HF1 4 Factor I (letter I) IF 4 Factor III F3 4 Factor IX F9 4 Factor V F5 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Factor XI F11 4 Factor XII F12 4 Factor XIII A & B F13A & 4 F13B Fanconi anemia, complementation group C FANCC 2 Fanconi anemia, complementation group D FANCD 2 Fc fragment of IgG, low affinity IIa, receptor for FCGR2A 6 (CD32) Fc receptor 4 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibronectin precursor FN1 6 Follicle stimulating hormone receptor FSHR, 6 ODG1 Follicle stimulating hormone, FSH FSHB 6 Follicular lymphoma variant translocation 1 FVT1 4 Forkhead rhabdomyosarcoma gene FKHR 6 Forkhead transcription factor 7 FKHL7 6 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1,3 GGTA1 6 Galactosyltransferase, beta 3 B3GALT 6 Glial-cell derived neurotrophic factor (GDNF) 5 receptor Glial-cell derived neurotrophic factor, GDNF GDNF 5 Glucosaminyl (N-acetyl) transferase 2, I- GCNT2 1 branching enzyme Glutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutamine synthase 1 Glutathione GSH 2 Glutathione peroxidase, GPX1 GPX1 1 Glutathione peroxidase, GPX2 GPX2 1 Glutathione S-transferase mu 1, GSTM1 GSTM1 1 Glutathione S-transferase mu 4, GSTM4 1 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glyceraldehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycophorin A GYPA 3 Glycophorin B GYPB 3 Glycophorin C GYPC 3 Glycosyltransferases, ABO blood group ABO 1 Glypican 3 GPC3, 6 SDYS Gonadotropin releasing hormone receptor GNRHR 6 Growth-regulated protein precursor, GRO GRO 4 Guanine nucleotide-binding protein, alpha GNAI1 5 inhibiting activity polypeptide 1, GNAI1 Guanine nucleotide-binding protein, alpha GNAI2 5 inhibiting activity polypeptide 2, GNAI2 Guanine nucleotide-binding protein, alpha GNAI3 5 inhibiting activity polypeptide 3, GNAI3 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, q GNAQ 5 polypeptide H(+), K(+) - ATPase ATP4B 5 Haemoglobin alpha 1 HBA1 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin gamma A HBG1 2 Haemoglobin gamma B HBG2 2 Haemoglobin gamma G HBGG 2 Haptoglobin, alpha 1 HPA1 4 Haptoglobin, alpha 2 HPA2 4 Haptoglobin, beta HPB 4 Hemochromatosis HFE 2 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor 11 HCF2 4 Hepatitis B virus integration site 1 HVBS1 4 Hepatitis B virus integration site 2 HVBS6 4 High mobility group protein C HMGIC 6 High mobility group protein Y HMGIY 6 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 Histatin 1 4 Histatin 2 4 Histatin 3 HTN3 4 HLA-B associated transcript 1 BAT1 4 Holocarboxylase synthetase HLCS 1 Homeobox II HOX11 6 Homeobox HB24 HLX1 6 IC7 A and B 4 Ikaros gene IKAROS 6 Immunoglobulin alpha (IgA) IGHA 4 Immunoglobulin delta (IgD) IGHD 4 Immunoglobulin E (IgE) reponsiveness gene IGER 4 Immunoglobulin E (IgE) serum concentration IGES 4 regulator gene Immunoglobulin epsilon (IgE) IGHE 4 Immunoglobulin gamma (IgG) 2 IGHG2 4 Immunoglobulin heavy mu chain IGHM 4 Immunoglobulin J polypeptide IGJ 4 Immunoglobulin kappa constant region IGKC 4 Immunoglobulin kappa variable region IGKV 4 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 Integrin beta 1 ITGB1 6 Integrin beta 2 ITGB2 6 Integrin beta 3 ITGB3 6 Integrin beta 4 ITGB4 6 Integrin beta 5 ITGB5 6 Integrin beta 6 ITGB6 6 Integrin beta 7 ITGB7 6 Integrin, alpha 1 ITGAI 6 Integrin, alpha 2 ITGA2 6 Integrin, alpha 4 ITGA4 6 Integrin, alpha 5 ITGA5 6 Integrin, alpha 6 ITGA6 6 Integrin, alpha M ITGAM 6 Intercellular adhesion molecule 1 ICAM1 4 Intercellular adhesion molecule 2 ICAM2 4 Intercellular adhesion molecule 3 ICAM3 4 Interferon alpha IFNA1 4 Interferon beta IFNB 4 Interferon gamma IFNG 4 Interferon gamma receptor 1 IFNGR1 4 Interferon gamma receptor 2 IFNGR2 4 Interferon regulatory factor 1 IRF1 4 Interferon regulatory factor 4 IRF4 4 Interleukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) 11 IL11 4 Interleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RB1 4 Interleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 Interleukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 Interleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 Interleukin(IL) 5 receptor IL5R 4 Interleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 Interleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 Interleukin(IL) 9 IL9 4 Interleukin(IL) 9 receptor IL9R 4 Interleukin(IL) receptor antagonist 1 IL1RN, 4 IL1RA Janus kinase 1 JAK1 6 Janus kinase 2 JAK2 6 Janus kinase 3 JAK3 6 Kallikrein 3 KAK3 4 Kell blood group precursor XK, KEL 2 Kininogen, High molecular weight KNG 4 Kynureninease 1 Lactotransferrin LTF 2 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMR1 6 Latent transforming growth factor-beta binding LTBP2 6 protein 2 Lectin, mannose-binding 1 LMAN1 4 Lectin, mannose-binding 2 MBL2 4 Leptin LEP 6 Leptin receptor LEPR 6 Leukaemia inhibitory factor LIF 6 Leukaemia inhibitory factor receptor LIFR 6 Leukin 4 Leukocyte-specific transcript I LST-1 4 Leukotriene A4 hydrolase 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 Leukotriene D4/E4 receptor 4 LIM homeobox protein 1 LHX1 6 LIM homeobox protein 2 LHX2 6 LIM homeobox protein 3 LHX3 6 LIM homeobox protein 4 LHX4 6 LIM-domain only protein 1 LM01 6 LIM-domain only protein 2 LM02 6 LIM-domain only protein 3 LM03 6 LIM-domain only protein 4 LM04 6 LIM-Kinase I (LINK-1) 4 Lipocortin 1 ANX4 4 Lipoprotein-associated coagulation factor LACI 4 Lipoxygenase 12 (platelets) LOG12 4 Lipoxygenase 5 (leukocytes) 4 Lymphoblastic leukemia derived sequence 1 LYLL 4 Lymphocyte-specific protein tyrosine kinase LCK 4 Lymphoid enhancer-binding factor LEF-1 6 lymphotoxin 4 Lysozyme LYZ 4 Macrophage activating factor MAF 4 Macrophage inflammatory protein-1 MIP1 4 Macrophage inflammatory protein-1 receptor 4 Macrophage inflammatory protein-2 MIP2 4 Macrophage inflammatory protein-2 receptor MAD (mothers against decapentaplegic, MADH3 6 Drosophila) homologue 3 MAD (mothers against decapentaplegic, MADH4 6 Drosophila) homologue 4 Malignant proliferation, eosinophil gene MPE 4 Mannose binding protein MBP 4 Mannosidase, alpha B lysosomal MANB 1 Marenostrin MEFV 2 Matrix metalloproteinase 1 MMP1 1 Matrix metalloproteinase 10 NMP10 1 Matrix metalloproteinase 11 MMP11 1 Matrix metalloproteinase 12 MMP12 1 Matrix metalloproteinase 13 MMP13 1 Matrix metalloproteinase 14 MMP14 1 Matrix metalloproteinase 15 MMP15 1 Matrix metalloproteinase 16 MMP16 1 Matrix metalloproteinase 17 MMP17 1 Matrix metalloproteinase 18 MMP18 1 Matrix metalloproteinase 19 MMP19 1 Matrix metalloproteinase 2 MMP2 1 Matrix metalloproteinase 3 MMP3, 1 STMY1 Matrix metalloproteinase 4 MMP4 1 Matrix metalloproteinase 5 MMP5 1 Matrix metalloproteinase 6 MMP6 1 Matrix metalloproteinase 7 MMP7 1 Matrix metalloproteinase 8 MMP8 1 Matrix metalloproteinase 9 MMP9 1 MHC Class I: A 4 MHC Class I: B 4 MHC Class I: C 4 MHC Class I: LMP-2, LMP-7 4 MHC Class I: Tap1 ABCR, 4 TAP1 MHC Class II: DP HLA-DPB1 4 MHC Class II: DQ 4 MHC Class II: DR 4 MHC Class II: Tap2 TAP2, PSF2 4 MHC Class II: Complementation group A MHC2TA 4 MHC Class II: Complementation group B RFXANK 4 MHC Class II: Complementation group C RFX5 4 MHC Class II: Complementation group D RFXAP 4 Monocyte chemoattractant protein I MCP1 Mucin 18 MUC18 2 Mutated in colorectal cancers, MCC MCC 6 MutL homolog 1 MLH1 6 MutS homolog 2 MSH2 6 MutS homolog 3 MSH3 6 Myeloid leukemia factor-1 MLF1 Myeloperoxidase MPO Myoglobin 2 Myosin 5A MY05A 3 N-acyl hydrolase 4 NADPH oxidase 4 reductase Natural resistance-associated macrophage NRAMP1 4 protein 1 NB6 4 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neutral endopeptidase 1 Neutrophil cystolic factor 1 NCF1 4 Neutrophil cystolic factor 2 NCF2 4 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Norrie disease protein NDP 6 Notch 3 NOTCH3 6 Notch ligand-jagged 1 JAG 1, AGS 6 Nuclear factor 1-kappa-B-like gene IKBL 4 Nuclear factor kappa beta NFKB 4 Nuclear factor of activated T cells (NFAT) NFATC 6 complex, cytosolic Nuclear factor of activated T cells (NFAT) NFATP 6 complex, preexisting component Nucleoside diphosphate kinase-A NDPKA 1 Oncogene bcI2 6 Oncogene ELK1 ELK1 6 Oncogene ELK2 ELK2 6 Oncogene ERG (early reponse gene) 6 Oncogene GLI1 GLI1 6 Oncogene GLI2 GLI2 6 Oncogene GLI3 GLI3 6 Oncogene spi1 6 Oncogene TEL ETV6 6 Oncostatin M OSM 6 Oncostatin M receptor OSMR 6 Ornithine delta-aminotransferase OAT 1 Osteonectin ON 6 Osteopontin OPN 6 Paired box homeotic gene 3 PAX3 6 Paired box homeotic gene 7 PAX7 6 Patched (Drosophila) homolog, PTCH PTCH 6 Peanut-like 1 PNUTL1 4 Phagocytin 4 Phenylethanolamine N-methyltransferase, PNMT 1 PNMT Phosphatidylinositol glycan, classA PIGA 6 (paroxysmal nocturnal hemoglobinuria) Phospholipase A2, group 10 PLA2G10 4 Phospholipase A2, group IB PLA2GIB 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Phosphomannomutase-2 PMM2 2 Plakophilin 1 PKP1 2 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI I 1 Plasminogen activator inhibitor 2 PA12 1 Plasminogen activator receptor, Urokinase UPAR; 3 PLAUR Plasminogen activator, Tissue PLAT, TPA 1 Plasminogen activator, Urokinase UPA; PLAU 1 Platelet glycoprotein lb, alpha GPIBA 4 Platelet glycoprotein lb, beta GPLBB 4 Platelet glycoprotein I b, gamma GPLBG 4 Platelet glycoprotein IX GP9 4 Platelet glycoprotein V GP5 4 Platelet-activating factor acetylhydrolase 1 B PAFAH1B1 4 or LIS1 Platelet-activating factor acetylhydrolase 2 PAFAH2 4 Platelet-activating factor receptor PAFR 4 Poliovirus receptor PVR, PVS 4 Potassium channel, calcium-activated, KCNN4 5 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium inwardly-rectifying channel J11 KCNJ11 5 Potassium voltage-gated channel A1 KCNA1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium vo tage-gated channel Q1 KCNQ1 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCNQ3 5 Prekallikrein 4 Preproenkephalin PENK 5 Procoliagen N-protease 1 Promyelocytic leukemia gene PML 6 Proopiomelanocortin POMC 5 Properdin P factor, complement PFC, PFD 4 Prostacyclin synthase 4 Prostaglandin (PG) D synthase, hematopoietic PGDS 1 Prostaglandin 15-OH dehydrogenase HGPD; 4 PGDH Prostaglandin D - DP receptor 4 Prostaglandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostaglandin I2 receptor 2 Prostaglandin IP receptor 4 Prostaglandin isomerase 6 Prostaglandin-endoperoxidase synthase 2 PTGS2 6 Protease inhibitor 1 2 Protein C PROC 4 Protein C inhibitor PCI 4 Protein kinase A 1 Protein kinase C, alpha PRKCA 1 Protein kinase C, gamma PRKCG 1 Protein kinase DNA-activated PRKDC 1 Protein kinase G 1 Protein phosphatase 1, regulatory (inhibitor) PPP1R3 1 subunit 3 Protein phosphatase 2, regulatory subunit A, PPP2R1B 1 beta isoform Protein S PROS1 4 Protein tyrosine phosphatase, non-receptor PTPNI2 6 type 12 Proteinase 3 Prothrombin precursor F2 4 Purine nucleoside phosphorylase NP 1 Pyruvate decarboxylase PDHA 1 Retinoblastoma 1 RB1 6 Retinol binding protein 4 RBP4 2 Rhesus blood group, CcEe antigens RHCE 2 Rhesus blood group, D antigen RHD 2 Rhesus blood group-associated glycoprotein RHAG 2 Ribosomal protein S 1 9 RPS19 1 RIGUI RIGUI 6 S100 calcium-binding protein A2 S100A2 5 S100 calcium-binding protein A3 S100A3 5 S100 calcium-binding protein A5 S100A5 5 S100 calcium-binding protein A6 S100A6 5 S100 calcium-binding protein A7 S100A7 5 S100 calcium-binding protein A8 S100A8 5 S100 calcium-binding protein P S100P 5 SAP (SLAM associated protein) SH2D1A 4 Selectin E SELE 5 Selectin L SELL 5 Selectin P SELP 5 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Severe combined immunodeficiency, type A SCIDA 4 (Athabascan) Signal transducer and activator of transcription 1 STAT1 6 Signal transducer and activator of transcription 2 STAT2 6 Signal transducer and activator of transcription 3 STAT3 6 Signal transducer and activator of transcription 4 STAT4 6 Signal transducer and activator of transcription 5 STAT5 6 Signaling lymphocyte activation molecule SLAM 4 Sine oculis homeobox, drosophila, homolog 1 SIX1 6 Sine oculis homeobox, drosophila, homolog 2 SIX2 6 Sjoegren (Sjogren) syndrome antigen A1 SSA1 4 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage gated, type V, alpha SCN5A 5 polypeptide Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 19 (folate transporter), SLC19A1 2 member 1 Solute carrier family 20, member 1 SLC20A1 2 Solute carrier family 20, member 2 SLC20A2 2 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Sorcin SRI 2 Sperm prolamine P1 PRM1 6 Sperm prolamine P2 PRM2 6 Stem cell factor SCF 6 Stromal derived factor 1 SDF1 6 Succinate dehydrogenase 1 SDHL 1 Succinate thiokinase 1 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 SYK-related tyrosine kinase SRK 4 Talin TLN 6 Talin, TLN 3 T-cell acute lymphocytic leukemia 1 TAL1 4 T-cell acute lymphocytic leukemia 2 TAL2 4 T-cell receptor, alpha TCRA 4 T-cell receptor, delta TCRD 4 Tenascin (cytotactin) 3 Tenascin XA TNXA 3 Terminal deoxynucleotidyltransferase TDT 4 Terminal deoxynucleotidyltransferase, TDT 1 Thrombin receptor F2R 4 Thrombopoietin THPO 6 Thrombospondin THBSI 6 Thromboxane A synthase I TBXAS1 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thy-1 T-cell antigen THY1 4 Thymic humoral factor 4 Thymopoietin TMPO 6 Thymosin 4 TIE receptor tyrosine kinase TIE-1 6 Tip-associated protein TAP 4 Toll-like receptor 4 TLR4 4 Topoisomerase I 1 Topoisomerase II 2 Transcobalamin 2, TCN2 TCN2 2 Transcription factor 3 TCF3 6 Transcription factor binding to IGHM enhancer 3 TFE3 6 Transferrin TF 6 Transferrin receptor TFRC 6 Transforming growth factor, alpha TGFA 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFBI 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tubulin 3 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tumour protein p73 TP73 6 Tumour protein, transiationally-controlled 1 TPT1 6 Tumour suppresssor gene DRA DRA 4 Ubiquitin 6 Ubiquitin activating enzyme, E1 1 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin fusion degeneration I-like UFD1L 6 Ubiquitin protein ligase E3A UBE3A 1 Undulin 1 COL14A1 3 Uridine monophosphate kinase UMPK 4 Uridine monophosphate synthetase UMPS 4 Uroporphyrinogen III synthase UROS 1 Vimentin VIM 4 v-myc avian myelocytomatosis viral oncogene MYC 6 homolog Von Hippel-Lindau gene VHL 6 Wemer syndrome helicase WRN 6 Wilms tumour gene 1 WT1 6 Wilms tumour gene 2 WT2 6 Wilms tumour gene 4 WT4 6 Winged helix nude WHN 6 Wiskott-Aldrich syndrome protein WASP, THC 4 Xanthine dehydrogenase XDH 1 X-ray repair gene XRCC9 6 Zinc finger protein HRX ALL1  4,

that the genes associated with malfunction, damage or disease of the body as a consequence of an abnormality in the development process are selected from: HUGO Protein- List of genes gene symbol function 17-Ketosteroid reductase 5 2,4-Dienoyl CoA reductase DECR 1 3 beta Hydroxysteroid dehydrogenase 2 HSD3B2 1 3-Oxoacid CoA transferase OXCT 1 6-Pyruvoyltetrahydropterin synthase PTS 1 Absent in melanoma 1 gene AIM1 6 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetyl CoA acyltransferase ACAA 1 Acetyl CoA carboxylase alpha ACACA 1 Acetylcholine receptor, nicotinic, alpha A1 CHRNA1 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor, nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNB1 5 Acetylcholine receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Achromatopsia 2 ACHM2 3 Acid phosphatase 2, lysosomal ACP2 1 Acrosin ACR 6 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTA1 3 Actin, alpha, smooth, aortic ACTA2 3 Activin 6 Activin A receptor, type 2B ACVR2B 6 Activin A receptor, type 2-like kinase 1 ACVRL1 6 Acyl CoA dehydrogenase, short chain ACADS 1 Acyl-CoA thioesterase 1 ADAM (A disintegrin and metalloproteinase) 1 ADAM1 1 ADAM (A disintegrin and metalloproteinase) 10 ADAM10 1 ADAM (A disintegrin and metalloproteinase) 11 ADAM11 1 ADAM (A disintegrin and metalloproteinase) 12 ADAM12 1 ADAM (A disintegrin and metalloproteinase) 13 ADAM13 1 ADAM (A disintegrin and metalloproteinase) 14 ADAM14 1 ADAM (A disintegrin and metalloproteinase) 15 ADAM15 1 ADAM (A disintegrin and metalloproteinase) 16 ADAM16 1 ADAM (A disintegrin and metalloproteinase) 17 ADAM17 1 ADAM (A disintegrin and metalloproteinase) 18 ADAM18 1 ADAM (A disintegdn and metalloproteinase) 19 ADAM19 1 ADAM (A disintegrin and metalloproteinase) 2 ADAM2 1 ADAM (A disintegrin and metalloproteinase) ADAM3A 1 3A ADAM (A disintegrin and metalloproteinase) ADAM3B 1 3B ADAM (A disintegrin and metalloproteinase) 4 ADAM4 1 ADAM (A disintegrin and metalloproteinase) 5 ADAM5 1 ADAM (A disintegrin and metalloproteinase) 6 ADAM6 1 ADAM (A disintegrin and metalloproteinase) 7 ADAM7 1 ADAM (A disintegrin and metalloproteinase) 8 ADAM8 1 ADAM (A disintegrin and metalloproteinase) 9 ADAM9 1 Adducin, alpha ADD1 3 Adducin, beta ADD2 3 Adenomatous polyposis coli tumour supressor APC 6 gene Adenosine deaminase ADA 1 Adenosine monophosphate deaminase AMPD 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A2B ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenyl cyclase 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adenylosuccinate lyase ADSL 1 ADP-ribosyltransferase ADPRT 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADR83 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Adrenoleukodystrophy gene ALD 1 Alanine-glyoxylate aminotransferase AGXT 1 Albumin, ALB ALB 2 Aldehyde dehydrogenase 1 ALDH1 1 Aldehyde dehydrogenase 10 ALDH10 1 Aldehyde dehydrogehase 2 ALDH2 1 Aldehyde dehydrogenase 5 ALDH5 1 Aldehyde dehydrogenase 6 ALDH6 1 Aldehyde dehydrogenase 7 ALDH7 1 Aldolase A ALDOA 1 Aldolase B ALDOB 1 Aldolase C ALDOC 1 Aldosterone receptor MLR 6 Alkaline phosphatase, liver/bone/kidney ALPL 2 Alkaptonuris gene AKU 6 Alkylglycerone phosphate synthase AGPS 1 Alpha 2 macroglobulin A2M 4 alpha tectorin TECTA 6 alpha thalassemia gene ATRX 5 alpha1-Antitrypsin PI 1 alpha2-Antiplasmin PLI 1 alpha-Actinin 2 ACTN2 6 alpha-Actinin 3 ACTN3 6 alpha-Amylase 1 Alpha-fetoprotein AFP 6 alpha-Galactosidase A GLA 1 alpha-ketoglutarate dehydrogenase 1 alpha-L-Iduronidase IDUA 1 alpha-Synuclein SNCA 5 Amelogenin AMELX 3 Aminomethyltransferase AMT 1 Aminopeptidase P XPNPEP2 1 Amphiregulin AREG 6 Amylo-1,6-glucosidase AGL 1 Amyloid beta (A4) precursor protein-binding, APBB1 5 APBB1 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Androgen binding protein ABP 2 Androgen receptor AR 6 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCP1 1 Angiotensinogen AGT 1 Ankyrin 1 ANK1 3 Ankyrin 2 ANK2 3 Ankyrin 3 ANK3 3 Antidiuretic hormone receptor ADHR 2 Anti-Mullerian hormone AMH 6 Anti-Mullerian hormone type 2 receptor AMHR2 6 Antithrombin III AT3 1 AP-2, alpha TFAP2A 6 AP-2, beta TFAP2B 6 AP-2, gamma TFAP2C 6 Apaf-1 3 Apical protein, xenopus laevis-like APXL 6 Apolipoprotein A 4 APOA4 2 Apolipoprotein A I APOA1 2 Apolipoprotein A II APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOC1 2 Apoiipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Apopain CPP32 6 Apoptosis antigen 1 APT1 4 Apoptosis antigen ligand 1 APT1LG1 4 Apoptosis-inducing factor AIF 4 Apurinic endonuclease APE 1 Archaete-scute homolog 1 ASH1 6 Archaete-scute homolog 2 ASH2 6 Arginosuccinate synthetase ASS 1 Arrestin SAG 3 Aryl hydrocarbon receptor AHR 2 Aryl hydrocarbon receptor nuclear translocator ARNT 2 Arylsulfatase A ARSA 1 Arylsulfatase B ARSB 1 Arylsulfatase C ARSC1 1 Arylsulfatase D ARSD 1 Arylsulfatase E ARSE 1 Arylsulfatase F ARSF 1 Aspartate transaminase 2 Aspartate transcarbamoylase 1 Aspartoacylase ASPA 1 Aspartylglucosaminidase AGA 1 Astrotactin ASTN 6 Ataxia telangiectasia complementation group D ATD, ATDC 6 Ataxia telangiectasia gene, AT ATM 6 Ataxin 1 SCA1 6 Ataxin 2 SCA2 6 Ataxin 3 MJD 6 ATP-binding cassette transporter 7 ABC7 4 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Atrophin 1 DRPLA 6 Affractin Autoimmune regulator, AIRE AIRE Azoospermia factor 1 AZF1 6 Bagpipe homeobox, drosophila homolog of, 1 BAPX1 6 B-cell CLL/lymphoma 1 BCL1 4 B-cell CLL/lymphoma 10 BCL10 4 B-cell CLL/lymphoma 3 BCL3 4 B-cell CLL/lymphoma 4 BCL4 4 B-cell CLL/lymphoma 5 BCL5 4 B-cell CLL/lymphoma 6 BCL6 4 B-cell CLL/lymphoma 7 BCL7 4 B-cell CLL/lymphoma 8 BCL8 4 B-cell CLL/lymphoma 9 BCL9 4 BCL2-associated X protein BAX 6 BCL2-related protein A1 BCL2A1 6 Beckwith-Wiedemann region 1A BWR1A 6 Bestrophin VMD2 2 beta 2 Microglobulin B2M 4 beta-Endorphin receptor 5 beta-Glucuronidase GUSB 1 beta-N-Acetylhexosaminidase, A 1 beta-N-Acetylhexosaminidase, B 1 Bilirubin UDP-glucuronosyltransferase 1 Bleomycin hydrolase BLMH 1 Bloom syndrome protein BLM 6 Blue cone pigment BCP 3 Bone morphogenetic protein, BMP1 BMP1 6 Bone morphogenetic protein, BMP2 BMP2 6 Bone morphogenetic protein, BMP3 BMP3 6 Bone morphogenetic protein, BMP4 BMP4 6 Bone morphogenetic protein, BMP5 BMP5 6 Bone morphogenetic protein, BMP6 BMP6 6 Bone morphogenetic protein, BMP7 BMP7 6 Bone morphogenetic protein, BMP8 BMP8 6 Brain derived neurotrophic factor BDNF 6 Brain derived neurotrophic factor (BDNF) BDNFR 6 receptor Branched chain aminotransferase 1, cytosolic BCAT1 1 Branched chain aminotransferase 2, BCAT2 1 mitochondrial BRCA1-associated RING domain gene 1 BARD1 6 Breakpoint cluster region BCR 6 Breast cancer 1 BRCA1 6 Breast cancer 2 BRCA2 6 Breast cancer, ductal, 1 BRCD1 6 Breast cancer, ducta, 2 BRCD2 6 Bruton agammaglobulinaemia tyrosine kinase BTK 6 Butyrylcholinesterase BCHE 1 C3 convertase 1 Ca(2+) transporting ATPase, fast twitch ATP2A1 2 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Cadherin E CDHI 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin 1 CALB1 6 Calbindin D9K CALB3 6 Calcium channel, voltage-dependent, Alpha 1 F CACNA1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA1C 5 1 C Calcium channel, voltage-dependent, Alpha- CACNA1D 5 1 D Calcium channel, voltage-dependent, Alpha- CACNA1E 5 1 E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNA1S 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calcium sensing receptor CASR 2 Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin dependent kinase 2 Calmodulin-dependant protein kinase II CAMK2A 6 Calnexin CANX 6 Calpain CAPN, CAPN3 1 Canalicular multispecific organic anion CMOAT 2 transporter Carbamoylphosphate synthetase 1 CPS1 1 Carbamoylphosphate synthetase 2 CPS2 1 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Cardiac-specific homeobox, CSX CSX 6 Carnitine acetyltransferase CRAT 1 Carnitine acylcarnitine translocase CACT 1 Carnitine transporter protein CDSP, SCD 2 Cartilage oligomeric matrix protein COMP, EDM1, 5 PSACH Cartilage-hair hypoplasia gene CHH 5 Caspase 1 CASP1 6 Caspase 10 CASP10 6 Caspase 2 CASP2 6 Caspase 3 CASP3 6 Caspase 4 CASP4 6 Caspase 5 CASP5 6 Caspase 6 CASP6 6 Caspase 7 CASP7 6 Caspase 8 CASP8 6 Caspase 9 CASP9 6 Catechol-o-methyltransferase COMT 1 Catenin, alpha CTNNA1 6 Catenin, beta CTNNB1 6 Catenin, gamma 6 Cathepsin K CTSK 1 Caveolin 3 CAV3 1 CD1 CD1 4 CD44 CD44 4 Cdc 25 phosphatase 6 Cdc2 CDC2 6 CDX1 6 CEA 6 Cell adhesion molecule, intercellular, ICAM ICAM1 6 Cell adhesion molecule, leukocyte-endothelial, LECAM1 6 LECAM (CD62) Cell adhesion molecule, liver, LCAM LCA 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 Cellubrevin CEB 5 c-erbB1 ERBB1 6 c-erbB2 ERBB2 6 c-erbB3 ERBB3 6 c-erbB4 ERBB4 6 Ceroid lipofuscinosis neuronal 2 CLN2 5 Ceroid lipofuscinosis neuronal 3 CLN3 5 Ceroid lipofuscinosis neuronal 4 CLN4 5 Ceroid lipofuscinosis neuronal 5 CLN5 5 Ceroid lipofuscinosis neuronal 6 CLN6 5 Chediak-Higashi syndrome 1 gene CHS1 2 Chemokine MCAF MCAF 4 Chemokine receptor CCR2 CCR2 4 Chemokine receptor CCR3 CCR3 4 Chemokine receptor CCR5 CCR5 4 Chemokine receptor CXCR1 CXCR1 4 Chemokine receptor CXCR2 CXCR2 4 Chemokine receptor CXCR4 CXCR4 4 Chloride channel 5 CLCN5 3 Cholestasis, progressive familial intrahepatic 1 FIC1 6 gene Cholesterol ester transfer protein CETP 2 Choline acetyltransferase CHAT 1 Choroideremia gene CHM 3 Chromogranin A CHGA 6 Ciliary neurotrophic factor (CNTF) CNTF 6 Ciliary neurotrophic factor (CNTF) receptor CNTFR 6 c-kit receptor tyrosine kinase 6 Clathrin 2 Cleavage signal-1 protein CS1 6 Cleft palate gene CPX 6 Clusterin CLU 6 CoA transferase 1 Cochlin COCH 4 Cockayne syndrome gene, CKN1 CKN1 6 Collagen I alpha 1 COL1A1 3 Collagen I alpha 2 COL1A2 8 Collagen II alpha 1 COL2A1 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, EDM2 3 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6A1 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen X alpha 1 COL11A1 3 Collagen XI alpha 2 COL11A2 3 Collagen XVII alpha 1 COL17A1 3 Collagenic-like tail subunit of asymmetric COLQ 1 acetylcholinesterase Collapsin 6 Colony-stimulating factor 1 CSF1 6 Colony-stimulating factor 1 receptor CSF1R 6 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 2 alpha receptor CSF2RA 6 Colony-stimulating factor 2 beta receptor CSF2RB 6 Colony-stimulating factor 3 CSF3 6 Colony-stimulating factor 3 receptor CSF3R 6 Complex V MTATP6 1 Cone-rod homeobox-containing gene CRX 6 Contactin CNTN1 6 Core-binding factor, alpha 1 CBFA1 6 Core-binding factor, alpha 2 CBFA2 6 Core-binding factor, beta CBFB 6 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Creatine kinase - B and m CKBE 1 Creb binding protein CREBBP 6 Cryptochrome 1 CRY1 3 Cryptochrome 2 CRY2 3 Crystallin, alpha A CRYAA 3 Crystallin, alpha B CRYAB 3 Crystallin, beta B2 CRYBB2 3 Crystallin, gamma A CRYGA 3 c-src tyrosine kinase CSK 6 Cu2+ transporting ATPase alpha polypeptide ATP7A 1 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cubilin CUBN 2 Cyclic AMP response element binding protein CREB 6 Cyclic AMP response element modulator CREM 6 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide gated channel alpha 1, CNGA1 5 CNGA1 Cyclic nucleotide gated channel alpha 3, CNGA3 5 CNGA3 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase 1B1 PDE1B1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin A CCNA 6 Cyclin B CCNB 6 Cyclin C CCNC 6 Cyclin D CCND1 6 Cyclin E CCNE 6 Cyclin F CCNF 6 Cyclin-dependent kinase 1 CDK1 6 Cyclin-dependent kinase 10 CDK10 6 Cyclin-dependent kinase 2 CDK2 6 Cyclin-dependent kinase 3 CDK3 6 Cyclin-dependent kinase 4 CDK4 6 Cyclin-dependent kinase 5 CDK5 6 Cyclin-dependent kinase 6 CDK6 6 Cyclin-dependent kinase 7 CDK7 6 Cyclin-dependent kinase 8 CDK8 6 Cyclin-dependent kinase 9 CDK9 6 Cyclin-dependent kinase inhibitor 1A (P21, CDKN1A 6 CIP1) Cyclin-dependent kinase inhibitor 1B (P27, CDKN1B 6 KIP1) Cyclin-dependent kinase inhibitor 1C (P57, CDKN1C 6 KIP2) Cyclin-dependent kinase inhibitor 2A (p16) CDKN2A 6 Cyclin-dependent kinase inhibitor 3 CDKN3 6 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cystinosin CTNS 2 Cytidine deaminase CDA 1 Cytochrome b-5 CYB5 1 DAX1 nuclear receptor DAX1 4 Deafness autosomal dominant 5 DFNA5 5 Deafness dystonia peptide DDP 5 Defender against cell death 1 DAD1 6 Deleted in azospermia DAZ 6 Deleted in colorectal carcinoma DCC 6 Deleted in malignant brain tumours 1 DMBT1 6 Delta aminolevulinate dehydratase ALAD 1 Delta(4)-3-oxosteroid 5-beta-reductase 1 Delta-7-dehydrocholesterol reductase DHCR7 1 Dentin sialophosphoprotein DSPP 6 Deoxyuridine triphosphatase; dUTPase 1 Desert hedgehog, dhh 6 DHEA sulfotransferase STD 1 Diaphanous 1 DIAPH1 5 Diaphanous 2 DIAPH2 5 Diastrophic dysplasia sulfate transporter DTD 2 Dihydrolipoamide branched chain transacylase DBT 5 Dihydrolipoamide dehydrogenase DLD 5 Dihydrolipoyl dehydrogenase 2 PDHA 1 Dihydrolipoyl transacetylase PDHA 1 Dihydroorotase 1 Dihydroxyacetonephosphate acyltransferase DHAPAT 1 Disrupted meiotic cDNA 1, homolog DMC1 6 Distal-less homeobox 1 DLX1 6 Distal-less homeobox 2 DLX2 6 Distal-less homeobox 3 DLX3 6 Distal-less homeobox 4 DLX4 6 Distal-less homeobox 5 DLX5 6 Distal-less homeobox 6 DLX6 6 DNA damage binding protein, DDB1 DDB1 3 DNA damage binding protein, DDB2 DDB2 3 DNA directed polymerase, alpha POLA 1 DNA glycosylases 1 DNA helicases 1 DNA Ligase 1 LIG1 1 DNA methyltransferase DNMT 1 DNA polymerase 1 1 DNA polymerase 2 1 DNA polymerase 3 1 DNA primase 1 DNA-damage-inducible transcript 3 DDIT3 3 DNA-dependant RNA polymerase 1 DOPA decarboxylase DDC 1 Doublecortin, DCX DCX 3 Duffy blood group FY 2 Dynamin DNM1 6 Dynein 6 Dyskerin DKC1 3 Dystonia 1 DYT1 3 Dystonia 3 DYT3 3 Dystonia 6 DYT6 3 Dystonia 7 DYT7 3 Dystonia 9 CSE 3 Dystrophia myotonica DM, DMPK 1 Dystrophia myotonica, atypical DM2 1 Dystrophin DMD 3 Dystrophin-associated glycoprotein 35 kD, SGCD 3 SCGD Dystrophin-associated glycoprotein 35 kD, SGCG 3 SGSG Dystrophin-associated glycoprotein 43 kD SGCB 3 Dystrophin-associated glycoprotein 5OkD SGCA 3 E74-like factor 1, ELF1 ELF1 6 EB1 6 Ectodermal Dysplasia 1 gene ED1 3 Electron-transfering-flavoprotein alpha ETFA 2 Electron-transfering-flavoprotein beta ETFB 2 Electron-transferring flavoprotein ETFDH 1 dehydrogenase Empty spiracles (drosophila) homologue 1 EMX1 6 Empty spiracles (drosophila) homologue 2 EMX2 6 Endobrevin VAMP8 5 Endocardial fibroelastosis 2 gene EFE2 3 Endometrial bleeding-associated factor EBAF 6 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Engrailed-1 ENI 6 Engrailed-2 EN2 6 Enolase ENO1 1 Enoyl CoA isomerase 1 Enterokinase PRSS7, ENTK 1 Ephrin receptor tyrosine kinase A EPHA 6 Ephrin receptor tyrosine kinase B EPHB 6 Ephrin-A EFNA 6 Ephrin-B EFNB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Epilepsy, benign neonatal 4 gene ICCA 1 Epilepsy, female restricted EFMR 1 Epilepsy, progressive myoclonic 2 gene EPM2A 1 Erythrocyte membrane protein band 4.1 EPB41 3 Erythrocyte membrane protein band 4.2 EPB42 3 Erythrocyte membrane protein band 7.2 EPB72 3 Erythroid kruppel-like factor EKLF 6 Erythropoietin EPO 4 Erythropoietin receptor EPOR 4 Estrogen receptor ESR 6 Eukaryotic initiation translation factor EIF4E 6 EWS RNA-binding protein EWSR1 6 Excision repair complementation group 1 ERCC1 1 protein Excision repair complementation group 2 ERCC2 1 protein Excision repair complementation group 2 ERCC3 1 protein Excision repair complementation group 4 ERCC4 1 protein Excision repair complementation group 6 ERCC6 1 protein Exostosin 1 EXT1 3 Exostosin 2 EXT2 3 Exostosin 3 EXT3 3 Eyes absent 1 EYA1 6 Eyes absent 2 EYA2 6 Eyes absent 3 EYA3 6 Faciogenital dyspiasia FGD1, FGDY 2 Factor 1 (No. one) F1 4 Factor B, properdin 4 Factor D 4 Factor H HF1 4 Factor I (letter 1) IF 4 Factor III F3 4 Factor IX F9 4 Factor V F5 4 Factor VII F7 4 Factor VIII F8 4 Factor X F10 4 Factor XI F11 4 Factor XII F12 4 Factor XIII A & B F13A & F13B 4 Fanconi anemia, complementation group A FANCA 2 Fanconi anemia, complementation group C FANCC 2 Fanconi anemia, complementation group D FANCD 2 Fc fragment of IgG, high affinity IA, receptor for FCGR1A 6 Fc fragment of IgG, low affinity IIa, receptor for FCGR2A 6 (CD32) Fc fragment of IgG, low affinity IIIa, receptor for FCGR3A 6 (CD16) Fc receptor 4 Fertilin protein FTNB 6 Fibrillin 1 FBN1 6 Fibrillin 2 FBN2 6 Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FN1 6 Flavin-containing monooxygenase 1 FMO1 1 Flavin-containing monooxygenase 2 FMO2 1 Flavin-containing monooxygenase 3 FMO3 1 Flavin-containing monooxygenase 4 FMO4 1 Flightless-II, Drosophila homolog of FLII 6 Folic acid receptor FOLR 6 Follicle stimulating hormone receptor FSHR, ODG1 6 Follicle stimulating hormone, FSH FSHB 6 Follicular lymphoma variant translocation 1 FVT1 4 Follistatin 6 Forkhead rhabdomyosarcoma gene FKHR 6 Forkhead transcription factor 10 FKHL10 6 Forkhead transcription factor 14 FKHL14 6 Forkhead transcription factor 7 FKHL7 6 Formiminotransferase 1 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Fragile site, folic acid type, rare, fra(X) E FRAXE 5 Fragile site, folic acid type, rare, fra(X) F FRAXF 5 Frataxin FRDA 6 Fringe secreted protein, lunatic LFNG 6 Fringe secreted protein, manic MFNG 6 Fringe secreted protein, radical RFNG 6 Fructose-1,6-diphosphatase FBP1 1 Fucosyltransferase 6 FUT6 2 Fukuyama type congenital muscular dystrophy FCMD 6 Fumarase FH 1 Fumarylacetoacetase FAH 1 G/T mismatch binding protein GTBP, MSH6 6 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Gadd45 (growth arrest & DNA-damage-inducible protein) 1 Galactocerebrosidase GALC 1 Galactokinase GALK1 1 Galactose 1-phosphate uridyl-transferase GALT 1 Galactosyltransferase 1 GT1 6 Galactosyltransferase, alpha 1,3 GGTA1 6 Galactosyltransferase, beta 3 B3GALT 6 Galanin GAL 5 Galanin receptor GALNR1 5 Gamma-glutamyl carboxylase GGCX 2 Gap junction protein alpha 1 GJA1 2 Gap junction protein alpha 3 GJA3 2 Gap junction protein alpha 8 GJA8 2 Gap junction protein beta 1 GJB1 2 Gap junction protein beta 2 GJB2 2 Gap junction protein beta 3 GJB3 2 Gastric Intrinsic factor, GIF GIF 1 Gastrin GAS 6 Gastrin releasing peptide GRP 2 Gastrulation brain homeobox 2 GBX2 6 GDP dissociation inhibitor I GDI 1 6 Gelsolin GSN 6 Geniospasm 1 GSM1 6 Gephyrin 5 Glial-cell derived neurotrophic factor (GDNF) 5 receptor Glial-cell derived neurotrophic factor, GDNF GDNF 5 Glioma chloride ion channel, GCC 6 Glucagon receptor GCGR 6 Glucagon-like peptide receptor 1 GLPLR 6 Glucocorticoid receptor GRL 6 Glucose-6-phosphatase translocase G6PT1 1 Glucosidase, acid alpha GAA 1 Glucosidase, acid beta GBA 1 Glutamate decarboxylase, GAD GAD1 1 Glutamate-cysteine ligase GLCLC 1 Glutathione GSH 2 Glutathione peroxidase, GPX1 GPX1 1 Glutathione peroxidase, GPX2 GPX2 1 Glutathione reductase, GSR GSR 1 Glutathione S-transferase mu 1, GSTM1 GSTM1 1 Glutathione S-transferase mu 4, GSTM4 1 Glutathione S-transferase theta 1, GSTT1 GSTTI 1 Glutathione S-transferase theta 2, GSTT2 1 Glutathione S-transferase, GSTP1 GSTP1 1 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glutathione synthetase GSS 1 Glyceraldehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycine dehydrogenase GLDC 1 Glycine receptor, alpha GLRA2 5 Glycine receptor, beta 5 Glycogen branching enzyme GBE1 1 Glycogen phosphorylase PYGL 1 Glycogen synthase 1 (muscle) GLYS1 1 Glycogen synthase 2 (liver) GYS2 1 Glycosyltransferases, ABO blood group ABO 1 Glypican 3 GPC3, SDYS 6 GM2 ganglioside activator protein, GM2A GM2A 1 Gonadotropin releasing hormone GNRH 6 Gonadotropin releasing hormone receptor GNRHR 6 Goosecoid GSC 6 Green cone pigment GCP 3 Growth arrest-specific homeobox GAX 6 Growth factor receptor-bound protein 2 GRB2 6 Growth hormone 1 GH1 6 Growth hormone 2 (placental) GH2 6 Growth hormone receptor GHR 6 Growth hormone releasing hormone (GHRH) GHRH 6 Growth hormone releasing hormone receptor GHRHR 6 Growth/differentiation factor 5 GDF5 6 Growth-regulated protein precursor, GRO GRO 4 GTP cylcohydrolase 1 GCH1 6 GTPase-activating protein, GAP RASA1 6 Guanidinoacetate N-methyltransferase GAMT 1 Guanine nucleotide-binding protein, alpha GNA01 5 activating activity polypeptide, GNAO Guanine nucleotide-binding protein, alpha GNA11 5 inhibiting activity polypeptide 1, GNA11 Guanine nucleotide-binding protein, alpha GNA12 5 inhibiting activity polypeptide 2, GNA12 Guanine nucleotide-binding protein, alpha GNA13 5 inhibiting activity polypeptide 3, GNA13 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, alpha GNAT1 5 transducing activity polypeptide, GNAT1 Guanine nucleotide-binding protein, alpha GNAT2 5 transducing activity polypeptide, GNAT2 Guanine nucleotide-binding protein, beta GNB3 5 polypeptide 3 Guanine nucleotide-binding protein, gamma GNG5 5 polypeptide 5 Guanine nucleotide-binding protein, q GNAQ 5 polypeptide Guanylate cyclase 2D, membrane (retina- GUCY2D 1 specific) Guanylate cyclase activator 1A (retina) GUCA1A 1 Guanylate kinase 1 Gustducin, alpha (taste-specific G protein) GDCA 5 Haeme regulated inhibitor kinase 1 Haemoglobin epsilon 2 Hairless HR 6 Haptoglobin, alpha 1 HPA1 4 Haptoglobin, alpha 2 HPA2 4 Haptoglobin, beta HPB 4 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Heat shock protein, HSPA1 4 Heat shock protein, HSPA2 4 Hela tumor suppression gene HTS1 6 Hemochromatosis HFE 2 Hemopexin HPX 4 Heparan sulfamidase 1 Heparin binding epidermal growth factor HBEGF 6 Hepatic nuclear factor-3-beta HNF3B 1 Hepatic nuclear factor-4-alpha HNF4A 1 Hepatitis B virus integration site 1 HVBS1 4 Hepatitis B virus integration site 2 HVBS6 4 Hepatocyte growth factor HGF 6 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 High mobility group protein 1 HMG1 6 High mobility group protein 2 HMG2 6 High mobility group protein C HMGIC 6 High mobility group protein Y HMGIY 6 Histone family H1 H1 6 Histone family H2 H2 6 Histone family H3 H3 6 Histone family H4 H4 6 HLA-B associated transcript 1 BAT1 4 HLH transcription factor HAND1 HAND1 6 HLH transcription factor HAND2 HAND2 6 HMG-CoA lyase HMGCL 1 HMG-CoA reductase HMGCR 1 HMG-CoA synthase HMGCS2 1 Holocarboxylase synthetase HLCS 1 Holoprosencephaly 1 HPE1 6 Holoprosencephaly 2 HPE2 6 Holoprosencephaly 3 HPE3 6 Holoprosencephaly 4 HPE4 6 Homeobox (HOX) gene A1 HOXA1 6 Homeobox (HOX) gene A10 HOXA10 6 Homeobox (HOX) gene A11 HOXA11 6 Homeobox (HOX) gene A12 HOXA12 6 Homeobox (HOX) gene A13 HOXA13 6 Homeobox (HOX) gene A2 HOXA2 6 Homeobox (HOX) gene A3 HOXA3 6 Homeobox (HOX) gene A4 HOXA4 6 Homeobox (HOX) gene A5 HOXA5 6 Homeobox (HOX) gene A6 HOXA6 6 Homeobox (HOX) gene A7 HOXA7 6 Homeobox (HOX) gene A8 HOXA8 6 Homeobox (HOX) gene A9 HOXA9 6 Homeobox (HOX) gene B1 HOXB1 6 Homeobox (HOX) gene B2 HOXB2 6 Homeobox (HOX) gene B3 HOXB3 6 Homeobox (HOX) gene B4 HOXB4 6 Homeobox (HOX) gene B5 HOXB5 6 Homeobox (HOX) gene B6 HOXB6 6 Homeobox (HOX) gene B7 HOXB7 6 Homeobox (HOX) gene B8 HOXB8 6 Homeobox (HOX) gene B9 HOXB9 6 Homeobox (HOX) gene C13 HOXC13 6 Homeobox (HOX) gene C4 HOXC4 6 Homeobox (HOX) gene C8 HOXC8 6 Homeobox (HOX) gene C9 HOXC9 6 Homeobox (HOX) gene D1 HOXD1 6 Homeobox (HOX) gene D10 HOXD10 6 Homeobox (HOX) gene D12 HOXD12 6 Homeobox (HOX) gene D13 HOXD13 6 Homeobox (HOX) gene D3 HOXD3 6 Homeobox (HOX) gene D4 HOXD4 6 Homeobox (HOX) gene D8 HOXD8 6 Homeobox (HOX) gene D9 HOXD9 6 Homeobox 11 HOX11 6 Homeobox HB24 HLX1 6 Homeobox HB9 HLXB9 6 Homeobox, PROX1 PROX1 6 HSSB, replication protein 1 Human atonal gene ATOH1 6 Human chorionic gonadtrophin, hCG CG 6 Human placental factogen CSH1 6 Huntingtin HD 2 Hypoxanthine-guanine HPRT 1 phosphoribosyltransferase, HGPRT Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 IC7 A and B 4 Iduronate 2 sulphatase IDS 1 Ikaros gene IKAROS 6 Immunoglobulin alpha (IgA) IGHA 4 Immunoglobulin delta (IgD) IGHD 4 lmmunoglobulin E (Ig) reponsivigness gene IGER 4 Immunoglobulin E (IgE) serum concentration IGES 4 regulator gene Immunoglobulin epsilon (IgE) IGHE 4 Immunoglobulin gamma (IgG) 2 IGHG2 4 Immunoglobulin heavy mu chain IGHM 4 Immunoglobulin J polypeptide IGJ 4 Immunoglobulin kappa constant region IGKC 4 lmmunoglobulin kappa variable region IGKV 4 Indian hedgehog, ihh IHH 6 Inhibin, alpha INHA 6 Inhibin, beta A INHBA 6 Inhibin, beta B INHBB 6 Inhibin, beta C INHBC 6 Inosine monophosphate dehydrogenase, 1 IMPDH Inositol 1,4,5-triphosphate receptor 1 ITPR1 6 Inositol 1,4,5-triphosphate receptor 3 ITPR3 6 Insulin INS 6 Insulin promotor factor 1 IPF1 6 Insulin receptor INSR 6 Insulin receptor substrate-1 IRS1 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 Integrin beta 1 ITGB1 6 Integrin beta 2 ITGB2 6 Integrin beta 3 ITGB3 6 Integrin beta 4 ITGB4 6 Integrin beta 5 ITGB5 6 Integrin beta 6 ITGB6 6 Integrin beta 7 ITGB7 6 Integrin, alpha 1 ITGA1 6 Integrin, alpha 2 ITGA2 6 Integrin, alpha 3 ITGA3 6 Integrin, alpha 4 ITGA4 6 Integrin, alpha 5 ITGA5 6 Integrin, alpha 6 ITGA6 6 Integrin, alpha 7 ITGA7 6 lntegrin, alpha 8 ITGA8 6 Integrin, alpha 9 ITGA9 6 Integrin, alpha M ITGAM 6 Integrin, alpha X ITGAX 6 Inter-alpha-trypsin inhibitor, IATI 1 lntercellular adhesion molecule 1 ICAM1 4 Intercellular adhesion molecule 2 ICAM2 4 lntercellular adhesion molecule 3 ICAM3 4 Interferon alpha IFNA1 4 Interferon beta IFNB 4 Interferon gamma IFNG 4 Interferon gamma receptor 1 IFNGR1 4 Interferon gamma receptor 2 IFNGR2 4 Interferon regulatory factor 1 IRF1 4 Interferon regulatory factor 4 IRF4 4 lnterleukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 Interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) 11 IL11 4 Interleukin(IL) 11 receptor IL11R 4 lnterleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RB1 4 Interleukin(IL) 13 IL13 4 Interleukin(IL) 13 receptor IL13R 4 lnterleukin(IL) 2 IL2 4 lnterleukin(IL) 2 receptor, alpha IL2RA 4 lnterleukin(IL) 2 receptor, gamma IL2RG 4 Interleukin(IL) 8 IL3 4 lnterleukin(IL) 3 receptor IL3R 4 lnterleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 lnterleukin(IL) 5 IL5 4 lnterleukin(IL) 5 receptor IL5R 4 lnterleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 lnterleukin(IL) 7 IL7 4 Interleukin(IL) 7 receptor IL7R 4 lnterleukin(IL) 8 IL8 4 lnterleukin(IL) 8 receptor IL8R 4 lnterleukin(IL) 9 IL9 4 lnterleukin(IL) 9 receptor IL9R 4 Interleukin(IL) receptor antagonist 1 IL1RN, ILLRA 4 IP3 kinase 1 Isocitrate dehydrogenase 1 Isovaleric acid CoA dehydrogenase IVD 1 Janus kinase 1 JAKI 6 Janus kinase 2 JAK2 6 Janus kinase 3 JAK3 6 Kallman syndrome gene 1 KAL1 6 Kell blood group precursor XK, KEL 2 Keratin 1 KRT1 3 Keratin 10 KRT10 3 Keratin 11 KRT11 3 Keratin 12 KRT12 3 Keratin 13 KRT13 3 Keratin 14 KRT14 3 Keratin 15 KRT15 3 Keratin 16 KRT16 3 Keratin 17 KRT17, PCHC1 3 Keratin 18 KRT18 3 Keratin 2 KRT2 3 Keratin 3 KRT3 3 Keratin 4 KRT4 3 Keratin 5 KRT5 3 Keratin 6 KRT6 3 Keratin 7 KRT7 3 Keratin 8 KRT8 3 Keratin 9 KRT9 3 Ketohexokinase KHK 1 Kinectin KTN1 6 Kinesin, heavy chain KNSL1 6 Kinesin, light chain KNS2 6 L1 cell adhesion molecule L1CAM 5 Lactotransferrin LTF 2 Lamin A/C LMNA 6 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMR1 6 Latent transforming growth factor-beta binding LTBP2 6 protein 2 Leptin LEP 6 Leptin receptor LEPR 6 Leukaemia inhibitory factor LIF 6 Leukaemia inhibitory factor receptor LIFR 6 Leukin 4 Leukocyte-specific transcript 1 LST-1 4 Leukotriene A4 hydrolase 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 Leukotriene D4/E4 receptor 4 LH/choriogonadotropin (CG) receptor LHCGR 6 LIM homeobox protein 1 LHX1 6 LIM homeobox protein 2 LHX2 6 LIM homeobox protein 3 LHX3 6 LIM homeobox protein 4 LHX4 6 LIM homeobox transcription factor 1, beta LMX1B 6 Limb girdle muscular dystrophy 1 A LGMD1A 6 Limb girdle muscular dystrophy 1 B LGMDI B 6 Limb girdle muscular dystrophy 2G LGMD2G 6 Limb girdle muscular dystrophy 2H LGMD2H 6 Limbic associated membrane protein LAMP 6 LIM-domain only protein 1 LM01 6 LIM-domain only protein 2 LM02 6 LIM-domain only protein 3 LM03 6 LIM-domain only protein 4 LM04 6 Lipoma-preferred partner gene LPP 6 Lipoprotein receptor, Low Density LDLR 2 Lipoxygenase 12 (platelets) LOG12 4 Lipoxygenase 5 (leukocytes) 4 Long QT-type 2 potassium channels LQT2, KCNH2 2 Loricrin LOR 3 Low density lipoprotein receptor-related protein LRP 2 precursor Luteinizing hormone, beta chain LHB 6 Lymphoblastic leukemia derived sequence 1 LYL1 4 Lymphocyte-specific protein tymsine kinase LCK 4 Lymphoid enhancer-binding factor LEF-1 6 Lysosome-associated membrane protein 1 LAMP1 6 Lysosome-associated membrane protein 2 LAMP2 6 MAD (mothers against decapentaplegic, MADH2 6 Drosophila) homologue 2 MAD (mothers against decapentaplegic, MADH3 6 Drosophila) homologue 3 MAD (mothers against decapentaplegic, MADH4 6 Dmsophila) homologue 4 MADS box transcription-enhancer factor 2A MEF2A 6 MADS box transcription-enhancer factor 2B MEF2B 6 MADS box transcription-enhancer factor 2C MEF2C 6 MADS box transcription-enhancer factor 2D MEF2D 6 Malate dehydrogenase, mitochondrial MDH2 1 Malignant proliferation, eosinophil gene MPE 4 Malonyl CoA decarboxylase 1 Malonyl CoA transferase 1 Mannosidase, alpha B lysosomal MANB 1 Mannosidase, beta A lysosomal MANBA 1 MAPK kinase 1 MAPKK1; MEK1 6 MAPK kinase 4 MAPKK4; MEK4; 6 SERK1 MAPK kinase 6 MAPKK6; MEK6 6 MAPKK kinase MAPKKK 6 Matrix Gla protein MGP 6 Matrix metalloproteinase 1 NMP1 1 Matrix metalloproteinase 10 NMP10 1 Matrix metalloproteinase 11 MMP11 1 Matrix metalloproteinase 12 MMP12 1 Matrix metalloproteinase 13 MMP13 1 Matrix metalloproteinase 14 MMP14 1 Matrix metalloproteinase 15 MMP15 1 Matrix metalloproteinase 16 MMP16 1 Matrix metalloproteinase 17 MMP17 1 Matrix metalloproteinase 18 MMP18 1 Matrix metalloproteinase 19 MMP19 1 Matrix metalloproteinase 2 MMP2 1 Matrix metalloproteinase 3 MMP3, STMY1 1 Matrix metalloproteinase 4 MMP4 1 Matrix metalloproteinase 5 MMP5 1 Matrix metalloproteinase 6 MMP6 1 Matrix metalloproteinase 7 MMP7 1 Matrix metalloproteinase 8 MMP8 1 Matrix metalloproteinase 9 MMP9 1 MAX-interacting protein 1 MXI1 6 MEK kinase, MEKK 1 Melanocortin 1 receptor MC1R 2 Melanocortin 2 receptor MC2R 2 Melanocortin 4 receptor MC4R 2 Menin MEN1 6 Mesoderm-specific transcript MEST 6 Methionine adenosyltransferase MAT1A, MAT2A 1 Methionine synthase MTR 1 Methionine synthase reductase MTRR 1 Methylguanine-DNA methyltransferase MGMT 1 Methylmalonyl-CoA mutase MUT 1 Mevalonate kinase MVK 1 MHC Class 1: A 4 MHC Class 1: B 4 MHC Class 1: C 4 MHC Class 1: LMP-2, LMP-7 4 MHC Class 1: Tap1 ABCR, TAP1 4 MHC Class II: DP HLA-DPB1 4 MHC Class II: DQ 4 MHC Class II: DR 4 MHC Class II: Tap2 TAP2, PSF2 4 MHC Class II: Complementation group A MHC2TA 4 MHC Class II: Complementation group B RFXANK 4 MHC Class II: Complementation group C RFX5 4 MHC Class II: Complementation group D RFXAP 4 Microphthalmia-associated transcription factor MITF 6 Microsomal triglyceride transfer protein MTP 2 Microtuble associated protein MAP 3 Midline I MID1 6 Mismatch repair gene, PMSL1 PMS1 6 Mismatch repair gene, PMSL2 PMS2 6 Mitochondrial trifunctional protein, alpha HADHA 1 subunit Mitochondrial trifunctional protein, beta subunit HADHB 1 Mitogen-activated protein (MAP) kinase MAPK 6 Molybdenum cofactor synthesis 1 MOCS1 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Monocyte chemoattractant protein 1 MCP1 4 Motilin MLN 6 Msh homeobox homolog 1 MSX1 6 Msh homeobox homolog 2 MSX2 6 Mucolipidoses GNPTA 1 Mulibrey nanism MUL 2 Multidrug resistance associated protein MRP 6 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Muscle phosphorylase PYGM 1 Mutated in colorectal cancers, MCC MCC 6 MutL homolog 1 MLH1 6 MutS homolog 2 MSH2 6 MutS homolog 3 MSH3 6 Myelin protein peripheral 22 PMP22 3 Myelin protein zero MPZ 3 Myelodysplasia syndrome 1 gene MDS1 6 Myeloid leukemia factor-1 MLF1 4 Myocilin MYOC 2 Myogenic factor 3 MYF3 6 Myogenic factor 4 MYF4 6 Myogenic factor 5 MYF5 6 Myomesin 1 MYOM1 3 Myomesin 2 MYOM2 3 Myosin 15 MYO15 3 Myosin 6 MY06 3 Myosin 7A MY07A 3 Myosin, cardiac MYH7 3 Myotubularin MTM1 3 Na+, K+ ATPase, alpha ATP1A1 6 Na+, K+ ATPase, beta 1 ATP1B1 6 Na+, K+ ATPase, beta 2 ATP1B2 6 Na+/H+ exchanger 1 NHE1 2 Na+/H+ exchanger 2 NHE2 2 Na+/H+ exchanger 3 NHE3 2 Na+/H+ exchanger 4 NHE4 2 Na+/H+ exchanger 5 NHE5 2 N-acetylgalactosamine-6-sulfate sulfatase GALNS 1 N-acetylglucosamine-6-sulfatase GNS 1 N-acetylglucosaminidase, alpha NAGLU 1 N-acetyltransferase 1 NAT1 1 N-acetyltransferase 2 NAT2 1 NADH dehydrogenase 1 NADH dehydrogenase (ubiquinone) Fe—S NDUFS1 1 protein 1 NADH dehydrogenase (ubiquinone) Fe—S NDUFS4 1 protein 4 NADH dehydrogenase (ubiquinone) NDUFV1 1 flavoprotein 1 NADH-cytochrome b5 reductase DIA1 1 reductase NADPH-dependent cytochrome P450 POR 1 reductase Natural resistance-associated macrophage NRAMP1 4 protein 1 NB6 4 Necdin NDN 6 Nephronophthisis 1 NPHP1 2 Nephronophthisis 2 NPHP2 2 Nephrosis 1 NPHS1 2 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neural retina-specific gene NRL 6 Neuraminidase sialidase NEU 2 Neuregulin HGL 6 Neurite growth-promoting factor 2 MDK 5 Neurite inhibitory protein 5 Neuroendocrine convertase 1 NEC1, PCSK1 1 Neurofibromin 1 NFI 6 Neurofibromin 2 NF2 6 Neurofliament protein, heavy NFH 3 Neurofliament protein, NF68 NF68 3 Neuronal apoptosis inhibitory protein NAIP 4 Neuronal molecule-1 4 Neuronal molecule-1 receptor 4 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1 R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neurotrophic tyrosine kinase receptor 1 NTRK1 6 Neurotrophin 3 NTF3 or NT3 6 Neurturin NRTN 6 Neutral endopeptidase 1 Neutrophil cystolic factor 1 NCF1 Neutrophil cystolic factor 2 NCF2 Niacin receptor 6 Nibrin NBS1 6 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Nodal NODAL 6 Noggin NOG 6 Norrie disease protein NDP 6 Notch 1 NOTCH1 6 Notch 2 NOTCH2 6 Notch 3 NOTCH3 6 Notch ligand-jagged 1 JAG 1, AGS 6 Nuclear factor I-kappa-B-like gene IKBL 4 Nuclear factor kappa beta NFKB 4 Nuclear factor of activated T cells (NFAT) NFATC 6 complex, cytosolic Nuclear factor of activated T cells (NFAT) NFATP 6 complex, preexisting component Nuclear mitotic apparatus protein 1 NUMA1 6 Nucleophosmin NPM1 2 Nucleoside diphosphate kinase-A NDPKA 1 Ocular albinism 1 OA1 3 Oculocutaneous albinism II OCA2 3 Oligophrenin-1 OPHN1 6 Oncogene abl1 ABL1 6 Oncogene abl2 6 Oncogene akt1 6 Oncogene akt2 AKT2 6 Oncogene axI AXL 6 Oncogene bcl2 6 Oncogene bcr/abl 6 Oncogene B-lym 6 Oncogene B-raf 6 Oncogene clk1 6 Oncogene c-myc 6 Oncogene cot 6 Oncogene crk 6 Oncogene crkI 6 Oncogene ect2 6 Oncogene ELK1 ELK1 6 Oncogene ELK2 ELK2 6 Oncogene emsl 6 Oncogene ERB 6 Oncogene ERB2 6 Oncogene ERBA 6 Oncogene ERBAL2 6 Oncogene ERG (early reponse gene) 6 Oncogene ETS1 6 Oncogene ETS2 6 Oncogene EVI1 EVI 1 6 Oncogene fes 6 Oncogene fgr 6 Oncogene fos FOS 6 Oncogene fps 6 Oncogene GLI1 GLI 6 Oncogene GLI2 GLI2 6 Oncogene GLI3 GLI3 6 Oncogene gro1 6 Oncogene gro2 6 Oncogene Ha-ras HRAS 6 Oncogene hs1 6 Oncogene hst FGF4 6 Oncogene int1 WNT1 6 Oncogene int2 FGF3 6 Oncogene int3 Notch4 6 Oncogene int4 WNT3 6 Oncogene jun JUN 6 Oncogene KIT KIT, PBT 6 Oncogene LCO LCO 6 Oncogene I-myc 6 Oncogene Ipsa 6 Oncogene lyn 6 Oncogene maf 6 Oncogene mas1 6 Oncogene mcf2 6 Oncogene mdm2 MDM2 6 Oncogene meI 6 Oncogene met MET 6 Oncogene mos 6 Oncogene mpI 6 Oncogene MUM1 MUM1 6 Oncogene myb MYB 6 Oncogene myc MYC 6 Oncogene n-myc 6 Oncogene N-ras (neuroblastoma v-ras) NRAS 6 Oncogene ovc 6 Oncogene pimi 6 Oncogene pti-1sea 6 Oncogene pvt1 6 Oncogene raf RAF 6 Oncogene ralb 6 Oncogene reI 6 Oncogene ret RET 6 Oncogene r-myc 6 Oncogene ros 6 Oncogene R-ras 6 Oncogene sis PDGFB 6 Oncogene ski 6 Oncogene sno 6 Oncogene spi1 6 Oncogene src 6 Oncogene tc21 6 Oncogene TEL ETV6 6 Oncogene tim 6 Oncogene vavtrk 6 Oncogene v-Ki-ras2 KRAS2 6 Oncogene yes 6 Oncogene yuasa 6 Oncostatin M OSM 6 Oncostatin M receptor OSMR 6 Orexin OX 6 Orexin 1 receptor OXIR 6 Orexin 2 receptor OX2R 6 Ornithine delta-aminotransferase OAT 1 Ornithine transcarbamoylase OTC, NME1 1 Orthodenticle (Drosophila) homolog 1 OTX1 6 Orthodenticle (Drosophila) homolog 2 OTX2 6 Osteocalcin 3 Osteonectin ON 6 Osteopontin OPN 6 Osteoprotegerin OPG 6 Otoferlin OTOF 5 Oxytocin OXT 5 Oxytocin receptor OXTR 5 p21-activated kinase 3 PAK3 6 Paired box homeotic gene 1 PAX1 6 Paired box homeotic gene 2 PAX2 6 Paired box homeotic gene 3 PAX3 6 Paired box homeotic gene 6 PAX6 6 Paired box homeotic gene 7 PAX7 6 Paired box homeotic gene 8 PAX8 6 Paired-like homeodomain transcription factor 2 PITX2 6 Paired-like homeodomain transcription factor 3 PITX3 6 Palmitoyl-protein thioesterase PPT 2 Pancreatic amylase 1 Parathyroid hormone PTH 6 Parathyroid hormone receptor PTHR1 6 Parathyroid hormone related-peptide PTHRP 6 Parathyroid hormone-like hormone PTHLH 6 Parvalbumin PVALB 6 Patched (Drosophila) homolog, PTCH PTCH 6 PCNA (proliferating cell nuclear antigen) 1 Peanut-like 1 PNUTL1 4 Pendrin, PDS PDS 2 Peptidylglycine alpha-amidating PAM 1 monooxygenase Peripherin, PRPH 3 Peroxisomal membrane protein 1 PXMP1 3 Peroxisomal membrane protein 3 PXMP3 2 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome proliferative activated receptor, PPARA 2 alpha Peroxisome proliferative activated receptor, PPARG 2 gamma Peroxisome receptor 1 PXR1 2 Phenylethanolamine N-methyltransferase, PNMT 1 PNMT Phosphatase & tensin homolog PTEN 6 Phosphate regulating gene with homologies to PHEX 6 endopeptidases on the X chromosome Phosphatidylinositol glycan, class A PIGA 6 (paroxysmal nocturnal hemoglobinuria) Phosphatidylinositol transfer protein PITPN 6 Phosphodiesterase 1/nucleotide PDNP1 6 pyrophosphatase 1 Phosphodiesterase 1/nucleotide PDNP2 6 pyrophosphatase 2 Phosphodiesterase 1/nucleotide PDNP3 6 pyrophosphatase 3 Phosphofructokinase, liver PFKL 1 Phosphofructokinase, muscle PFKM 1 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase 1 PGKL 1 Phosphoglycerate mutase 2 PGAM2 1 Phospholipase A2, group 10 PLA2G10 4 Phospholipase A2, group 1B PLA2G1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Phosphomannomutase 1 PMM1 6 Phosphomannomutase 2 PMM2 6 Phosphomannomutase 2 PMM2 2 Phosphorylase kinase deficiency, liver PHK 1 Phosphorylase kinase, alpha 2 PHKA2 1 Phytanoyl-CoA hydroxylase PHYH 6 Plakophilin 1 PKP1 2 Plasminogen PLG 1 Plasminogen activator inhibitor 1 PAI 1 1 Plasminogen activator inhibitor 2 PAI 2 1 Plasminogen activator receptor, Urokinase UPAR; PLAUR 3 Plasminogen activator, Tissue PLAT; TPA 1 Plasminogen activator, Urokinase UPA; PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Plectin 1 PLEC1 2 Poly (ADP-ribose) synthetase PARS 1 Poly(A) binding protein 2 PABP2 6 Postsynaptic density-95 protein PSD95 5 Potassium inwardly-rectifying channel J1 KCNJL 5 Potassium inwardly-rectifying channel J11 KCNJL11 5 Potassium voltage-gated channel A1 KCNA1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCNQ3 5 Potassium voltage-gated channel Q4 KCNQ4 5 POU domain, class 1, transcription factor 1 POU1F1 6 (Piti) POU domain, class 3, transcription factor 4 POU3F4 6 POU domain, class 4, transcription factor 3 POU4F3 6 Pre-B-cell leukemia transcription factor 1 PBX1 6 Preproglucagon GCG; GLPL; GLP2 6 Procoliagen N-protease 1 Procollagen peptidase 1 Profibrinolysin 6 receptor) Prohibitin PHB 6 Prolactin PRL 6 Prolactin receptor PRLR 6 Prolactin releasing hormone PRH 6 Proliferin PLF 6 Proline dehydrogenase PRODH 1 Pro-melanin-concentrating hormone PMCH 6 Promyelocytic leukemia gene PML 6 Proopiomeianocortin POMC 5 Prophet of Pit1 PROP1 6 Propionyl-CoA carboxylase, alpha PCCA 1 Propionyl-CoA carboxylase, beta PCCB 1 Prosaposin PSAP 5 Prostaglandin (PG) D synthase, hematopoietic PGDS 1 Prostaglandin isomerase 6 Prostaglandin-endoperoxidase synthase 2 PTGS2 6 Prostate cancer anti-metastasis gene KAI 1 KAI 1 6 Protease nexin 2 PN2 1 Protective protein for beta-galactosidase PPGB 1 Protein C PROC 4 Protein kinase A 1 Protein kinase B PRKB Protein kinase C, alpha PRKCA 1 Protein kinase C, gamma PRKCG 1 Protein kinase DNA-activated PRKDC 1 Protein kinase G 1 Protein phosphatase 1, regulatory (inhibitor) PPP1R3 1 subunit 3 Protein phosphatase 2, regulatory subunit A, PPP2R1B 1 beta isoform Protein tyrosine phosphatase, non-receptor PTPN12 6 type 12 Protoporphyrinogen oxidase PPOX 1 Pterin-4-alpha-carbinolamine PCBD Purine nucleoside phosphorylase NP 1 Purinergic receptor P1A1 5 Purinergic receptor P1A2 5 Purinergic receptor P1A3 5 Purinergic receptor P2X, 1 P2RX1 5 Purinergic receptor P2X, 2 P2RX2 5 Purinergic receptor P2X, 3 P2RX3 5 Purinergic receptor P X, 4 P2RX4 5 Purinergic receptor P2X, 5 P2RX5 5 Purinergic receptor P9X, 6 P2RX6 5 Purinergic receptor P2X, 7 P2RX7 5 Purinergic receptor P2Y, 1 P2RY1 5 Purinergic receptor P2Y, 11 P2RY11 5 Purinergic receptor P2Y, 2 P2RY2 5 Pyrroline-5-carboxylate synthetase PYCS 1 Pyruvate carboxylase PC 1 Pyruvate decarboxylase PDHA 1 Pyruvate kinase PKLR 1 RAD51, DNA repair protein RAD51 6 RAD52, DNA repair protein RAD52 6 RAD54, DNA repair protein RAD54 6 RAD55, DNA repair protein RAD55 6 RAD57, DNA repair protein RAD57 6 Ras-G-protein RAS 6 Rathke pouch homeobox, RPX RPX 6 Receptor tyrosine kinase (RTK), Nsk2 NSK2 6 Recombination activating gene 1 RAG1 6 Recombination activating gene 2 RAG2 6 Red cone pigment RCP 3 Relaxin H1 RLN1 6 Relaxin H2 RLN2 6 Replication factor A 1 Replication factor C RFC2 1 Retinal pigment epithelium specific protein RPE65 3 (65 kD) Retinitis pigmentosa gene 1 RP1 3 Retinitis pigmentosa gene 2 RP2 3 Retinitis pigmentosa gene 3 RP3 3 Retinitis pigmentosa gene 6 RP6 3 Retinitis pigmentosa gene 7 RP7, RDS 3 Retinoblastoma 1 RB1 6 Retinoic acid receptor, alpha RARA 6 Retinoic acid receptor, beta RARB 6 Retinoic acid receptor, gamma RARG 6 Retinoid X receptor, alpha RXRA 6 Retinoid X receptor, beta RXRB 6 Retinoid X receptor, gamma RXRG 6 Retinoschisis, X-linked, juvenile RS 6 Rhabdoid tumors SMARCB1 6 Rhodopsin RHO 3 Ribonucleotide reductase, RRM 1 Ribosomal protein L13A RPL13A 6 Ribosomat protein L17 RPL17 6 Ribosomal protein S19 RPS19 1 Ribosomal protein S4, X-linked RPS4X 1 Ribosomat protein S6 kinase RPS6KA3 1 Ribosomal protein S9 RPS9 6 RIGUI RIGUI 6 Rod outer segment membrane protein 1 ROM1 3 Ryanodine receptor 1, skeletal RYR1 6 SA homolog SAH 6 Sal-like 1 SALL1 6 Secretin SCT 2 Semaphorin A4 SEMA4 3 Semaphorin A5 SEMA5 3 Semaphorin D 3 Semaphorin E SEMAE 3 Semaphorin F SEMA3/F 3 Semaphorin W SEMAW 3 Serine/threonine kinase 11 STK11 6 Serine/threonine kinase 2 STK2 6 Serotonin N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Serum amyloid A SAA 2 Serum amyloid P SAP 2 Sex determining region Y, SRY SRY 6 Short stature homeobox SHOX 6 Sialoprotein, bone BSP 6 Signal transducer and activator of transcription 1 STAT1 6 Signal transducer and activator of transcription 2 STAT2 6 Signal transducer and activator of transcription 3 STAT3 6 Signal transducer and activator of transcription 4 STAT4 6 Signal transducer and activator of transcription 5 STAT5 6 Signaling lymphocyte activation molecule SLAM 4 Sine oculis homeobox, drosophila, homolog 1 SIX1 6 Sine oculis homeobox, drosophila, homolog 2 SIX2 6 Sine oculis homeobox, drosophila, homolog 5 SIX5 6 Sjoegren (Siogren) syndrome antigen A1 SSAL 4 Slug protein 6 Small nuclear ribonucleoprotein polypeptide N SNRPN 3 Smoothelin SMTN 6 Smoothened (Drosophila) homolog SMOH 6 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage gated, type IV, alpha SCN4A 5 polypeptide Sodium channel, voltage gated, type V, alpha SCN5A 5 polypeptide Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 1 (amino acid transporter), SLC1A6 2 member 6 Solute carrier family 1 (glial high affinity SLC1A3 2 glutamate transporter), member 3 Solute carrier family 1 (glutamate transporter), SLC1A1 2 member 1 Solute carrier family 1 (glutamate transporter), SLC1A2 2 member 2 Solute carrier family 1 (neutral amino acid SLC1A4 2 transporter), member 4 Solute carrier family 10 (sodium/bile acid SLC10A1 2 cotransporter family), member 1 Solute carrier family 10 (sodium/bile acid SLC10A2 2 cotransporter family), member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 14, member 2 SLC14A2 2 Solute carrier family 15 (H+/peptide SLC15A1 2 transporter, intestinal), member 1 Solute carrier family 15 (H+/peptide SLC15A2 2 transporter, kidney), member 2 Solute carrier family 16 (monocarboxylate SLC16A1 2 transporter), member 1 Solute carrier family 16 (monocarboxylate SLC16A7 2 transporter), member 7 Solute carrier family 17, member 1 SLC17A1 2 Solute carrier family 17, member 2 SLC17A2 2 Solute carrier family 18, member 3 SLC18A3 2 Solute carrier family 19 (folate transporter), SLC19A1 2 member 1 Solute carrier family 2 (facilitated glucose SLC2A1 2 transporter), member 1 Solute carrier family 2 (facilitated glucose SLC2A2 2 transporter), member 2 Solute carrier family 2 (facilitated glucose SLC2A3 2 transporter), member 3 Solute carrier family 2 (facilitated glucose SLC2A4 2 transporter), member 4 Solute carrier family 2 (facilitated glucose SLC2A5 2 transporter), member 5 Solute carrier family 20, member 1 SLC20A1 2 Solute carrier family 20, member 2 SLC20A2 2 Solute carrier family 20, member 3 SLC20A3 2 Solute carder family 21, member 2 SLC21A2 2 Solute carrier family 21, member 3 SLC21A3 2 Solute carrier family 22, member 1 SLC22A1 2 Solute carrier family 22, member 2 SLC22A2 2 So ute carrier family 22, member 5 SLC22A5 2 Solute carrier family 25, member 12 SLC25A12 2 Solute carrier family 3 (facilitated glucose SLC3A1 2 transporter), member 1 Solute carrier family 4 (anion exchanger), SLC4A1 2 member 1 Solute carrier family 4 (anion exchanger), SLC4A2 2 member 2 Solute carrier family 4 (anion exchanger), SLC4A3 2 member 3 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Solute carder family 6 (neurotransmitter SLC6A4 2 transporter, serotonin), member 4 Solute carrier family 6, member 10 SLC6A10 2 Solute carrier family 6, member 6 SLC6A6 2 Solute carrier family 6, member 8 SLC6A8 2 Solute carrier family 7(amino acid transporter), SLC7A1 2 member 1 Solute carrier family 7(amino acid transporter), SLC7A2 2 member 2 Solute carrier family 7(amino acid transporter), SLC7A7 2 member 7 So ute carrier family 8 (sodium/calcium SLC8A1 2 exchanger), member 1 Somatostatin receptor, SSTR2 SSTR2 6 Somatotrophin 6 Sonic hedgehog, SHH SHH 6 Sorbitol dehydrogenase SORD 1 Sorcin SRI 2 SOSI guanine nucleotide exchange factor SOS1 6 Spastic paraplegia 7 SPG7 6 Spectrin alpha SPTAL 3 Spectdn beta SPTB 3 Sperm adhesion molecule SPAM1 6 Sperm prolamine P1 PRM1 6 Sperm prolamine P2 PRM2 6 Sphingomyelinase SMPDI 1 Spinocerebellar ataxia 8 gene SCA8 5 Split hand/foot malformation gene DSS1 6 SRY-box 10 SOX10 6 SRY-box 11 SOX11 6 SRY-box 3 SOX3 6 SRY-box 4 SOX4 6 SRY-box 9 SOX9 6 Stem cell factor SCF 6 Steroid 5 alpha reductase 1 SRD5A1 1 Steroid 5 alpha reductase 2 SRD5A2 1 Steroid hormone receptor responsive DNA 6 elements Steroid sulphatase STS 1 Steroidogenic acute regulatory protein STAR 2 Stromal derived factor 1 SDF1 6 Succinate dehydrogenase 1 SDH1 1 Succinate dehydrogenase 2 SDH2 1 Succinate thiokinase 1 Succinic semi-aldehyde dehydrogenase SSADH 1 Suffamidase SGSH 6 Sulfite oxidase SUOX 1 Sulfonylurea receptor SUR 6 Suppression of tumorigenicity 3 gene ST3 6 Suppression of tumorigenicity 8 gene ST8 6 Surfactant pulmonary-associated protein A1 SFTPA1 2 Surfactant pulmonary-associated protein A2 SFTPA2 2 Surfactant pulmonary-associated protein B SFTPB 2 Surfactant pulmonary-associated protein C SFTPC 2 Surfactant pulmonary-associated protein D SFTPD 2 Surfeit 1 SURF1 6 Survival of motor neuron 1, telomeric SMN1 2 SYK-related tyrosine kinase SRK 4 Syndecan 1 SYND1 6 Syndecan 2 SYND2 6 Syndecan 3 SYND3 6 Syndecan 4 SYND4 6 Synovial sarcoma gene 1 SSX1 6 Synovial sarcoma gene 2 SSX2 6 Talin TLN 6 TATA binding protein TBP 6 TATA binding protein associated factor 2A TAF2A 6 TATA binding protein associated factor 2C2 TAF2C2 6 TATA binding protein associated factor 2D TAF2E 6 TATA binding protein associated factor 2F TAF2F 6 TATA binding protein associated factor 2H TAF2H 6 TATA binding protein associated factor 2I TAF21 6 TATA binding protein associated factor 2J TAF2J 6 TATA binding protein associated factor 2K TAF2K 6 Tau protein MAPT 3 T-BOX 1 TBX1 6 T-BOX 2 TBX2 6 T-BOX 3 TBX3 6 T-BOX 4 TBX4 6 T-BOX 5 TBX5 6 T-BOX 6 TBX6 6 T-cell acute lymphocytic leukemia 1 TAL1 4 T-cell acute lymphocytic leukemia 2 TAL2 4 T-cell receptor, alpha TCRA 4 T-cell receptor, delta TCRD 4 Telomerase protein component 1 Tenascin (cytotactin) 3 Tenascin XA TNXA 3 Terminal deoxynucleotidyltransferase, TDT 1 Testis-specific protein Y TSPY 6 Thiolase, perioxisomal 1 Thiopurine S-methyltransferase TPMT 1 Thrombopoietin THPO 6 Thrombospondin THBS1 6 Thromboxane A synthase 1 TBXAS1 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thy-1 T-cell antigen THY1 4 Thymidylate synthase TYMS 1 Thymopoietin TMPO 6 Thyroglobulin TG 6 Thyroid hormone receptor, alpha THRA 6 Thyroid hormone receptor, beta THRB 6 Thyroid peroxidase TPO 6 Thyroid receptor auxiliary protein TRAP 6 Thyroid-stimulating hormone receptor TSHR 6 Thyroid-stimulating hormone, alpha TSHA 6 Thyroid-stimulating hormone, beta TSHB 6 Thyrotroph embryonic factor TEF 6 Thyrotropin releasing hormone TRH 6 Thyrotropin releasing hormone receptor TRHR 6 Thyroxin-binding globulin TBG 2 TIE receptor tyrosine kinase TIE-1 6 Tip-associated protein TAP 4 Tissue inhibitor of metalloproteinase 1, TIMP1 TIMP1 1 Tissue inhibitor of metalloproteinase 2, TIMP2 TIMP2 1 Tissue inhibitor of metalloproteinase 3, TIMP3 TIMP3 1 Tissue inhibitor of metalloproteinase 4, TIMP4 TIMP4 1 Tissue non-specific alkaline phosphatase 1 TNSAP Titin TTN 3 Tocopherol (alpha) transfer protein TTPA 2 Toll-like receptor 4 TLR4 4 Topoisomerase I 1 Topoisomerase II 1 Torticollis, keloids, cryptorchidism and renal TKCR 6 dysplasia gene Transacylase 1 Transcobalamin 1, TCN1 2 Transcobalamin 2, TCN2 TCN2 2 Transcription factor 1, hepatic TCF1 6 Transcription factor 2, hepatic TCF2 6 Transcription factor 3 TCF3 6 Transcription factor binding to IGHM enhancer 3 TFE3 6 Transcription factor, TUPLE1 TUPLE1 5 Transcription termination factor, RNA TTF1 6 polymerase 1 Transcription termination factor, RNA TTF2 6 polymerase 2 Transcription termination factor, RNA TTF3 6 polymerase 3 Transferrin TF 6 Transferrin receptor TFRC 6 Transforming growth factor, alpha TGFA 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFB1 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transglutaminase 1 TGMI 6 Transglutaminase 2 TGM2 6 Transglutaminase 4 TGM4 6 Transketolase TKT 1 Transketolase-like 1 TKTL1 1 Translocation in renal carcinoma on TRC8 6 chromosome 8 gene Transthyretin TTR 2 Treacle gene TCOF1 6 Triosephosphate isomerase TPI 1 1 Tropomyosin 1 alpha TPM1 3 Tropomyosin 3 (non-muscle) TPM3 3 Troponin C 3 Troponin I TNNI3 3 Troponin T2, cardiac TNNT2 3 Trypsin inhibitor 1 Trypsinogen 1 TRY1 1 Trypsinagen 2 TRY2 1 Tryptophan hydroxylase TPH 1 Tubby-like protein 1 TULP1 6 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tubulin 3 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tumour protein p73 TP73 6 Tumour protein, transiationally-controlled 1 TPT1 6 Tumour suppresssor gene DRA DRA 4 Twist (Drosophila) homolog TWIST 6 Tyrosinase TYR 1 Tyrosinase-related protein 1 TYRP1 1 Tyrosine aminotransferase TAT 1 Tyrosine hydroxylase TH 1 Ubiquitin 6 Ubiquitin activating enzyme, E1 1 Ubiquitin B UBB 6 Ubiquitin C UBC 6 Ubiquitin carboxyl-terminal esterase L1 UCHL1 6 Ubiquitin fusion degeneration I-like UFD1L 6 Ubiquitin protein ligase E3A UBE3A 1 UDP-glucose pyrophosphorylase 1 UDP-glucuronosyltransferase 1 ugt1d, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Uncoupling protein 1 2 Uncoupling protein 3 UCP3 2 Undulin 1 COL14A1 3 Uridine monophosphate kinase UMPK 4 Uridine monophosphate synthetase UMPS 4 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Uroporphyrinogen decarboxylase UROD 1 Uroporphyrinogen III synthase UROS 1 Usher syndrome 2A USH2A 3 Vascular endothelial growth factor VEGF 6 Vasoinhibitory peptide 6 Vitamin B12-binding (R) protein 6 Vitamin D receptor VDR 6 Vitelliform macular dystrophy, atypical gene VMD1 2 v-myc avian myelocytomatosis viral oncogene MYC 6 homolog Von Hippel-Lindau gene VHL 6 Werner syndrome helicase WRN 6 Wilms tumour gene 1 WT1 6 Wilms tumour gene 2 WT2 6 Wilms tumour gene 4 WT4 6 Winged helix nude WHN 6 Wingless family, wnt2 WNT2 6 Wingless family, wnt4 WNT4 6 Wingless family, wnt5 WNT5 6 Wingless family, wnt7 WNT7 6 Wingless family, wnt8 WNT8 6 Wiskoft-Aldrich syndrome protein WASP, THC 4 Wnt inhibitory factor, WIF-1 WIF1 6 Wolf-Hirschhorn syndrome candidate 1 gene WHSC1 6 Wolfram syndrome 1 gene WFS1 3 X (inactive)-specific transcript XIST 6 Xanthine dehydrogenase XDH 1 Xeroderma pigmentosum, complementation XPA 1 group A Xeroderma pigmentosum, complementation XPB 1 group B Xeroderma pigmentosum, complementation XPC 1 group C Xeroderma pigmentosum, complementation 1 group D Xeroderma pigmentosum, complementation 1 group E Xeroderma pigmentosum, complementation XPF 1 group F Xeroderma pigmentosum, complementation ERCC5 1 group G X-ray repair gene XRCC9 6 Xylitol dehydrogenase 6 YY1 transcription factor YY1 6 Zinc finger protein 2 ZIC2 3 Zinc finger protein 3 ZIC3 3 Zinc finger protein HRX ALL1 4 Zona pellucida glycoprotein I ZP1 6 Zona pellucida glycoprotein 2 ZP2 6 Zona pellucida glycoprotein 3 ZP3 6 Zona pellucida receptor tyrosine kinase ZRK 6 Zonadhesin ZAN 6

that the genes associated with a malfunction, damage or disease of the skin, the muscles, the connective tissue or the bones are selected from: HUGO Protein- List of genes gene symbol function 17beta Hydroxysteroid oxidoreductase 1 5,10-methylenetetrahydrofolate reductase MTHFR 1 (NADPH) 6-Phosphofructo-2-kinase PFKFB1 1 Acetoacetyl 2-CoA-thiolase ACAT2 1 Acetylcholine receptor, nicotinic, alpha A1 CHRNA1 5 Acetylcholine receptor, nicotinic, alpha A2 CHRNA2 5 Acetylcholine receptor, nicotinic, alpha A3 CHRNA3 5 Acetylcholine receptor, nicotinic, alpha A4 CHRNA4 5 Acetylcholine receptor, nicotinic, alpha A5 CHRNA5 5 Acetylcholine receptor, nicotinic, alpha A6 CHRNA6 5 Acetylcholine receptor, nicotinic, alpha A7 CHRNA7 5 Acetylcholine receptor, nicotinic, beta 1 CHRNB1 5 Acetylcholine receptor, nicotinic, beta 2 CHRNB2 5 Acetylcholine receptor, nicotinic, beta 3 CHRNB3 5 Acetylcholine receptor, nicotinic, beta 4 CHRNB4 5 Acetylcholine receptor, nicotinic, epsilon CHRNE 5 Acetylcholine receptor, nicotinic, gamma CHRNG 5 Acetylcholinesterase ACHE 1 Achromatopsia 2 ACHM2 3 Acid phosphatase 2, lysosomal ACP2 1 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTA1 3 Actin, alpha, smooth, aortic ACTA2 3 Actin, beta ACTB 3 Actin, gamma 2 ACTG2 3 Activin 6 Acyl CoA dehydrogenase, short chain ACADS 1 Acyl-CoA thioesterase 1 Adaptin, beta 3A ADTB3A 2 Adducin, alpha ADD1 3 Adducin, beta ADD2 3 Adenosine deaminase ADA 1 Adenosine monophosphate deaminase AMPD 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A26 ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenyl cyclase 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 AOCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adenylate kinase AK1 1 Adenylosuccinate lyase ADSL 1 Adrenergic receptor, alphal ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenocorticotrophic hormone (ACTH) ACTHR 6 receptor Adrenoleukodystrophy gene ALD 1 Alanine aminotransferase 2 Alanine-glyoxylate aminotransferase AGXT 1 Albumin, ALB ALB 2 Alcohol dehydrogenase 1 ADH1 1 Alcohol dehydrogenase 2 ADH2 1 Alcohol dehydrogenase 3 ADH3 1 Alcohol dehydrogenase 4 ADH4 1 Alcohol dehydrogenase 5 ADH5 1 Alcohol dehydrogenase 6 ADH6 1 Alcohol dehydrogenase 7 ADH7 1 Aldehyde dehydrogenase 1 ALDH1 1 Aldehyde dehydrogenase 10 ALDH10 1 Aldehyde dehydrogenase 2 ALDH2 1 Aldehyde dehydrogenase 5 ALDH5 1 Aldehyde dehydrogenase 6 ALDH6 1 Aldehyde dehydrogenase 7 ALDH7 1 Aldolase A ALDOA 1 Aldolase B ALDOB 1 Aldolase C ALDOC 1 Aldosterone receptor MLR 6 Alkaline phosphatase, liver/bone/kidney ALPL 2 Alkaptonuria gene AKU 6 Alkylglycerone phosphate synthase AGPS 1 alpha tectorin TECTA 6 alpha thalassemia gene ATRX 5 alpha 1-antichymotrypsin AACT 1 alpha1-antitrypsin PI 1 alpha2-antiplasmin PLI 1 alpha-actinin 2 ACTN2 6 alpha-actinin 3 ACTN3 6 alpha-Galactosidase A GLA 1 Alpha-galactosidase B, GALB NAGA 1 alpha-synuclein SNCA 5 Amelogenin AMELX 3 Aminopeptidase P XPNPEP2 1 Amphiregulin AREG 6 Amylo-1,6-glucosidase AGL 1 Amyloid beta A4 precursor protein APP 5 Amyloid beta A4 precursor-like protein APLP 5 Androgen binding protein ABP 2 Androgen receptor AR 6 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCPI 1 Angiotensinogen AGT 1 Antidiuretic hormone receptor ADHR 2 Anti-Mulledan hormone AMH 6 Apolipoprotein A 4 APOA4 2 Apolipoprotein A I APOA1 2 Apolipoprotein A II APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOC1 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 1B AVPR1B 5 Arginine vasopressin receptor 2 AVPR2 5 Arrestin SAG 3 Aryl hydrocarbon receptor nuclear ARNT 2 translocator Arylsuffatase A ARSA 1 Arylsulfatase B ARSB 1 Arylsulfatase C ARSCI 1 Arylsulfatase D ARSD 1 Arylsulfatase E ARSE 1 Arylsulfatase F ARSF 1 Aspartate receptor 5 Aspartoacylase ASPA 1 Aspartylglucosaminidase AGA 1 Ataxia telangiectasia complementation group D ATD, ATDC 6 Ataxia telangiectasia gene, AT ATM 6 ATP cobalamin adenoxyltransferase 1 ATP sulphurylase atpsk2 1 ATP/ADP translocase 1 Aftractin 4 Autoimmune regulator, AIRE AIRE 4 BCL2-related protein A1 BCL2A1 6 Benzodiazepine receptor 5 Bestrophin VMD2 2 beta 2 Microglobulin B2M 4 beta-endorphin receptor 5 beta-galactosidase GLBI 1 beta-Glucuronidase GUSB 1 beta-synuclein SNCB 5 Bilirubin UDP-glucuronosyltransferase 1 Bloom syndrome protein BLM 6 Blue cone pigment BCP 3 Bone morphogenetic protein, BMP1 BMP1 6 Bone morphogenetic protein, BMP2 BMP2 6 Bone morphogenetic protein, BMP3 BMP3 6 Bone morphogenetic protein, BMP4 BMP4 6 Bone morphogenetic protein, BMP5 BMP5 6 Bone morphogenetic protein, BMP6 BMP6 6 Bone morphogenetic protein, BMP7 BMP7 6 Bone morphogenetic protein, BMP8 BMP8 6 Bradykinin receptor B1 4 Bradykinin receptor B2 4 Branched chain aminotransferase 1, cytosolic BCAT1 1 Branched chain aminotransferase 2, BCAT2 1 mitochondrial Breast cancer, ductal, 1 BRCD1 6 Breast cancer, ductal, 2 BRCD2 6 Butyrylcholinesterase BCHE 1 Ca(2+) transporting ATPase, fast twitch ATP2A1 2 Ca(2+) transporting ATPase, slow twitch ATP2A2 2 Cadherin E CDH1 6 Cadherin EP 6 Cadherin N CDH2 6 Cadherin P CDH3 6 Calbindin 1 CALB1 6 Calbindin D9K CALB3 6 Calcitonin receptor/Calcitonin gene-related CALCR 5 peptide receptor Calcitonin/Calcitonin gene-related peptide CALCA 5 alpha Calcium channel, voltage-dependent, L type, CACNA1S 5 alpha 1S subunit Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calmodulin 1 CALM1 6 Calmodulin 2 CALM2 6 Calmodulin 3 CALM3 6 Calnexin CANX 6 Calpain CAPN, 1 CAPN3 Cannabinoid receptor CNR1 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Camitine acetyltransferase CRAT 1 Camitine acylcarnitine translocase CACT 1 Carnitine palmitoyltransferase I CPT1A 1 Carnitine paimitoyltransferase II CPT2 1 Camitine transporter protein CDSP, SCD 2 Cartilage oligomeric matrix protein COMP, 5 EDM1, PSACH Cartilage-hair hypoplasia gene CHH 5 Catenin, beta CTNNB1 6 Cathepsin K CTSK 1 Caveolin 3 CAV3 1 CD1 CD1 C04 CD4 Ceroid lipofuscinosis neuronal 3 CLN3 5 Ce loplasmin precursor CP 1 Chemokine MCAF MCAF 4 Chloride channel 1, skeletal muscle CLCN1 3 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Cholesterol ester hydroxylase 1 Choline acetyltransferase CHAT 1 Choroideremia gene CHM 3 Citrate synthase 1 Clathdn 2 Cleft palate gene CPX 6 Cockayne syndrome gene, CKN1 CKN1 6 Coenzyme Q (CoQ)/ubiquinone 1 Collagen I alpha 1 COL1A1 3 Collagen I alpha 2 COL1A2 3 Collagen II alpha 1 COL2A1 3 Collagen III alpha 1 COL3A1 3 Collagen IV alpha 1 COL4A1 3 Collagen IV alpha 2 COL4A2 3 Collagen IV alpha 3 COL4A3 3 Collagen IV alpha 4 COL4A4 3 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Collagen IX alpha 2 COL9A2, 3 EDM2 Collagen IX alpha 3 COL9A3 3 Collagen receptor COLR 3 Collagen V alpha 1 COL5A1 3 Collagen V alpha 2 COL5A2 3 Collagen VI alpha 1 COL6AI 3 Collagen VI alpha 2 COL6A2 3 Collagen VI alpha 3 COL6A3 3 Collagen VII alpha 1 COL7A1 3 Collagen X alpha 1 COL10A1 3 Collagen X alpha 1 COLL11A1 3 Collagen XI alpha 2 COLL11A2 3 Collagen XVI I alpha 1 COL17A1 3 Collagenic-like tail subunit of asymmetric COLQ 1 acetylcholinesterase Collapsin 6 Colony-stimulating factor 1 CSF1 6 Colony-stimulating factor 1 receptor CSF1R 6 Colony-stimulating factor 2 CSF2 6 Colony-stimulating factor 2 alpha receptor CSF2RA 6 Colony-stimulating factor 2 beta receptor CSF2RB 6 Colony-stimulating factor 3 CSF3 6 Colony-stimulating factor 3 receptor CSF3R 6 Complement component C1 inhibitor C1NH 4 Complement component C1QA C1QA 4 Complement component C1QB C1QB 4 Complement component C1QG C1QG 4 Complement component C1r C1R 4 Complement component C1s C1S 4 Complement component C2 C2 4 Complement component C3 C3 4 Complement component C4A C4A 4 Complement component C4B C4B 4 Complement component C5 C5 4 Complement component C6 C6 4 Complement component C7 C7 4 Complement component C8 C8B 4 Complement component C9 C9 4 Complement component receptor 1 CR1 4 Complement component receptor 2 CR2 4 Complement component receptor 3 CR3 4 Complex 1 Complex II 1 Complex III 1 Complex III 1 Complex V MTATP6 1 Cone-rod homeobox-containing gene CRX 6 Coproporphyrinogen oxidase CPO 1 Core-binding factor, alpha 1 CBFAL 6 Core-binding factor, alpha 2 CBFA2 6 Core-binding factor, beta CBFB 6 Corticosteroid binding globulin CBG 5 Corticosteroid binding protein 2 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Cortisol receptor 4 C-reactive protein CRP 4 Creatine kinase - B and m CKBE 1 Creb binding protein CREBBP 6 Crystallin, alpha A CRYAA 3 Crystallin, alpha B CRYAB 3 Crystallin, beta B2 CRYBB2 3 Crystallin, gamma A CRYGA 3 c-src tyrosine kinase CSK 6 Cu2+ transporting ATPase alpha polypeptide ATP7A 1 Cu2+ transporting ATPase beta polypeptide ATP7B 1 Cyclic AMP response element binding protein 6 CREB Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase 1B1 PDE1B1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin-dependent kinase 2 CDK2 6 Cyclin-dependent kinase inhibitor IC (P57, CDKN1C 6 KIP2) Cyclin-dependent kinase inhibitor 2A (p16) CDKN2A 6 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cystinosin CTNS 2 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome b-5 CYB5 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 DAX1 nuclear receptor DAX1 4 Deafness dystonia peptide DDP 5 Delta-4,5-alpha-reductase 1 Delta aminolevulinate dehydratase ALAD 1 Delta(4)-3-oxosteroid 5-beta-reductase 1 Delta-7-dehydrocholesterol reductase DHCR7 1 Dentin sialophosphoprotein DSPP 6 Desmin DES 3 DHEA sulfotransferase STD 1 Diastrophic dysplasia sulfate transporter DTD 2 Dihydrolipoamide dehydrogenase DLD 5 Dihydroxyacetonephosphate acyltransferase DHAPAT 1 DNA damage binding protein, DDB1 DDB1 3 DNA damage binding protein, DDB2 DDB2 3 DNA methyltransferase DNMT 1 DNA-damage-inducible transcript 3 DDIT3 3 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Dynamin DNM1 6 Dynorphin receptor 5 Dyskehn DKC1 3 Dystonia 1 DYT1 3 Dystonia 3 DYT3 3 Dystonia 6 DYT6 3 Dystonia 7 DYT7 3 Dystrophia myotonica DM, DMPK 1 Dystrophia myotonica, atypical DM2 1 Dystrophin DMD 3 Dystrophin-associated glycoprotein 35 kD, SGCD 3 SCGD Dystrophin-associated glycoprotein 35 kD, SGCG 3 SGSG Dystrophin-associated glycoprotein 43 kD SGCB 3 Dystrophin-associated glycoprotein 50 kD SGCA 3 Ectodermal Dysplasia 1 gene ED1 3 Elastase 1 ELAS1 1 Elastase 2 ELAS2 1 Elastin ELN 3 Electron-transfering-flavoprotein alpha ETFA 2 Electron-transfe ng-flavoprotein beta ETFB 2 Electron-transferdng flavoprotein ETFDH 1 dehydrogenase Emerin EMD 2 Endocardial fibroelastosis 2 gene EFE2 3 Endometrial bleeding-associated factor EBAF 6 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 ED 3 5 Endothelin converting enzyme ECE1 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type 8 EDNRB 5 Engrailed-1 EN1 6 Engrailed-2 EN2 6 Enolase ENO1 1 Enoyl CoA hydratase 1 Enoyl CoA isomerase 1 Enoyl CoA reductase 1 Enterokinase PRSS7, 1 ENTK Ephrin receptor tyrosine kinase A EPHA 6 Ephrin receptor tyrosine kinase B EPHB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Erythrocyte membrane protein band 4.1 EPB41 3 Erythropoietin EPO 4 Erythropoietin receptor EPOR 4 Estrogen receptor ESR 6 Exostosin 1 EXT1 3 Exostosin 2 EXT2 3 Exostosin 3 EXT3 3 Eye colour gene 3 (brown) EYCL3 3 Eyes absent 1 EYA1 6 Faciogenital dysplasia FGDI, 2 FGDY Factor I (No. one) F1 Factor B, properdin Factor D Factor H HF1 Factor X F10 Fanconi anemia, complementation group A FANCA 2 Fanconi anemia, complementation group C FANCC 2 F nconi anemia, complementation group D 2 FANCD Fc fragment of IgG, high affinity IA, receptor FCGR1A 6 for Fc fragment of IgG, low affinity IIa, receptor FCGR2A 6 for (CD32) Ferritin, H subunit 2 Ferritin, L subunit FTL 2 Fibrillin 1 FBN1 6 Fibrillin 2 FBN2 6 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibroblast growth factor FGF1 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Fibronectin precursor FN1 6 Flightless-II, Drosaphila homolog of FLII 6 Folic acid receptor FOLR 6 Follicle stimulating hormone receptor FSHR, 6 ODG1 Follicle stimulating hormone, FSH FSHB 6 Forkhead transcription factor 10 FKHL10 6 Forkhead transcription factor 14 FKHL14 6 Forkhead transcription factor 7 FKHL7 6 Fragile site, folic acid type, rare, fra(X) A FRAXA 5 Frataxin FRDA 6 Fringe secreted protein, lunatic LFNG 6 Fringe secreted protein, manic MFNG 6 Fringe secreted protein, radical RFNG 6 Fructose-1,6-diphosphatase FBP1 1 Fucosidase alpha-L-1 FUCA1 1 Fucosidase alpha-L-2 1 Fukuyama type congenital muscular FCMD 6 dystrophy Fumarase FH 1 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma I GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 Galactocerebrosidase GALC 1 Galactokinase GALK1 1 Galactose I-phosphate uridyl-transferase GALT 1 Gamma-glutamyl carboxylase GGCX 2 Gap junction protein alpha 3 GJA3 2 Gap junction protein alpha 8 GJA8 2 Gap junction protein beta 3 GJB3 2 Gastrulation brain homeobox 2 GBX2 6 Glucosidase, acid alpha GAA 1 Glucosidase, acid beta GBA 1 Glutamate receptor 1 GLUR1 5 Glutamate receptor 2 GLUR2 5 Glutamate receptor 3 GLUR3 5 Glutamate receptor 4 GLUR4 5 Glutamate receptor 5 GLUR5 5 Glutamate receptor 6 GLUR6 5 Glutamate receptor 7 GLUR7 5 Glutamate receptor, ionotropic, NMDA 1 NMDAR1 5 Glutamate receptor, ionotropic, NMDA 2A NMDAR2A 5 Glutamate receptor, ionotropic, NMDA 2B NMDAR2B 5 Glutamate receptor, ionotropic, NMDA 2C NMDAR2C 5 Glutamate receptor, ionotropic, NMDA 2D NMDAR2D 5 Glutathione GSH 2 Glutathione peroxidase, GPX1 GPX1 1 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glyceraldehyde-3-phosphate GAPDH 1 dehydrogenase, GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycine receptor, alpha GLRA2 5 Glycine receptor, beta 5 Glycine transporter GLYT 5 Glycogen phosphorylase PYGL 1 Glycosyltransferases, ABO blood group ABO 1 GM2 ganglioside activator protein, GM2A GM2A 1 Green cone pigment GCP 3 Growth arrest-specific homeobox GAX 6 Growth factor receptor-bound protein 2 GRB2 6 Growth hormone 1 GH1 6 Growth hormone 2 (placental) GH2 6 Growth hormone receptor GHR 6 Growth hormone releasing hormone (GHRH) GHRH 6 Growth hormone releasing hormone receptor GHRHR 6 Growth/differentiation factor 5 GDF5 6 GTP cylcohydrolase 1 GCH1 6 GTPase-activating protein, GAP RASAL 6 Guanidinoacetate N-methyltransferase GAMT 1 Guanine nucleotide-binding protein, alpha GNAO1 5 activating activity polypeptide, GNAO y Guanine nucleotide-binding protein, alpha GNAI1 5 inhibiting activity polypeptide 1, GNA[L Guanine nucleotide-binding protein, alpha GNAI2 5 inhibiting activity polypeptide 2, GNA 2 Guanine nucleotide-binding protein, alpha GNAI3 5 inhibiting activity polypeptide 3, GNA[3 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS I Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, alpha GNAT1 5 transducing activity polypeptide, GNATI Guanine nucleotide-binding protein, alpha GNAT2 5 transducing activity polypeptide, GNAT2 Guanine nucleotide-binding protein, beta GNB3 5 polypeptide 3 Guanine nucleotide-binding protein, gamma GNG5 5 polypeptide 5 Guanine nucleotide-binding protein, q GNAQ 5 polypeptide Guanylate cyclase 2D, membrane (retina- GUCY2D 1 specific) Guanylate cyclase activator 1A (retina) GUCALA 1 H(+), K(+) - ATPase ATP4B 5 Haeme regulated inhibitor kinase 1 Haemoglobin alpha 1 HBAL 2 Haemoglobin alpha 2 HBA2 2 Haemoglobin beta HBB 2 Haemoglobin delta HBD 2 Haemoglobin gamma A HBG1 2 Haemoglobin gamma B HBG2 2 Haemoglobin gamma G HBGG 2 Hairless HR 6 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Heat shock protein, HSPA1 4 Heat shock protein, HSPA2 4 Heparan sulfamidase 1 Heparin binding epidermal growth factor HBEGF 6 Heparin Cofactor II HCF2 4 Hepatocyte growth factor HGF 6 Hermansky-pudiak syndrome gene HPS 2 Hexokinase 2 HK2 1 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 HLA-B associated transcript 1 BAT1 4 Holocarboxylase synthetase HLCS 1 Holoprosencephaly 1 HPEI 6 Holoprosencephaly 2 HPE2 6 Holoprosencephaly 3 HPE3 6 Holoprosencephaly 4 HPE4 6 Homeobox (HOX) gene A1 HOXA1 6 Homeobox (HOX) gene A10 HOXA10 6 Homeobox (HOX) gene A11 HOXA11 6 Homeobox (HOX) gene A12 HOXA12 6 Homeobox (HOX) gene A13 HOXA13 6 Homeobox (HOX) gene A2 HOXA2 6 Homeobox (HOX) gene A3 HOXA3 6 Homeobox (HOX) gene A4 HOXA4 6 Homeobox (HOX) gene A5 HOXA5 6 Homeobox (HOX) gene A6 HOXA6 6 Homeobox (HOX) gene A7 HOXA7 6 Homeobox (HOX) gene A8 HOXA8 6 Homeobox (HOX) gene A9 HOXA9 6 Homeobox (HOX) gene Bl HOXBL 6 Homeobox (HOX) gene B2 HOXB2 6 Homeobox (HOX) gene B3 HOXB3 6 Homeobox (HOX) gene B4 HOXB4 6 Homeobox (HOX) gene B5 HOXB5 6 Homeobox (HOX) gene B6 HOXB6 6 Homeobox (HOX) gene B7 HOXB7 6 Homeobox (HOX) gene B8 HOXB8 6 Homeobox (HOX) gene B9 HOXB9 6 Homeobox (HOX) gene C13 HOXC13 6 Homeobox (HOX) gene C4 HOXC4 6 Homeobox (HOX) gene C8 HOXC8 6 Homeobox (HOX) gene C9 HOXC9 6 Homeobox (HOX) gene D1 HOXD1 6 Homeobox (HOX) gene D10 HOXD10 6 Homeobox (HOX) gene D12 HOXD12 6 Homeobox (HOX) gene D13 HOXD13 6 Homeobox (HOX) gene D3 HOXD3 6 Homeobox (HOX) gene D4 HOXD4 6 Homeobox (HOX) gene D8 HOXD8 6 Homeobox (HOX) gene D9 HOXD9 6 Homeobox 11 HOX11 6 Homeobox HB24 HLX1 6 Homeobox HB9 HLXB9 6 Homeobox, PROX1 PROX1 6 Homogentisate 1,2 dioxygenase HGD 1 Human placental lactogen CSH1 6 Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 IC7 A and B 4 Immunoglobulin E (IgE) reponsiveness gene IGER 4 Indian hedgehog, ihh IHH 6 Inhibin, alpha INHA 6 Inhibin, beta A INHBA 6 Inhibin, beta B INHBB 6 Inhibin, beta C INHBC 6 Inositol 1,4,5-triphosphate receptor 3 ITPR3 6 Insulin promotor factor 1 IPF1 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 Integrin beta 1 ITGBL 6 Integrin beta 3 ITGB3 6 Integrin beta 4 ITGB4 6 Integrin, alpha 5 ITGA5 6 Integrin, alpha 7 ITGA7 6 Inter-alpha-trypsin inhibitor, IATI 1 Interferon alpha IFNA1 4 Interferon beta IFNB 4 Interferon gamma IFNG 4 Interferon gamma receptor 1 IFNGR1 4 Interferon gamma receptor 2 IFNGR2 4 Interferon regulatory factor 1 IRF1 4 Interferon regulatory factor 4 IRF4 4 Interleukin(IL) 1 receptor IL1R 4 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) 10 IL10 4 interleukin(IL) 10 receptor IL10R 4 Interleukin(IL) 11 IL11 4 Interleukin(IL) 11 receptor IL11R 4 Interleukin(IL) 12 IL12 4 Interleukin(IL) 12 receptor, beta 1 IL12RB1 4 lnterleukin(IL) 13 IL13 4 lnterleukin(IL) 13 receptor IL13R 4 lnterleukin(IL) 2 IL2 4 Interleukin(IL) 2 receptor, alpha IL2RA 4 Interleukin(IL) 2 receptor, gamma IL2RG 4 lnterleukin(IL) 3 IL3 4 Interleukin(IL) 3 receptor IL3R 4 Interleukin(IL) 4 IL4 4 Interleukin(IL) 4 receptor IL4R 4 Interleukin(IL) 5 IL5 4 lnterleukin(IL) 5 receptor IL5R 4 Interleukin(IL) 6 IL6 4 Interleukin(IL) 6 receptor IL6R 4 Interleukin(IL) 7 IL7 4 lnterleukin(IL) 7 receptor IL7R 4 lnterleukin(IL) 8 IL8 4 Interleukin(IL) 8 receptor IL8R 4 lnterleukin(IL) 9 IL9 4 Interleukin(IL) 9 receptor IL9R 4 lnterleukin(IL) receptor antagonist I 1L1RN, 4 IL1RA lsocitrate dehydrogenase 1 Kaliman sypdrome gene 1 KAL1 6 Keratin 1 KRT1 3 Keratin 10 KRT10 3 Keratin 11 KRT11 3 Keratin 12 KRT12 3 Keratin 13 KRT13 3 Keratin 14 KRT14 3 Keratin 15 KRTI 5 3 Keratin 16 KRT16 3 Keratin 17 KRT17, 3 PCHC1 Keratin 18 KRT18 3 Keratin 2 KRT2 3 Keratin 3 KRT3 3 Keratin 4 KRT4 3 Keratin 5 KRT5 3 Keratin 6 KRT6 3 Keratin 7 KRT7 3 Keratin 8 KRT8 3 Keratin 9 KRT9 3 Keratin, hair acidic 1 KRTHA1 3 Keratin, hair basic 2 KRTHB1 3 Keratin, hair basic 6 KRTHB6 3 Kininogen, High molecular weight KNG 4 Lactate dehydrogenase, A LDHA 1 Lactate dehydrogenase, B LDHB 1 Lamin A/C LMNA 6 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin 5, gamma 2 LAMC2 6 Laminin M LAMM 6 Laminin receptor 1 LAMRI 6 Latent transforming growth factor-beta LTBP2 6 binding protein 2 Leukocyte-specific transcript 1 LST-1 4 Leukotriene A4 hydrolase 4 Leukotriene A4 synthase LTA4S 1 Leukotriene B4 receptor 4 Leukotriene B4 synthase LTB4S 1 Leukotriene C4 receptor 4 Leukotriene C4 synthase LTC4S 1 LIM homeobox transcription factor 1, beta LMX1B 6 Limb girdle muscular dystrophy 1A LGMD1A 6 Limb girdle muscular dystrophy 1B LGMD1B 6 Limb girdle muscular dystrophy 2G LGMD2G 6 Limb girdle muscular dystrophy 2H LGMD2H 6 Limbic associated membrane protein LAMP 6 Lipoprotein receptor, Low Density LDLR 2 Lipoxygenase 12 (platelets) LOG12 4 Loricrin LOR 3 Low density lipoprotein receptor-related LRP 2 protein precursor Luteinizing hormone-releasing hormone 5 Luteinizing hormone-releasing hormone 5 receptor Lymphotoxin 4 Lysosome-associated membrane protein 1 LAMP1 6 Lysosome-associated membrane protein 2 LAMP2 6 Lysozyme LYZ 4 Lysyl hydroxylase PLOD 1 Lysyl oxidase LOX 1 Macrophage activating factor MAF 4 Macrophage inflammatory protein-1 MIP1 4 Macrophage inflammatory protein-1 receptor 4 Macrophage inflammatory protein-2 MIP2 4 Macrophage inflammatory protein-2 receptor 4 MADS box transcription-enhancer factor 2A MEF2A 6 MADS box transcription-enhancer factor 2B MEF2B 6 MADS box transcription-enhancer factor 2C MEF2C 6 MADS box transcription-enhancer factor 2D MEF2D 6 Mannose binding protein MBP 4 Mannosidase, alpha B lysosomal MANB 1 Mannosidase, beta A lysosomal MANBA 1 Marenostrin MEFV 2 Matrix Gla protein MGP 6 Matrix metalloproteinase 1 MMP1 1 Matrix metalloproteinase 10 MMP10 1 Matrix metalloproteinase 11 MMP11 1 Matrix metalloproteinase 12 MMP12 1 Matrix metalloproteinase 13 MMP13 1 Matrix metalloproteinase 14 MMP14 1 Matrix metalloproteinase 15 MMPI 5 1 Matrix metalloproteinase 16 MMP16 1 Matrix metalloproteinase 17 MP17 1 Matrix metalloproteinase 18 MMP18 1 Matrix metalloproteinase 19 MMP19 1 Matrix metalloproteinase 2 MMP2 1 Matrix metalloproteinase 3 MMP3, 1 STMYJ Matrix metalloproteinase 4 MMP4 1 Matrix metalloproteinase 5 MMP5 1 Matrix metalloproteinase 6 MMP6 1 Matrix metalloproteinase 7 MMP7 1 Matrix metalloproteinase 8 MMP8 1 Matrix metalloproteinase 9 MMP9 1 MEK kinase, MEKK 1 Melanocortin 1 receptor MC1R 2 Melanocortin 2 receptor MC2R 2 Melanocortin 4 receptor MC4R 2 Mesoderm-specific transcript MEST 6 Methylguanine-DNA methyltransferase MGMT 1 Methylmalonyl-CoA mutase MUT 1 Mevalonate kinase MVK 1 MHC Class 1: A 4 MHC Class 1: B 4 MHC Class 1: C 4 MHC Class 1: LMP-2, LMP-7 4 MHC Class 1: Tap1 ABCR, 4 TAP1 MHC Class II: DP HLA-DPB1 4 MHC Class II: DQ 4 MHC Class II: DR 4 MHC Class II: Tap2 TAP2, PSF2 4 MHC Class II: Complementation group A MHC2TA 4 MHC Class II: Complementation group B RFXANK 4 MHC Class II: Complementation group C RFX5 4 MHC Class II: Complementation group D RFXAP 4 Microphthalmia-associated transcription MITF 6 factor Midline 1 MID1 6 Mitochondrial trifunctional protein, alpha HADHA 1 subunit Mitochondrial trifunctional protein, beta HADHB 1 subunit Moesin, MSN 3 Molybdenum cofactor synthesis 1 MOCS1 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Monocyte chemoattractant protein 1 MCP1 4 Mucolipidoses GNPTA 1 Mulibrey nanism MUL 2 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Muscle phosphoylase PYGM 1 Mutated in colorectal cancers, MCC MCC 6 MutS homolog 3 MSH3 6 Myeloperoxidase MPO 4 Myocilin MYOC 2 Myogenic factor 3 MYF3 6 Myogenic factor 4 MYF4 6 Myogenic factor 5 MYF5 6 Myoglobin 2 Myomesin 1 MYOM1 3 Myomesin 2 MYOM2 3 Myopia 1 MYP1 2 Myopia 2 MYP2 2 Myosin 15 MYO15 3 Myosin 5A MYO5A 3 Myosin 6 MYO6 3 Myosin 7A MYO7A 3 Myosin, cardiac MYH7 3 Myosin, light chain 2 MYL2 3 Myosin, light chain 3 MYL3 3 Myotubuladn MTM1 3 Na+, K+ ATPase, alpha ATP1A1 6 Na+, K+ ATPase, beta 1 ATP1B1 6 Na+, K+ ATPase, beta 2 ATP1B2 6 Na+, K+ ATPase, beta 3 ATP1B3 6 Na+/H+ exchanger 1 NHEI 2 Na+/H+ exchanger 2 NHE2 2 Na+/H+ exchanger 3 NHE3 2 Na+/H+ exchanger 4 NHE4 2 Na+/H+ exchanger 5 NHE5 2 N-acetylgalactosamine-6-sulfate sulfatase GALNS 1 N-acetylglucosamine-6-suffatase GNS 1 N-acetylglucosaminidase, alpha NAGLU 1 NADH dehydrogenase 1 NADH-cytochrome b5 reductase DIA1 1 reductase NB6 4 Nebulin EB 3 Nephrosis 1 NPHS1 2 Neural retina-specific gene NRL 6 Neuraminidase sialidase NEU 2 Neuregulin HGL 6 Neurexin 5 Neuroendocrine convertase 1 NEC1, 1 PCSK1 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neurotensin NTS 5 Neurotensin receptor NTSR1 5 Nibrin NBS1 6 Noggin NOG 6 Notch ligand - jagged 1 JAG 1, AGS 6 Nuclear factor 1-kappa-B-like gene IKBL 4 Nuclear factor kappa beta NFKB 4 Nuclear factor of activated T cells (NFAT) NFATC 6 complex, cytosolic Nuclear factor of activated T cells (NFAT) NFATP 6 complex, preexisting component Ocular albinism 1 OA1 3 Oculocutaneous albinism 11 OCA2 3 Oncogene ERG (early reponse gene) 6 Oncogene fos FOS 6 Oncogene GLI1 GLI 6 Oncogene GLI2 GLI2 6 Oncogene GLI3 GLI3 6 Oncogene sis PDGFB 6 Oncogene src 6 Opioid receptor, delta OPRD1 5 Opioid receptor, kappa OPRK1 5 Opioid receptor, mu OPRM1 5 Ornithine delta-aminotransferase OAT 1 Osteocalcin 3 Osteonectin ON 6 Osteopontin OPN 6 Osteoprotegerin OPG 6 Oxytocin OXT 5 Oxytocin receptor OXTR 5 p21-activated kinase 3 PAK3 6 Paired box homeotic gene 1 PAX1 6 Paired box homeotic gene 2 PAX2 6 Paired box homeotic gene 3 PAX3 6 Paired box homeotic gene 6 PAX6 6 Paired box homeotic gene 7 PAX7 6 Paired box homeotic gene 8 PAX8 6 Paired-like homeodomain transcription factor 2 PITX2 6 Paired-like homeodomain transcription factor 3 PITX3 6 Parathyroid hormone PTH 6 Parathyroid hormone receptor PTHR1 6 Parathyroid hormone related-peptide PTHRP 6 Parathyroid hormone-like hormone PTHLH 6 Patched (Drosophila) homolog, PTCH PTCH 6 Peanut-like 1 PNUTL1 4 Peripherin, PRPH 3 Peroxisomal membrane protein 1 PXMP1 3 Peroxisoma membrane protein 3 PXMP3 2 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome receptor 1 PXR1 2 Phenylethanolamine N-methyltransferase, PNMT 1 PNMT Phosphate regulating gene with homologies PHEX 6 to endopeptidases on the X chromosome Phosphodiesterase 1/nucleotide PDNP1 6 pyrophosphatase 1 Phosphodiesterase 1/nucleotide PDNP2 6 pyrophosphatase 2 Phosphodiesterase 1/nucleotide PDNP3 6 pyrophosphatase 3 Phosphofructokinase, muscle PFKM 1 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase 1 PGK1 1 Phosphoglycerate mutase 2 PGAM2 1 Phospholipase A2, group 10 PLA2G10 4 Phospholipase A2, group 1B PLA2G1B Phospholipase A2, group 2A PLA2G2A Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PG4A 4 Phospholipase A2, group 4C P 2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phosphomannomutase 2 PMM2 6 Phosphoribosyl pyrophosphate synthetase PRPS1 1 Phosphorylase kinase, alpha 1 (muscle) PHKA1 1 Phosphorylase kinase, beta PHKB 1 Phosphorylase kinase, delta 1 Phosphorylase kinase, gamma 2 PHKG2 1 Phytanoyi-CoA hydroxylase PHYH 6 Pineolytic beta-receptors 1 Plakophilin 1 PKP1 2 Plasminogen PLG 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Plectin 1 PLEC1 2 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCN03 5 POU domain, class 3, transcription factor 4 POU3F4 6 POU domain, class 4, transcription factor 3 POU4F3 6 Prion protein PRNP 5 Procollagen N-protease 1 Procollagen peptidase 1 Prodynorphin 5 Profibrinolysin 6 Prolactin receptor PRLR 6 Prolactin releasing hormone PRH 6 Proliferin PLF 6 Proopiomelanocortin POMC 5 Properdin P factor, complement PFC, PFD 4 Prophet of Pit1 PROP1 6 Propionyl-CoA carboxylase, alpha PCCA 1 Prosaposin PSAP 5 Prostacyclin synthase 4 Prostaglandin 15-OH dehydrogenase HGPD; 4 PGDH Prostaglandin D - DP receptor 4 Prostaglandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostaglandin F2 alpha receptor 4 Prostaglandin I2 receptor 2 Prostaglandin IP receptor 4 Prostaglandin isomerase 6 Protease nexin 2 PN2 1 Protective protein for beta-galactosidase PPGB 1 Protein C PROC 4 Proteinase 3 4 Purine nucieoside phosphorylase NP 1 Purinergic receptor P1A1 5 Purinergic receptor P1A2 5 Purinergic receptor P1A3 5 Purinergic receptor P2X, 1 P2RX1 5 Purinergic receptor P2X, 2 P2RX2 5 Purinergic receptor P2X, 3 P2RX3 5 Pudnergic receptor P2X, 4 P2RX4 5 Purinergic receptor P2X, 5 P2RX5 5 Purinergic receptor P2X, 6 P2RX6 5 Purinergic receptor P2X, 7 P2RX7 5 Purinergic receptor P2Y, 1 P2RY1 5 Purinergic receptor P2Y, 11 P2RY11 5 Purinergic receptor P2Y, 2 P2RY2 5 Pyrroline-5-carboxylate synthetase PYCS 1 Pyruvate kinase PKLR 1 Rabphilin 5 Radixin RDX 3 RAS-associated protein, RAB3A RAB3A 5 Rathke pouch homeobox, RPX RPX 6 Receptor tyrosine kinase (RTK), NSK2 NSK2 6 Retina pigment epithelium specific protein RPE65 3 (65 kD) Retinitis pigmentosa gene 1 RP1 3 Retinitis pigmentosa gene 2 RP2 3 Retinitis pigmentosa gene 3 RP3 3 Retinitis pigmentosa gene 6 RP6 3 Retinitis pigmentosa gene 7 RP7, RDS 3 Retinoblastoma 1 RB1 6 Retinoic acid receptor, alpha RARA 6 Retinoic acid receptor, beta RARB 6 Retinoic acid receptor, gamma RARG 6 Retinoid X receptor, alpha RXRA 6 Retinoid X receptor, beta RXRB 6 Retinoid X receptor, gamma RXRG 6 Retinol binding protein 4 RBP4 2 Rhodopsin RHO 3 RIGUI RIGUI 6 Rim 5 Rod outer segment membrane protein 1 ROM1 3 Ryanodine receptor 1, skeletal RYR1 6 Serotonin N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTRI1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sex hormone binding globulin, SHBG 2 Sialoprotein, bone BSP 6 Signal transducer and activator of STAT1 6 transcription 1 Signaling lymphocyte activation molecule SLAM 4 Sine oculis homeobox, drosophila, homolog 1 SIX1 6 Sine oculis homeobox, drosophila, homolog 2 SIX2 6 Sine oculis homeobox, drosophila, homolog 5 SIX5 3 Sjoegren (Sjogren) syndrome antigen A1 SSA1 4 Slug protein 6 Small nuclear ribonucleoprotein polypeptide N SNRPN 3 Smoothelin SMTN 6 Smoothened (Drosophila) homolog SMOH 6 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, SCNN1G 5 gamma Sodium channel, voltage gated, type IV, SCN4A 5 alpha polypeptide Sodium channel, voltage gated, type V, alpha SCN5A 5 polypeptide Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 1 (glutamate SLC1A1 2 transporter), member 1 Solute carrier family 1 (glutamate SLC1A2 2 transporter), member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 16 (monocarboxylate SLC16A1 2 transporter), member 1 Solute carrier family 16 (monocarboxylate SLC16A7 2 transporter), member 7 Solute carrier family 17, member 1 SLC17A1 2 Solute carrier family 17, member 2 SLC17A2 2 Solute carder family 19 (folate transporter), SLC19A1 2 member 1 Solute carrier family 21, member 2 SLC21A2 2 Solute carrier family 21, member 3 SLC21A3 2 Solute carrier family 25, member 12 SLC25A12 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmifter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmifter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6, member IO SLC6A10 2 Solute carrier family 6, member 8 SLC6A8 2 Solute carrier family 7(amino acid SLC7A1 2 transporter), member 1 Solute carrier family 7(amino acid SLC7A2 2 transpo er), member 2 Solute carrier family 7(amino acid SLC7A7 2 transporter), member 7 Solute carrier family 8 (sodium/calcium SLC8A1 2 exchanger), member 1 Somatostatin SST 5 Somatostatin receptor, SSTR1 SSTR1 5 Somatostatin receptor, SSTR2 SSTR2 6 Somatostatin receptor, SSTR3 SSTR3 5 Somatostatin receptor, SSTR4 SSTR4 5 Somatostatin receptor, SSTR5 SSTR5 5 Sonic hedgehog, SHH SHH 6 Sorbitol dehydrogenase SORD 1 Sorcin SRI 2 Spectrin alpha SPTA1 3 Spectrin beta SPTB 3 Sperm adhesion molecule SPAM1 6 Sperm prolamine P1 PRM1 6 Sperm prolamine P2 PRM2 6 Sphingomyelinase SMPD1 1 Split hand/foot malformation gene DSS1 6 SRY-box 10 SOX10 6 SRY-box 11 SOX11 6 SRY-box 3 SOX3 6 SRY-box 4 SOX4 6 SRY-box 9 SOX9 6 Steroid 5 alpha reductase 1 SRD5A1 1 Steroid 5 alpha reductase 2 SRD5A2 1 Steroid sulphatase STS 1 Substance P 5 Succinate dehydrogenase 1 SDH1 1 Succinate dehydrogenase 2 SDH2 1 Sulfamidase SGSH 6 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 Survival of motor neuron 1, telomeric SMN1 2 Synapsin I a & I b SYN1 5 Synapsin 2a & 2b SYN2 5 Synaptic vesicle protein 2 SV2 5 Synaptobrevin 1 SYB1 5 Synaptobrevin 2 SYB2 5 Synaptogyrin 5 Synaptophysin SYP 5 Synaptosomal-associated protein, 25 KD SNAP25 5 Synaptotagmin 1 SYT1 5 Synaptotagmin 2 SYT2 5 Synovial sarcoma gene 1 SSX1 6 Synovial sarcoma gene 2 SSX2 6 Syntaxin 1 STX1 5 Tachykinin receptor, NK1R TACR1 5 Tachykinin receptor, NK2R TACR2 5 Tachykinin receptor, NK3R TACR3 5 Talin, TLN 3 T-BOX 1 TBX1 6 T-BOX 2 TBX2 6 T-BOX 3 TBX3 6 T-BOX 4 TBX4 6 T-BOX 5 TBX5 6 T-BOX 6 TBX6 6 TEK, tyrosine kinase, endothelial TEK 1 Telomerase protein component 1 Tetranectin TNA 2 Thrombospondin THBS1 6 Thromboxane A synthase 1 TBXAS1 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thymosin 4 Thyrotropin releasing hormone TRH 5 Thyrotropin releasing hormone TRH 6 Thyrotropin releasing hormone receptor TRHR 5 Tip-associated protein TAP 4 Tissue non-specific alkaline phosphatase 1 TNSAP Titin TTN 3 Tocopherol (alpha) transfer protein TTPA 2 Torticollis, keloids, cryptorchidism and renal TKCR 6 dysplasia gene Transforming growth factor, alpha TGFA 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFBI 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transglutaminase 1 TGM1 6 Transglutaminase 2 TGM2 6 Transglutaminase 4 TGM4 6 Transthyretin TTR 2 Treacle gene TCOF1 6 Triosephosphate isomerase TPI 1 1 Tropomyosin 1 alpha TPM1 3 Tropomyosin 3 (non-muscle) TPM3 3 Troponin C 3 Troponin I TNNI3 3 Troponin T2, cardiac TNNT2 3 Tryypsinogen 1 TRYI 1 Trypsinogen 2 TRY2 1 Tubby-like protein TULP1 6 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tumor susceptibility gene 101 TSG101 6 Tumour necrosis factor (TNF) receptor TRAF1 4 associated factor 1 Tumour necrosis factor (TNF) receptor TRAF2 4 associated factor 2 Tumour necrosis factor (TNF) receptor TRAF3 4 associated factor 3 Tumour necrosis factor (TNF) receptor TRAF4 4 associated factor 4 Tumour necrosis factor (TNF) receptor TRAF5 4 associated factor 5 Tumour necrosis factor (TNF) receptor TRAF6 4 associated factor 6 Tumour necrosis factor alpha TNFA 4 Tumour necrosis factor alpha receptor TNFAR 4 Tumour necrosis factor beta TNFB 4 Tumour necrosis factor beta receptor TNFBR 4 Tumour protein p53 TP53, P53 6 Tumour protein p63 TP63 6 Tumour protein p73 TP73 6 Tumour protein, translationally-controlled 1 TPT1 6 Tumour suppresssor gene DRA DRA 4 Tyrosinase TYR 1 Tyrosinase-related protein 1 TYRP1 1 Tyrosine aminotransferase TAT 1 Ubiquitin activating enzyme, E1 1 Ubiquitin protein ligase E3A UBE3A 1 Uncoupling protein 3 UCP3 2 Undulin 1 COL14AI 3 Uroporphyrinogen decarboxylase UROD 1 Usher syndrome 2A USH2A 3 Vacuolar proton pump, subunit 1 VPP1 5 Vacuolar proton pump, subunit 3 VPP3 5 Vascular endothelial growth factor VEGF 6 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Villin 3 Vinculin 3 Vitamin D receptor VDR 6 Vitelliform macular dystrophy, atypical gene VMD1 2 Von Hippel-Lindau gene VHL 6 Von Willebrand factor VWF 2 Werner syndrome helicase WRN 6 Winged helix nude WHN 6 Wingless family, wnt2 WNT2 6 Wingless family, wnt4 WNT4 6 Wingless family, wnt5 WNT5 6 Wingless family, wnt7 WNT7 6 Wingless family, wnt8 WNT8 6 Wiskoft-Aldrich syndrome protein WASP, THC 4 Wnt inhibitory factor, WIF-1 WIF1 6 Wolf-Hirschhorn syndrome candidate 1 gene WHSC1 6 Wolfram syndrome 1 gene WFS1 3 Xeroderma pigmentosum, complementation XPA 1 group A Xeroderma pigmentosum, complementation XPB 1 group B Xeroderma pigmentosum, complementation XPC 1 group C Xeroderma pigmentosum, complementation 1 group D Xeroderma pigmentosum, complementation 1 group E Xeroderma pigmentosum, complementation XPF 1 group F Xeroderma pigmentosum, complementation ERCC5 1 group G X-ray repair gene XRCC9 6,

that the genes associated with endocrine and metabolic malfunction, damage or disease are selected from: HUGO List of genes gene symbol Protein-function 17beta Hydroxysteroid dehydrogenase 1 HSD17B1 1 17beta Hydroxysteroid dehydragenase 3 HSD17B3 1 17beta Hydroxysteroid dehydrogenase 4 HSD17B4 1 17beta Hydroxysteroid oxidoreductase 1 17-Ketosteroid reductase 5 18-Hydroxysteroid oxidoreductase 1 2,3-Bisphosphoglycerate mutase BPGM 1 2,4-Dienoyl CoA reductase DECR 1 3 beta Hydroxysteroid dehydrogenase 2 HSD3B2 1 3-Oxoacid CoA transferase OXCT 1 5-Adenosyl homocysteine hydrolase 1 6-Phosphofructo-2-kinase PFKFBL 1 6-Pyruvoyltetrahydropterin synthase PTS 1 Acetoacetyl 1-CoA-thiolase ACAT1 1 Acetyl CoA acyltransferase ACAA 1 Acetyl CoA carboxylase ACC 1 Acetyl CoA carboxylase alpha ACACA 1 Acetylcholinesterase ACHE 1 Acid phosphatase 2, lysosomal ACP2 1 Actin, alpha, cardiac ACTC 3 Actin, alpha, skeletal ACTA1 3 Actin, alpha, smooth, aortic ACTA2 3 Activin 6 Activin A receptor, type 2B ACVR2B 6 Activin A receptor, type 2-like kinase 1 ACVRL1 6 Acyl CoA dehydrogenase, long chain ACADL 1 Acyl CoA dehydrogenase, medium chain ACADM 1 Acyl CoA dehydrogenase, short chain ACADS 1 Acyl CoA dehydrogenase, very long chain ACADVL 1 Acyl CoA synthetase, long chain, 1 LACS1 1 Acyl CoA synthetase, long chain, 2 LACS2 1 Acyl CoA synthetase, long chain, 4 ACS4 1 Acyl malonyl condensing enzyme 1 Adenomatous polyposis coli tumour APC 6 supressor gene Adenosine deaminase ADA 1 Adenosine monophosphate deaminase AMPD 1 Adenosine receptor A1 ADORA1 5 Adenosine receptor A2A ADORA2A 5 Adenosine receptor A28 ADORA2B 5 Adenosine receptor A3 ADORA3 5 Adenyl cyclase 5 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adenylate transferase 1 ADP-ribosyltransferase ADPRT 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenoleukodystrophy gene ALD 1 Albumin, ALB ALB 2 Alcohol dehydrogenase ADH 1 Alcohol dehydrogenase 2 ADH2 1 Alcohol dehydrogenase 3 ADH3 1 Alcohol dehydrogenase 4 ADH4 1 Alcohol dehydrogenase 5 ADH5 1 Alcohol dehydrogenase 6 ADH6 1 Alcohol dehydrogenase 7 ADH7 1 Aldehyde dehydrogenase 1 ALDH1 1 Aldehyde dehydrogehase 10 ALDH10 1 Aldehyde dehydrogenase 2 ALDH2 1 Aldehyde dehydrogenase 5 ALDH5 1 Aldehyde dehydrogenase 6 ALDH6 1 Aldehyde dehydrogenase 7 ALDH7 1 Aldolase A ALDOA 1 Aldolase B ALDOB 1 Aldolase C ALDOC 1 Aldosterone receptor MLR 6 Alkaline phosphatase, liver/bone/kidney ALPL 2 Alkylglycerone phosphate synthase AGPS 1 Alpha 1 acid glycoprotein AAG; AGP 2 alpha1-antitrypsin PI 1 alpha-actinin 2 ACTN2 6 alpha-actinin 3 ACTN3 6 alpha-amino adipic semialdehyde synthase 1 alpha-glucosidase, neutral AB GANAB 1 alpha-glucosidase, neutral C GANC 1 alpha-ketoglutarate dehydrogenase 1 Aminomethyltransferase AMT 1 Aminopeptidase P XPNPEP2 1 Amphiregulin AREG 6 Amylo-1,6-glucosidase AGL 1 Androgen receptor AR 6 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCPL 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Anglotensinogen AGT 1 Anti-Multerian, hormone AMH 6 Anti-Mullerian hormone type 2 receptor AMHR2 6 Apolipoprotein A I APOA1 2 Apolipoprotein A II APOA2 2 Apolipoprotein B APOB 2 Apolipoprotein C1 APOC1 2 Apolipoprotein C2 APOC2 2 Apolipoprotein C3 APOC3 2 Apolipoprotein D APOD 2 Apolipoprotein E APOE 2 Apolipoprotein H APOH 2 Aquaporin 1 AQP1 2 Aquaporin 2 AQP2 2 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 2B AVPR1B 5 Arginine vasopressin receptor 2 AVPR2 5 Asparagine synthetase AS 1 Aspartate transcarbamoylase 1 Ataxia telangiectasia complementation group D ATD, ATDC 6 Ataxia telangiectasia gene, AT ATM 6 ATP cobalamin adenoxyltransferase 1 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atdal natriuretic peptide receptor C NPR3 6 Attractin Autoimmune regulator, AIRE AIRE beta-endorphin receptor 5 beta-galactosidase GLB I 1 beta-ketoacyl reductase 1 Bile acid coenzyme A: amino acid N- BAAT 1 acyltransferase Bile salt export pump BSEP, PFIC2 2 Bile salt-stimulated lipase CEL 1 Bilirubin UDP-glucuronosyltransferase 1 Bloom syndrome protein BLM 6 Bradykinin receptor B1 4 Bradykinin receptor B2 4 Branched chain aminotransferase 1, cytosolic BCAT1 1 Branched chain aminotransferase 2, BCAT2 1 mitochondrial Branched chain keto acid dehydrogenase E1, BCKDHA 1 alpha polypeptide Branched chain keto acid dehydrogenase E1, BCKDHB 1 beta polypeptide Butyrylcholinesterase BCHE 1 C17-20 desmolase 1 C3 convertase 1 Calbindin 1 CALB1 6 Calbindin DgK CALB3 6 Calcineurin A1 CALNA1 4 Calcineurin A2 CALNA2 4 Calcineurin A3 CALNA3 4 Calcineurin B 4 Calcitonin receptor/Calcitonin gene-related CALCR 5 peptide receptor Calcitonin/Calcitonin gene-related peptide alpha CALCA 5 Calcium channel, voltage-dependent, alpha CACNA1F 5 I F subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 I B (CACNL1A5) Calcium channel, voltage-dependent, Alpha-1 C CACNA1C 5 Calcium channel, voltage-dependent, Alpha-I D CACNA1D 5 Calcium channel, voltage-dependent, Alpha- CACNA1E 5 1 E (CACN1A6) Calcium channel, voltage-dependent, Alpha- CACNA2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, L type, CACNALS 5 alpha 1S subunit Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calcium sensing receptor CASR 2 Calmodulin 1 CALM1 6 Calmodutin 2 CALM2 6 Calmodulin 3 CALM3 6 Calmodulin-dependant protein kinase II CAMK2A 6 Calnexin CANX 6 Calpain CAPN, CAPN3 1 Calretinin CALB2 5 Canalicular multispecific organic anion CMOAT 2 transporter Cannabinoid receptor CNR1 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Carboxylesterase 1 CES1 1 Cardiac-specific homeobox, CSX CSX 6 Carnitine acetyltransferase CRAT 1 Carnitine acylcarnitine translocase CACT 1 Camitine palmitoyltransferase I CPT1A 1 Carnitine palmitoyltransferase II CPT2 1 Camitine transporter protein CDSP, SCD 2 Carnosinase 5 Cartilage-hair hypoplasia gene CHH 5 Catechol-o-methyltransferase COMT 1 Cell adhesion molecule, intercellular, ICAM ICAM1 6 Cell adhesion molecule, leukocyte- LECAM1 6 endothelial, LECA (CD62) Cell adhesion molecule, liver, LCAM LCAM 6 Cell adhesion molecule, neural, NCAM1 NCAM1 6 Cell adhesion molecule, neural, NCAM2 NCAM2 6 Cell adhesion molecule, platelet-endothelial, PECAM1 6 PECAM Cell adhesion molecule, vascular, VCAM VCAM1 6 c-erbB2 ERBB2 6 c-erbB3 ERBB3 6 c-erbB4 ERBB4 6 Chitotriosidase CHIT 1 Cholecystokinin CCK 5 Cholecystokinin B receptor CCKBR 5 Cholesterol ester hydroxylase 1 Cholesterol ester transfer protein CETP 2 Choline acetyltransferase CHAT 1 Chromogranin A CHGA 6 Chymase CHY1 Citrate synthase 1 Clathrin 2 Clusterin CLU 6 CoA transferase 1 Collagen IV alpha 5 COL4A5 3 Collagen IV alpha 6 COL4A6 3 Complex III 1 Complex V MTATP6 1 Corticosteroid binding globulin CBG 5 Corticotrophin-releasing hormone CRH 2 Corticotrophin-releasing hormone receptor CRHR1 2 Cortisol receptor 4 Cubilin CUBN 2 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase 1B1 PDE1B1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclin-dependent kinase inhibitor 1C (P57, CDKN1C 6 KIP2) Cyclin-dependent kinase inhibitor 2A (pl 6) CDKN2A 6 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYPIA2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4AII CYP4AII 1 CYP4BI CYP4BI 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cystic fibrosis transmembrane conductance CFTR 5 regulator, CFTR Cystinosin CTNS 2 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 DAX1 nuclear receptor DAX1 4 D-beta-hydroxybutyrate dehydrogenase 1 Dehydratase 1 Delta 4-5 oxosteroid isomerase 1 Delta aminolevulinate synthase 1 ALAS1 1 Delta aminolevuiinate synthase 2 ALAS2 1 Deoxycorticosterone (DOC) receptor 1 Deoxyuridine triphosphatase; dUTPase 1 DHEA sulfotransferase STD 1 Dihydrodiol dehydrogenase 1 DDH1 1 Dihydrolipoamide branched chain DBT 5 transacylase Dihydrolipoamide dehydrogenase DLD 5 Dihydrolipoyl dehydrogenase 2 PDHA 1 Dihydrolipoyl transacetylase PDHA 1 Dihydroorotase 1 Dihydropyramidinase DPYS 1 Dihydroxyacetonephosphate acyltransferase DHAPAT 1 Dihyropyrimidine dehydrogenase DPYD 1 DNA glycosylases 1 DNA helicases 1 DNA Ligase 1 LIG1 1 DNA methyltransferase DNMT 1 DOPA decarboxylase DDC 1 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Dynamin DNM1 6 Electron-transfering-flavoprotein alpha ETFA 2 Electron-transfering-flavoprotein beta ETFB 2 Electron-transferring flavoprotein ETFDH 1 dehydrogenase Endometrial bleeding-associated factor EBAF 6 Endothelin converting enzyme ECEI 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENO1 1 Enoyl CoA reductase 1 Enterokinase PRSS7, ENTK 1 Ephrin receptor tyrosine kinase A EPHA 6 Ephrin receptor tyrosine kinase B EPHB 6 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Erythropoietin EPO 4 Estrogen receptor ESR 6 Excision repair complementation, group 1 ERCC1 1 protein Factor 1 (No. one) F1 4 FADH dehydrogenase 1 Fatty acid binding proteins FABP2 FABP2 2 Fc fragment of IgG, high affinity IA, receptor FCGRIA 6 for Fc fragment of IgG, low affinity IIa, receptor FCGR2A 6 for (CD32) Fc fragment of IgG, low affinity IIIa, receptor FCGR3A 6 for (CDI 6) Ferritin, H subunit 2 Ferritin, L subunit FTL 2 Fibrinogen alpha FGA 3 Fibrinogen beta FGB 3 Fibrinogen gamma FGG 3 Fibroblast growth factor FGFI 6 Fibroblast growth factor receptor 1 FGFR1 6 Fibroblast growth factor receptor 2 FGFR2 6 Fibroblast growth factor receptor 3 FGFR3 6 Flavin-containing monooxygenase 1 FMOL 1 Flavin-containing monooxygenase 2 FMO2 1 Flavin-containing monooxygenase 3 FMO3 1 Flavin-containing monooxygenase 4 FMO4 1 Follicle stimulating hormone receptor FSHR, ODG1 6 Follicle stimulating hormone, FSH FSHB 6 Follistatin 6 Frataxin FRDA 6 Fructose-1,6-diphosphatase FBP1 1 Fumarase FH 1 Fumarylacetoacetase FAH 1 GABA receptor, alpha 1 GABRA1 5 GABA receptor, alpha 2 GABRA2 5 GABA receptor, alpha 3 GABRA3 5 GABA receptor, alpha 4 GABRA4 5 GABA receptor, alpha 5 GABRA5 5 GABA receptor, alpha 6 GABRA6 5 GABA receptor, beta 1 GABRB1 5 GABA receptor, beta 2 GABRB2 5 GABA receptor, beta 3 GABRB3 5 GABA receptor, gamma 1 GABRG1 5 GABA receptor, gamma 2 GABRG2 5 GABA receptor, gamma 3 GABRG3 5 GABA transaminase ABAT 1 Galactocerebrosidase GALC 1 Galactokinase GALK1 1 Galactose 1-phosphate uridyl-transferase GALT 1 Galanin GAL 5 Galanin receptor GALNRI 5 Gamma-glutamyl carboxylase GGCX 2 Gamma-glutamyltransferase 1 GGT1 2 Gamma-glutamyltransferase 2 GGT2 2 Gap junction protein beta 1 GJB1 2 Gap junction protein beta 3 GJB3 2 Gastric inhibitory polypeptide GIP GIP 2 Gastric inhibitory polypeptide receptor, GIPR GIPR 2 Gastric Intrinsic factor, GIF GIF 1 Gastric lipase, LIPF 2 Gastrin GAS 6 Gastrin releasing peptide GRP 2 Gastrin releasing peptide receptor GRPR 2 Glucagon receptor GCGR 6 Glucagon synthase 2 Glucagon-like peptide receptor 1 GLP1 R 6 Glucocorticoid receptor GRL 6 Glucokinase GCK 1 Glucosaminyl (N-acetyl) transferase 2, I- GCNT2 1 branching enzyme Glucose-6-phosphatase G6PC 1 Glucose-6-phosphatase translocase G6PT1 1 Glucose-6-phosphate dehydrogenase G6PD 1 Glucosidase, acid beta GBA 1 Glutamate decarboxylase, GAD GAD1 1 Glutamate dehydrogenase GLUD1 1 Glutamine phosphoribosylpyrophosphate 1 amidotransferase/PRPP amidotransferase Glutamine synthase 1 Glutathione GSH 2 Glutathione peroxidase, GPX2 GPX2 1 Glutathione reductase, GSR GSR 1 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glutathione synthetase GSS 1 Glyceraldehyde-3-phosphate dehydmgenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycerophosphate d hydrogenase 2 GPD2 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycine dehydrogenase GLDC 1 Glycogen branching enzyme GBE1 1 Glycogen phosphorylase PYGL 1 Glycogen synthase 1 (muscle) GLYS1 1 Glycogen synthase 2 (liver) GYS2 1 Glycosyltransferases, ABO blood group ABO 1 Gonadotropin releasing hormone GNRH 6 Gonadotropin releasing hormone receptor GNRHR 6 Growth arrest-specific homeobox GAX 6 Growth hormone 1 GH1 6 Growth hormone 2 (placental) GH2 6 Growth hormone receptor GHR 6 Growth hormone releasing hormone (GHRH) GHRH 6 Growth hormone releasing hormone receptor GHRHR 6 GTP cylcohydrolase I GCHI 6 GTPase-activating protein, GAP RASAI 6 Guanidinoacetate N-methyltransferase GAMT 1 Guanine nucleotide-binding protein, alpha GNA01 5 activating activity polypeptide, GNAO Guanine nucleotide-binding protein, alpha GNA11 5 inhibiting activity polypeptide 1, GNA11 Guanine nucleotide-binding protein, alpha GNA12 5 inhibiting activity polypeptide 2, GNA12 Guanine nucleotide-binding protein, alpha GNA13 5 inhibiting activity polypeptide 3, GNA13 Guanine nucleotide-binding protein, alpha GNAS1 5 stimulating activity polypeptide, GNAS1 Guanine nucleotide-binding protein, alpha GNAS2 5 stimulating activity polypeptide, GNAS2 Guanine nucleotide-binding protein, alpha GNAS3 5 stimulating activity polypeptide, GNAS3 Guanine nucleotide-binding protein, alpha GNAS4 5 stimulating activity polypeptide, GNAS4 Guanine nucleotide-binding protein, alpha GNAT1 5 transducing activity polypeptide, GNAT1 Guanine nucleotide-binding protein, alpha GNAT2 5 transducing activity polypeptide, GNAT2 Guanine nucleotide-binding protein, beta GNB3 5 polypeptide 3 Guanine nucleotide-binding protein, gamma GNG5 5 polypeptide 5 Guanine nucleotide-binding protein, q GNAQ 5 polypeptide Guanylate cyclase 2D, membrane (retina- GUCY2D 1 specific) Guanylate cyclase activator 1A (retina) GUCA1A 1 Guanylate kinase 1 Guanylin GUCA2 2 Guanylyl cyclase 1 Heat shock protein, HSP60 4 Heat shock protein, HSP70 4 Heat shock protein, HSP90 4 Heat shock protein, HSPA1 4 Heat shock protein, HSPA2 4 Hemopexin HPX 4 Heparin binding epidermal growth factor HBEGF 6 Hepatic lipase LIPC 1 Hepatic nuclear factor-3-beta HNF3B 1 Hepatic nuclear factor-4-alpha HNF4A 1 Hexokinase 1 HK1 1 Hexokinase 2 HK2 1 Hexosaminidase A HEXA, TSD 1 Hexosaminidase B HEXB 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 HMG-CoA lyase HMGCL 1 HMG-CoA reductase HMGCR 1 HMG-CoA synthase HMGCS2 1 Holocarboxylase synthetase HLCS 1 Holoprosencephaly 1 HPE1 6 Holoprosencephaly 2 HPE2 6 Holoprosencephaly 3 HPE3 6 Holoprosencephaly 4 HPE4 6 Homeobox (HOX) gene A13 HOXA13 6 Hormone-sensitive lipase HSL 1 HSSB, replication protein 1 Human chorionic gonadtrophin, hCG CG 6 Human placental lactogen CSH1 6 Hydroxyacyl glutathione hydrolase HAGH 1 Hypoxanthine-guanine HPRT 1 phosphoribosyltransferase, HGPRT Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 Iduronate 2 sulphatase IDS 1 Immunoglobulin E (IgE) reponsiveness gene IGER 4 Immunoglobulin E (IgE) serum concentration IGES 4 regulator gene Immunoglobulin gamma (IgG) 2 IGHG2 Indian hedgehog, ihh IHH 6 Inhibin, alpha INHA 6 Inhibin, beta A INHBA 6 Inhibin, beta B INHBB 6 Inhibin, beta C INHBC 6 Inosine monophosphate dehydrogenase, 1 IMPDH Inosine triphosphatase ITPA 1 Inositol 1,4,5-triphosphate receptor I ITPR1 6 lnositol monophosphatase IMPA1 5 Inositol polyphosphate 1-phosphatase INPP1 5 Insulin INS 6 Insulin receptor INSR 6 Insulin receptor substrate-1 IRS1 6 Insulin-like growth factor 1 IGF1 6 Insulin-like growth factor 1 receptor IGF1R 6 Insulin-like growth factor 2 IGF2 6 Insulin-like growth factor 2 receptor IGF2R 6 lntegrin beta 1 TGB1 6 Integrin beta 2 ITGB2 6 lnterleukin(IL) 1 receptor IL1R lnterleukin(IL) 1, alpha IL1A Interleukin(IL) 1, beta IL1B Interleukin(IL) 10 IL10 Interleukin(IL) 10 receptor IL10R Interleukin(IL) 11 IL11 Interleukin(IL) 11 receptor IL11R Interleukin(IL) 12 IL12 Interleukin(IL) 12 receptor, beta 1 IL12RB1 Interleukin(IL) 13 IL13 lnterleukin(IL) 13 receptor IL13R Interleukin(IL) 2 IL2 Interleukin(IL) 2 receptor, alpha IL2RA Interleukin(IL) 2 receptor, gamma IL2RG Interleukin(IL) 3 IL3 Interleukin(IL) 3 receptor IL3R Interleukin(IL) 4 IL4 Interleukin(IL) 4 receptor IL4R lnterleukin(IL) 5 IL5 Interleukin(IL) 5 receptor IL5R Interleukin(IL) 6 IL6 Interleukin(IL) 6 receptor IL6R lnterleukin(IL) 7 IL7 lnterleukin(IL) 7 receptor IL7R Interleukin(IL) 8 IL8 Interleukin(IL) 8 receptor IL8R Interleukin(IL) 9 IL9 Interleukin(IL) 9 receptor IL9R Interleukin(IL) receptor antagonist 1 IL1RN, IL1RA 4 Iodothyronine-5′-deiodinase, type 1 and 2 1 IP3 kinase 1 Islet amyloid polypeptide IAPP 5 Isocitrate dehydrogenase 1 Isovaleric acid CoA dehydrogenase IVD 1 Janus kinase 1 JAK1 6 Janus kinase 2 JAK2 6 Janus kinase 3 JAK3 6 Kallman syndrome gene KAL1 6 Ketohexokinase KHK 1 Ketolase 1 Lactase 1 Lactotransferrin LTF 2 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin receptor 1 LAMR1 6 Lecithin-cholesterol acyltransferase LCAT 1 Leptin LEP 6 Leptin receptor LEPR 6 Leukotriene C4 synthase LTC4S 1 LH/choriogonadotropin (CG) receptor LHCGR 6 Lipoamide dehydrogenase OGDH 1 Lipoprotein lipase LPL 4 Lipoprotein, High Density HDLDT1 2 Lipoprotein, Intermediate Density 2 Lipoprotein, Low Density 1 2 Lipoprotein, Low Density 2 2 Lipoprotein, Very Low Density VLDLR 2 Lipoprotein-associated coagulation factor LACI 4 Lipoxygenase 1 Lipoxygenase 12 (platelets) LOG12 Lipoxygenase 5 (leukocytes) Luteinizing hormone, beta chain LHB 6 Lymphocyte-specific protein tyrosine kinase LCK 4 Lysosomal acid lipase LIPA 1 MAD (mothers against decapentaplegic, MADH2 6 Drosophila) homologue 2 Malate dehydrogenase, mitochondrial MDH2 1 Malonyl CoA decarboxylase 1 Malonyl CoA transferase 1 Maltase-glucoamylase 1 Mannosidase, alpha B lysosomal MANB 1 Mannosyl (alpha-1,6-)-glycoprotein beta-1,2- MGAT2 2 N-acetylglucosaminyltransferase Marenostrin MEFV 2 Matrix Gla protein MGP 6 MEK kinase, MEKK 1 Melanocortin 2 receptor MC2R 2 Melanocortin 4 receptor MC4R 2 Menin MEN1 6 Methionine adenosyltransferase MAT1A, MAT2A 1 Methionine synthase MTR 1 Methionine synthase reductase MTRR 1 Methylguanine-DNA methyltransferase MGMT 1 Methylmalonyl-CoA mutase MUT 1 Mitochondrial trifunctional protein, alpha HADHA 1 subunit Mitochondrial trifunctional protein, beta HADHB 1 subunit Molybdenum cofactor synthesis 1 MOCS1 1 Molybdenum cofactor synthesis 2 MOCS2 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Multidrug resistance associated protein MRP 6 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Muscle phosphorylase PYGM 1 Na+, K+ ATPase, alpha ATP1A1 6 Na+, K+ ATPase, beta 1 ATP1B1 6 Na+, K+ ATPase, beta 2 ATP1B2 6 Na+, K+ ATPase, beta 3 ATP1B3 6 Na+/H+ exchanger 1 NHE1 2 Na+/H+ exchanger 2 NHE2 2 Na+/H+ exchanger 3 NHE3 2 Na+/H+ exchanger 4 NHE4 2 Na+/H+ exchanger 5 NHE5 2 N-acetyltransferase 1 NAT1 1 N-acetyltransferase 2 NAT2 1 NADH dehydrogenase (ubiquinone) Fe—S NDUFS1 1 protein 1 NADH dehydrogenase (ubiquinone) Fe—S NDUFS4 1 protein 4 NADH dehydrogenase (ubiquinone) NDUFV1 1 avoprotein 1 NADH-cytochrome b5 reductase DIA1 1 reductase NADPH-dependent cytochrome P450 reductase POR 1 Nephronophthisis 1 NPHP1 2 Nephrosis 1 NPHS1 2 Nerve growth factor NGF 6 Nerve growth factor receptor NGFR 6 Neuraminidase sialidase NEU 2 Neuregulin HGL 6 Neuroendocrine convertase 1 NEC1, PCSK1 1 Neurofibromin 1 NF1 6 Neurofibromin 2 NF2 6 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPYI R 5 Neuropeptide Y receptor Y2 NPY2R 5 Neurotensin NTS 5 Neurotensin receptor NTSR1 5 Neurotrophin 3 NTF3 or NT3 6 Neutral endopeptidase 1 Niemann-Pick disease protein NPC1 2 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Notch ligand-jagged JAG1, AGS 6 Nucleoside diphosphate kinase-A NDPKA 1 Oncogene ret RET 6 Oncogene sis PDGFB 6 Orexin OX 6 Orexin 1 receptor OX1R 6 Orexin 2 receptor OX2R 6 Omithine delta-aminotransferase OAT 1 Ornithine transcarbamoylase OTC, NME1 1 Oxytocin OXT 5 Oxytocin receptor OXTR 5 Paired box homeotic gene 6 PAX6 6 Paired box homeotic gene 8 PAX8 6 Palmitoyi-protein thioesterase PPT 2 Pancreatic lipase PNLIP 1 Paraoxonase PON1 PON1 1 Paraoxonase PON2 PON2 1 Paraoxonase PON3 1 Parathyroid hormone PTH 6 Parathyroid hormone receptor PTHR1 6 Parathyroid hormone related-peptide PTHRP 6 Parathyroid hormone-like hormone PTHLH 6 Peanut-like 1 PNUTL1 4 Peptidylglycine alpha-amidating PAM 1 monooxygenase Peroxidase, salivary SAPX 1 Peroxisomal membrane protein 3 PXMP3 2 Peroxisome biogenesis factor 1 PEX1 2 Peroxisome biogenesis factor 19 PEX19 2 Peroxisome biogenesis factor 6 PEX6 2 Peroxisome biogenesis factor 7 PEX7 2 Peroxisome proliferative activated receptor, PPARA 2 alpha Peroxisome proliferative activated receptor, PPARG 2 gamma P-glycoprotein I PGY1 2 P-glycoprotein 3 PGY3 2 Phenylaianine hydroxylase PAH 1 Phenylatanine monooxygenase 1 Phenylethanolamine N-methyltransferase, PNMT 1 PNMT Phosphodiesterase 1/nucleotide PDNP1 6 pyrophosphatase 1 Phosphodiesterase 1/nucleotide PDNP2 6 pyrophosphatase 2 Phosphodiesterase 1/nucleotide PDNP3 6 pyrophosphatase 3 Phosphoenolpyruvate carboxykinase PCK1 1 Phosphofructokinase, liver PFKL 1 Phosphofructokinase, muscle PFKM 1 Phosphoglucomutase 1 Phosphoglucose isomerase GPI 1 Phosphoglycerate kinase 1 PGK1 1 Phosphoglycerate mutase 2 PGAM2 1 Phospholipase A2, group 10 PLA2G10 4 Phospholipase A2, group 1B PLA2G 1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Phosphomannomutase 2 PMM2 6 Phosphomannomutase 2 PMM2 2 Phosphomannose isomerase-1, PMI MPI 2 Phosphoribosyl pyrophosphate synthetase PRPS1 1 Phosphorylase kinase deficiency, liver PHK 1 Phosphorylase kinase, alpha 1 (muscle) PHKA1 1 Phosphorylase kinase, alpha 2 PHKA2 1 Phosphorylase kinase, beta PHKB 1 Phosphorylase kinase, delta 1 Phosphorylase kinase, gamma 2 PHKG2 1 Phytanoyl-CoA hydroxylase PHYH 6 Pineolytic beta-receptors 1 Pituitary adenylate cyclase activating peptide PACAP 5 Pituitary adenylate cyclase activating peptide PACAPIR 5 receptor Plasminogen activator receptor, Urokinase UPAR; PLAUR 3 Plasminogen activator, Tissue PLAT; TPA 1 Plasminogen activator, Urokinase UPA; PLAU 1 Platelet derived growth factor PDGF 6 Platelet derived growth factor receptor PDGFR 6 Poly (ADP-ribose) synthetase PARS 1 Polycystin 1 PKD1 2 Polycystin 2 PKD2 2 Porphobilinogen deaminase HMBS 1 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium inwardly-rectifying channel J11 KCNJ11 5 Potassium voltage-gated channel A1 KCNA1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Preproenkephalin PENK 5 Preproglucagon GCG; GLP1; GLP2 6 Preproglucagon 2 Preproinsulin 2 Profibrinolysin 6 receptor) Prolactin PRL 6 Prolactin receptor PRLR 6 Prolactin releasing hormone PRH 6 Proliferin PLF 6 Proline dehydrogenase PRODH 1 Proline-rich protein BstNI subfamily 1 PRB1 3 Proline-rich protein BstNI subfamily 3 PRB3 3 Proline-rich protein BstNI subfamily 4 PRB4 3 Pro-melanin-concentrating hormone PMCH 6 Proopiomelanocortin POMC 5 Prophet of Pit1 PROP1 6 Prostacyclin synthase 4 Prostaglandin (PG) D synthase, PGDS 1 hematopoietic Prostaglandin 15-OH dehydrogenase HGPD; PGDH 4 Prostaglandin D - DP receptor 4 Prostaglandin E1 receptor 4 Prostaglandin E2 receptor 4 Prostaglandin E3 receptor 4 Prostaglandin F - FP receptor 4 Prostaglandin I2 receptor 2 Prostaglandin IP receptor 4 Prostaglandin isomerase 6 Prostasin, PRSS8 PRSS8 1 Protease nexin 2 PN2 1 Protein kinase B PRKB Protein kinase C, alpha PRKCA 1 Protein S PROS 4 Protoporphyrinogen oxidase PPOX 1 Pterin-4-alpha-carbinolamine PCBD Pyrroline-5-carboxylate synthetase PYCS 1 Pyruvate carboxylase PC 1 Pyruvate decarboxylase PDHA 1 Pyruvate kinase PKLR 1 Quinoid dihydropteridine reductase QDPR 1 Rathke pouch homeobox, RPX RPX 6 Relaxin H1 RLN1 6 Relaxin H2 RLN2 6 Renin REN 1 Replication factor C RFC2 1 Retinal pigment epithelium specific protein RPE65 3 (65 kD) Retinaldehyde binding protein 1 RLBP1 2 Retinoic acid receptor, alpha RARA 6 Retinoic acid receptor, beta RARB 6 Retinoic acid receptor, gamma RARG 6 Retinoid X receptor, alpha RXRA 6 Retinoid X receptor, beta RXRB 6 Retinoid X receptor, gamma RXRG 6 Retinol binding protein 1 2 Retinol binding protein 2 2 Ribosephosphate pyrophosphokinase 1 RIGUI RIGUI 6 Ryanodine receptor 1, skeletal RYRI 6 S100 calcium-binding protein A3 S100A3 5 S100 calcium-binding protein A4 S100A4 5 S100 calcium-binding protein A7 S100A7 5 S100 calcium-binding protein A8 S100A8 5 S100 calcium-binding protein A9 S100A9 5 S100 calcium-binding protein B S100B 5 S100 calcium-binding protein P S100P 5 S-Adenosylmethionine decarboxylase, AMD 1 Salivary amylase, AMY1 2 Secretin SCT 2 Secretin receptor, SCTR SCTR 2 Serine hydroxymethyltransferase SHMT 1 Serotonin N-acetyltransferase SNAT 1 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Serum amyloid A SAA 2 Serum amyloid P SAP 2 Sex determining region Y, SRY SRY 6 Sex hormone binding globulin, SHBG 2 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, SCNN1G 5 gamma Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 1 (amino acid SLC1A6 2 transporter), member 6 Solute carrier family 1 (neutral amino acid SLC1A4 2 transporter), member 4 Solute carrier family 10 (sodium/bile acid SLC1OAL 2 cotransporter family), member 1 Solute carrier family 10 (sodium/bile acid SLC1OA2 2 cotransporter family), member 2 Solute carrier family 12, member 1 SLC12A1 2 Solute carrier family 12, member 2 SLC12A2 2 Solute carrier family 12, member 3 SLC12A3 2 Solute carrier family 14, member 2 SLC14A2 2 Solute carrier family 15 (H+/peptide SLC15A1 2 transporter, intestinal), member 1 Solute carrier family 15 (H+/peptide SLC15A2 2 transporter, kidney), member 2 Solute carder family 16 (monocarboxylate SLC16A1 2 transporter), member 1 Solute carrier family 16 (monocarboxylate SLC16A7 2 transporter), member 7 Solute carrier family 17, member 1 SLC17A1 2 Solute carrier family 17, member 2 SLC 17A2 2 Solute carrier family 2 (facilitated glucose SLC2A1 2 transporter), member 1 Solute carrier family 2 (facilitated glucose SLC2A2 2 transporter), member 2 Solute carrier family 2 (facilitated glucose SLC2A3 2 transporter), member 3 Solute carrier family 2 (facilitated glucose SLC2A4 2 transporter), member 4 Solute carrier family 2 (facilitated glucose SLC2A5 2 transporter), member 5 Solute carrier family 20, member 3 SLC2OA3 2 Solute carrier family 21, member 2 SLC21 2 Solute carrier family 21, member 3 SLC2lA3 2 Solute carrier family 22, member 1 SLC22A1 2 Solute carrier family 22, member 2 SLC22A2 2 Solute carrier family 22, member 5 SLC22A5 2 Solute carrier family 3 (facilitated glucose SLC3A1 2 transporter), member 1 Solute carrier family 4 (anion exchanger), SLC4A1 2 member 1 Solute carrier family 4 (anion exchanger), SLC4A2 2 member 2 Solute carrier family 4 (anion exchanger), SLC4A3 2 member 3 Solute carrier family 5 (sodium/glucose SLC5A1 2 transporter), member 1 Solute carrier family 5 (sodium/glucose SLC5A2 2 transporter), member 2 Solute carrier family 5 (sodium/glucose SLC5A5 2 transporter), member 5 Solute carrier family 5, member 3 SLC5A3 2 Solute carrier family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Solute carrier family 6 (neurotransmitter SLC6A4 2 transporter, serotonin), member 4 Solute carrier family 6, member 10 SLC6A10 2 Solute carrier family 6, member 6 SLC6A6 2 Solute carrier family 6, member 8 SLC6A8 2 Solute carrier family 7(amino acid SLC7A 2 transporter), member 1 Solute carrier family 7(amino acid SLC7A2 2 transporter), member 2 Solute carrier family 7(amino acid SLC7A7 2 transporter), member 7 Solute carrier family 8 (sodium/calcium SLC8A1 2 exchanger), member 1 Somatostatin SST 5 Somatostatin receptor, SSTR1 SSTR1 5 Somatostatin receptor, SSTR2 SSTR2 6 Somatostatin receptor, SSTR3 SSTR3 5 Somatostatin receptor, SSTR4 SSTR4 5 Somatostatin receptor, SSTR5 SSTR5 5 Somatotrophin 6 Sorcin SRI 2 SOS1 guanine nucleotide exchange factor SOS1 6 Sperm prolamine P1 PRM1 6 Sperm prolamine P2 PRM2 6 Sphingomyelinase SMPD1 1 SRY-box 10 SOX10 6 SRY-box 11 SOX11 6 SRY-box 3 SOX3 6 SRY-box 4 SOX4 6 SRY-box 9 SOX9 6 Steroid sulphatase STS 1 Steroidogenic acute regulatory protein STAR 2 Substance P 5 Succinyl CoA synthase 1 Sucrase 1 Sulfonylurea receptor SUR 6 Superoxide dismutase 1 SOD1 1 Superoxide dismutase 3 SOD3 1 Surfeit SURF1 6 T-BOX 1 TBX1 6 T-BOX 3 TBX3 6 Thiolase, perioxisomal 1 Thiopurine S-methyltransferase TPMT 1 Thrombospondin THBS1 6 Thromboxane A synthase 1 TBXAS1 4 Thromboxane A2 TXA2 4 Thromboxane A2 receptor TBXA2R 4 Thymopoietin TMPO 6 Thymosin 4 Thyroglobulin TG 6 Thyroid hormone receptor, alpha THRA 6 Thyroid hormone receptor, beta THRB 6 Thyroid peroxidase TPO 6 Thyroid receptor auxiliary protein TRAP 6 Thyroid-stimulating hormone receptor TSHR 6 Thyroid-stimulating hormone, alpha TSHA 6 Thyroid-stimulating hormone, beta TSHB 6 Thyrotropin releasing hormone TRH 6 Thyrotropin releasing hormone receptor TRHR 6 Thyroxin-binding globulin TBG 2 Transacylase 1 Transcobalamin 2, TCN2 TCN2 2 Transcription factor 1, hepatic TCF1 6 Transcription factor 2, hepatic TCF2 6 Transcription termination factor, RNA TTF1 6 polymerase 1 Transferrin TF 6 Transferrin receptor TFRC 6 Transforming growth factor, beta 2 TGFB2 6 Transforming growth factor, beta induced TGFBI 6 Transforming growth factor, beta receptor 2 TGFBR2 6 Transketolase TKT 1 Transketolase-like 1 TKTL1 1 Transthyretin TTR 2 Tubby-like protein 1 TULP1 6 Tuberous sclerosis 1 TSC1 6 Tuberous sclerosis 2 TSC2 6 Tyrosinase TYR 1 Tyrosinase-related protein 1 TYRPI 1 Tyrosine aminotransferase TAT 1 Tyrosine hydroxylase TH 1 Ubiquitin activating enzyme, E1 1 Ubiquitin protein ligase E3A UBE3A 1 UDP-glucose pyrophosphorylase 1 UDP-glucuronosyltransferase 1 ugt1d, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Uncoupling protein 1 2 Uncoupling protein 3 UCP3 2 Urate oxidase UOX 1 Ureidopropionase 1 Uridine monophosphate kinase UMPK 4 Uddine monophosphate synthetase UMPS 4 Uridinediphosphate(UDP)-galactose-4- GALE 1 epimerase Uroporphyrinogen decarboxylase UROD 1 Uteroglobin UGB 2 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VPR 5 Vasoinhibitory peptide 6 Von Hippel-Lindau gene VHL 6 Werner syndrome helicase WRN 6 Wolfram syndrome I gene WFS1 3 Xylito dehydrogenase  1,

that the genes associated with headaches are selected from: List of genes HUGO gene symbol Protein-function Acetylcholinesterase ACHE 1 Adenyfate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCPL 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Arginase ARG1 1 Arginine vasopressin AVP 5 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Calcitonin/Calcitonin gene-related peptide alpha CALCA 5 Calcium channel, voltage-dependent, alpha 1F CACNA1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA1B 5 1B (CACNL1A5) Calcium channel, voltage-dependent, Alpha-I C CACNA1C 5 Calcium channel, voltage-dependent, Alpha-I D CACNA1D 5 Calcium channel, voltage-dependent, Alpha- CACNA1E 5 I E (CACNL1A6) Calcium channel, voltage-dependent, Alpha-2/delta CACNA2 5 Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, P/Q CACNA1A 5 type, alpha 1A subunit Calcium channel, voltage-dependent, T-type 5 Calnexin CANX 6 Cannabinoid receptor CNR1 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Catechol-o-methyltransferase COMT 1 Choline acetyltransferase CHAT 1 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase 1B1 PDE1B1 1 Cyclic nucleotide phosphodiesterase 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDE4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucleotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 68 PD 6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDE8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2FI 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Dystonia 9 CSE 3 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECEI 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENO1 1 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Erythropoietin receptor EPOR 4 Glutathione GSH 2 Glutathione S-transferase, GSTZ1 GSTZ1 1 Glyceraldehyde-3-phosphate dehydrogenase, GAPDH GAPDH 1 Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Hexosaminidase B HEXB 1 Histamine receptors, H1 5 Histamine receptors, H2 5 Histamine receptors, H3 5 Hypoxia inducible factor 1 HIF1A 1 Hypoxia inducible factor 2 1 Insulin INS 6 Insulin receptor INSR 6 Interleukin(IL) 1, alpha IL1A 4 Interleukin(IL) 1, beta IL1B 4 Interleukin(IL) receptor antagonist 1 IL1RN, IL1RA 4 IP3 kinase 1 Marenostrin MEFV 2 Methylmalonyl-CoA mutase MUT 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 Myogenic factor 3 MYF3 6 Myogenic factor 4 MYF4 6 Myogenic factor 5 MYF5 6 NADH dehydrogenase reductase 1 Neurokinin A NKNA 5 Neurokinin B NKNB 5 Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Phospho ipase A2, group 10 PLA2G10 1 Phospholipase A2, group 1B PLA2G1B 4 Phospholipase A2, group 2A PLA2G2A 4 Phospholipase A2, group 2B PLA2G2B 4 Phospholipase A2, group 4A PLA2G4A 4 Phospholipase A2, group 4C PLA2G4C 4 Phospholipase A2, group 5 PLA2G5 4 Phospholipase A2, group 6 PLA2G6 4 Phospholipase C alpha 4 Phospholipase C beta 4 Phospholipase C delta PLCD1 4 Phospholipase C epsilon 4 Phospholipase C gamma PLCG1 4 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Pmopiometanocortin POMC 5 RIGUI RIGUI 6 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 5, member 3 SLC5A3 2 Solute carder family 6 (GAMMA- SLC6A1 2 AMINOBUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmitter SLC6A2 2 transporter, noradrenaline), member 2 Substance P 5 Tyrosine hydroxylase TH 1 UDP-glucuronosyltransferase 1 ugt1d, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5

that the genes associated with seaual malfunctions are selected from: HUGO Protein- List of genes gene symbol function 11 beta Hydroxysteroid dehydrogenase 2 HSD11B2 1 Acetylcholinesterase ACHE 1 Activin 6 Adenylate cyclase 1 ADCY1 1 Adenylate cyclase 2 ADCY2 1 Adenylate cyclase 3 ADCY3 1 Adenylate cyclase 4 ADCY4 1 Adenylate cyclase 5 ADCY5 1 Adenylate cyclase 6 ADCY6 1 Adenylate cyclase 7 ADCY7 1 Adenylate cyclase 8 ADCY8 1 Adenylate cyclase 9 ADCY9 1 Adrenergic receptor, alpha1 ADRA1 5 Adrenergic receptor, alpha2 ADRA2 5 Adrenergic receptor, beta1 ADRB1 5 Adrenergic receptor, beta2 ADRB2 5 Adrenergic receptor, beta3 ADRB3 5 Adrenoleukodystrophy gene ALD 1 alpha thalassemia gene ATRX 5 Androgen binding protein ABP 2 Angiopoietin 1 ANGPT1 6 Angiopoietin 2 ANGPT2 6 Angiotensin converting enzyme ACE, DCP1 1 Angiotensin receptor 1 AGTR1 2 Angiotensin receptor 2 AGTR2 2 Angiotensinogen AGT 1 Anti-Mullerian hormone AMH 6 Anti-Mullerian hormone type 2 receptor AMHR2 6 Arginase ARG1 1 Arginine vasopressin AVP 5 Arginine vasopressin receptor 1A AVPR1A 5 Arginine vasopressin receptor 1B AVPR1B 5 Arginine vasopressin receptor 2 AVPR2 5 Atrial natriuretic peptide ANP 6 Atrial natriuretic peptide receptor A NPR1 6 Atrial natriuretic peptide receptor B NPR2 6 Atrial natriuretic peptide receptor C NPR3 6 Autoimmune regulator, AIRE AIRE 4 BCL2-associated X protein BAX 6 Bloom syndrome protein BLM 6 Calcium channel, voltage-dependent, alpha 1F CACNA 1F 5 subunit Calcium channel, voltage-dependent, Alpha- CACNA 1B 5 1 B (CACNL1A5) Calcium channel, voltage-dependent, Alpha- CACNA 1C 5 1 C Calcium channel, voltage-dependent, Alpha- CACNA 1D 5 1 D Calcium channel, voltage-dependent, Alpha- CACNA 1E 5 1 E (CACNL1A6) Calcium channel, voltage-dependent, Alpha- CACNA 2 5 2/delta Calcium channel, voltage-dependent, Beta 1 CACNB1 5 Calcium channel, voltage-dependent, Beta 3 CACNB3 5 Calcium channel, voltage-dependent, CACNG2 5 Neuronal, Gamma Calcium channel, voltage-dependent, T-type 5 Carbonic anhydrase 3 CA3 1 Carbonic anhydrase 4 CA4 1 Carbonic anhydrase, alpha CA1 1 Carbonic anhydrase, beta CA2 1 Catechol-o-methyltransferase COMT 1 Choline acetyltransferase CHAT 1 Cyclic AMP response element modulator CREM 6 Cyclic AMP-dependent protein kinase PKA 1 Cyclic nucleotide phosphodiesterase 1B PDE1B 1 Cyclic nucleotide phosphodiesterase 1B1 PDE1B1 1 Cyclic nucleotide phosphodiesteease 2A3 PDE2A3 1 Cyclic nucleotide phosphodiesterase 3A PDE3A 1 Cyclic nucleotide phosphodiesterase 3B PDE3B 1 Cyclic nucleotide phosphodiesterase 4A PDE4A 1 Cyclic nucleotide phosphodiesterase 4C PDF4C 1 Cyclic nucleotide phosphodiesterase 5A PDE5A 1 Cyclic nucteotide phosphodiesterase 6A PDE6A 1 Cyclic nucleotide phosphodiesterase 6B PDE6B 1 Cyclic nucleotide phosphodiesterase 7 PDE7 1 Cyclic nucleotide phosphodiesterase 8 PDF8 1 Cyclic nucleotide phosphodiesterase 9A PDE9A 1 Cyclooxygenase 1 COX1 1 Cyclooxygenase 2 COX2 1 CYP11A1 CYP11A1 1 CYP11B1 CYP11B1 1 CYP11B2 CYP11B2 1 CYP17 CYP17 1 CYP19 CYP19 1 CYP1A1 CYP1A1 1 CYP1A2 CYP1A2 1 CYP1B1 CYP1B1 1 CYP21 CYP21 1 CYP24 CYP24 1 CYP27 CYP27 1 CYP27B1 PDDR 1 CYP2A1 CYP2A1 1 CYP2A13 CYP2A13 1 CYP2A3 CYP2A3 1 CYP2A6V2 CYP2A6V2 1 CYP2A7 CYP2A7 1 CYP2B6 CYP2B6 1 CYP2C18 CYP2C18 1 CYP2C19 CYP2C19 1 CYP2C8 CYP2C8 1 CYP2C9 CYP2C9 1 CYP2D6 CYP2D6 1 CYP2E1 CYP2E1 1 CYP2F1 CYP2F1 1 CYP2J2 CYP2J2 1 CYP3A3 CYP3A3 1 CYP3A4 CYP3A4 1 CYP3A5 CYP3A5 1 CYP3A7 CYP3A7 1 CYP4A11 CYP4A11 1 CYP4B1 CYP4B1 1 CYP4F2 CYP4F2 1 CYP4F3 CYP4F3 1 CYP51 CYP51 1 CYP5A1 CYP5A1 1 CYP7A CYP7A 1 CYP8 CYP8 1 Cystathionase CTH 1 Cystathione beta synthase CBS 1 Cytidine deaminase CDA 1 Cytidine-5-prime-triphosphate synthetase CTPS 1 Cytochrome a 1 Cytochrome c 1 Cytochrome c oxidase, MTCO 1 Cytokine-suppressive antiinflammatory drug- CSBP1 4 binding protein 1 Cytokine-suppressive antiinflammatory drug- CSBP2 4 binding protein 2 DAX1 nuclear receptor DAX1 Deleted in azoospermia DAZ 6 Diaphanous 2 DIAPH2 5 Disrupted meiotic CDNA 1, homolog DMC1 6 Dopamine beta hydroxylase DBH 1 Dopamine receptors D1 DRD1 5 Dopamine receptors D2 DRD2 5 Dopamine receptors D3 DRD3 5 Dopamine receptors D4 DRD4 5 Dopamine receptors D5 DRD5 5 Electron-transfering-flavoprotein alpha ETFA 2 Electron-transfering-flavoprotein beta ETFB 2 Electron-transferring flavoprotein ETFDH 1 dehydrogenase Endometrial bleeding-associated factor EBAF 6 Endothelin 1 EDN1 5 Endothelin 2 EDN2 5 Endothelin 3 EDN3 5 Endothelin converting enzyme ECEI 5 Endothelin receptor type A EDNRA 5 Endothelin receptor type B EDNRB 5 Enolase ENO1 1 Enoyl CoA isomerase 1 Enterokinase PRSS7, ENTK 1 Epidermal growth factor EGF 6 Epidermal growth factor receptor EGFR 6 Faciogenital dysplasia FGD1, FGDY 2 Factor XIll A & B F13A & F13B 4 Fanconi anemia, complementation group A FANCA 2 Fertilin protein FTNB 6 Flightless-II, Drosophila homolog of FLII 6 Folic acid receptor FOLR 6 Glutathione GSH 2 Glutathione 5-transferase, GSTZ1 GSTZ1 1 G yceraldehyde-3-phosphate dehydrogenase, GAPDH 1 GAPDH Glycerol kinase GK 1 Glycinamide ribonucleotide (GAR) GART 1 transformylase Glycogen phosphorylase PYGL 1 Gonadotropin releasing hormone GNRH 6 Gonadotropin releasing hormone receptor GNRHR 6 Guanine nucleotide-binding protein, aloha GNA11 5 inhibiting activity polypeptide 1, GNA11 Guanine nucleotide-binding protein, alpha GNA12 5 inhibiting activity polypeptide 2, GNA12 Guanine nucleotide-binding protein, alpha GNA13 5 inhibiting activity polypeptide 3, GNA13 Hexosaminidase B HEXB 1 Holoprosencephaly 1 HPE1 6 Holoprosencephaly 2 HPE2 6 Holoprosencephaly 3 HPE3 6 Holoprosencephaly 4 HPE4 6 Human placental lactogen CSH1 6 Inhibin, alpha INHA 6 inhibin, beta A INHBA 6 Inhibin, beta B INHBB 6 Inhibin, beta C NHBC 6 Insulin INS 6 Insulin receptor INSR 6 IP3 kinase 1 Kallman syndrome gene 1 KAL1 6 Laminin 5, alpha 3 LAMA3 6 Laminin 5, beta 3 LAMB3 6 Laminin receptor 1 LAMR1 6 Long QT-type 2 potassium channels LQT2, KCNH2 2 Luteinizing hormone, beta chain LHB 6 MAD (mothers against decapentaplegic, MADH2 6 Drosophila) homologue 2 Methylmalonyl-CoA mutase MUT 1 Monoamine oxidase A MAOA 1 Monoamine oxidase B MAOB 1 Muscarinic receptor, M1 CHRM1 5 Muscarinic receptor, M2 CHRM2 5 Muscarinic receptor, M3 CHRM3 5 Muscarinic receptor, M4 CHRM4 5 Muscarinic receptor, M5 CHRM5 5 reductase Neuropeptide Y NPY 5 Neuropeptide Y receptor Y1 NPY1R 5 Neuropeptide Y receptor Y2 NPY2R 5 Nitric oxide synthase 1, NOS1 NOS1 1 Nitric oxide synthase 2, NOS2 NOS2 1 Nitric oxide synthase 3, NOS3 NOS3 1 Oncogene ELK1 ELK1 6 Oncogene ELK2 ELK2 6 Paired box homeotic gene 3 PAX3 6 Patched (Drosophila) homolog, PTCH PTCH 6 Potassium inwardly-rectifying channel J1 KCNJ1 5 Potassium inwardly-rectifying channel J11 KCNJ11 5 Potassium voltage-gated channel A1 KCNA1 5 Potassium voltage-gated channel E1 KCNE1 5 Potassium voltage-gated channel Q1 KCNQ1 5 Potassium voltage-gated channel Q2 KCNQ2 5 Potassium voltage-gated channel Q3 KCNQ3 5 receptor) Proopiomelanocortin POMC 5 Prostasin, PRSS8 PRSS8 1 Ribosomal protein S4, X-linked RPS4X 1 RIGUI RIGUI 6 Serotonin receptor, 5HT1A HTR1A 5 Serotonin receptor, 5HT1B HTR1B 5 Serotonin receptor, 5HT1C HTR1C 5 Serotonin receptor, 5HT1D HTR1D 5 Serotonin receptor, 5HT1E HTR1E 5 Serotonin receptor, 5HT1F HTR1F 5 Serotonin receptor, 5HT2A HTR2A 5 Serotonin receptor, 5HT2B HTR2B 5 Serotonin receptor, 5HT2C HTR2C 5 Serotonin receptor, 5HT3 HTR3 5 Serotonin receptor, 5HT4 HTR4 5 Serotonin receptor, 5HT5 HTR5 5 Serotonin receptor, 5HT6 HTR6 5 Serotonin receptor, 5HT7 HTR7 5 Sodium channel, non-voltage gated 1, alpha SCNN1A 5 Sodium channel, non-voltage gated 1, beta SCNN1B 5 Sodium channel, non-voltage gated 1, gamma SCNN1G 5 Sodium channel, voltage gated, pe V, alpha SCN5A 5 potypeptide Sodium channel, voltage-gated, type 1, beta SCN1B 5 polypeptide Solute carrier family 6 (GAMMAAMINO- SLC6A1 2 BUTYRIC ACID transporter), member 1 Solute carrier family 6 (neurotransmitter SLC6A3 2 transporter, dopamine), member 3 Solute carrier family 6 (neurotransmifter SLC6A2 2 transporter, noradrenaline), member 2 Sperm prolamine P1 PRM1 6 Sperm prolamine P2 PRM2 6 T-BOX 3 TBX3 6 Testis-specific protein Y TSPY 6 Tyrosine hydroxylase TH 1 UDP-glucuronosyltransferase 1 ugt1d, UGT1 1 UDP-glucuronosyltransferase 2 UGT2 1 Vasoactive intestinal polypeptide VIP 5 Vasoactive intestinal polypeptide receptor VIPR 5 Zona pellucida glycoprotein 1 ZP1 6 Zona pellucida glycoprotein 2 ZP2 6 Zona pellucida glycoprotein 3 ZP3 6 Zona pellucida receptor tyrosine kinase ZRK 6 Zonadhosin ZAN  6,

wherein the numbers listed in the column of protein function indicate: 1 enzyme 2 transport and storage 3 structure 4 immunity 5 neuronal transmission 6 growth and differentiation


4. The set of oligonucleotides according to claim 1, in which oligonucleotides containing up to 5% of the listed genes are not included..
 5. The set of oligonucleotides according to claim 1, in which oligonucleotides containing at least 95% of the listed genes together with a limited number of additional unlisted oligonucleotides are included.
 6. The set of oligonucleotides according to claim 1, in which up to 5% of the corresponding oligonucleotides of the listed genes are replaced by a complete set of 25% of other unlisted oligonucleotides.
 7. The set of oligonucleotides for a target group of genes according to at least one of the preceding claims in which the chemically pretreated DNA sequence of the genes to be detected coincides at least up to 95% with the correspondingly pretreated DNA sequence of genes from the above list.
 8. The set of oligonucleotides according to at least one of the preceding claims, wherein the chemical pretreatment is conducted by means of the solution of a bisulfite, hydrogen sulfite or disulfite.
 9. The set of oligonucleotides according to at least one of the preceding claims, comprising a subgroup of the target groups of genes.
 10. The set of oligonucleotides according to at least one of the preceding claims, in which the oligonucleotides are arranged on a support at known sites in a rectangular or hexagonal grid.
 11. The set of oligonucleotides according to at least one of the preceding claims, wherein the oligonucleotides are arranged on a support which is comprised of silicon, glass, polystyrene, aluminum, steel, iron, copper, nickel, silver, or gold.
 12. The set of oligonucleotides according to at least one of the preceding claims, wherein the oligonucleotide probes are labeled by means of their mass, electrostatics, charge or fluorescence, or are labeled with radionuclides.
 13. Use of a set of oligonucleotides according to at least one of the preceding claims in a biological investigation for the detection of said gene variants with respect to DNA methylation.
 14. A technical medical device, which contains a set of oligonucleotides according to one or more of claims 1 to 12, for use in an investigation for the detection of said gene variants, particularly as an indication of a higher risk of a patient or individual of developing symptoms and consequential signs of cancer or as an indication of a higher risk of the development of CNS malfunction, damage or disorder, or for the patient or individual to experience symptoms and consequences of CNS malfunction, damage or disorder.
 15. A technical medical device, which contains a set of oligonucleotides according to one or more of claims 1 to 12, for use in an investigation for the detection of variable gene expression and/or for the prognosis and for the management of patients, who suffer the risk of developing symptoms and consequential signs of cancer and/or for use in an investigation of whether a patient or individual may develop CNS malfunction, damage or disorder or whether it is probable that the patient or individual will experience symptoms and consequences of CNS malfunction, damage or disorder.
 16. A method for the investigation of the DNA methylation profile of a patient or individual, which detects the presence or the lack of the relevant methylation variants from the target group of genes, by hybridizing a chemically pretreated nucleic acid sample of said patient or individual to a set of oligonucleotides according to one or more of claims 1-12 and relating the hybridization pattern to the variations.
 17. Use of a set of oligonucleotides according to one or more of claims 1 to 12 or a device according to at least one of claims 14 or 15 to the prognosis and/or planned treatment for patients who suffer from a health problem or in whom the risks exists of the occurrence of a health problem.
 18. The use according to claim 17, for the prognosis and/or planned treatment for patients who suffer from the consequences of undesired drug interactions or in whom the risk exists of the occurrence of undesired drug interactions, who suffer from the risk of developing symptoms and consequential signs of cancer, who are affected by an increased risk of CNS malfunction, damage or disorder, who suffer from the consequences of symptoms of aggression or behavioral disturbances or in whom the risk exists of the occurrence of symptoms of aggression or behavioral disturbances, who suffer from the consequences of clinical, psychological and social consequences of a brain lesion, or in whom the risk exists of the occurrence of consequences of clinical, psychological and social consequences of a brain lesion, who suffer from dementia and/or associated syndromes or in whom the risk exists of the occurrence of dementia and/or associated syndromes, who suffer from the symptoms and consequences of psychotic disturbances and personality disorders, or in whom the risk exists of the occurrence of psychotic disturbances and personality disorders, who suffer from the symptoms or consequences of cardiovascular disorder, malfunction or damage, or in whom the risk exists of the occurrence of symptoms or consequences of cardiovascular disorder, malfunction or damage, who suffer from the symptoms and consequences of malfunction, damage or disease of the gastrointestinal tract, or in whom the risk exists of the occurrence of symptoms and consequences of malfunction, damage or disease of the gastrointestinal tract, who experience clinical or social consequences which result from malfunction, damage or disease of the respiratory system or in whom the risk exists of clinical or social consequences which result from malfunction, damage or disease of the respiratory system, who suffer from symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence, or in whom the risk exists of the occurrence of symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence, who suffer from the consequences of malfunction, damage or disorder of the body as a consequence of an abnormality in the developmental process or in whom the risk exists of the occurrence of malfunction, damage or disorder of the body as a consequence of an abnormality in the developmental process, who suffer from the consequences of a malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones or in whom the risk exists of the occurrence of a malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones, who suffer from the consequences of endocrine and metabolic malfunction, damage or disorder or in whom the risk exists of the occurrence of endocrine and metabolic malfunction, damage or disorder, who suffer from the consequences of headaches or in whom the risk exists of the occurrence of headaches, and/or who suffer from the consequences of sexual malfunctions or in whom the risk exists of the occurrence of sexual malfunctions.
 19. Use of a set of oligonucleotides according to one or more of claims 1 to 12 or a device according to at least one of claims 14 or 15 for predicting the probable therapeutic consequences of undesired drug interactions as a consequence of a therapeutic intervention and/or for predicting probable therapeutic consequences and adverse results as a consequence of a therapeutic intervention.
 20. Use of a set of oligonucleotides according to one or more of claims 1 to 12 or a device according to at least one of claims 14 or 15 for predicting probable therapeutic risks or undesired drug interactions as a consequence of ingestion of specific medications.
 21. Use of a set of oligonucleotides according to one or more of claims 1 to 12 or a device according to at least one of claims 14 or 15 for predicting probable symptoms in the case of occurrence of undesired drug interactions and the probability of the occurrence of consequential disorders or other symptoms and/or for the prediction of probable patterns of disorder symptoms and the probability of the occurrence of consequential disorders or other symptoms.
 22. Use of a set of oligonucleotides according to one or more of claims 1 to 12 or a device according to at least one of claims 14 or 15 for the development of new strategies in therapeutic intervention and in clinical studies and/or for the prognosis or the management of patients who suffer from developing symptoms of aggression or behavioral disturbances or who belong to risk groups for said disturbances, and/or for modeling and evaluating the effects of disorders and precautionary health measures for individuals, ethnic groups, patient groups, and populations and/or for generating a model in order to estimate the risk for individuals, ethnic groups, patient groups, and populations, of developing symptoms and consequential signs of cancer, and/or to generate a model for the evaluation of the risk of developing symptoms and consequential signs of CNS malfunction, damage or disorder and/or for optimizing the therapeutic intervention.
 23. A method for constructing a model for evaluating whether a health problem will occur or will probably occur in a patient, an individual or an ethnic group, which comprises the following steps: a) A DNA sample is taken from a patient or individual in which a health problem has been diagnosed; b) DNA samples taken from a control group of individuals, in which the presence of this health problem has been concluded diagnostically; c) The samples obtained in a) and b) are analyzed to determine the DNA methylation variation within the target group of genes according to one or more of claims 1 to 12; d) The frequency of alleles with different methylation patterns in samples from a) and b) is calculated; e) The frequencies of the alleles in the samples from a) and b) are compared; f) A statistical analysis is conducted of the results obtained under e) in order to obtain a model for evaluating the risk of the occurrence of health problems.
 24. The method according to claim 23, wherein the health problem is selected from: undesired drug interactions; cancer; symptoms and consequential signs of CNS malfunction, damage or disorder; developing symptoms of aggression or behavioral disturbances; consequences of clinical, psychological and social consequences of a brain lesion; dementia and/or associated syndromes; psychotic disturbances and personality disorders; symptoms or consequences of cardiovascular disorder, malfunction or damage; symptoms and consequences of malfunction, damage or disease of the gastrointestinal tract; malfunction, damage or disease of the respiratory system; symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence; malfunction, damage or disease of the body as a consequence of an abnormality in the development process; malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones; endocrine and metabolic malfunction, damage or disorder; headaches; sexual malfunctions.
 25. A method for evaluating whether a specific individual bears the risk of the occurrence of health problems, wherein the methylation profile is compared with the model constructed according to claim 23 or
 24. 26. The method according to one or more of claims 16 or 23 to 25, wherein at least one of the steps is conducted by a computer.
 27. A configured assay [kit] for utilizing the estimation of the risk of a patient or individual of experiencing adverse events and/or health problems, said kit containing: a) Possibilities for testing for the presence or absence of key relevant polymorphic DNA variations of the core group of genes as they are defined in claims 1 to 9 in a sample of genomic DNA. b) Reagents for use in the detection method. c) A script, which describes the probability of a patient or individual of experiencing adverse events and/or health problems.
 28. The configured assay [kit]for utilizing the estimation of the risk of a patient or individual of experiencing adverse events and/or health problems according to claim 27, further characterized in that the adverse event or the health problem is selected from: undesired drug interactions; cancer; symptoms and consequential signs of CNS malfunction, damage or disorder; developing symptoms of aggression or behavioral disturbances; consequences of clinical, psychological and social consequences of a brain lesion; dementia and/or associated syndromes; psychotic disturbances and personality disorders; symptoms or consequences of cardiovascular disorder, malfunction or damage; symptoms and consequences of malfunction, damage or disease of the gastrointestinal tract; malfunction, damage or disease of the respiratory system; symptoms and consequences of lesion, inflammation, infection, immunity and/or convalescence; malfunction, damage or disease of the body as a consequence of an abnormality in the development process; malfunction, damage or disorder of the skin, the muscles, the connective tissue or the bones; endocrine and metabolic malfunction, damage or disorder; headaches; sexual malfunctions. 